Elizabeth C Finger
Affiliation: University of Western Ontario
- Disrupted reinforcement signaling in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traitsElizabeth C Finger
Department of Clinical Neurological Sciences, Schulich School of Medicine, University of Western Ontario, Canada
Am J Psychiatry 168:152-62. 2011....
- Oxytocin for frontotemporal dementia: a randomized dose-finding study of safety and tolerabilityElizabeth C Finger
From the Departments of Clinical Neurological Sciences E C F, J M, M B, S J, S P, A K, Medicine M B, J W, Psychiatry D G V M, and Anatomy and Cell Biology D G V M, and Graduate Program in Neuroscience L D O, Schulich School of Medicine and Dentistry, Western University, London, Ontario Tanz Centre for Research in Neurodegenerative Disease M C T, University of Toronto, Canada Freie Universität Berlin I D, Cluster of Excellence Languages of Emotion, Berlin, Germany and Department of Neurology K R, A B, University of California San Francisco School of Medicine
Neurology 84:174-81. 2015..To determine the safety and tolerability of 3 doses of intranasal oxytocin (Syntocinon; Novartis, Bern, Switzerland) administered to patients with frontotemporal dementia (FTD)...
- Genetic modifiers in carriers of repeat expansions in the C9ORF72 geneMarka van Blitterswijk
Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Mol Neurodegener 9:38. 2014..Substantial phenotypic heterogeneity has been described in patients with these expansions. We set out to identify genetic modifiers of disease risk, age at onset, and survival after onset that may contribute to this clinical variability...
- TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's diseaseSruti Rayaprolu
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
Mol Neurodegener 8:19. 2013..With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders...
- Impaired functional but preserved structural connectivity in limbic white matter tracts in youth with conduct disorder or oppositional defiant disorder plus psychopathic traitsElizabeth Carrie Finger
Department of Clinical Neurological Sciences, Schulich School of Medicine, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada N6A 35A5
Psychiatry Res 202:239-44. 2012..If white matter tracts are intact in youths with this disorder, childhood may provide a critical window for intervention and treatment, before significant structural brain abnormalities solidify...
- Dissociable roles of medial orbitofrontal cortex in human operant extinction learningElizabeth C Finger
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Neuroimage 43:748-55. 2008..These findings suggest that in humans, frontopolar OFC modulates activity in caudal mOFC, rACC and amygdala during successful operant extinction learning...
- New potential therapeutic approaches in frontotemporal dementia: oxytocin, vasopressin, and social cognitionElizabeth C Finger
Department of Clinical Neurological Sciences, Schulich School of Medicine, University of Western Ontario, B10 004, 339 Windermere Rd, London, ON, N6A 5A5, Canada
J Mol Neurosci 45:696-701. 2011..Here, we review the effects of oxytocin and vasopressin on social cognition and behavior and discuss the potential implications for these agents as novel treatments in FTD...
- Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learningElizabeth C Finger
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Arch Gen Psychiatry 65:586-94. 2008....
- Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disordersAbigail A Marsh
Mood and Anxiety Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
Am J Psychiatry 165:712-20. 2008..Moreover, despite high comorbidity of callous-unemotional traits and attention deficit hyperactivity disorder (ADHD), no research has attempted to distinguish neural correlates of pediatric callous-unemotional traits and ADHD...
- Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traitsAbigail A Marsh
Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA
Psychiatry Res 194:279-86. 2011..These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population...
- Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletionAbigail A Marsh
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Psychopharmacology (Berl) 189:387-94. 2006..Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed...
- Adapting to dynamic stimulus-response values: differential contributions of inferior frontal, dorsomedial, and dorsolateral regions of prefrontal cortex to decision makingDerek G V Mitchell
National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 29:10827-34. 2009..These data are interpreted with reference to models of dmPFC, dlPFC, and IFG functioning...
- The effects of oxytocin on social cognition and behaviour in frontotemporal dementiaSarah Jesso
Department of Clinical Neurological Sciences, University of Western Ontario, B10 004, 339 Windermere Rd, London, ON, Canada N6A 5A5
Brain 134:2493-501. 2011....
- The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasksElizabeth C Finger
Mood and Anxiety Disorders Program, Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 32:206-15. 2007..Furthermore, they demonstrate behavioral differences in responses to punishing stimuli between long allele homozygotes and short allele carriers when serotonin levels are acutely reduced...
- Altered neural function in pediatric bipolar disorder during reversal learningDaniel P Dickstein
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Bipolar Disord 12:707-19. 2010..Here, we use event-related functional magnetic resonance imaging (fMRI) to elucidate neural correlates of reversal learning deficits in euthymic BD youth compared to typically developing controls...
- Parsing decision making processes in prefrontal cortex: response inhibition, overcoming learned avoidance, and reversal learningSteven G Greening
Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada
Neuroimage 54:1432-41. 2011..The approach has implications for models of prefrontal function and neurocognitive perspectives on a range of behavioural abnormalities associated with impairments in decision making...
- Psychosis and hallucinations in frontotemporal dementia with the C9ORF72 mutation: a detailed clinical cohortAndrew Kertesz
Departments of Clinical Neurological Sciences and Pathology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada Department of Neuroscience, Mayo Clinic, Jacksonville, FL
Cogn Behav Neurol 26:146-54. 2013..To specify the presenting symptoms and clinical course of patients with frontotemporal dementia (FTD) and chromosome 9 open reading frame 72 (C9ORF72) repeat expansion...
- Parsing cognitive and emotional empathy deficits for negative and positive stimuli in frontotemporal dementiaLindsay D Oliver
Schulich School of Medicine and Dentistry, Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada Department of Psychology, Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada
Neuropsychologia 67:14-26. 2015....
- Caught in the act: the impact of audience on the neural response to morally and socially inappropriate behaviorElizabeth C Finger
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K, North Drive, MSC 2670, Bethesda, MD 20892, USA
Neuroimage 33:414-21. 2006..These regions have been implicated in the representation of the mental states of others (Theory of Mind). The presence of an audience was associated with increased left amygdala activity across all conditions...
- Is the emotion recognition deficit associated with frontotemporal dementia caused by selective inattention to diagnostic facial features?Lindsay D Oliver
Graduate Program in Neuroscience, University of Western Ontario, London, ON, Canada Department of Psychology, Brain and Mind Institute, University of Western Ontario, London, ON, Canada
Neuropsychologia 60:84-92. 2014..This work suggests that the emotional expression recognition deficit associated with FTD is unlikely to be rectified by adjusting selective attention to diagnostic features, as has proven useful in other select disorders. ..
- Detection and Differentiation of Frontotemporal Dementia and Related Disorders From Alzheimer Disease Using the Montreal Cognitive AssessmentKristy K L Coleman
Parkwood Institute Cognitive Neurology, Parkwood Institute Clinical Neurological Sciences, Schulich School of Medicine, Western University, London Infectious Disease Epidemiologic Research Unit, Mount Sinai Hospital, Toronto, ON, Canada
Alzheimer Dis Assoc Disord 30:258-63. 2016..The results indicate that the MoCA is a useful tool to identify and track progression of CI in FTD. Further, the data informs future research on scoring models for the MoCA to enhance cognitive screening and detection of FTD patients. ..