Dustin S Hittel

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Increased secretion and expression of myostatin in skeletal muscle from extremely obese women
    Dustin S Hittel
    Human Performance Laboratory, Faculty of Kinesiology, Roger Jackson Center for Health and Wellness, University of Calgary, Calgary, Alberta, Canada
    Diabetes 58:30-8. 2009
  2. pmc Myostatin decreases with aerobic exercise and associates with insulin resistance
    Dustin S Hittel
    Human Performance Laboratory, Faculty of Kinesiology, Roger Jackson Center for Health and Wellness, University of Calgary, Calgary, Alberta, Canada
    Med Sci Sports Exerc 42:2023-9. 2010
  3. pmc Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart
    Curtis C Hughey
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, 2500 University Drive N, W, Calgary, AB, Canada, T2N 1N4
    Cardiovasc Diabetol 12:128. 2013
  4. doi request reprint Metabolomic Modeling To Monitor Host Responsiveness to Gut Microbiota Manipulation in the BTBR(T+tf/j) Mouse
    Matthias S Klein
    Departments of Paediatrics and Clinical Neurosciences, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 2T9, Canada
    J Proteome Res 15:1143-50. 2016
  5. pmc Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity
    Virginia L Johnsen
    Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
    Physiol Genomics 45:17-25. 2013
  6. doi request reprint Unconventional microarray design reveals the response to obesity is largely tissue specific: analysis of common and divergent responses to diet-induced obesity in insulin-sensitive tissues
    Robyn K Lee
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada
    Appl Physiol Nutr Metab 37:257-68. 2012
  7. pmc Mesenchymal stem cell transplantation for the infarcted heart: a role in minimizing abnormalities in cardiac-specific energy metabolism
    Curtis C Hughey
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, 2500 University Dr NW, Calgary, Alberta, Canada
    Am J Physiol Endocrinol Metab 302:E163-72. 2012
  8. pmc The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults
    Chelsea L Deschamps
    Faculty of Kinesiology, University of Calgary, 2500 University Drive, Calgary, Alberta, T2N 1N4, Canada
    PLoS ONE 10:e0130644. 2015
  9. doi request reprint Examination of Lifestyle Behaviors and Cardiometabolic Risk Factors in University Students Enrolled in Kinesiology Degree Programs
    Gina M Many
    1Children s National Medical Center, Research Center for Genetic Medicine, Washington, District of Columbia 2Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada 3Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada 4Human Performance Laboratory, College of Agriculture, Health and Natural Resources, University of Connecticut, Storrs, Connecticut and 5Human Performance Laboratory, East Carolina University, Greenville, North Carolina
    J Strength Cond Res 30:1137-46. 2016
  10. doi request reprint SORT1 protective allele is associated with attenuated postprandial: lipaemia in young adults
    Kimberly E Connors
    From the Faculty of Kinesiology K E C, E A G, J S, R A R, Faculty of Medicine A E K, J S, R A R, Department of Biochemistry and Molecular Biology within the Faculty of Medicine J S, R A R, D S H, University of Calgary, Calgary, Alberta, Canada
    Circ Cardiovasc Genet 7:576-82. 2014

Collaborators

Detail Information

Publications20

  1. pmc Increased secretion and expression of myostatin in skeletal muscle from extremely obese women
    Dustin S Hittel
    Human Performance Laboratory, Faculty of Kinesiology, Roger Jackson Center for Health and Wellness, University of Calgary, Calgary, Alberta, Canada
    Diabetes 58:30-8. 2009
    ..8 +/- 14.8 kg/m(2); homeostasis model assessment [HOMA] 3.6 +/- 1.0) relative to lean healthy subjects (BMI 25.7 +/- 3.2 kg/m(2); HOMA 0.8 +/- 0.2)...
  2. pmc Myostatin decreases with aerobic exercise and associates with insulin resistance
    Dustin S Hittel
    Human Performance Laboratory, Faculty of Kinesiology, Roger Jackson Center for Health and Wellness, University of Calgary, Calgary, Alberta, Canada
    Med Sci Sports Exerc 42:2023-9. 2010
    ..Despite these intriguing findings, there have been few studies linking myostatin and insulin resistance...
  3. pmc Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart
    Curtis C Hughey
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, 2500 University Drive N, W, Calgary, AB, Canada, T2N 1N4
    Cardiovasc Diabetol 12:128. 2013
    ....
  4. doi request reprint Metabolomic Modeling To Monitor Host Responsiveness to Gut Microbiota Manipulation in the BTBR(T+tf/j) Mouse
    Matthias S Klein
    Departments of Paediatrics and Clinical Neurosciences, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 2T9, Canada
    J Proteome Res 15:1143-50. 2016
    ..These results show very robust relationships and provide a basis for future work wherein the compositional and functional associations of the microbiome can be modeled in the context of the metabolome. ..
  5. pmc Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity
    Virginia L Johnsen
    Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
    Physiol Genomics 45:17-25. 2013
    ....
  6. doi request reprint Unconventional microarray design reveals the response to obesity is largely tissue specific: analysis of common and divergent responses to diet-induced obesity in insulin-sensitive tissues
    Robyn K Lee
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada
    Appl Physiol Nutr Metab 37:257-68. 2012
    ..Many identified genes were associated with a variety of disorders, thereby serving as potential links between obesity and its related health risks...
  7. pmc Mesenchymal stem cell transplantation for the infarcted heart: a role in minimizing abnormalities in cardiac-specific energy metabolism
    Curtis C Hughey
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, 2500 University Dr NW, Calgary, Alberta, Canada
    Am J Physiol Endocrinol Metab 302:E163-72. 2012
    ..Restoration of metabolic flexibility is important given the metabolic demands of the heart and the role of energetics in the progression to heart failure...
  8. pmc The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults
    Chelsea L Deschamps
    Faculty of Kinesiology, University of Calgary, 2500 University Drive, Calgary, Alberta, T2N 1N4, Canada
    PLoS ONE 10:e0130644. 2015
    ..Taken together, these results identify significant cardiometabolic effects associated with possessing one or more functional copies of the ACTN3 gene. ..
  9. doi request reprint Examination of Lifestyle Behaviors and Cardiometabolic Risk Factors in University Students Enrolled in Kinesiology Degree Programs
    Gina M Many
    1Children s National Medical Center, Research Center for Genetic Medicine, Washington, District of Columbia 2Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada 3Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada 4Human Performance Laboratory, College of Agriculture, Health and Natural Resources, University of Connecticut, Storrs, Connecticut and 5Human Performance Laboratory, East Carolina University, Greenville, North Carolina
    J Strength Cond Res 30:1137-46. 2016
    ..Practical outcomes of this research indicate that implementing components of a comprehensive kinesiology curriculum encourages improved health behaviors and associated cardiometabolic risk factors. ..
  10. doi request reprint SORT1 protective allele is associated with attenuated postprandial: lipaemia in young adults
    Kimberly E Connors
    From the Faculty of Kinesiology K E C, E A G, J S, R A R, Faculty of Medicine A E K, J S, R A R, Department of Biochemistry and Molecular Biology within the Faculty of Medicine J S, R A R, D S H, University of Calgary, Calgary, Alberta, Canada
    Circ Cardiovasc Genet 7:576-82. 2014
    ..The aim of the study to determine whether young adults, when stratified by genotype at the rs646776 variant of the 1p13 locus, displayed differential postprandial responses to an oral fat tolerance test...
  11. doi request reprint Myostatin inhibits proliferation and insulin-stimulated glucose uptake in mouse liver cells
    Rani Watts
    a Faculty of Kinesiology, University of Calgary, 2500 University Dr Calgary, AB T2N 1N4, Canada
    Biochem Cell Biol 92:226-34. 2014
    ..Together, these findings reveal a plausible mechanism by which circulating myostatin contributes to the diminished regenerative capacity of the liver and diseases characterized by liver insulin resistance. ..
  12. doi request reprint Enhanced stem cell engraftment and modulation of hepatic reactive oxygen species production in diet-induced obesity
    Vongai Z Nyamandi
    Department of Biomedical Engineering Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada
    Obesity (Silver Spring) 22:721-9. 2014
    ..The objectives of this study were to examine the impact of DIO on the survival and efficacy of intravenous bone marrow-derived mesenchymal stem cell (MSC) administration in the conscious C57BL/6 mouse...
  13. pmc O-GlcNAc modification is associated with insulin sensitivity in the whole blood of healthy young adult males
    Jason P Myslicki
    Faculty of Kinesiology, University of Calgary, 3300 University Drive NW, Calgary, Alberta T2N 4N1 Canada
    Diabetol Metab Syndr 6:96. 2014
    ..Healthy, young males (18-35 y) from the Assessing Inherited Metabolic syndrome Markers in the Young study (AIMMY), were divided into low (LH,0.60) or high (HH,1.61) homeostatic model assessment of insulin resistance (HOMA-IR) cohorts...
  14. pmc Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat
    Marie S A Palmnäs
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 9:e109841. 2014
    ..How aspartame influences gut microbial composition and the implications of these changes on the development of metabolic disease require further investigation. ..
  15. doi request reprint Metabolomics reveals the sex-specific effects of the SORT1 low-density lipoprotein cholesterol locus in healthy young adults
    Matthias S Klein
    Faculty of Kinesiology, Department of Biochemistry and Molecular Biology, Faculty of Medicine, and Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    J Proteome Res 13:5063-70. 2014
    ..Thus, the analysis of metabolic biomarkers might reveal early disease development that may be overlooked by relying on standard clinical parameters. ..
  16. doi request reprint Myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis
    Rani Watts
    Faculty of Kinesiology, University of Calgary, Calgary, Canada
    Am J Physiol Cell Physiol 304:C995-1001. 2013
    ..The identification of new targets of myostatin will have important repercussions for regenerative biology through inhibition and/or reversal of muscle atrophy and wasting diseases...
  17. doi request reprint Effect of the SORT1 low-density lipoprotein cholesterol locus is sex-specific in a fit, Canadian young-adult population
    Angela Karlos
    Faculty of Kinesiology, University of Calgary, 2500 University Drive, Calgary, AB T2N 1N4, Canada
    Appl Physiol Nutr Metab 38:188-93. 2013
    ..SORT1 is a valuable target for identifying individuals who would most benefit from early interventions to prevent cardiovascular disease...
  18. doi request reprint Metabolomic response to exercise training in lean and diet-induced obese mice
    Gavin E Duggan
    Department of Biological Sciences, Bio NMR Center, Faculty of Science, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 110:1311-8. 2011
    ..The results demonstrate metabolomics to effectively characterize obesity-induced perturbations in metabolism and support the concept that exercise is beneficial for this condition...
  19. doi request reprint Exercise training does not correct abnormal cardiac glycogen accumulation in the db/db mouse model of type 2 diabetes
    Jane Shearer
    Kinesiology, University of Calgary, Calgary, Alberta, Canada
    Am J Physiol Endocrinol Metab 301:E31-9. 2011
    ..Novel observations show that exercise training does not correct diabetes-induced elevations in cardiac glycogen but, rather, precipitates further accumulation...
  20. doi request reprint Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats
    Jasmine M Tunnicliffe
    Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada
    Appl Physiol Nutr Metab 36:650-9. 2011
    ..In conclusion, CGA treatment resulted in beneficial effects on blood glucose response, with alterations seen in GIP concentrations. Given the widespread consumption and availability of coffee, CGA may be a viable prevention tool for T2D...