Petra C Kienesberger

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. doi Myocardial triacylglycerol metabolism
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
    J Mol Cell Cardiol 55:101-10. 2013
  2. pmc Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy
    Thomas Pulinilkunnil
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 62:1464-77. 2013
  3. doi Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice
    Jeevan Nagendran
    University of Alberta, Edmonton, Alberta, Canada
    Heart 99:1041-7. 2013
  4. pmc Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Cardiovasc Res 99:442-51. 2013
  5. pmc Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Mol Cell Biol 32:740-50. 2012
  6. doi Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery
    Jeevan Nagendran
    Cardiovascular Research Centre, Department of Pediatrics, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Division of Cardiac Surgery, Department of Surgery, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    J Mol Cell Cardiol 63:180-8. 2013
  7. doi AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation
    Beshay N M Zordoky
    From the Department of Pediatrics, Faculty of Medicine and Dentistry, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada B N M Z, J N, T P, P C K, G M, T J W, J R B D Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, Melbourne, Victoria, Australia B E K and Division of Endocrinology and Metabolism, Department of Medicine and Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada G R S
    Circ Res 115:518-24. 2014
  8. doi Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury
    Phing How Lou
    Cardiovascular Research Centre, University of Alberta, Edmonton, Canada
    Cardiovasc Res 97:251-61. 2013
  9. pmc Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice
    Bernard P C Kok
    Signal Transduction Research Group, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    J Lipid Res 53:105-18. 2012
  10. doi Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling
    Brent A McLean
    Department of Physiology, Department of Medicine, University of Alberta, Edmonton, Canada
    J Mol Cell Cardiol 54:9-18. 2013

Collaborators

Detail Information

Publications11

  1. doi Myocardial triacylglycerol metabolism
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
    J Mol Cell Cardiol 55:101-10. 2013
    ..This article is part of a Special Issue entitled "Focus on Cardiac Metabolism"...
  2. pmc Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy
    Thomas Pulinilkunnil
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 62:1464-77. 2013
    ....
  3. doi Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice
    Jeevan Nagendran
    University of Alberta, Edmonton, Alberta, Canada
    Heart 99:1041-7. 2013
    ....
  4. pmc Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Cardiovasc Res 99:442-51. 2013
    ..However, whether ATGL deficiency specifically in adult cardiomyocytes contributes to impaired PPARα activity, cardiac function, and metabolism is not known...
  5. pmc Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Mol Cell Biol 32:740-50. 2012
    ..Overall, this study shows that ATGL overexpression is sufficient to alter myocardial energy metabolism and improve cardiac function...
  6. doi Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery
    Jeevan Nagendran
    Cardiovascular Research Centre, Department of Pediatrics, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Division of Cardiac Surgery, Department of Surgery, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    J Mol Cell Cardiol 63:180-8. 2013
    ..As such, targeting cardiomyocyte FA uptake and FAO via inhibition of CD36 in the adult myocardium may provide therapeutic benefit during ischemia-reperfusion. ..
  7. doi AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation
    Beshay N M Zordoky
    From the Department of Pediatrics, Faculty of Medicine and Dentistry, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada B N M Z, J N, T P, P C K, G M, T J W, J R B D Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, Melbourne, Victoria, Australia B E K and Division of Endocrinology and Metabolism, Department of Medicine and Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada G R S
    Circ Res 115:518-24. 2014
    ..However, studies supporting this have not directly assessed whether the maintenance of FAO rates and subsequent cardiac function requires AMPK-dependent inhibitory phosphorylation of ACC...
  8. doi Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury
    Phing How Lou
    Cardiovascular Research Centre, University of Alberta, Edmonton, Canada
    Cardiovasc Res 97:251-61. 2013
    ..Understanding preservation of energy metabolism in diseased vs. healthy hearts may help to develop anti-ischaemic strategies effective also in jeopardized myocardium...
  9. pmc Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice
    Bernard P C Kok
    Signal Transduction Research Group, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    J Lipid Res 53:105-18. 2012
    ..However, lipin-1 deficiency increases the accumulation of newly synthesized phosphatidate and induces aberrant cell signaling...
  10. doi Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling
    Brent A McLean
    Department of Physiology, Department of Medicine, University of Alberta, Edmonton, Canada
    J Mol Cell Cardiol 54:9-18. 2013
    ..We then investigated parallel signaling pathways, and found that mitogen-activated protein kinase signaling was increased in PI3KαDN hearts, possibly through the inhibition of negative feedback loops downstream of PI3Kα...
  11. doi Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization
    David N Brindley
    Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, AB, Canada
    Am J Physiol Endocrinol Metab 298:E897-908. 2010
    ....