Eric B Higley
Affiliation: University of Saskatchewan
- Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect-directed analysisEric Higley
Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada
Environ Toxicol Chem 31:1053-62. 2012..Furthermore, to our knowledge this is the first study using the recently developed H295R assay within EDA strategies...
- Assessment of chemical effects on aromatase activity using the H295R cell lineEric B Higley
Toxicology Centre and Department Veterinary Biomedical Sciences, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, Canada
Environ Sci Pollut Res Int 17:1137-48. 2010..Furthermore, we compare the predictability of the different types of AA measurements for 17beta-estradiol (E2) and testosterone (T) production in vitro...
- Classification of chemicals based on concentration-dependent toxicological data using ToxClustXiaowei Zhang
Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon SK S7N 5B3, Canada
Environ Sci Technol 43:3926-32. 2009..These observations demonstrate that ToxClust not only provides an effective data analysis and visualization tool, but also has value in hypothesis generation and mechanism-based chemical classification...
- In vitro endocrine disruption and TCDD-like effects of three novel brominated flame retardants: TBPH, TBB, & TBCODavid M V Saunders
Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, Canada S7N 5B3 Electronic address
Toxicol Lett 223:252-9. 2013..8-fold, 5.4-fold, and 3.3-fold increase in concentrations of E2. This is one of the first studies to demonstrate the in vitro endocrine disrupting potentials of TBB, TBPH, and TBCO. ..