William D Hutchison

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordings
    William D Hutchison
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
    J Neurosci 24:9240-3. 2004
  2. ncbi request reprint Pallidal neuronal activity: implications for models of dystonia
    William D Hutchison
    Department of Surgery, Division of Neurosurgery and Toronto Western Research Institute, Toronto Western Hospital and Faculty of Medicine, University of Toronto, Ontario, Canada
    Ann Neurol 53:480-8. 2003
  3. ncbi request reprint Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
    Moran Weinberger
    Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 96:3248-56. 2006
  4. doi request reprint Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 20:1549-53. 2009
  5. doi request reprint Pedunculopontine nucleus microelectrode recordings in movement disorder patients
    Moran Weinberger
    Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
    Exp Brain Res 188:165-74. 2008
  6. doi request reprint High-frequency microstimulation in human globus pallidus and substantia nigra
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Medical Sciences Building Room 3302, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Exp Brain Res 205:251-61. 2010
  7. doi request reprint Modulation of Beta oscillations in the subthalamic nucleus with prosaccades and antisaccades in Parkinson's disease
    Akihiro Yugeta
    Division of Neurology, Toronto Western Research Institute, and the Edmond J Safra Program in Parkinson s Disease, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 33:6895-904. 2013
  8. ncbi request reprint Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease
    Joyce K H Tang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:720-9. 2007
  9. doi request reprint Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:110-4. 2009
  10. ncbi request reprint Eye movement-related responses of neurons in human subthalamic nucleus
    Adrian P Fawcett
    Dept of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Exp Brain Res 162:357-65. 2005

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordings
    William D Hutchison
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
    J Neurosci 24:9240-3. 2004
  2. ncbi request reprint Pallidal neuronal activity: implications for models of dystonia
    William D Hutchison
    Department of Surgery, Division of Neurosurgery and Toronto Western Research Institute, Toronto Western Hospital and Faculty of Medicine, University of Toronto, Ontario, Canada
    Ann Neurol 53:480-8. 2003
    ..The widely accepted pathophysiological models of dystonia that propose global decreases in basal ganglia output need to be viewed with caution in light of these findings...
  3. ncbi request reprint Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
    Moran Weinberger
    Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 96:3248-56. 2006
    ..The study also suggests that LFP beta oscillatory activity is generated largely within the dorsal portion of the STN and can produce synchronous oscillatory activity of the local neuronal population...
  4. doi request reprint Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 20:1549-53. 2009
    ..These findings confirm and extend earlier findings suggesting that in PD there are marked changes in basal ganglia oscillatory activity and that these can be reversed after dopaminergic therapy...
  5. doi request reprint Pedunculopontine nucleus microelectrode recordings in movement disorder patients
    Moran Weinberger
    Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
    Exp Brain Res 188:165-74. 2008
    ..It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy...
  6. doi request reprint High-frequency microstimulation in human globus pallidus and substantia nigra
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Medical Sciences Building Room 3302, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Exp Brain Res 205:251-61. 2010
    ..The findings suggest that high-frequency microstimulation of the GPi and SNr depresses local neuronal activity and synaptic transmission, and such mechanisms may contribute to the therapeutic effects of DBS...
  7. doi request reprint Modulation of Beta oscillations in the subthalamic nucleus with prosaccades and antisaccades in Parkinson's disease
    Akihiro Yugeta
    Division of Neurology, Toronto Western Research Institute, and the Edmond J Safra Program in Parkinson s Disease, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 33:6895-904. 2013
    ..Beta-band desynchronization in the STN may reflect the additional processes associated with suppression of reflexive responses and volitional execution of saccades in the opposite direction...
  8. ncbi request reprint Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease
    Joyce K H Tang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:720-9. 2007
    ..These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders...
  9. doi request reprint Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:110-4. 2009
    ..This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114...
  10. ncbi request reprint Eye movement-related responses of neurons in human subthalamic nucleus
    Adrian P Fawcett
    Dept of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Exp Brain Res 162:357-65. 2005
    ....
  11. doi request reprint Spatial extent of β oscillatory activity in and between the subthalamic nucleus and substantia nigra pars reticulata of Parkinson's disease patients
    Mahan Alavi
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Exp Neurol 245:60-71. 2013
    ....
  12. doi request reprint Frequency-dependent effects of electrical stimulation in the globus pallidus of dystonia patients
    Liu D Liu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neurophysiol 108:5-17. 2012
    ....
  13. ncbi request reprint Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia
    Joyce K H Tang
    Department of Physiology, Med Sci Bldg 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Exp Neurol 204:845-8. 2007
    ..These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia...
  14. ncbi request reprint Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease
    Panida Piboolnurak
    Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 22:990-7. 2007
    ..1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years...
  15. ncbi request reprint Very fast oscillations evoked by median nerve stimulation in the human thalamus and subthalamic nucleus
    Ritsuko Hanajima
    Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada
    J Neurophysiol 92:3171-82. 2004
    ..The VFOs from STN probably represent volume conduction, possibly from the medial lemniscus. We conclude that the thalamic VFOs are generated within Vc and that they induce time-locked firing in a network of neurons...
  16. doi request reprint Oscillatory activity in the globus pallidus internus: comparison between Parkinson's disease and dystonia
    Moran Weinberger
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Clin Neurophysiol 123:358-68. 2012
    ....
  17. ncbi request reprint Dual microelectrode technique for deep brain stereotactic surgery in humans
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Neurosurgery 60:277-83; discussion 283-4. 2007
    ..To improve functional stereotactic microelectrode localization of small deep brain structures by developing and evaluating a recording system with two closely separated independently controlled microelectrodes...
  18. ncbi request reprint Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Brain 125:1196-209. 2002
    ....
  19. ncbi request reprint Neuronal activity in the globus pallidus of multiple system atrophy patients
    Luiz C M Pereira
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1485-92. 2004
    ....
  20. ncbi request reprint Stimulation-induced inhibition of neuronal firing in human subthalamic nucleus
    Mohammed Filali
    Department of Physiology, Rm 3305 Medical Sciences Building, University of Toronto, University Health Network, 1 King s College Circle, M5S 1A8, Toronto, Ontario, Canada
    Exp Brain Res 156:274-81. 2004
    ..Therefore, the overall effects of DBS stimulation in STN are likely to be inhibition of intrinsic and synaptically mediated activity, and its replacement by regular high-frequency firing...
  21. doi request reprint Microstimulation-induced inhibition as a tool to aid targeting the ventral border of the subthalamic nucleus
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosurg 111:724-8. 2009
    ..The presence of inhibition in the SNr but not in the STN could be used as an additional criterion to help identify the location of the border between the STN and SNr...
  22. doi request reprint Neuronal coding of implicit emotion categories in the subcallosal cortex in patients with depression
    Adrian W Laxton
    Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston Salem, North Carolina Department of Surgery, Toronto Western Hospital, Institute of Medical Science, University of Toronto, Toronto, Canada Electronic address
    Biol Psychiatry 74:714-9. 2013
    ..On the basis of imaging studies, it is unclear whether the SCC predominantly processes 1) negatively valenced affective content, 2) affective arousal, or 3) category-specific affective information...
  23. doi request reprint Pathological subthalamic nucleus oscillations in PD: can they be the cause of bradykinesia and akinesia?
    Moran Weinberger
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Exp Neurol 219:58-61. 2009
    ..This commentary reviews some of the recent findings on beta oscillatory activity in PD and highlights the possible role of these pathological oscillations in mediating PD symptoms...
  24. ncbi request reprint Saccade-related potentials recorded from human subthalamic nucleus
    Adrian P Fawcett
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Clin Neurophysiol 118:155-63. 2007
    ..To investigate an ocular motor role for the STN in Parkinson's disease (PD) patients...
  25. doi request reprint Deep brain stimulation of the ventral intermediate nucleus of the thalamus for tremor in patients with multiple sclerosis
    Cristina V Torres
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Neurosurgery 67:646-51; discussion 651. 2010
    ..Tremor is an important cause of disability in patients with multiple sclerosis (MS). Deep brain stimulation (DBS) in the ventral intermediate nucleus (VIM) of the thalamus is said to be beneficial for MS tremor...
  26. ncbi request reprint Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease
    Aviva Abosch
    Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
    J Neurosurg 97:1167-72. 2002
    ..The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields...
  27. ncbi request reprint Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patients
    Joyce K H Tang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Exp Brain Res 166:230-6. 2005
    ..Furthermore, the findings did reveal a difference between firing patterns in the HD and PD groups, thereby supporting the role of altered firing patterns in the pathophysiology of these diseases...
  28. doi request reprint Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation
    Lili Naz Hazrati
    Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Mov Disord 27:1304-7. 2012
    ..However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP)...
  29. doi request reprint Enhanced synchronization of thalamic theta band local field potentials in patients with essential tremor
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Exp Neurol 217:171-6. 2009
    ....
  30. doi request reprint Unilateral pedunculopontine stimulation improves falls in Parkinson's disease
    Elena Moro
    Division of Neurosurgery, 4 447 Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8 Canada
    Brain 133:215-24. 2010
    ..Our results suggest that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required...
  31. doi request reprint Basal ganglia physiology and deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, Toronto, Ontario, Canada
    Mov Disord 25:S71-5. 2010
    ..In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease...
  32. doi request reprint Unilateral pallidal deep brain stimulation in a patient with cervical dystonia and tremor
    Cristina V Torres
    Division of Neurosurgery, Department of Surgery, Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada
    J Neurosurg 113:1230-3. 2010
    ..The authors report on a case of unilateral GPi implantation that resulted in sustained benefit with marked improvement in pain and dystonia...
  33. ncbi request reprint Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease
    Adrian P Fawcett
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 20:371-7. 2005
    ..Our data demonstrate a task-specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control...
  34. ncbi request reprint Somatosensory evoked potentials (SEPs) recorded from deep brain stimulation (DBS) electrodes in the thalamus and subthalamic nucleus (STN)
    Ritsuko Hanajima
    Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst St, Toronto, ON M5T 2S8, Canada
    Clin Neurophysiol 115:424-34. 2004
    ..To examine the location of deep brain stimulation (DBS) electrode somatosensory evoked potentials (SEPs) and determine the generators of the median nerve SEPs recorded in thalamus and subthalamic nucleus (STN)...
  35. ncbi request reprint Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
    ..These results also suggest that overt neuronal synchronization, which may be attributable to an increase in direct synaptic connections or common collateral afferent inputs, is not present in the basal ganglia of patients with PD...
  36. ncbi request reprint Human anterior cingulate cortex neurons encode cognitive and emotional demands
    Karen D Davis
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:8402-6. 2005
    ....
  37. pmc Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada
    Sleep 30:823-7. 2007
    ..We sought to identify and characterize human PGO waves...
  38. ncbi request reprint Microelectrode recording findings within the tractography-defined ventral intermediate nucleus
    Nicolas Kon Kam King
    Division of Neurosurgery, Department of Surgery, University of Toronto
    J Neurosurg . 2016
    ..CONCLUSIONS The electrophysiological findings within the VIM thalamus defined by tractography, or T-VIM, correspond with the known microelectrode recording characteristics of the VIM in patients with tremor...
  39. doi request reprint Pallidal deep brain stimulation for a case of hemidystonia secondary to a striatal stroke
    Jonathan Fuller
    Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Stereotact Funct Neurosurg 91:190-7. 2013
    ..More variable outcomes have been reported in the treatment of secondary dystonia with GPi DBS...
  40. doi request reprint Effects of cobalt and bicuculline on focal microstimulation of rat pallidal neurons in vivo
    Gordon D Chin
    Department of Physiology, University of Toronto, Ontario, Canada
    Brain Stimul 1:134-50. 2008
    ..Deep brain stimulation (DBS) administered in the basal ganglia is an effective therapy for movement disorders; however, the mechanism(s) of action remain poorly understood...
  41. ncbi request reprint Bilateral globus pallidus stimulation for Huntington's disease
    Elena Moro
    Movement Disorders Center, Toronto Western Hospital, Toronto, Ontario, Canada
    Ann Neurol 56:290-4. 2004
    ..Adjustment of stimulation parameters in GPi DBS may have the potential to optimize the motor response in HD, improving chorea without aggravating bradykinesia...
  42. ncbi request reprint Localization of clinically effective stimulating electrodes in the human subthalamic nucleus on magnetic resonance imaging
    Jean A Saint-Cyr
    Department of Surgery, Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Neurosurg 97:1152-66. 2002
    ..The authors sought to determine the location of deep brain stimulation (DBS) electrodes that were most effective in treating Parkinson disease (PD)...
  43. ncbi request reprint The globus pallidus, deep brain stimulation, and Parkinson's disease
    Jonathan O Dostrovsky
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Neuroscientist 8:284-90. 2002
    ....
  44. ncbi request reprint Microelectrode recordings in the pallidum
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, The Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Mov Disord 17:S150-4. 2002
    ..Because the clinical features of movement disorders can be differentially affected as a function of location within the pallidal complex, further refinements in intraoperative targeting may become important...
  45. pmc Preliminary evidence for human globus pallidus pars interna neurons signaling reward and sensory stimuli
    Nicholas A Howell
    Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada Division of Brain Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Neuroscience 328:30-9. 2016
    ..These results are broadly consistent with previous findings in the animal literature and suggest non-motor information may be represented in the single-unit activity of human GPi neurons. ..
  46. doi request reprint Anterior thalamus deep brain stimulation at high current impairs memory in rats
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    Exp Neurol 225:154-62. 2010
    ..Though translating data from animals to humans has to be considered with caution, our study underscores the need for carefully monitoring memory function while selecting stimulation parameters during the clinical evaluation of AN DBS...
  47. doi request reprint The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation
    Hiroki Toda
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    J Neurosurg 108:132-8. 2008
    ..To examine the influence of deep brain stimulation on hippocampal neurogenesis in an adult rodent model...
  48. pmc Uncoupling PSD-95 interactions leads to rapid recovery of cortical function after focal stroke
    Luka R Srejic
    Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 33:1937-43. 2013
    ..05). Tat-NR2B9c significantly reduces stroke-related cortical dysfunction as evidenced by greater recovery of fEPs and EEG power; illustrating the immediate effects of the compound on poststroke brain function. ..
  49. doi request reprint Beta oscillatory neurons in the motor thalamus of movement disorder and pain patients
    Diellor Basha
    University of Toronto, Ontario, Canada
    Exp Neurol 261:782-90. 2014
    ..05). The findings suggest that beta oscillations are found predominantly in Vim and are involved in movement but are not enhanced in tremor-dominant Parkinson's patients. ..
  50. doi request reprint Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex--single unit recording in an intracranial study
    Nir Lipsman
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Canada
    Cortex 60:139-44. 2014
    ..These results suggest specific relationship between resting state and self-related activity, rest-self overlap, in specifically SCC as core region of the default-mode network. ..
  51. doi request reprint Attenuation of long-term depression in human striatum after anterior capsulotomy
    Felipe E Allendes
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Toronto, Ont, Canada
    Stereotact Funct Neurosurg 86:224-30. 2008
    ..Our observation of human striatal LTD attenuation concomitant with reduced anxiety following anterior capsulotomy suggests that reduction in synaptic plasticity is related to an acute improvement of OCD symptoms...
  52. doi request reprint High-frequency stimulation of the medial prefrontal cortex decreases cellular firing in the dorsal raphe
    Luka R Srejic
    Institute of Medical Science, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
    Eur J Neurosci 41:1219-26. 2015
    ..Taken together, our results suggest that mPFC-HFS may exert a preferential effect on DR neurons with GABAA receptors. ..
  53. doi request reprint High-frequency cortical activity associated with postischemic epileptiform discharges in an in vivo rat focal stroke model
    Luka R Srejic
    Institute of Medical Sciences, University of Toronto, Toronto, Canada
    J Neurosurg 118:1098-106. 2013
    ..Epileptiform discharges are thought to exacerbate postischemic brain function. The aim of this study was to develop an in vivo focal stroke model in rats to characterize epileptiform activity...
  54. doi request reprint The effect of dexmedetomidine on the firing properties of STN neurons in Parkinson's disease
    Vibhor Krishna
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, ON M5T2S8, Canada
    Eur J Neurosci 42:2070-7. 2015
    ..3 and P = 0.5, respectively) and LFP analysis (Beta power, P = 0.17). As bursting pattern is often used to identify STN and guide electrode placement, we recommend that high-dose dexmedetomidine should be avoided during DBS surgery...
  55. pmc Increased ventral striatal volume in college-aged binge drinkers
    Nicholas A Howell
    Toronto Western Research Institute, Division of Brain Imaging and Behaviour Systems Neuroscience, Toronto Western Hospital, University Health Network, Toronto, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e74164. 2013
    ..To address this, we compared the grey matter volumes of college-age binge drinkers and healthy controls, focusing on the ventral striatum, hippocampus and amygdala...
  56. doi request reprint Dose-response curve of associative plasticity in human motor cortex and interactions with motor practice
    Behzad Elahi
    Division of Neurology, Toronto Western Hospital, University of Toronto, and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    J Neurophysiol 111:594-601. 2014
    ..In conclusion, we found a dose-dependent effect of the number of stimulus pairs used in the PAS protocol on cortical plasticity. Homeostatic interaction between PAS and DMP was observed only after PAS270. ..
  57. ncbi request reprint Cingulotomy for psychiatric disease: microelectrode guidance, a callosal reference system for documenting lesion location, and clinical results
    Erich O Richter
    Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
    Neurosurgery 54:622-28; discussion 628-30. 2004
    ....