A A House

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. doi request reprint The burden of cardiovascular risk in chronic kidney disease and dialysis patients (cardiorenal syndrome type 4)
    Andrew A House
    Schulich School of Medicine and Dentistry, University of Western Ontario Division of Nephrology, Division of Nephrology, University Hospital, London, Ont, Canada
    Contrib Nephrol 171:50-6. 2011
  2. pmc Pharmacological management of cardiorenal syndromes
    Andrew A House
    Division of Nephrology, London Health Sciences Centre, University Hospital, 339 Windermere Road, London, ON, Canada N6A 5A5
    Int J Nephrol 2011:630809. 2011
  3. pmc Volume assessment in mechanically ventilated critical care patients using bioimpedance vectorial analysis, brain natriuretic Peptide, and central venous pressure
    Andrew A House
    Division of Nephrology, London Health Sciences Center, London, Canada N6A 5A5
    Int J Nephrol 2011:413760. 2010
  4. pmc Quinolone prophylaxis for the prevention of BK virus infection in kidney transplantation: study protocol for a randomized controlled trial
    Atul Humar
    Department of Medicine, Faculty of Medicine and Dentistry, 2J2 00 WC Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB T6G 2R7, Canada
    Trials 14:185. 2013
  5. doi request reprint Cardio-renal syndrome type 4: epidemiology, pathophysiology and treatment
    Andrew A House
    Schulich School of Medicine and Dentistry, University of Western Ontario Division of Nephrology, University Hospital, London, Ontario, Canada
    Semin Nephrol 32:40-8. 2012
  6. pmc Relationship of the metabolic syndrome to carotid ultrasound traits
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 4:28. 2006
  7. pmc A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 3:15. 2005
  8. pmc Carotid ultrasound phenotypes in vulnerable populations
    Silvia A Riccio
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario, N6A 5K8, Canada
    Cardiovasc Ultrasound 4:44. 2006
  9. doi request reprint Therapeutic strategies for heart failure in cardiorenal syndromes
    Andrew A House
    London Health Sciences Centre, Division of Nephrology, London, Canada
    Am J Kidney Dis 56:759-73. 2010
  10. pmc Nephrology: 2. Evaluation of asymptomatic hematuria and proteinuria in adult primary care
    Andrew A House
    Department of Medicine, University of Western Ontario, London Health Sciences Centre
    CMAJ 166:348-53. 2002

Detail Information

Publications51

  1. doi request reprint The burden of cardiovascular risk in chronic kidney disease and dialysis patients (cardiorenal syndrome type 4)
    Andrew A House
    Schulich School of Medicine and Dentistry, University of Western Ontario Division of Nephrology, Division of Nephrology, University Hospital, London, Ont, Canada
    Contrib Nephrol 171:50-6. 2011
    ....
  2. pmc Pharmacological management of cardiorenal syndromes
    Andrew A House
    Division of Nephrology, London Health Sciences Centre, University Hospital, 339 Windermere Road, London, ON, Canada N6A 5A5
    Int J Nephrol 2011:630809. 2011
    ..In this paper, an overview of pharmacological management of acute and chronic Cardiorenal Syndromes is presented, and the need for high-quality future studies in this field is highlighted...
  3. pmc Volume assessment in mechanically ventilated critical care patients using bioimpedance vectorial analysis, brain natriuretic Peptide, and central venous pressure
    Andrew A House
    Division of Nephrology, London Health Sciences Center, London, Canada N6A 5A5
    Int J Nephrol 2011:413760. 2010
    ..Conclusions. BNP seems to be a valuable noninvasive measure of volume status in critical care and should be assessed in a prospective manner...
  4. pmc Quinolone prophylaxis for the prevention of BK virus infection in kidney transplantation: study protocol for a randomized controlled trial
    Atul Humar
    Department of Medicine, Faculty of Medicine and Dentistry, 2J2 00 WC Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB T6G 2R7, Canada
    Trials 14:185. 2013
    ..We hypothesize that administration of a quinolone antibiotic, when given early post-transplantation, will prevent the establishment of BK viral replication in the urine and thus prevent systemic BK virus infection...
  5. doi request reprint Cardio-renal syndrome type 4: epidemiology, pathophysiology and treatment
    Andrew A House
    Schulich School of Medicine and Dentistry, University of Western Ontario Division of Nephrology, University Hospital, London, Ontario, Canada
    Semin Nephrol 32:40-8. 2012
    ....
  6. pmc Relationship of the metabolic syndrome to carotid ultrasound traits
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 4:28. 2006
    ..We evaluated two carotid ultrasound measurements, namely intima media thickness and total plaque volume, in a Canadian Oji-Cree population with a high metabolic syndrome prevalence rate...
  7. pmc A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 3:15. 2005
    ..Thus, the objective of this study was to compare the traditional intima-media thickness measurement against the novel total plaque volume measurement in analyzing carotid atherosclerosis development in individuals with type 2 diabetes...
  8. pmc Carotid ultrasound phenotypes in vulnerable populations
    Silvia A Riccio
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario, N6A 5K8, Canada
    Cardiovasc Ultrasound 4:44. 2006
    ..In this study we measured and compared intima media thickness (IMT), total plaque volume (TPV) and total plaque area (TPA) in two separate populations, both vulnerable to carotid atherosclerosis...
  9. doi request reprint Therapeutic strategies for heart failure in cardiorenal syndromes
    Andrew A House
    London Health Sciences Centre, Division of Nephrology, London, Canada
    Am J Kidney Dis 56:759-73. 2010
    ....
  10. pmc Nephrology: 2. Evaluation of asymptomatic hematuria and proteinuria in adult primary care
    Andrew A House
    Department of Medicine, University of Western Ontario, London Health Sciences Centre
    CMAJ 166:348-53. 2002
  11. ncbi request reprint Apparent low absorbers of cyclosporine microemulsion have higher requirements for tacrolimus in renal transplantation
    Andrew A House
    Department of Medicine, University of Western Ontario, and Multi Organ Transplant Unit, University of Western Ontario and London Health Sciences Centre, London, ON, Canada
    Clin Transplant 21:518-22. 2007
    ..Based on our data, a starting dose of 0.25 mg/kg/d in divided doses may be warranted for low absorbers converting to tacrolimus; however, we encourage larger studies with formal pharmacokinetic analysis in this population...
  12. ncbi request reprint Cardiovascular risk in hemodialysis patients: a mechanistic approach
    A A House
    University of Western Ontario Division of Nephrology, University Hospital, London Health Sciences Centre, London, Ontario, Canada
    Int J Artif Organs 30:1020-7. 2007
    ..Drug treatment may serve to mitigate some of the risk unique to this population...
  13. doi request reprint Extracorporeal blood purification in sepsis and sepsis-related acute kidney injury
    Andrew A House
    Division of Nephrology, University Hospital, London Health Sciences Centre, London, Ontario, Canada
    Blood Purif 26:30-5. 2008
    ..As a therapy that has the potential to influence the course of disease in sepsis, EBP in sepsis and sepsis-related AKI is the subject of this review...
  14. ncbi request reprint Anti-inflammatory drugs and the kidney
    A A House
    Department of Medicine, Division of Nephrology, University of Western Ontario, London, Canada
    Int J Artif Organs 30:1042-6. 2007
    ..Careful monitoring of renal function is advisable in patients at increased risk such as elderly individuals with compromised cardiac reserve, and diabetics...
  15. ncbi request reprint Sirolimus use in recipients of expanded criteria donor kidneys
    Andrew A House
    University of Western Ontario Faculty of Medicine, London, Ontario, Canada
    Drugs 68:41-9. 2008
    ..Banff chronic/sclerosing allograft nephropathy scores were 42% grade I, 25% grades II and III, and 33% grade 0. Thus, a sirolimus-based CNI-free regimen may improve outcomes in ECD kidney transplant recipients and merits further study...
  16. ncbi request reprint Re-exposure to mismatched HLA class I is a significant risk factor for graft loss: multivariable analysis of 259 kidney retransplants
    Andrew A House
    Multi Organ Transplant Program, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Transplantation 84:722-8. 2007
    ..Conflicting publications have assessed this risk, so to examine our experience 259 kidney retransplants were analyzed...
  17. doi request reprint Pharmacological therapy of cardiorenal syndromes and heart failure
    Andrew A House
    Division of Nephrology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ont, Canada
    Contrib Nephrol 164:164-72. 2010
    ....
  18. ncbi request reprint Dimercaptosuccinic acid for the treatment of hyperhomocysteinemia in hemodialysis patients: a placebo-controlled, double-blind, randomized trial
    Andrew A House
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am J Kidney Dis 44:689-94. 2004
    ..We designed a randomized, double-blind, placebo-controlled trial to determine the effect of prolonged administration of oral dimercaptosuccinic acid (DMSA) on plasma tHcy levels in vitamin-replete hemodialysis patients...
  19. ncbi request reprint Cardiac troponin T in hemodialyzed patients
    D S Ooi
    Department of Laboratory Medicine, Ottawa Civic Hospital, Ontario, Canada
    Clin Chem 44:1410-6. 1998
    ....
  20. doi request reprint Fate of the mate: the influence of delayed graft function in renal transplantation on the mate recipient
    J F Johnson
    Department of Medicine, Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Am J Transplant 9:1796-801. 2009
    ..We believe strategies that may preserve allograft function in these'at-risk'recipients should be developed and tested...
  21. doi request reprint Mesna for the treatment of hyperhomocysteinemia in hemodialysis patients
    Murray J Cutler
    Division of Clinical Pharmacology, University of Western Ontario, London, Ont, Canada
    Blood Purif 27:306-10. 2009
    ..We hypothesized that 12 mg/kg intravenous mesna administered predialysis would cause a significant decrease in plasma tHcy compared to placebo...
  22. pmc Mesna for treatment of hyperhomocysteinemia in hemodialysis patients: a placebo-controlled, double-blind, randomized trial
    Bradley L Urquhart
    Department of Physiology and Pharmacology, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
    Clin J Am Soc Nephrol 3:1041-7. 2008
    ..It was hypothesized 5 mg/kg intravenous mesna administered thrice weekly, before dialysis, for 8 wk would cause a significant decrease in plasma total homocysteine compared with placebo...
  23. doi request reprint Focal segmental glomerular sclerosis in renal transplant recipients: predicting early disease recurrence may prolong allograft function
    Alp Sener
    Division of Urology, Department of Surgery, University of Western Ontario, London, Ontario, Canada
    Clin Transplant 23:96-100. 2009
    ..These patients should be monitored closely for early recurrence and may benefit from early plasmapheresis to restore and facilitate long-term graft function...
  24. ncbi request reprint Regular monitoring of access flow compared with monitoring of venous pressure fails to improve graft survival
    Louise M Moist
    Department of Medicine, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
    J Am Soc Nephrol 14:2645-53. 2003
    ..Results reveal that graft surveillance that uses Qa increases the detection of stenosis, compared with standard surveillance; however, intervention with angioplasty does not improve the time to graft thrombosis or time to graft loss...
  25. doi request reprint Effect of N-acetylcysteine on serum creatinine and kidney function: results of a randomized controlled trial
    Louise Moist
    Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am J Kidney Dis 56:643-50. 2010
    ..Study objectives are to investigate whether NAC affects serum creatinine level independently of alterations in other measures of kidney function...
  26. doi request reprint Perfusion of renal allografts with verapamil improves graft function
    Chris Y Nguan
    Multi Organ Transplant Program, London Health Sciences Center, London, ON, Canada
    Transplantation 86:1463-7. 2008
    ..Additionally, rates of hypotension during graft reperfusion and other adverse reactions were similar in both groups. In conclusion, verapamil supplemented perfusate significantly improved renal function posttransplantation...
  27. doi request reprint Immunosuppression without calcineurin inhibition: optimization of renal function in expanded criteria donor renal transplantation
    Patrick P W Luke
    Multi Organ Transplant Program, London Health Sciences Center, London, ON, Canada
    Clin Transplant 23:9-15. 2009
    ..To assess the efficacy of calcineurin inhibitor (CNI)-free immunosuppression vs. calcineurin-based immunosuppression in patients receiving expanded criteria donor (ECD) kidneys...
  28. ncbi request reprint Erythropoietin dose requirements when converting from subcutaneous to intravenous administration among patients on hemodialysis
    Louise M Moist
    University of Western Ontario, London Health Sciences Centre Victoria Hospital, London, Ontario, Canada
    Ann Pharmacother 40:198-203. 2006
    ..In Canada, the majority of hemodialysis units have converted to the intravenous route for administration of erythropoietin to potentially decrease the risk of pure red cell aplasia...
  29. ncbi request reprint Increased mortality in hemodialyzed patients with elevated serum troponin T: a one-year outcome study
    D S Ooi
    Department of Laboratory Medicine, Ottawa Hospital Civic Campus, Ontario, Canada
    Clin Biochem 32:647-52. 1999
    ..To determine the significance of elevated serum troponin T (cTnT) occurring in hemodialysis patients in the absence of clinical evidence of acute coronary ischemia...
  30. ncbi request reprint The impact of allograft nephrectomy on percent panel reactive antibody and clinical outcome
    A K Khakhar
    Department of Surgery Urology, London Health Sciences Centre, London, Ontario, Canada
    Transplant Proc 35:862-3. 2003
  31. ncbi request reprint The effect of mesna on plasma total homocysteine concentration in hemodialysis patients
    Bradley L Urquhart
    Department of Medicine, University of Western Ontario, Canada
    Am J Kidney Dis 49:109-17. 2007
    ..The objective of this study is to determine whether a single intravenous dose of mesna, a thiol-containing drug analogue of taurine, facilitates tHcy clearance during hemodialysis...
  32. ncbi request reprint Use of a pelvic kidney for living transplantation: case report and review of the literature
    Patrick P W Luke
    Departments of Surgery and Medicine, London Health Sciences Center, The Multi Organ Transplant Program, The University of Western Ontario, London, Ontario, Canada
    Am J Transplant 3:235-8. 2003
    ..Therefore, careful radiologic and functional evaluation of these kidneys must be performed prior to procurement for transplantation. We report the successful use of a pelvic kidney for living-related transplantation...
  33. doi request reprint Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial
    Andrew A House
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    JAMA 303:1603-9. 2010
    ..Hyperhomocysteinemia is frequently observed in patients with diabetic nephropathy. B-vitamin therapy (folic acid, vitamin B(6), and vitamin B(12)) has been shown to lower the plasma concentration of homocysteine...
  34. ncbi request reprint Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipients
    Alp Sener
    Department of Surgery, Division of Urology, London Health Sciences Center, London, Ontario, Canada
    Transplantation 81:117-20. 2006
    ..The benefit of concomitant IVIG and reduction of immunosuppressive therapy in BKVAN needs to be further addressed in randomized, multicentered trials...
  35. ncbi request reprint Mesna as a nonvitamin intervention to lower plasma total homocysteine concentration: implications for assessment of the homocysteine theory of atherosclerosis
    Bradley L Urquhart
    Division of Clinical Pharmacology, Department of Medicine and Physiology, University of Western Ontario and Lawson Health Research Institute, London, Ontario, Canada
    J Clin Pharmacol 47:991-7. 2007
    ..9 +/- 2.4 mumol) compared to vehicle (0.4 +/- 0.1 mumol), P < .01. Oral mesna decreases plasma total homocysteine and is a potential nonvitamin treatment for assessing the homocysteine theory of atherosclerosis...
  36. ncbi request reprint Assessing plasma total homocysteine in patients with end-stage renal disease
    Bradley L Urquhart
    Department of Medicine, The University of Western Ontario, London, Ontario, Canada
    Perit Dial Int 27:476-88. 2007
    ....
  37. doi request reprint Longitudinal ultrasound evaluation of carotid atherosclerosis in one, two and three dimensions
    Christiane Mallett
    Imaging Research Laboratories, Robarts Research Institute, London, Canada
    Ultrasound Med Biol 35:367-75. 2009
    ....
  38. ncbi request reprint Epstein-Barr virus seronegativity is a risk factor for late-onset posttransplant lymphoroliferative disorder in adult renal allograft recipients
    Vahakn B Shahinian
    Multi Organ Transplant Unit, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada
    Transplantation 75:851-6. 2003
    ..We investigated risk factors for PTLD in the adult renal transplant setting...
  39. doi request reprint Prospective comparison of magnetic resonance angiography with selective renal angiography for living kidney donor assessment
    Christopher Neville
    Division of Urology, London Health Sciences Centre, The University of Western Ontario, London, Ontario, Canada
    Urology 71:385-9. 2008
    ..Because of the potential morbidity associated with SRA, we prospectively evaluated magnetic resonance angiography (MRA) in the assessment of renal donors...
  40. pmc Kidney and liver transplants from donors after cardiac death: initial experience at the London Health Sciences Centre
    Roberto Hernandez-Alejandro
    The Multi Organ Transplant Program, London Health Sciences Centre, The Division of General Surgery, Department of Surgery, University of Western Ontario, London, ON
    Can J Surg 53:93-102. 2010
    ..Donation after cardiac death (DCD), following withdrawal of life support in patients with hopeless prognoses, is a means of addressing the shortage with the potential to increase the number of transplantable organs...
  41. ncbi request reprint Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review
    Suma Prakash
    London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada, N6A 5A5
    Nephrol Dial Transplant 19:2553-8. 2004
    ..Dialysis-induced hypotension is an important complication of haemodialysis. Midodrine is an oral alpha-1 agonist that has been used in several small studies to prevent intradialytic hypotension (IDH)...
  42. ncbi request reprint Moderate renal insufficiency and the risk of cardiovascular mortality: results from the NHANES I
    Amit X Garg
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Kidney Int 61:1486-94. 2002
    ..S. general non-institutionalized population...
  43. ncbi request reprint Successful treatment of primary bilateral renal mucormycosis with bilateral nephrectomy
    Blayne Welk
    Division of Urology, London Health Sciences Centre, The University of Western Ontario, London, Ontario, Canada
    Urology 64:590. 2004
    ..We report a case of bilateral invasive renal mucormycosis in a patient treated with amphotericin B and bilateral nephrectomy who survived and is currently disease-free...
  44. ncbi request reprint Thiol exchange: an in vitro assay that predicts the efficacy of novel homocysteine lowering therapies
    Bradley L Urquhart
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    J Pharm Sci 95:1742-50. 2006
    ..001. Our in vitro results indicate that mesna, captopril, and NAC effectively exchange with covalently bound Hcy. This assay can act as screening tool for novel tHcy lowering therapies and should spare the expense of negative trials...
  45. ncbi request reprint Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease
    Neil Boudville
    Department of Medicine, University of Western Ontario, London, Ontario
    Am J Hypertens 18:1300-5. 2005
    ..The aim of this study was to assess the sodium balance in a CKD clinic and its effect on BP management...
  46. ncbi request reprint An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 40:1756-61. 2005
    ..We describe an immune reconstitution syndrome (IRS)-like entity in the course of evolution of Cryptococcus neoformans infection in organ transplant recipients...
  47. pmc Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, PA 15240, USA
    J Infect Dis 195:756-64. 2007
    ..Additionally, discerning the basis for transplant type-specific differences in disease severity has implications relevant for yielding further insights into the pathogenesis of C. neoformans infection in transplant recipients...
  48. doi request reprint Cardiorenal and renocardiac syndromes: the need for a comprehensive classification and consensus
    Claudio Ronco
    Department of Nephrology, Dialysis and Transplantation at St Bortolo Hospital, Vicenza, Italy
    Nat Clin Pract Nephrol 4:310-1. 2008
  49. doi request reprint Potential interventions in sepsis-related acute kidney injury
    Claudio Ronco
    Department of Nephrology, St Bortolo Hospital, International Renal Research Institute Vicenza, Vicenza, Italy
    Clin J Am Soc Nephrol 3:531-44. 2008
    ..This review provides an update on the current state of the science and a glimpse toward the future of intervention in sepsis-related acute kidney injury...
  50. ncbi request reprint Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 80:1131-3. 2005
    ..0004). Temporal association of graft loss with IRS suggests a common pathophysiologic basis for these entities with implications relevant for the optimal management of renal transplant recipients with cryptococcosis...
  51. pmc Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis
    Dimitrios P Kontoyiannis
    M D Anderson Cancer Center, University of Texas, Houston, Texas 77030 3930, USA
    Antimicrob Agents Chemother 52:735-8. 2008
    ....