Lisa E Kalynchuk
Affiliation: University of Saskatchewan
- Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled ratsLisa E Kalynchuk
Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Sask, Canada S7N 5A5
Neurosci Lett 396:38-43. 2006..These results suggest that alterations in 5-HT1A receptors in the dentate gyrus may play a role in the expression of kindled fear...
- Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler miceApril L Lussier
Neural Systems and Plasticity Research Group, Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan S7V1C2, Canada
Neuropharmacology 60:1064-74. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
- The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrusApril L Lussier
Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A5, Canada
Neuropharmacology 71:174-83. 2013..These results support our hypothesis that reelin plays a role in the pathogenesis of depression and suggest that reelin could be an important target for the development of novel therapeutics for the treatment of depression...
- Altered synapsin I immunoreactivity and fear behavior in male and female rats subjected to long-term amygdala kindlingNeil M Fournier
Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Saskatchewan, Canada
Behav Brain Res 196:106-15. 2009..These results suggest that altered synaptic plasticity in specific brain regions might be involved in the exaggerated fearfulness produced by long-term amygdala kindling, especially in male rats...
- Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturationErin Y Fenton
Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Prog Neuropsychopharmacol Biol Psychiatry 60:52-9. 2015..All of these behavioral and cellular phenotypes were prevented by imipramine, providing further support for the idea that reelin is involved in the pathogenesis of depression. ..
- Decreased levels of disrupted-in-schizophrenia 1 (DISC1) are associated with expansion of the dentate granule cell layer in normal and kindled ratsNeil M Fournier
Department of Psychology, University of Saskatchewan, Saskatoon, SK, Canada
Neurosci Lett 455:134-9. 2009..These novel findings suggest that seizure activity affects DISC1 signaling in the dentate gyrus and that DISC1 expression may regulate the cytoarchitectural organization of the granule cell layer...
- Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: relevance to depressionErin Y Sterner
Department of Psychology, 9 Campus Drive, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A5
Prog Neuropsychopharmacol Biol Psychiatry 34:777-90. 2010..Further study with this model may provide important new data regarding the neurobiological bases of depression...
- Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strengthWendie Marks
Department of Psychology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A5
Physiol Behav 98:67-72. 2009..These results show that repeated CORT injections increase depression-like behavior regardless of the specific parameters of forced swim testing, and that these effects are independent of changes in locomotor activity or muscle strength...
- Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampusApril L Lussier
Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Saskatchewan S7N 5A5, Canada
Neurosci Lett 460:170-4. 2009..These novel findings suggest that altered reelin signaling could play a role in the expression of depressive symptomatology after exposure to high levels of glucocorticoids...
- Amygdala kindling decreases insulin-like growth factor-I receptor binding sites in the rat hippocampusLisa E Kalynchuk
Department of Psychology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
Brain Res 935:118-23. 2002..These results, in keeping with the established neurotrophic effects of IGF-I, suggest a potential role for this growth factor in mediating the structural alterations associated with kindling...
- Environmental enrichment facilitates amygdala kindling but reduces kindling-induced fear in male ratsNicole A Young
Department of Psychology, Dalhousie University, 1355 Oxford Street, Halifax, NS B3H 4J1, Canada
Behav Neurosci 118:1128-33. 2004..These results suggest that environmental enrichment has differential effects on kindling acquisition and its behavioral consequences...
- Amygdala kindling increases fear responses and decreases glucocorticoid receptor mRNA expression in hippocampal regionsLisa E Kalynchuk
Department of Psychology and Neuroscience Institute, Dalhousie University, 1355 Oxford Street, B3H 4J1, Halifax, Nova Scotia, Canada
Prog Neuropsychopharmacol Biol Psychiatry 27:1225-34. 2003..These results suggest that alterations in GR mRNA expression in hippocampal regions may play a role in the development of kindling-induced fear...
- Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressorSarah A Johnson
Centre for Addiction and Mental Health, Institute of Medical Science, University of Toronto, R 56, 250 College Street, Toronto, Ont, Canada M5T 1R8
Behav Brain Res 168:280-8. 2006..These results support the hypothesis that high levels of cortisol contribute to the etiology of depressive symptomatology in humans...
- Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female ratsLisa E Kalynchuk
Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada
Behav Neurosci 118:1365-77. 2004..These results suggest that repeated exposure to corticosterone increases depression-like behavior, with some effects on anxiety, and that male rats may be more affected than female rats by this manipulation...
- Sex and repeated restraint stress interact to affect cat odor-induced defensive behavior in adult ratsTara S Perrot-Sinal
Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
Brain Res 1027:161-72. 2004..These findings indicate the utility of the predator odor paradigm in detecting subtle shifts in naturally occurring anxiety-like behaviors that may occur differentially in males and females...
- Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male ratsAndrea Gregus
Molecular Psychiatry Laboratory, Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, NS, Canada B3H 4J1
Behav Brain Res 156:105-14. 2005..These results suggest that repeated CORT injections warrant further investigation as an animal model to study the role of stress in depression...
- Kindling-induced emotional behavior in male and female ratsAmanda J Wintink
Department of Psychology, Dalhousie University, 1355 Oxford Street, Halifax, Nova Scotia B3H 4J1, Canada
Behav Neurosci 117:632-40. 2003..These results suggest that kindling-induced fear is generally similar in male and female rats and that kindling does not appear to induce depression-like behavior...
- Postnatal inflammation increases seizure susceptibility in adult ratsMichael A Galic
Epilepsy and Brain Circuits Program, Hotchkiss Brain Institute, Department of Neuroscience, University of Calgary, Calgary, Alberta, Canada
J Neurosci 28:6904-13. 2008..These novel results indicate that a single LPS injection during a critical postnatal period causes a long-lasting increase in seizure susceptibility that is strongly dependent on TNFalpha...