J E Jan
Affiliation: University of British Columbia
- Clinical trials of controlled-release melatonin in children with sleep-wake cycle disordersJ E Jan
Visually Impaired Program, BC s Children s Hospital, Vancouver, Canada
J Pineal Res 29:34-9. 2000..7 mg (2-12 mg). The studies showed that the FR melatonin was most effective when there was only delayed sleep onset, but CR formulations were more useful for sleep maintenance. Children appeared to require higher doses than adults...
- Evidence supporting the use of melatonin in short gestation infantsJames E Jan
Melatonin Research Group, Department of Psychiatry, BC Children s Hospital, Vancouver, BC, Canada, and Child Health, Chelsea and Westminster Campus, Imperial College, London, UK
J Pineal Res 42:22-7. 2007..We believe that this treatment might result in a wide range of health benefits, improved quality of life and reduced healthcare costs...
- Sleep hygiene for children with neurodevelopmental disabilitiesJames E Jan
Child and Family Research Institute, University of British Columbia and BC Children s Hospital, 4500 Oak St, Vancouver, British Columbia, Canada V6H 3N1
Pediatrics 122:1343-50. 2008....
- Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilitiesJames E Jan
Pediatric Neurology, University of British Columbia, Vancouver, BC, Canada
Eur J Paediatr Neurol 16:403-12. 2012..In the future, the existing definitions for the different forms of CRSD should be modified by experts in pediatric sleep medicine in order to include children with neurodevelopmental disabilities...
- Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade?James E Jan
BC s Children s Hospital, Vancouver, Canada
Dev Med Child Neurol 46:776-82. 2004
- The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disordersJames E Jan
Melatonin Research Group, BC Children s Hospital, Vancouver, Canada
J Pineal Res 46:1-7. 2009..Together, the thalamic and chronobiological control of sleep leads to a new and improved understanding of the pathophysiology of circadian rhythm sleep disorders and also of the principles of sleep hygiene interventions...
- Long-term sleep disturbances in children: a cause of neuronal lossJames E Jan
Pediatric Neurology and Developmental Pediatrics, University of British Columbia, BC, Canada
Eur J Paediatr Neurol 14:380-90. 2010..Further research is urgently needed because these findings have major implications for the treatment of sleep disorders...
- Melatonin has membrane receptor-independent hypnotic action on neurons: an hypothesisJames E Jan
Diagnostic Neurophysiology, BC Children s Hospital, Vancouver, BC, Canada
J Pineal Res 50:233-40. 2011..Thus, the hypnotic action of melatonin and the mechanisms involving the circadian rhythms are separate neurological functions. This is contrary to the presently accepted view...
- Melatonin replacement therapy in a child with a pineal tumorJ E Jan
Division of Developmental Paediatrics, University of British Columbia, Vancouver
J Child Neurol 16:139-40. 2001..Sleep difficulties should be considered in the management of pineal lesions. Melatonin replacement therapy is beneficial for those patients who have deficient melatonin synthesis...
- Cerebral modulation of circadian sleep-wake rhythmsJames E Jan
Diagnostic Neurophysiology, British Columbia Children s Hospital, 4500 Oak Street, Vancouver, BC, Canada
J Clin Neurophysiol 28:165-9. 2011....
- Long-term outcome of children with cortical visual impairmentCarey A Matsuba
BC s Children s Hospital, Vancouver, BC, Canada
Dev Med Child Neurol 48:508-12. 2006..Additional disabilities were common, but those children with better visual acuity outcomes faired better. Given the frequency of comorbid conditions, appropriate diagnostic assessment services are needed...
- Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiologyR Brennan
Department of Ophthalmology, British Columbia Children s Hospital, Vancouver, British Columbia, Canada
Eye (Lond) 21:901-8. 2007..In this review, we discuss the physiological roles of melatonin in the eye, as well as the potential therapeutic avenues currently under study...
- Eye-pokingJ E Jan
Department of Paediatrics, University of British Columbia, Vancouver, Canada
Dev Med Child Neurol 36:321-5. 1994..The treatment is exceedingly difficult. Further studies are needed to develop specific management techniques to prevent eye-poking, which adds to the physical and emotional burden on the caregivers...
- Visual impairment due to a dyskinetic eye movement disorder in children with dyskinetic cerebral palsyJ E Jan
Division of Developmental Pediatrics, Visually Impaired Program, British Columbia's Children's Hospital, Vancouver, Canada
Dev Med Child Neurol 43:108-12. 2001..They are often misdiagnosed as blind, due to cortical visual impairment. Early recognition of dyskinetic eye moment disorder and appropriate developmental and educational management are important...
- Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disordersRoxanne Carr
Melatonin Research Group, Department of Psychiatry, BC Children s Hospital, Vancouver, BC, Canada
J Pineal Res 43:351-9. 2007..Hypnotics for children with CRSD should be considered a second line of treatment for those who fail to respond to sleep hygiene and/or melatonin...
- A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilitiesMichael B Wasdell
Melatonin Research Group, Department of Psychiatry, BC Children s Hospital, Vancouver, Canada
J Pineal Res 44:57-64. 2008..Children with neurodevelopmental disabilities, who had treatment resistant chronic delayed sleep phase syndrome and impaired sleep maintenance, showed improvement in melatonin therapy...
- Conscious visual abilities in a patient with early bilateral occipital damageDeborah Giaschi
Department of Ophthalmology, University of British Columbia UBC, Vancouver, Canada
Dev Med Child Neurol 45:772-81. 2003..This case demonstrates remarkable plasticity in the human visual system and may have implications for understanding the functional organization of the motion pathways...
- Optic nerve hypoplasia with intracranial arachnoid cystChristopher Lyons
Department of Ophthalmology, British Columbia Children s Hospital, Bancouver, British Columbia, Canada
J AAPOS 8:61-6. 2004..The frequent association between optic nerve hypoplasia (ONH) and other central nervous system abnormalities has been widely reported in the literature. Occasional reference has been made to arachnoid cyst as one of the associated findings...
- 'Visual impairment in children with brain damage'Carey A Matsuba
Dev Med Child Neurol 46:720. 2004
- Re: Mann--melatonin for ulcerative colitis?James E Jan
Am J Gastroenterol 98:1446. 2003
- Melatonin--an orphan drugJames E Jan
Dev Med Child Neurol 50:558. 2008
- Visual development in preterm infantsAshima Madan
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
Dev Med Child Neurol 47:276-80. 2005