Abhijit Guha

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Advances in the biology of astrocytomas
    Abhijit Guha
    Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    Curr Opin Neurol 17:655-62. 2004
  2. doi Loss of collapsin response mediator Protein1, as detected by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EGFRvIII
    Joydeep Mukherjee
    Arthur and Sonia Labatts Brain Tumor Research Center, Hospital for Sick Children s Research Institute, University of Toronto, Toronto, Canada
    Cancer Res 69:8545-54. 2009
  3. pmc Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1
    Gelareh Zadeh
    Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Neoplasia 7:1081-90. 2005
  4. ncbi Role of Ang1 and its interaction with VEGF-A in astrocytomas
    Gelareh Zadeh
    From Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Canada
    J Neuropathol Exp Neurol 63:978-89. 2004
  5. pmc Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
    Amparo Wolf
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
    J Exp Med 208:313-26. 2011
  6. pmc Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb
    Jonathan R Krieger
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    Mol Cell Proteomics 12:499-514. 2013
  7. doi Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft
    Priya Bhola
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Int J Cancer 126:563-71. 2010
  8. pmc Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model
    Patrick Shannon
    Department of Neuropathology, The University of Toronto, Toronto, Ontario, Canada, M5T 2S8
    Am J Pathol 167:859-67. 2005
  9. doi Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme
    Amparo Wolf
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, 11 401E, 101 College Street, East Tower, Ontario, Canada, M5G 1L7
    Neurobiol Dis 44:84-91. 2011
  10. ncbi High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model
    Qingxia Wei
    Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University Health Network, Toronto, Ontario, Canada
    Cancer Res 66:7429-37. 2006

Collaborators

Detail Information

Publications53

  1. ncbi Advances in the biology of astrocytomas
    Abhijit Guha
    Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    Curr Opin Neurol 17:655-62. 2004
    ..This review highlights some of the findings over the past year (June 2003-2004) that have contributed to this slow but essential journey towards our understanding of the biology of astrocytomas...
  2. doi Loss of collapsin response mediator Protein1, as detected by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EGFRvIII
    Joydeep Mukherjee
    Arthur and Sonia Labatts Brain Tumor Research Center, Hospital for Sick Children s Research Institute, University of Toronto, Toronto, Canada
    Cancer Res 69:8545-54. 2009
    ..Collectively, these results show that the loss of CRMP1 contribute to the increased invasive phenotype of human GBMs expressing mutant EGFRvIII...
  3. pmc Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1
    Gelareh Zadeh
    Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Neoplasia 7:1081-90. 2005
    ..Collectively, these results support our hypothesis that Ang1 is a key molecular regulator of pathological vascularization characteristic of malignant astrocytomas...
  4. ncbi Role of Ang1 and its interaction with VEGF-A in astrocytomas
    Gelareh Zadeh
    From Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Canada
    J Neuropathol Exp Neurol 63:978-89. 2004
    ..Collectively, our data suggest that Ang1 regulates GBM vascularity in a VEGF-A dependent manner, synergizing the initial pro-angiogenic response that is triggered by VEGF-A and promoting the vascular growth of GBM...
  5. pmc Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
    Amparo Wolf
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
    J Exp Med 208:313-26. 2011
    ..Collectively, these findings suggest that therapeutic strategies to modulate the Warburg effect, such as targeting of HK2, may interfere with growth and therapeutic sensitivity of some GBMs...
  6. pmc Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb
    Jonathan R Krieger
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    Mol Cell Proteomics 12:499-514. 2013
    ..Hence, quantitative mass spectrometric analysis of Numb protein-protein interactions has provided new insights into the assembly and regulation of protein complexes important in development and cancer...
  7. doi Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft
    Priya Bhola
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Int J Cancer 126:563-71. 2010
    ..This study demonstrates the therapeutic potential and limitations of rapamycin in NF1-associated, and likely sporadic, MPNSTs...
  8. pmc Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model
    Patrick Shannon
    Department of Neuropathology, The University of Toronto, Toronto, Ontario, Canada, M5T 2S8
    Am J Pathol 167:859-67. 2005
    ..Of interest, many of these acquired alterations occur in human astrocytomas, further validating GFAP-RAS as a useful model for studying astrocytoma development and progression...
  9. doi Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme
    Amparo Wolf
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, 11 401E, 101 College Street, East Tower, Ontario, Canada, M5G 1L7
    Neurobiol Dis 44:84-91. 2011
    ..Overall, our results demonstrate that proliferative states including the developing embryo and malignant gliomas, which rely on aerobic glycolysis, preferentially express the HK2 isoform, found to be regulated in part epigenetically...
  10. ncbi High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model
    Qingxia Wei
    Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University Health Network, Toronto, Ontario, Canada
    Cancer Res 66:7429-37. 2006
    ..This novel preclinical model of high-grade glioma will be useful in evaluating brain tumor therapies targeted to the pathways specifically dysregulated by EGFR expression or Pten loss...
  11. doi Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner
    Diana Marcela Muñoz
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada
    Glia 61:1862-72. 2013
    ....
  12. doi Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice
    Kristin McLarty
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada M5T 1R8
    Nucl Med Biol 38:953-9. 2011
    ..Studies of [(18)F]-2-fluoro-2-deoxy-d-glucose ([(18)F]-FDG) under the same conditions were also performed...
  13. doi Human schwannomas express activated platelet-derived growth factor receptors and c-kit and are growth inhibited by Gleevec (Imatinib Mesylate)
    Joydeep Mukherjee
    Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 69:5099-107. 2009
    ..However, the established long track record and tolerable toxicity of Gleevec already in clinical use and our preclinical data lead us to propose that Gleevec should be evaluated in human schwannomas with shown progressive growth...
  14. pmc A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas
    Sameer Agnihotri
    The Arthur and Sonia Labatt s Brain Tumor Research Centre, The Hospital for Sick Children s Research Institute, Toronto Western Hospital, University of Toronto, Toronto M5A 2N4, Ontario, Canada
    J Exp Med 208:689-702. 2011
    ..Identification and validation of GATA4 as a TSG and its downstream targets in GBM may yield promising novel therapeutic strategies...
  15. pmc Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients
    Sameer Agnihotri
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:253-66. 2012
    ..Collectively, our data demonstrate that APNG contributes to TMZ resistance in GBM and may be useful in the diagnosis and treatment of the disease...
  16. pmc GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model
    Deepak Kamnasaran
    The Arthur and Sonia Labatts Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada M5G 1X8
    Proc Natl Acad Sci U S A 104:8053-8. 2007
    ..This work also demonstrates the utility of random mutagenesis strategies, such as gene trapping, on murine cancer models toward discovery of novel genetic alterations in corresponding human cancers...
  17. doi Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes
    Vedant Arun
    The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada Cell Biology Program, Hospital for Sick Children, Toronto, Canada
    FEBS Lett 587:1466-73. 2013
    ..Our studies suggest that NF1 is involved in melanosomal localization, and that disruptions in NF1-DHC interactions may contribute to the abnormal pigmentary features commonly associated with this debilitating syndrome...
  18. pmc Investigation of the in vitro therapeutic efficacy of nilotinib in immortalized human NF2-null vestibular schwannoma cells
    Nesrin Sabha
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada
    PLoS ONE 7:e39412. 2012
    ..These anti-tumorigenic effects of nilotinib were correlated to inhibited activation of PDGFR-α and PDGFR-β and major downstream signalling pathways. These experiments support a therapeutic potential for Nilotinib in VS...
  19. pmc Targeting the Tie2/Tek receptor in astrocytomas
    Gelareh Zadeh
    Arthur and Sonia Labatt Brain Tumor Center, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Pathol 164:467-76. 2004
    ..We postulate that targeting Tie2 activation, either independently or in conjunction with other anti-angiogenic therapies, such as against vascular endothelial growth factor, is of potential clinical interest...
  20. doi Potential role of 18fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with neurofibromatosis 1
    Konstantina Karabatsou
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Neurosurgery 65:A160-70. 2009
    ..18FDG-PET/CT has the added advantage of fusing metabolic and anatomic imaging data sets...
  21. ncbi Molecular regulators of angiogenesis in the developing nervous system and adult brain tumors (review)
    Gelareh Zadeh
    Arthur and Sonia Labatt Brain Tumor Center, Hospital for Sick Children, Toronto, Ontario, Canada
    Int J Oncol 23:557-65. 2003
    ..In this review we summarize the role of the main angiogenic factors in both normal embryonal vascularization of the embryonal nervous system together with the main brain tumors seen in adults...
  22. pmc Glioblastoma multiforme after stereotactic radiotherapy for acoustic neuroma: case report and review of the literature
    Anandh Balasubramaniam
    Arthur and Sonia Labatt Brain Tumor Center, Hospital for Sick Children, University of Toronto, 399 Bathurst St, 4W 446, Toronto, ON M5T 2S8, Canada
    Neuro Oncol 9:447-53. 2007
    ..However, the risk is not zero and requires discussion with the patient, with specific consideration in young patients and those with a cancer predisposition...
  23. pmc High-resolution longitudinal screening with magnetic resonance imaging in a murine brain cancer model
    Nicholas A Bock
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Neoplasia 5:546-54. 2003
    ....
  24. ncbi A human transferrin-vascular endothelial growth factor (hnTf-VEGF) fusion protein containing an integrated binding site for (111)In for imaging tumor angiogenesis
    Conrad Chan
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    J Nucl Med 46:1745-52. 2005
    ..The hnTf domain allowed labeling with (111)In at a site remote from the VEGF receptor-binding domain...
  25. ncbi Targeting metabolic remodeling in glioblastoma multiforme
    Amparo Wolf
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
    Oncotarget 1:552-62. 2010
    ..Targeting key metabolic enzymes involved in modulating the "Warburg Effect" may provide a novel therapeutic approach either singularly or in combination with existing therapies in GBMs...
  26. pmc Role of angiopoietin-2 in regulating growth and vascularity of astrocytomas
    Gelareh Zadeh
    Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Canada M5G 2G4
    J Oncol 2010:659231. 2010
    ....
  27. pmc Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stress
    Kevin C Hadley
    Department of Medical Biophysics, University of Toronto Ontario Cancer Institute, 101 College Street, Toronto, ON, M5G 1L7, Canada
    Cell Stress Chaperones 16:549-61. 2011
    ..Multiphoton imaging of ANS binding should be a useful probe for monitoring protein misfolding stress in cells...
  28. ncbi Angiogenesis in nervous system disorders
    Gelareh Zadeh
    Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children s Research Institute, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 53:1362-74; discussion 1374-6. 2003
    ..This review summarizes the current understanding of the role of principal angiogenic factors relevant to neurosurgical abnormalities...
  29. ncbi Neoangiogenesis in human astrocytomas: expression and functional role of angiopoietins and their cognate receptors
    Gelareh Zadeh
    Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Childrens, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada
    Front Biosci 8:e128-37. 2003
    ....
  30. ncbi Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression
    Nelson Lau
    Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Int J Oncol 22:195-200. 2003
    ....
  31. doi A proximity ligation assay using transiently transfected, epitope-tagged proteins: application for in situ detection of dimerized receptor tyrosine kinases
    Aaron Gajadhar
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Canada
    Biotechniques 48:145-52. 2010
    ..This assay also holds promise as a general RTK dimerization screening tool in tissue specimens to identify potential dimerization inhibitors with clinical relevance...
  32. ncbi Radiation induced peripheral nerve tumors: case series and review of the literature
    Gelareh Zadeh
    Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    J Neurooncol 83:205-12. 2007
    ..The clinical and pathologic features of six cases of post-radiation PNT's are reported here, more than doubling the number of known cases reported in the literature...
  33. pmc Malignant and benign ganglioglioma: a pathological and molecular study
    Ajay Pandita
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Neuro Oncol 9:124-34. 2007
    ..Deciphering the specific genes residing in these chromosomal regions may further our understanding of not only these rare tumors but also the more common gliomas...
  34. doi Proteomics: present and future implications in neuro-oncology
    Johann Micallef
    Arthur and Sonia Labatt Brain Tumour Center, Hospital for Sick Children s Research Institute, University of Toronto, Toronto, Canada
    Neurosurgery 62:539-55; discussion 539-55. 2008
    ..In addition to reviewing the principles and potential utilization of these two techniques, we highlight their application in neuro-oncology research...
  35. doi A novel neurofibromin (NF1) interaction with the leucine-rich pentatricopeptide repeat motif-containing protein links neurofibromatosis type 1 and the French Canadian variant of Leigh's syndrome in a common molecular complex
    Vedant Arun
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosci Res 91:494-505. 2013
    ..Our findings provide clues to how loss or mutation of NF1 and LRPPRC may contribute to the manifestations of NF-1 and LSFC...
  36. pmc Mouse models to interrogate the implications of the differentiation status in the ontogeny of gliomas
    Diana Marcela Muñoz
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1L7
    Oncotarget 2:590-8. 2011
    ..This is an area of high interest in cancer in general, with potential significant therapeutic and prognostic implications...
  37. doi Vestibular Schwannomas presenting with haemorrhage: clinical presentation and histopathological evaluation of an unusual entity
    Amir R Dehdashti
    Division of Neurosurgery, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Br J Neurosurg 23:431-6. 2009
    ..Tumor size may not be a major risk factor for haemorrhage. Good outcomes can be achieved with microsurgical management. The histological features presented here differ clearly from findings in previously published case reports...
  38. ncbi Fiber density index correlates with reduced fractional anisotropy in white matter of patients with glioblastoma
    Tim P L Roberts
    Department of Medical Imaging, University of Toronto, Toronto, Canada
    AJNR Am J Neuroradiol 26:2183-6. 2005
    ..In this report, FDi is computed in 10 patients with glioblastoma multiforme, in white matter that is peritumoral and contralateral. FDi is shown to correlate significantly with fractional anisotropy...
  39. doi Surgical management of cervical spine manifestations of neurofibromatosis Type 1: long-term clinical and radiological follow-up in 22 cases
    Faisal S Taleb
    Neuroscience Center, Toronto Western Hospital, Spinal Program, West Wing 4th Floor, 399 Bathurst Street, Toronto, Ontario, Canada
    J Neurosurg Spine 14:356-66. 2011
    ..Iatrogenic instability following resection of tumors is underappreciated in the literature. The focus of this study was to understand the indications for stabilization in this specific group of patients...
  40. doi Lipoma compressing the brachial plexus in a patient with sarcoidosis: case report
    Daipayan Guha
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Br J Neurosurg 25:530-1. 2011
    ..We document a unique case of a sarcoidosis patient with an extraneural lipoma compressing the brachial plexus, and present a review of the current literature...
  41. pmc Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells
    Stacy A Woods
    The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Neuro Oncol 4:242-52. 2002
    ..This study suggests that modulation of signaling pathways implicated in proliferation of astrocytoma cell lines may have varying effects in vivo depending on the role these pathways play in regulating tumor angiogenesis...
  42. ncbi Aberrant G protein signaling in nervous system tumors
    Stacey A Woods
    Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 97:627-42. 2002
    ..In this paper, the authors review G protein signaling in general and its aberrations in four human nervous system tumors...
  43. doi Three-dimensional in vivo modeling of vestibular schwannomas and surrounding cranial nerves with diffusion imaging tractography
    David Qixiang Chen
    Division of Neurosurgery, Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 68:1077-83. 2011
    ..However, imaging of the CN fibers surrounding vestibular schwannomas has been limited with 2-dimensional imaging alone...
  44. ncbi Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing
    Sophia S Cheon
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    FASEB J 20:692-701. 2006
    ..These results demonstrate a crucial role for beta-catenin in regulating cutaneous wound size. Furthermore, these data implicate mesenchymal cells as playing a critical role regulating wound size...
  45. ncbi Metaplastic bone formation in a low grade conus glioma: case report and review of the literature
    Vitaly Siomin
    Division of Neurosurgery Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    J Neurooncol 62:275-80. 2003
    ..We present a case of bony metaplasia in the conus medullaris associated with a low grade astrocytoma. Radiological, pathological and clinical features of this unique case are discussed...
  46. ncbi Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR
    Ajay Pandita
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario
    Genes Chromosomes Cancer 39:29-36. 2004
    ....
  47. ncbi Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6
    Alec C Kimmelman
    The Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncogene 23:5077-83. 2004
    ..Our results provide the first evidence of functional tumor suppression by KFL6, and its loss may contribute to glial tumor progression...
  48. ncbi Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model
    Hao Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, USA
    Cancer Res 63:1106-13. 2003
    ....
  49. pmc Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors
    Isamu Okamoto
    Department of Microbiology and Immunology, Kimmel Cancer Institute, BLSB 2002, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107, USA
    Am J Pathol 160:441-7. 2002
    ..Tumors expressing a CD44 splice variant showed a significantly higher incidence of enhanced CD44 cleavage. The wide prevalence of CD44 cleavage suggests that it plays an important role in the pathogenesis of human tumors...
  50. doi Intermittent atlantoaxial subluxation caused by a prolapsing neurofibroma. Case report
    Michael O Kelleher
    Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Ontario, Canada
    J Neurosurg Spine 8:288-91. 2008
    ..The authors discuss this unusual lesion and describe the associated operative findings and surgical management...
  51. pmc Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients
    Fatima W Khwaja
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road NE, Atlanta, GA 30322, USA
    J Proteome Res 6:559-70. 2007
    ....
  52. ncbi Expression of GATA6 in the human and mouse central nervous system
    Deepak Kamnasaran
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada M5G 1X8
    Brain Res Dev Brain Res 160:90-5. 2005
    ..2 kb transcript in the adult mouse brain and several regions of the adult human brain. Furthermore, cellular characterization demonstrates GATA6 nuclear expression in neurons, astrocytes, choroids plexus epithelium, and endothelial cells...
  53. ncbi Mouse glioma gene expression profiling identifies novel human glioma-associated genes
    David H Gutmann
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 51:393-405. 2002
    ..The use of this transgenic mouse model to identify novel genetic changes that might underlie the pathogenesis of human high-grade astrocytomas provides a unique opportunity to discover future targets for brain tumor therapy...