Shizu Hayashi

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi Adenovirus infections and lung disease
    Shizu Hayashi
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver, BC V6Z 1Y6, Canada
    Curr Opin Pharmacol 7:237-43. 2007
  2. ncbi Latent adenovirus infection in COPD
    Shizu Hayashi
    McDonald Research Laboratory, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Chest 121:183S-187S. 2002
  3. pmc Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
    Respir Res 6:87. 2005
  4. doi Adenovirus E1A regulates lung epithelial ICAM-1 expression by interacting with transcriptional regulators at its promoter
    Kiyoshi Morimoto
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L361-71. 2009
  5. ncbi Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10
    Takeshi Fujii
    McDonald Research Laboratory and iCAPTURE Center, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 284:L290-7. 2003
  6. ncbi Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells
    Noriho Sakamoto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 225:134-41. 2007
  7. ncbi Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10)
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L176-83. 2004
  8. doi Patterns of retention of particulate matter in lung tissues of patients with COPD: potential role in disease progression
    Sean H Ling
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada
    Chest 140:1540-9. 2011
  9. pmc Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease
    John V Gosselink
    The iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 181:1329-35. 2010
  10. doi Effect of atorvastatin on PM10-induced cytokine production by human alveolar macrophages and bronchial epithelial cells
    Noriho Sakamoto
    University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
    Int J Toxicol 28:17-23. 2009

Collaborators

Detail Information

Publications26

  1. ncbi Adenovirus infections and lung disease
    Shizu Hayashi
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver, BC V6Z 1Y6, Canada
    Curr Opin Pharmacol 7:237-43. 2007
    ..These results support its additional role in the airway remodeling process reported in COPD...
  2. ncbi Latent adenovirus infection in COPD
    Shizu Hayashi
    McDonald Research Laboratory, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Chest 121:183S-187S. 2002
    ....
  3. pmc Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
    Respir Res 6:87. 2005
    ....
  4. doi Adenovirus E1A regulates lung epithelial ICAM-1 expression by interacting with transcriptional regulators at its promoter
    Kiyoshi Morimoto
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L361-71. 2009
    ..E1A regulation of the LPS response may play a role in acute exacerbations as a consequence of bacterial infections in COPD...
  5. ncbi Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10
    Takeshi Fujii
    McDonald Research Laboratory and iCAPTURE Center, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 284:L290-7. 2003
    ..We suggest that this amplified inflammatory response may contribute to the pathogenesis of exacerbations of chronic obstructive pulmonary disease associated with exposure to particulate matter air pollution...
  6. ncbi Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells
    Noriho Sakamoto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 225:134-41. 2007
    ..The aim of the present study was to determine the nature and mechanism of calcium responses induced by PM(10) in HBECs and its relationship to cytokine synthesis...
  7. ncbi Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10)
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L176-83. 2004
    ..We conclude that AM-derived TNF-alpha and IL-1 beta provide a major stimulus for the production of proinflammatory mediators by lung epithelial cells and that their relative importance may depend on the type of epithelial cell target...
  8. doi Patterns of retention of particulate matter in lung tissues of patients with COPD: potential role in disease progression
    Sean H Ling
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada
    Chest 140:1540-9. 2011
    ..Particulate matter (PM) is present in lung tissues of smokers and urban dwellers. This study was designed to quantify the burden of PM in different lung tissues of subjects with COPD and determine its relationship to disease severity...
  9. pmc Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease
    John V Gosselink
    The iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 181:1329-35. 2010
    ..The airflow limitation that defines severity of chronic obstructive pulmonary disease (COPD) is caused by a combination of small airway obstruction and emphysematous lung destruction...
  10. doi Effect of atorvastatin on PM10-induced cytokine production by human alveolar macrophages and bronchial epithelial cells
    Noriho Sakamoto
    University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
    Int J Toxicol 28:17-23. 2009
    ..It is concluded that statins can modulate the PM(10)-induced inflammatory response in the lung by reducing mediator production by AMs...
  11. pmc The lung tissue microbiome in chronic obstructive pulmonary disease
    Marc A Sze
    The James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, Departments of Medicine and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:1073-80. 2012
    ..Based on surface brushings and bronchoalveolar lavage fluid, Hilty and coworkers demonstrated microbiomes in the human lung characteristic of asthma and chronic obstructive pulmonary disease (COPD), which have now been confirmed by others...
  12. ncbi Latent adenoviral infection induces production of growth factors relevant to airway remodeling in COPD
    Emiko Ogawa
    McDonald Research Laboratories iCAPTURE Centre, Department of Pathology and Laboratory Medicine, St Paul s Hospital Providence Health Care, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 286:L189-97. 2004
    ..We conclude that latent infection of epithelial cells by adenovirus E1A could contribute to airway remodeling in COPD by the viral E1A gene, inducing TGF-beta 1 and CTGF expression and shifting cells to a more mesenchymal phenotype...
  13. pmc Role of genetic susceptibility to latent adenoviral infection and decreased lung function
    Ikuma Kasuga
    The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Respir Med 103:1672-80. 2009
    ..Therefore, we investigated the contribution of HLA, CXADR, and ITGB5 genetic variants to the presence of the E1A gene and to level of lung function...
  14. pmc Genes related to emphysema are enriched for ubiquitination pathways
    Sergey Stepaniants
    University of British Columbia Centre for Heart and Lung Innovation, St Paul s Hospital, 1081 Burrard St, Vancouver V6Z 1Y6, BC, Canada
    BMC Pulm Med 14:187. 2014
    ..Despite their convergence in altered physiology, different mechanisms contribute to these processes. The relationships between gene expression and these specific phenotypes may be more revealing than comparison with lung function...
  15. ncbi Inflammatory mediator mRNA expression by adenovirus E1A-transfected bronchial epithelial cells
    Yuji Higashimoto
    University of British Columbia, McDonald Research Laboratory, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 166:200-7. 2002
    ..We conclude that adenoviral E1A transfection transforms primary HBE cells and upregulates their production of mediators that are clinically relevant to the pathogenesis of chronic obstructive pulmonary disease...
  16. pmc Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease
    Marc A Sze
    1 Centre for Heart Lung Innovation, Providence Heart Lung Institute at St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 192:438-45. 2015
    ..This article examines the relationship of this microbiome to emphysematous tissue destruction, number of terminal bronchioles, infiltrating inflammatory cells, and host gene expression...
  17. ncbi A lung tissue bank for gene expression studies in chronic obstructive pulmonary disease
    Lily Ding
    Department of Pathology, University of British Columbia iCAPTURE Centre McDonald Research Laboratories, Vancouver, British Columbia, Canada
    COPD 1:191-204. 2004
    ..Storage time had no detectable effect on RNA quality. We conclude that both frozen and paraffin-embedded tissues as well as laser-captured cells are suitable for gene expression studies but frozen tissue offered greater sensitivity...
  18. pmc What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease?
    James C Hogg
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Proc Am Thorac Soc 6:668-72. 2009
    ....
  19. ncbi Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer
    I Ming Wang
    McDonald Research Wing, Room 166, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 177:402-11. 2008
    ..Chronic obstructive lung disease (COPD) is a common and disabling lung disease for which there are few therapeutic options...
  20. ncbi Molecular mechanisms of decreased steroid responsiveness induced by latent adenoviral infection in allergic lung inflammation
    Katsuhiko Yamada
    UBC McDonald Research Laboratory The iCAPTURE Centre, St Paul s Hospital, Vancouver, Canada
    J Allergy Clin Immunol 109:35-42. 2002
    ..We recently reported that allergic lung inflammation in guinea pigs became steroid resistant in the presence of latent adenoviral infection...
  21. ncbi Evaluation of small sample cDNA amplification for microdissected airway expression profiling in COPD
    John V Gosselink
    St Paul s Hospital, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, Vancouver, British Columbia
    COPD 4:91-105. 2007
    ..We conclude that SMART amplification provides cDNA sufficient for studying large numbers of genes even in laser-captured small airways and this cDNA maintains the relative expression found in corresponding unamplified RNAs...
  22. ncbi Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow
    Takeshi Fujii
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 27:34-41. 2002
    ..01). These results suggest that the interaction between AMs and HBECs during PM(10) exposure contributes to the production of mediators that induce a systemic inflammatory response...
  23. ncbi Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response
    Bernard Meshi
    UBC McDonald Research Laboratories, The iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 26:52-7. 2002
    ..In this study, the increase in CD4 was associated with cigarette smoke and the increase in CD8 cells with latent Ad infection...
  24. ncbi The effect of smoking cessation and steroid treatment on emphysema in guinea pigs
    Julie Milot
    Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, 2725 Chemin Ste Foy, Quebec, Canada G1V 4G5
    Respir Med 101:2327-35. 2007
    ..Latent adenoviral infection (Ad5) increases emphysema development and the inflammatory response to cigarette smoke and, in allergic lung inflammation, suppresses anti-inflammatory effects of steroids...
  25. ncbi Decreased histone deacetylase activity in chronic obstructive pulmonary disease
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 352:1967-76. 2005
    ..HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages...
  26. pmc Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease
    Wen Ning
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 101:14895-900. 2004
    ..Our study represents the first comprehensive analysis of gene expression on GOLD-2 versus GOLD-0 smokers and reveals previously unreported candidate genes that may serve as potential molecular targets in COPD...