Michael A S Jewett

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Lactate dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma
    Hala Girgis
    The Keenan Research Center in the Li Ka Shing Knowledge Institute, St, Michael s Hospital, Toronto M5B 1 W8, Canada
    Mol Cancer 13:101. 2014
  2. doi request reprint Active surveillance of small renal masses: progression patterns of early stage kidney cancer
    Michael A S Jewett
    Division of Urology, Department of Surgery and of Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada
    Eur Urol 60:39-44. 2011
  3. ncbi request reprint Nerve-sparing retroperitoneal lymphadenectomy
    Michael A S Jewett
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital and the University Health Network, Toronto, ON, Canada
    Urol Clin North Am 34:149-58; abstract viii. 2007
  4. ncbi request reprint Management of recurrence and follow-up strategies for patients with nonseminoma testis cancer
    Michael A S Jewett
    Division of Urology, University of Toronto, 610 University Avenue, 3 130 Toronto, Ontario, Canada M5G 2M9
    Urol Clin North Am 30:819-30. 2003
  5. doi request reprint Renal tumor natural history: the rationale and role for active surveillance
    Michael A S Jewett
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, 610 University Avenue, 3 124, Toronto, Ontario, Canada M5G 2C4
    Urol Clin North Am 35:627-34; vii. 2008
  6. pmc Radical prostatectomy as treatment for prostate cancer
    Michael A S Jewett
    Uro Oncology Program, Division of Urology, University of Toronto
    CMAJ 168:44-5. 2003
  7. ncbi request reprint The use of genetic markers to determine risk for prostate cancer at prostate biopsy
    Robert K Nam
    Division of Urology and Department of Pathology, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Clin Cancer Res 11:8391-7. 2005
  8. ncbi request reprint Clinical predictors of Gleason score upgrading: implications for patients considering watchful waiting, active surveillance, or brachytherapy
    Girish S Kulkarni
    Department of Surgery, Division of Urology, University Health Network, University of Toronto, Toronto, Canada
    Cancer 109:2432-8. 2007
  9. ncbi request reprint Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy
    Robert K Nam
    Division of Urology Department of Pathology, Sunnybrook Health Sciences Centre, University Health Network, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Clin Cancer Res 12:6452-8. 2006
  10. ncbi request reprint Correlation of the primary Gleason pattern on prostate needle biopsy with clinico-pathological factors in Gleason 7 tumors
    Ethan D Grober
    Division of Urology, Department of Surgery and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Urol 11:2157-62. 2004

Detail Information

Publications101 found, 100 shown here

  1. pmc Lactate dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma
    Hala Girgis
    The Keenan Research Center in the Li Ka Shing Knowledge Institute, St, Michael s Hospital, Toronto M5B 1 W8, Canada
    Mol Cancer 13:101. 2014
    ....
  2. doi request reprint Active surveillance of small renal masses: progression patterns of early stage kidney cancer
    Michael A S Jewett
    Division of Urology, Department of Surgery and of Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada
    Eur Urol 60:39-44. 2011
    ..Most early stage kidney cancers are renal cell carcinomas (RCCs), and most are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence suggests that most small RCCs grow slowly and rarely metastasize...
  3. ncbi request reprint Nerve-sparing retroperitoneal lymphadenectomy
    Michael A S Jewett
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital and the University Health Network, Toronto, ON, Canada
    Urol Clin North Am 34:149-58; abstract viii. 2007
    ..It behooves urologic oncologists to offer patients maximal therapeutic benefit combined with minimal morbidity and that retroperitoneal lymphadenectomy should be nerve sparing by definition...
  4. ncbi request reprint Management of recurrence and follow-up strategies for patients with nonseminoma testis cancer
    Michael A S Jewett
    Division of Urology, University of Toronto, 610 University Avenue, 3 130 Toronto, Ontario, Canada M5G 2M9
    Urol Clin North Am 30:819-30. 2003
    ..Therefore, to ensure improvement in salvage rates, patients are best managed in centers with extensive experience in NSGCT...
  5. doi request reprint Renal tumor natural history: the rationale and role for active surveillance
    Michael A S Jewett
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, 610 University Avenue, 3 124, Toronto, Ontario, Canada M5G 2C4
    Urol Clin North Am 35:627-34; vii. 2008
    ..Initial active surveillance with delayed treatment for progression for selected patients should be considered. This should result in an overall decrease in treatment burden and cost saving...
  6. pmc Radical prostatectomy as treatment for prostate cancer
    Michael A S Jewett
    Uro Oncology Program, Division of Urology, University of Toronto
    CMAJ 168:44-5. 2003
  7. ncbi request reprint The use of genetic markers to determine risk for prostate cancer at prostate biopsy
    Robert K Nam
    Division of Urology and Department of Pathology, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Clin Cancer Res 11:8391-7. 2005
    ..We examined a panel of 13 polymorphisms in 13 different genes to determine whether specific genotypes can help predict prostate cancer at the time of biopsy among men prescreened with prostate-specific antigen and digital rectal exam...
  8. ncbi request reprint Clinical predictors of Gleason score upgrading: implications for patients considering watchful waiting, active surveillance, or brachytherapy
    Girish S Kulkarni
    Department of Surgery, Division of Urology, University Health Network, University of Toronto, Toronto, Canada
    Cancer 109:2432-8. 2007
    ..However, many of these men harbor undetected high-grade disease (Gleason pattern > or =4). The ability to identify those individuals with occult high-grade disease may help guide treatment decisions in this patient cohort...
  9. ncbi request reprint Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy
    Robert K Nam
    Division of Urology Department of Pathology, Sunnybrook Health Sciences Centre, University Health Network, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Clin Cancer Res 12:6452-8. 2006
    ..We examined five variants of the KLK2 gene to further define its relevance to prostate cancer susceptibility and hK2 levels...
  10. ncbi request reprint Correlation of the primary Gleason pattern on prostate needle biopsy with clinico-pathological factors in Gleason 7 tumors
    Ethan D Grober
    Division of Urology, Department of Surgery and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Urol 11:2157-62. 2004
    ..To correlate the primary Gleason pattern among patients with biopsy-derived Gleason 7 tumors with the radical prostatectomy specimen Gleason grading and other clinical and pathologic outcomes...
  11. doi request reprint Pathological, oncologic and functional outcomes of radical prostatectomy following active surveillance
    Raj Satkunasivam
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    J Urol 190:91-5. 2013
    ..We examined prostatectomy pathology, and oncologic and functional outcomes of men progressing from active surveillance to radical prostatectomy...
  12. ncbi request reprint Stage II testicular seminoma: patterns of recurrence and outcome of treatment
    Peter W M Chung
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Eur Urol 45:754-59; discussion 759-60. 2004
    ..To review treatment outcome and patterns of failure for patients with stage II testicular seminoma and to identify prognostic factors for relapse...
  13. ncbi request reprint Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma
    Michelle L Gervais
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Lab Invest 87:1252-64. 2007
    ..These findings provide the first evidence of aberrant nuclear localization of E-cadherin in CC-RCC harboring VHL mutations, and suggest potential prognostic value of VHL and E-cadherin in CC-RCC...
  14. doi request reprint Nonprimary pT1 nonmuscle invasive bladder cancer treated with bacillus Calmette-Guerin is associated with higher risk of progression compared to primary T1 tumors
    Sultan S Alkhateeb
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, Toronto, Canada
    J Urol 184:81-6. 2010
    ..We examined this issue by comparing the prognosis of primary vs nonprimary T1 nonmuscle invasive bladder cancer treated with bacillus Calmette-Guerin...
  15. ncbi request reprint Making sense of prostate specific antigen: improving its predictive value in patients undergoing prostate biopsy
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Urol 175:489-94. 2006
    ..The clinical usefulness of PSA for prostate cancer screening is unclear, although the test remains in common use. New methods to interpret PSA are needed...
  16. ncbi request reprint Assessing individual risk for prostate cancer
    Robert K Nam
    Division of Urology, Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Clin Oncol 25:3582-8. 2007
    ..To construct a clinical nomogram instrument to estimate individual risk for having prostate cancer (PC) for patients undergoing prostate specific antigen (PSA) screening, using all risk factors known for PC...
  17. doi request reprint Effect of healthcare provider characteristics on nodal yield at radical cystectomy
    Girish S Kulkarni
    Department of Surgical Oncology, Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Urology 72:128-32. 2008
    ..We hypothesized that the final lymph node (LN) counts would be associated with the service provider (surgeon, pathologist) and the level of experience of the provider's assistant...
  18. doi request reprint A new and highly prognostic system to discern T1 bladder cancer substage
    Bas W G van Rhijn
    Department of Surgical Oncology, Division of Urology, University Health Network, Princess Margaret Hospital, Toronto, Canada
    Eur Urol 61:378-84. 2012
    ..Management of T1 bladder cancer (BCa) is controversial...
  19. doi request reprint A phase I trial of pre-operative radiotherapy for prostate cancer: clinical and translational studies
    Stephane Supiot
    Princess Margaret Hospital University Health Network, Toronto, Ont, Canada
    Radiother Oncol 88:53-60. 2008
    ..In a phase I trial, we investigated the feasibility of pre-operative radiotherapy for this patient subset...
  20. ncbi request reprint Nomogram prediction for prostate cancer and aggressive prostate cancer at time of biopsy: utilizing all risk factors and tumor markers for prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Can J Urol 13:2-10. 2006
    ..There is a large amount of confusion in interpreting prostate specific antigen (PSA) values for prostate cancer. More precise risk assessments for prostate cancer detection are needed for men faced with an abnormal PSA...
  21. ncbi request reprint Serum insulin-like growth factor-I levels and prostatic intraepithelial neoplasia: a clue to the relationship between IGF-I physiology and prostate cancer risk
    Robert K Nam
    Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, MG 406 Toronto, Ontario, Canada, M4N 3M5
    Cancer Epidemiol Biomarkers Prev 14:1270-3. 2005
    ..Larger studies will be required to confirm this relationship...
  22. doi request reprint Long-term follow-up of T1 high-grade bladder cancer after intravesical bacille Calmette-Guérin treatment
    David M Kakiashvili
    Department of Surgical Oncology Division of Urology, Princess Margaret Hospital, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    BJU Int 107:540-6. 2011
    ..To report the long-term results of bacille Calmette-Guérin (BCG) intravesical therapy in relation to disease progression and recurrence in primary T1 high-grade (HG) bladder cancer (BC) confirmed by central pathological review...
  23. ncbi request reprint Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 12:1429-37. 2003
    ..The GST-T1 and IGF-I polymorphisms demonstrated modest associations with prostate cancer risk. IGF-I levels were not helpful in identifying patients with prostate cancer at the time of biopsy...
  24. ncbi request reprint Delay in surgical therapy for clinically localized prostate cancer and biochemical recurrence after radical prostatectomy
    Robert K Nam
    Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Urol 10:1891-8. 2003
    ..We examined whether delay from diagnosis for patients undergoing surgery for clinically localized prostate cancer affects cancer cure rates...
  25. doi request reprint Upper urinary tract and urethral recurrences following radical cystectomy: review of risk factors and outcomes between centres with different follow-up protocols
    Nathan Perlis
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, M5G 2M9, Canada
    World J Urol 31:161-7. 2013
    ..Secondary objective is to evaluate whether or not recurrence patterns are similar between two centres with different post-RC follow-up (F/U) protocols...
  26. doi request reprint Prognostic value of molecular markers, sub-stage and European Organisation for the Research and Treatment of Cancer risk scores in primary T1 bladder cancer
    Bas W G van Rhijn
    Division of Urology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada
    BJU Int 110:1169-76. 2012
    ..Future studies may lead to the incorporation of sub-stage (T1m/T1e) in the TNM classification system for urinary BC to guide clinical decision-making in T1 BC...
  27. doi request reprint Cost-effectiveness analysis of immediate radical cystectomy versus intravesical Bacillus Calmette-Guerin therapy for high-risk, high-grade (T1G3) bladder cancer
    Girish S Kulkarni
    Division of Urology, Department of Surgical Oncology, University Health Network, Toronto, Ontario, Canada
    Cancer 115:5450-9. 2009
    ..Because bladder cancer is the most expensive malignancy to treat per patient, decisions regarding the optimal treatment strategy should consider costs...
  28. ncbi request reprint Techniques, safety and accuracy of sampling of renal tumors by fine needle aspiration and core biopsy
    Alessandro Volpe
    Department of Surgical Oncology Division of Urology, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Urol 178:379-86. 2007
    ..There have been concerns about safety and accuracy. This review provides an update on the current techniques, indications and accuracy of needle biopsy of renal tumors...
  29. doi request reprint No role for routine chest radiography in stage I seminoma surveillance
    Shaun Tolan
    Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada
    Eur Urol 57:474-9. 2010
    ..The optimal follow-up protocol for surveillance is yet to be determined but includes frequent chest radiography (CXR) and computed tomography (CT) scan of the abdomen and pelvis (CT-AP)...
  30. doi request reprint Select screening in a specific high-risk population of patients suggests a stage migration toward detection of non-muscle-invasive bladder cancer
    Alexandre R Zlotta
    Division of Urology, Mount Sinai Hospital, Toronto, Canada
    Eur Urol 59:1026-31. 2011
    ..Screening is unproven to enable the detection of more non-muscle-invasive tumors. BC association with aristolochic acid nephropathy (AAN) was reported after intake of slimming pills containing Chinese herbs...
  31. pmc The association between institution at orchiectomy and outcomes on active surveillance for clinical stage I germ cell tumours
    Madhur Nayan
    Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada
    Can Urol Assoc J 10:204-209. 2016
    ..The present study evaluated whether institution at orchiectomy was associated with outcomes on active surveillance (AS) for clinical stage (CS) I germ cell tumours (GCT)...
  32. doi request reprint Obesity is associated with risk of progression for low-risk prostate cancers managed expectantly
    Bimal Bhindi
    Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada Electronic address
    Eur Urol 66:841-8. 2014
    ..Active surveillance (AS) is an expectant management strategy for prostate cancer (PCa). The impact of obesity on progression is not well characterized in this population...
  33. doi request reprint Outcomes of small renal mass needle core biopsy, nondiagnostic percutaneous biopsy, and the role of repeat biopsy
    Michael J Leveridge
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    Eur Urol 60:578-84. 2011
    ..Percutaneous needle core biopsy has become established in the management of small renal masses ≤ 4 cm (SRMs). Recent series have reported success rates of ≥ 80%. Nondiagnostic results continue to be problematic...
  34. ncbi request reprint Variation in patterns of practice in diagnosing screen-detected prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    BJU Int 94:1239-44. 2004
    ....
  35. doi request reprint Partial orchiectomy for presumed malignancy in patients with a solitary testis due to a prior germ cell tumor: a large North American experience
    Nathan Lawrentschuk
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Urol 185:508-13. 2011
    ..Most data originate from Europe. Thus, we reviewed our North American experience with such men who underwent partial orchiectomy for a presumed contralateral testicular malignancy...
  36. ncbi request reprint Stage I nonseminomatous germ cell tumors: the case for management by risk stratification
    Abdullah M Al Ghamdi
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital and the University Health Network, and the University of Toronto, Toronto, Ontario, Canada
    Can J Urol 12:62-5; discussion 103-4. 2005
    ..Prognostic factors for high risk however, while well defined, do not identify all patients at risk and those that are destined to progress, can usually be salvaged with delayed therapy...
  37. doi request reprint MR elastography to measure the effects of cancer and pathology fixation on prostate biomechanics, and comparison with T 1, T 2 and ADC
    Deirdre M McGrath
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2M9, Canada
    Phys Med Biol 62:1126-1148. 2017
    ..The data obtained will improve the precision of prostate pathology correlation, leading to more accurate disease detection and targeting...
  38. doi request reprint The clinical utility of miR-21 as a diagnostic and prognostic marker for renal cell carcinoma
    Hala Faragalla
    Department of Laboratory Medicine, and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Mol Diagn 14:385-92. 2012
    ..Moreover, it has potential as a prognostic marker in RCC, although it is not independent of tumor stage and grade...
  39. ncbi request reprint A novel serum marker, total prostate secretory protein of 94 amino acids, improves prostate cancer detection and helps identify high grade cancers at diagnosis
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre and University Health Network, Toronto, Ontario, Canada
    J Urol 175:1291-7. 2006
    ..New biomarkers for prostate cancer are needed. We determined whether a novel serum marker, total PSP94 can be used to accomplish these goals...
  40. ncbi request reprint Long-term outcome of radiation-based conservation therapy for invasive bladder cancer
    Peter W M Chung
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario M5G 2M9, Canada
    Urol Oncol 25:303-9. 2007
    ..To report the long-term results and examine factors associated with bladder preservation, risk of relapse, and survival in patients treated with radical radiotherapy for invasive bladder cancer...
  41. doi request reprint Contemporary results of percutaneous biopsy of 100 small renal masses: a single center experience
    Alessandro Volpe
    Department of Surgical Oncology, Division of Urology, Medical Imaging, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Urol 180:2333-7. 2008
    ..We reviewed our experience with percutaneous needle biopsy of small renal masses to assess the safety and accuracy of the procedure, the potential predictors of a diagnostic result and the role of biopsy in clinical decision making...
  42. pmc Optimal management of high-risk T1G3 bladder cancer: a decision analysis
    Girish S Kulkarni
    Division of Urology, Department of Surgical Oncology, University of Toronto, Toronto, Ontario, Canada
    PLoS Med 4:e284. 2007
    ..We estimated life expectancy (LE) and quality-adjusted life expectancy (QALE) for both of these treatments for men and women of different ages and comorbidity levels...
  43. doi request reprint Conditional Risk of Relapse in Surveillance for Clinical Stage I Testicular Cancer
    Madhur Nayan
    Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Canada
    Eur Urol 71:120-127. 2017
    ..The conditional risk of relapse (cRR), which provides prognostic information on patients who have survived for a period of time without relapse, have not been determined for CSI testicular cancer...
  44. doi request reprint Testicular cancer survivors' supportive care needs and use of online support: a cross-sectional survey
    Jacqueline L Bender
    ELLICSR Health, Wellness and Cancer Survivorship Centre, Toronto General Hospital, 200 Elizabeth Street, Toronto, M5G 2C4, ON, Canada
    Support Care Cancer 20:2737-46. 2012
    ..Likewise, there is limited research on their use of the Internet or social media applications--tools that are popular among young adults and which could be used to address their needs...
  45. doi request reprint The FGFR3 mutation is related to favorable pT1 bladder cancer
    Bas W G van Rhijn
    Division of Urology, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Urol 187:310-4. 2012
    ..We determined the frequency of FGFR3 mutations and P53 alterations in patients with pT1 bladder cancer and correlated these data to histopathological variables and clinical outcomes...
  46. doi request reprint High risk NSGCT: case for surveillance
    David Michael Kakiashvili
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, ON, M5G 2M9, Canada
    World J Urol 27:441-7. 2009
    ....
  47. ncbi request reprint Spermatocytic seminoma: a review
    Peter W M Chung
    Department of Radiation Oncology, Princess Margaret Hospital, 610, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Eur Urol 45:495-8. 2004
    ..Spermatocytic seminoma is a rare testicular tumour that has an extremely low rate of metastasis. We present a review of the management of this malignancy at our institution...
  48. pmc Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus
    Frederik C Roos
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    EMBO Mol Med 2:275-88. 2010
    ..These findings provide compelling pre-clinical evidence for the usage of EMCV in the treatment of CCRCC and potentially other tumours with elevated HIF/NF-kappaB-survival signature...
  49. ncbi request reprint The natural history of incidentally detected small renal masses
    Alessandro Volpe
    Division of Urology, Department of Surgical Oncology, University Health Network Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer 100:738-45. 2004
    ..Most renal tumors are detected incidentally as small, asymptomatic masses. To study their natural history, the authors prospectively followed a series of patients with this type of lesion who were unsuited for or refused surgery...
  50. doi request reprint Statin use and kidney cancer outcomes: A propensity score analysis
    Madhur Nayan
    Department of Surgery, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada
    Urol Oncol 34:487.e1-487.e6. 2016
    ..Our objective was to evaluate this association in a large clinical cohort by using propensity score methods to reduce confounding from measured covariates...
  51. doi request reprint Hematologic Parameters to Predict Small Renal Mass Biopsy Pathology
    Madhur Nayan
    Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada Electronic address
    Clin Genitourin Cancer 14:226-30. 2016
    ..The present study evaluated various hematologic parameters and their association with renal tumor biopsy pathology...
  52. pmc The initiation of a multidisciplinary bladder cancer clinic and the uptake of neoadjuvant chemotherapy: A time-series analysis
    Madhur Nayan
    Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada
    Can Urol Assoc J 10:25-30. 2016
    ....
  53. doi request reprint Metformin Use and Kidney Cancer Outcomes in Patients With Diabetes: A Propensity Score Analysis
    Madhur Nayan
    Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, ON, Canada
    Clin Genitourin Cancer . 2016
    ..However, studies evaluating the association between metformin use and kidney cancer survival outcomes have demonstrated conflicting results...
  54. doi request reprint The effect of metformin on cancer-specific survival outcomes in diabetic patients undergoing radical cystectomy for urothelial carcinoma of the bladder
    Madhur Nayan
    Department of Surgery, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Canada Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Canada Electronic address
    Urol Oncol 33:386.e7-13. 2015
    ..Our objective was to evaluate the association between metformin use and oncologic outcomes in diabetic patients undergoing radical cystectomy (RC) for bladder cancer (BC)...
  55. doi request reprint Lymph Node Yield in Primary Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumors
    Madhur Nayan
    Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Urol 194:386-91. 2015
    ..However, there are limited data on the significance of the number of nodes removed at retroperitoneal lymph node dissection performed for testicular nonseminoma germ cell tumors...
  56. doi request reprint The importance of surgeon characteristics on impacting oncologic outcomes for patients undergoing radical cystectomy
    Bimal Bhindi
    Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada Electronic address
    J Urol 192:714-9. 2014
    ..Therefore, we assessed associations between various surgeon characteristics and long-term oncologic outcomes for patients undergoing radical cystectomy for bladder cancer...
  57. ncbi request reprint Diagnosis and treatment of small renal masses: the role for molecular biology
    Ghada Kurban
    Ontario Cancer Institute, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
    Arch Esp Urol 66:505-16. 2013
    ..Tumor growth rate also appears to identify potential progressive tumours. Identifying signatures for progression and the utilization of needle biopsies will be important for SRM patients and will guide therapy. ..
  58. doi request reprint Pathological stage review is indicated in primary pT1 bladder cancer
    Bas W G van Rhijn
    Department of Surgical Oncology, Mount Sinai Hospital, Toronto, Canada
    BJU Int 106:206-11. 2010
    ..To evaluate the effect of a pathology review on the clinical outcome of patients with primary pT1 bladder cancer (BC), as the clinical course of such patients is variable...
  59. doi request reprint The once and future role of cytoreductive nephrectomy
    Mischel G Neill
    Division of Urology, Departments of Surgery and of Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada
    Urol Oncol 26:346-52. 2008
    ..This article reviews the evolution of cytoreductive nephrectomy and speculates on its role in the new frontier of molecular targeting for metastatic renal cell carcinoma...
  60. ncbi request reprint Prevention and management of osteoporosis in men receiving androgen deprivation therapy: a survey of urologists and radiation oncologists
    Shabbir M H Alibhai
    Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
    Urology 68:126-31. 2006
    ..To determine the current practice of clinicians in the diagnosis and management of osteoporosis among men taking androgen deprivation therapy (ADT), because ADT leads to decreased bone mineral density (BMD) and fractures...
  61. pmc VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
    Andrew J Evans
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Cell Biol 27:157-69. 2007
    ..These findings reveal a critical HIF-dependent molecular pathway connecting VHL, an established "gatekeeper" of the renal epithelium, with a major epithelial tumor suppressor, E-cadherin...
  62. ncbi request reprint Evidence for a biopsy derived grade artifact among larger prostate glands
    Girish S Kulkarni
    Division of Urology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    J Urol 175:505-9. 2006
    ..One plausible explanation for this finding is that tumor grade as assigned by TRUS guided biopsy is artifactually associated with prostate volume...
  63. pmc Identification of the best complete blood count-based predictors for bladder cancer outcomes in patients undergoing radical cystectomy
    Bimal Bhindi
    Division of Urology, Department of Surgery, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Br J Cancer 114:207-12. 2016
    ..We sought to determine which parsimonious combination of complete blood count (CBC)-based biomarkers most efficiently predicts oncologic outcomes in patients undergoing radical cystectomy (RC) for bladder cancer (BC)...
  64. doi request reprint Renal Tumor Biopsy for Small Renal Masses: A Single-center 13-year Experience
    Patrick O Richard
    Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Ontario, Canada
    Eur Urol 68:1007-13. 2015
    ..Renal tumor biopsy (RTB) for the characterization of small renal masses (SRMs) has not been widely adopted despite reported safety and accuracy. Without pretreatment biopsy, patients with benign tumors are frequently overtreated...
  65. doi request reprint Molecular and clinical support for a four-tiered grading system for bladder cancer based on the WHO 1973 and 2004 classifications
    Bas W G van Rhijn
    1 Division of Urology, Department of Surgical Oncology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada 2 Department of Urology, Erasmus MC, Rotterdam, The Netherlands 3 Department of Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada 4 Department of Urology, Sint Franciscus Hospital, Rotterdam, The Netherlands
    Mod Pathol 28:695-705. 2015
    ....
  66. doi request reprint Small renal mass: what the urologist needs to know for treatment planning and assessment of treatment results
    Oleksandr Stakhovskyi
    Division of Urology, Department of Surgery, Princess Margaret Hospital and the University Health Network, University of Toronto, 610 University Ave, 3 124, Toronto, Ontario M5G 2C4, Canada
    AJR Am J Roentgenol 196:1267-73. 2011
    ..Small renal mass is a new distinct clinical entity. Detection of these tumors has increased with increased use of imaging...
  67. doi request reprint MicroRNAs in kidney disease: an emerging understanding
    Heba W Z Khella
    Department of Laboratory Medicine and the Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Canada
    Am J Kidney Dis 61:798-808. 2013
    ..Moreover, miRNAs represent an attractive therapeutic target for a number of kidney diseases. We close by discussing a number of potential challenges that face the field of miRNA research and clinical use...
  68. doi request reprint Needle core biopsies provide ample material for genomic and proteomic studies of kidney cancer: observations on DNA, RNA, protein extractions and VHL mutation detection
    Ghada Kurban
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Pathol Res Pract 208:22-31. 2012
    ..They are good representatives of their corresponding tumors for VHL mutation detection using both bulk and LCM extractions. LCM does not increase sensitivity of VHL mutation detection...
  69. ncbi request reprint The role of surveillance for small renal masses
    Alessandro Volpe
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, Canada
    Nat Clin Pract Urol 4:2-3. 2007
  70. ncbi request reprint Nerve-sparing retroperitoneal lymphadenectomy using hydro-jet dissection: initial experience
    Bijan Shekarriz
    Division of Urology, Princess Margaret Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Endourol 18:273-6. 2004
    ..A small high-pressure stream of water is used to delineate surgical planes, with preservation of vascular and neural structures. We have examined the utility of this technology for RPL in a porcine model and in human subjects...
  71. doi request reprint Assessing outcomes in probe ablative therapies for small renal masses
    Michael J Leveridge
    Urooncology Fellowship Program, University of Toronto, Toronto, Ontario, Canada
    J Endourol 24:759-64. 2010
    ..This review highlights these potential pitfalls in the assessment of outcomes of probe ablation of SRMs...
  72. doi request reprint Most renal oncocytomas appear to grow: observations of tumor kinetics with active surveillance
    Sarah Kawaguchi
    Division of Urology, Department of Surgery, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    J Urol 186:1218-22. 2011
    ..We examined the growth of tissue proven renal oncocytoma on serial imaging to improve our understanding of its natural history...
  73. ncbi request reprint Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma
    Mindy A Maynard
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    FASEB J 19:1396-406. 2005
    ..These results demonstrate an important dominant-negative regulation of HIF-1-mediated gene transcription by HIF-3alpha4 in vivo and underscore its potential significance in renal epithelial oncogenesis...
  74. ncbi request reprint Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection
    Robert K Nam
    Division of Urology, 2075 Bayview Ave, MG 406, Toronto, Ontario, Canada, M4N 3M5
    J Clin Oncol 21:2312-9. 2003
    ..We examined the relationship between a mutant (T) for wild-type (C) allele substitution of the human kallikrein-2 gene (KLK2), circulating human kallikrein-2 (hK2) levels and prostate cancer risk...
  75. ncbi request reprint Testicular radiation for primary seminoma in a solitary testis
    Peter W M Chung
    Department of Radiation, Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Can J Urol 13:2975-7. 2006
    ..He was treated with radiotherapy to the testis. Post treatment biopsy revealed no evidence of disease. At 32 months follow-up, he has not required androgen replacement. He has preservation of total testosterone level and libido...
  76. doi request reprint A fast and simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS)
    Mohamed Abdelgawad
    Department of Mechanical and Industrial Engineering, University of Toronto, 5 King s College Road, Toronto, Ontario M5S 3G8, Canada
    Lab Chip 11:545-51. 2011
    ..A comparison between the performance of square and circular microchannels in trapping SiHa cells (cervical cancer cell line) is shown...
  77. doi request reprint Structured electronic operative reporting: comparison with dictation in kidney cancer surgery
    Darryl N Hoffer
    Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
    Int J Med Inform 81:182-91. 2012
    ..To do this, we compared completeness and timeliness of eKidney template-generated nephrectomy OR notes with standard narrative dictation...
  78. ncbi request reprint Appropriate radiation volume for stage IIA/B testicular seminoma
    Peter W M Chung
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 56:746-8. 2003
    ..To address this issue, we reviewed patterns of failure and treatment outcome in patients treated with radiation therapy at our institution...
  79. ncbi request reprint The uncertainty of radio frequency treatment of renal cell carcinoma: findings at immediate and delayed nephrectomy
    Ricardo A Rendon
    Division of Urology, Department of Surgery, University Health Network, University of Toronto, Ontario, Canada
    J Urol 167:1587-92. 2002
    ..We now report our early experience in the treatment of renal cell carcinoma in patients who underwent post-radio frequency radical or partial nephrectomy...
  80. ncbi request reprint Changes in dielectric properties at 460 kHz of kidney and fat during heating: importance for radio-frequency thermal therapy
    Mihaela Pop
    Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Phys Med Biol 48:2509-25. 2003
    ..Structural events occurring during heating at different target temperatures as determined by histological analyses were correlated with the changes in the measured dielectric properties...
  81. ncbi request reprint The natural history of small renal masses
    Alessandro Volpe
    Division of Urology, Department of Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, Canada
    Nat Clin Pract Urol 2:384-90. 2005
    ....
  82. doi request reprint Organ-sparing approaches for testicular masses
    Alvaro Zuniga
    Department of Surgical Oncology, Division of Urology, Princess Margaret Hospital and the University Health Network, University of Toronto, 610 University Avenue, 3 124, Toronto, ON M5G 2C4, Canada
    Nat Rev Urol 7:454-64. 2010
    ..However, the safety and efficacy of these procedures needs to be demonstrated in comparison with partial orchiectomy in larger and prospective studies with longer follow-up...
  83. ncbi request reprint Treatment of the inguinal regions in penile cancer: a review of the literature and treatment proposal
    Daniel Taussky
    Department of Radiation Oncology and Surgical Oncology, Princess Margaret Hospital and the University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Urol 13:2978-83. 2006
    ..The literature, which consists mainly of retrospective studies of patients treated over several decades, is not conclusive. We undertook a literature review to address this issue and to propose...
  84. ncbi request reprint Variability in size measurement of renal masses smaller than 4 cm on computerized tomography
    Sanoj Punnen
    Department of Surgery Urology, University of Toronto, Toronto, Ontario, Canada
    J Urol 176:2386-90; discussion 2390. 2006
    ..We assessed the degree of interobserver and intra-observer variability in the size measurement of small renal tumors with computerized tomography...
  85. ncbi request reprint Consolidative renal cell carcinoma metastatectomy for partial response after multitargeted tyrosine kinase inhibitor therapy
    Mischel G Neill
    Department of Urologic Oncology, University Health Network, Toronto, Ontario, Canada
    Urology 70:178.e9-11. 2007
    ..Some of the issues complicating operative intervention in the setting of multitargeted tyrosine kinase inhibitors are discussed...
  86. pmc The Canadian Urology Fair: a model for minimizing the financial and academic costs of the residency selection process
    Ethan D Grober
    Division of Urology, Department of Surgery, University of Toronto, Toronto, Ont
    Can J Surg 46:458-62. 2003
    ..The objective of the current study was to evaluate the success of the Urology Fair in achieving its original goals of decreasing the financial burden and minimizing time away from medical training for applicants and faculty...
  87. pmc The concept and trajectory of "operative competence" in surgical training
    Ethan D Grober
    Faculty of Medicine Centre for Research in Education and the Division of Urology, University Health Network, University of Toronto, Toronto, ON
    Can J Surg 49:238-40. 2006
  88. ncbi request reprint Watchful waiting for small renal masses
    Kamal Mattar
    Department of Surgery Urology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, 3 124, Toronto, ON, M5G 2C4, Canada
    Curr Urol Rep 9:22-5. 2008
    ..Needle core use for improved histopathologic characterization of SRMs should be considered before recommending treatment...
  89. ncbi request reprint Cryotherapy and radiofrequency ablation: pathophysiologic basis and laboratory studies
    Antonio Finelli
    Department of Surgical Oncology, Princess Margaret Hospital and University of Toronto, Ontario, Canada
    Curr Opin Urol 13:187-91. 2003
    ..We will review the recent clinical and laboratory studies that have formed the scientific foundation of the current clinical protocols and how these protocols may change in light of recent observations...
  90. ncbi request reprint The ten-year rule revisited: accuracy of clinicians' estimates of life expectancy in patients with localized prostate cancer
    Murray D Krahn
    Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Urology 60:258-63. 2002
    ....
  91. ncbi request reprint The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma
    Roxana I Sufan
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8
    Am J Physiol Renal Physiol 287:F1-6. 2004
    ..Recent insights into the molecular mechanisms regulating the function of pVHL, and thereby HIF, in the context of kidney cancer are the focus of this review...
  92. ncbi request reprint Laparoscopic prostatectomy: here to stay
    Michael A S Jewett
    Division of Urology and Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Ontario, Canada
    Can J Urol 9:14-7. 2002
    ..Laparoscopic radical prostatectomy is a procedure that will be more widely practiced in North America as several of the technological limitations are overcome and as surgeons become more experienced with laparoscopic surgery...
  93. pmc The Y deletion gr/gr and susceptibility to testicular germ cell tumor
    Katherine L Nathanson
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 77:1034-43. 2005
    ..0; 95% CI 1.6-5.4; P = .0004) than with nonseminoma TGCT (aOR 1.5; 95% CI 0.72-3.0; P = .29). These data indicate that the Y microdeletion gr/gr is a rare, low-penetrance allele that confers susceptibility to TGCT...
  94. pmc Personal finances of residents at three Canadian universities
    Joel M H Teichman
    Division of Urology, University of Texas Health Science Center, San Antonio, Tex, USA
    Can J Surg 48:27-32. 2005
    ....
  95. pmc Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors
    Rachel Linger
    Testicular Cancer Genetics Team, Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Genes Chromosomes Cancer 47:247-52. 2008
    ..Whether it is disease-causing or not, mutations in DND1 make, at most, a very small contribution to TGCT susceptibility in adults and adolescents...
  96. pmc Advances in the medical management of benign prostatic hyperplasia
    Michael A S Jewett
    Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ont
    CMAJ 176:1850-1. 2007
  97. ncbi request reprint Re: can restaging transurethral resection of T1 bladder cancer select patients for immediate cystectomy? H. W. Herr, S. M. Donat and G. Dalbagni J Urol 2007; 177: 75-79
    Alan M Nieder
    J Urol 178:352. 2007
  98. pmc Defining a 0.5-mb region of genomic gain on chromosome 6p22 in bladder cancer by quantitative-multiplex polymerase chain reaction
    Andrew J Evans
    Department of Pathology, University Health Network Princess Margaret Hospital, Toronto Ontario, Canada
    Am J Pathol 164:285-93. 2004
    ..This also represents the first study identifying DNA copy number increases for DEK in bladder cancer...
  99. ncbi request reprint Expectant management for the treatment of small renal masses
    Ricardo A Rendon
    Department of Urology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Urol Oncol 24:62-7. 2006
    ..We conclude that expectant management is a viable and safe option for the patient with a short life expectancy but potentially unsafe outside a well-controlled clinical trial in the younger and fit patient...
  100. ncbi request reprint Management of stage T1 tumors of the bladder: International Consensus Panel
    Alan M Nieder
    Department of Urology, State University New York, Stony Brook, New York, USA
    Urology 66:108-25. 2005
    ..Finally, what therapies exist if initial intravesical bacille Calmette-Guérin fails to eradicate the disease or prevent recurrence? The panel thoroughly explored all these subjects and has made recommendations with supporting evidence...
  101. ncbi request reprint Genome-wide linkage screen for testicular germ cell tumour susceptibility loci
    Gillian P Crockford
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    Hum Mol Genet 15:443-51. 2006
    ..Overall, the results indicate that no single major locus can account for the majority of the familial aggregation of TGCT, and suggests that multiple susceptibility loci with weak effects contribute to the disease...