Susantha Gomis

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. pmc Protection of chickens against Escherichia coli infections by DNA containing CpG motifs
    Susantha Gomis
    Veterinary Infectious Disease Organization, Saskatoon, Saskatchewan, Canada S7N 5E3
    Infect Immun 71:857-63. 2003
  2. ncbi request reprint Protection of chickens against a lethal challenge of Escherichia coli by a vaccine containing CpG oligodeoxynucleotides as an adjuvant
    Susantha Gomis
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4
    Avian Dis 51:78-83. 2007
  3. ncbi request reprint Protection of neonatal chicks against a lethal challenge of Escherichia coli using DNA containing cytosine-phosphodiester-guanine motifs
    Susantha Gomis
    Department of Veterinary Pathology, Western College of Veterinary Medicine, 52 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Avian Dis 48:813-22. 2004
  4. ncbi request reprint Pathotypic and molecular characterization of a fowl adenovirus associated with inclusion body hepatitis in Saskatchewan chickens
    Arshud Dar
    Vaccine and Infectious Disease Organization, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3
    Avian Dis 56:73-81. 2012
  5. doi request reprint Oligodeoxynucleotides containing CpG motifs (CpG-ODN) predominantly induce Th1-type immune response in neonatal chicks
    Bhavini A Patel
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Dev Comp Immunol 32:1041-9. 2008
  6. doi request reprint IL-12p40 gene-deficient BALB/c mice exhibit lower weight loss, reduced lung pathology and decreased sensitization to allergen in response to infection with pneumonia virus of mice
    Pratima Shrivastava
    VIDO Intervac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Virology 497:1-10. 2016
  7. doi request reprint Role of Hsp90 in CpG ODN mediated immunostimulation in avian macrophages
    Audesh Bhat
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Mol Immunol 47:1337-46. 2010
  8. ncbi request reprint Inclusion body hepatitis as a primary disease in broilers in Saskatchewan, Canada
    Susantha Gomis
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4
    Avian Dis 50:550-5. 2006
  9. doi request reprint Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice
    Elisa C Martinez
    Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, 107 Wiggins Road, S7N 5E5, Canada Vaccine and Infectious Disease Organization International Vaccine Centre VIDO InterVac, University of Saskatchewan, Saskatoon, Saskatchewan, 120 Veterinary Road, S7N 5E3, Canada
    Antiviral Res 135:108-119. 2016
  10. doi request reprint Blunted inflammatory and mucosal IgA responses to pneumonia virus of mice in C57BL/6 neonates are correlated to reduced protective immunity upon re-infection as elderly mice
    Pratima Shrivastava
    VIDO Intervac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Virology 485:233-43. 2015

Collaborators

Detail Information

Publications14

  1. pmc Protection of chickens against Escherichia coli infections by DNA containing CpG motifs
    Susantha Gomis
    Veterinary Infectious Disease Organization, Saskatoon, Saskatchewan, Canada S7N 5E3
    Infect Immun 71:857-63. 2003
    ..This is the first time that CpG-ODN((2007)) has been demonstrated to have an immunoprotective effect against an extracellular bacterial infection in any food animal species...
  2. ncbi request reprint Protection of chickens against a lethal challenge of Escherichia coli by a vaccine containing CpG oligodeoxynucleotides as an adjuvant
    Susantha Gomis
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4
    Avian Dis 51:78-83. 2007
    ..This study is the first study in which CpG-ODN has been demonstrated to produce an adaptive immune response, at a significant level, against an extracellular bacterial infection in chickens...
  3. ncbi request reprint Protection of neonatal chicks against a lethal challenge of Escherichia coli using DNA containing cytosine-phosphodiester-guanine motifs
    Susantha Gomis
    Department of Veterinary Pathology, Western College of Veterinary Medicine, 52 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Avian Dis 48:813-22. 2004
    ..coli infections. This is the first time that CpG ODN has been demonstrated to have an immunoprotective effect against a bacterial infection in chicks following in ovo delivery...
  4. ncbi request reprint Pathotypic and molecular characterization of a fowl adenovirus associated with inclusion body hepatitis in Saskatchewan chickens
    Arshud Dar
    Vaccine and Infectious Disease Organization, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3
    Avian Dis 56:73-81. 2012
    ....
  5. doi request reprint Oligodeoxynucleotides containing CpG motifs (CpG-ODN) predominantly induce Th1-type immune response in neonatal chicks
    Bhavini A Patel
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Dev Comp Immunol 32:1041-9. 2008
    ..To our knowledge, this is the first report evaluating the induction of cytokines/chemokines in neonatal chicks following administration of CpG-ODN...
  6. doi request reprint IL-12p40 gene-deficient BALB/c mice exhibit lower weight loss, reduced lung pathology and decreased sensitization to allergen in response to infection with pneumonia virus of mice
    Pratima Shrivastava
    VIDO Intervac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Virology 497:1-10. 2016
    ..In conclusion, these data suggest that a depressed regulatory capacity in BALB/c mice to PVM infection results in enhanced immunopathology and sensitization to allergen. ..
  7. doi request reprint Role of Hsp90 in CpG ODN mediated immunostimulation in avian macrophages
    Audesh Bhat
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Mol Immunol 47:1337-46. 2010
    ..To our knowledge, this is the first report evaluating the involvement of Hsp90 and kinase (MAPK/ERK and PI3K/AKT) pathways in CpG mediated immunostimulation in avian macrophage cells...
  8. ncbi request reprint Inclusion body hepatitis as a primary disease in broilers in Saskatchewan, Canada
    Susantha Gomis
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4
    Avian Dis 50:550-5. 2006
    ....
  9. doi request reprint Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice
    Elisa C Martinez
    Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, 107 Wiggins Road, S7N 5E5, Canada Vaccine and Infectious Disease Organization International Vaccine Centre VIDO InterVac, University of Saskatchewan, Saskatoon, Saskatchewan, 120 Veterinary Road, S7N 5E3, Canada
    Antiviral Res 135:108-119. 2016
    ..On day 14 post-infection, P-I-P-treated mice were confirmed to be PVM-free. These results demonstrate the capacity of this formulation to prevent PVM and possibly other viral respiratory infections...
  10. doi request reprint Blunted inflammatory and mucosal IgA responses to pneumonia virus of mice in C57BL/6 neonates are correlated to reduced protective immunity upon re-infection as elderly mice
    Pratima Shrivastava
    VIDO Intervac, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Virology 485:233-43. 2015
    ..These results suggest that an effective local innate response, as well as priming of mucosal adaptive responses in neonates after PVM-15 infection is correlated to decreased susceptibility and protection upon re-infection. ..
  11. pmc Innate and adaptive immune response to pneumonia virus of mice in a resistant and a susceptible mouse strain
    Ellen R T Watkiss
    VIDO Intervac, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada
    Viruses 5:295-320. 2013
    ..Overall, the difference in susceptibility of these two strains appeared to be related not to an inherent T helper bias, but to the capacity of the C57Bl/6 mice to control both viral replication and the immune response elicited by PVM...
  12. ncbi request reprint Formulation with CpG oligodeoxynucleotides increases cellular immunity and protection induced by vaccination of calves with formalin-inactivated bovine respiratory syncytial virus
    John W Mapletoft
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    Virology 353:316-23. 2006
    ..Based on these observations, CpG ODN appears to be a suitable candidate adjuvant for inactivated BRSV vaccines...
  13. pmc Association of increased rate of condemnation of broiler carcasses due to hepatic abnormalities with immunosuppressive diseases in the broiler chicken industry in Saskatchewan
    Keyvan Amini
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4 Amini, Zachar, Popowich, Goodhope, Gomis Department of Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A8 Knezacek Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5 Willson
    Can J Vet Res 79:261-7. 2015
    ..The results of this study demonstrate that hepatic lesions in Saskatchewan chickens are not currently caused by a primary bacterial pathogen but are associated with indicators of immunosuppression that is likely due to variant IBDV. ..
  14. doi request reprint Genotyping of Canadian isolates of fowl adenoviruses
    Davor Ojkic
    Animal Health Laboratory, University of Guelph, Guelph, Ontario, Canada
    Avian Pathol 37:95-100. 2008
    ..Co-infection rates in non-IBH submissions were 50.00% for infectious bursal disease virus, 40.70% for infectious bronchitis virus, 27.91% for reoviruses and 1.16% for Newcastle disease virus...