Carlos Fernandez-Patron

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. doi request reprint Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 54:575-82. 2009
  2. doi request reprint MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE
    Jeffrey Odenbach
    Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 57:123-30. 2011
  3. ncbi request reprint Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway
    Li Hao
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Circ Res 94:68-76. 2004
  4. doi request reprint Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis
    Prabhakara Reddy Nagareddy
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada T6G 2H7
    Cardiovasc Res 84:368-77. 2009
  5. pmc Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver
    Samuel Hernandez-Anzaldo
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada S H A, E B, D L, C F P
    J Am Heart Assoc 4:. 2015
  6. doi request reprint Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Circulation 119:2480-9. 2009
  7. pmc Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever
    Evan Berry
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada E B, S H A, X W, C F P
    J Am Heart Assoc 4:. 2015
  8. doi request reprint Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heart
    Xiang Wang
    From the Departments of Biochemistry X W, E B, S H A, C F P and Physiology A T, Z K, Mazankowski Alberta Heart Institute Z K, C F P, Cardiovascular Research Group Z K, C F P, and Faculty of Medicine and Dentistry X W, E B, S H A, C F P, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 65:882-8. 2015
  9. doi request reprint Insights into the activity, differential expression, mutual regulation, and functions of matrix metalloproteinases and a disintegrin and metalloproteinases in hypertension and cardiac disease
    Evan Berry
    Department of Biochemistry, School of Translational Medicine, University of Alberta, Edmonton, Alta, Canada
    J Vasc Res 50:52-68. 2013
  10. doi request reprint Mitochondrial dysfunction in the hypertensive rat brain: respiratory complexes exhibit assembly defects in hypertension
    Ana Lopez-Campistrous
    Department of Biochemistry, Institute for Biomolecular Design, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 51:412-9. 2008

Collaborators

  • Zamaneh Kassiri
  • Richard Lehner
  • Gavin Y Oudit
  • Liang Li
  • Wang Zheng
  • John H McNeill
  • Richard Schulz
  • Makoto Murakami
  • Dawei Zhang
  • Fan Zhang
  • Xiang Wang
  • Samuel Hernandez-Anzaldo
  • Evan Berry
  • Li Hao
  • Ana Lopez-Campistrous
  • Jeffrey Odenbach
  • Fung Lan Chow
  • Tatsujiro Oka
  • Mengcheng Shen
  • Pu Zhang
  • Dong Fan
  • Dickson Leung
  • Gerard Lambeau
  • Janos G Filep
  • Vesna Brglez
  • Abhijit Takawale
  • Stephan Cooper
  • Prabhakara Reddy Nagareddy
  • Gary D Lopaschuk
  • Tamiko Nishimura
  • John M Seubert
  • Roger H Lijnen
  • Dennis E Vance
  • Ratnadeep Basu
  • Vaibhav Patel
  • Jean E Vance
  • Bianca Hemmeryckx
  • Victor Samokhvalov
  • Xiuhua Wang
  • Farideh Ghomashchi
  • Ayinuer Adijiang
  • Tae Jin Yun
  • Michael H Gelb
  • Jun Seong Lee
  • Cheolho Cheong
  • Difei Sun
  • Ana Maria Bosonea
  • Gary Lopaschuk
  • Sandra Kelly
  • Fung L Chow
  • Kathleen M Macleod
  • Barry A Finegan
  • Stephan B Cooper
  • Jeff Odenbach
  • Dong Ton
  • Michael J Ellison
  • Paul Semchuk
  • Joerg Sander
  • Wang Xiang
  • Hua Wo
  • Min Du

Detail Information

Publications19

  1. doi request reprint Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 54:575-82. 2009
    ..Targeting TACE has potential therapeutic importance for modulating agonist-induced cardiac remodeling...
  2. doi request reprint MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE
    Jeffrey Odenbach
    Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 57:123-30. 2011
    ..This suggests a functional specialization of MMP-2 in agonist-induced cardiovascular disease development that has potential implications for the design of metalloproteinase-based therapeutic strategies...
  3. ncbi request reprint Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway
    Li Hao
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Circ Res 94:68-76. 2004
    ..Because this mechanism is triggered by agonists typically overexpressed in hypertension, its blockade may have therapeutic potential for simultaneously inhibiting pathological vasoconstriction and growth in hypertensive disorders...
  4. doi request reprint Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis
    Prabhakara Reddy Nagareddy
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada T6G 2H7
    Cardiovasc Res 84:368-77. 2009
    ..In the present study, we examined whether MMP modulation of vascular tone involves phosphoinositide 3-kinase (PI3K) and mitochondrial ATP synthesis...
  5. pmc Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver
    Samuel Hernandez-Anzaldo
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada S H A, E B, D L, C F P
    J Am Heart Assoc 4:. 2015
    ....
  6. doi request reprint Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Circulation 119:2480-9. 2009
    ..Here, we report that matrix metalloproteinase-7 (MMP-7) and a disintegrin and metalloproteinase-12 (ADAM-12) form a novel signaling axis in these processes...
  7. pmc Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever
    Evan Berry
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada E B, S H A, X W, C F P
    J Am Heart Assoc 4:. 2015
    ..Here, we reveal an MMP-2-mediated mechanism that modulates the inflammatory response via secretory phospholipase A2 (sPLA2), a phospholipid hydrolase that releases fatty acids, including precursors of eicosanoids...
  8. doi request reprint Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heart
    Xiang Wang
    From the Departments of Biochemistry X W, E B, S H A, C F P and Physiology A T, Z K, Mazankowski Alberta Heart Institute Z K, C F P, Cardiovascular Research Group Z K, C F P, and Faculty of Medicine and Dentistry X W, E B, S H A, C F P, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 65:882-8. 2015
    ..This complex phenotype is, at least in part, because of the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway being upregulated in MMP-2 deficiency. ..
  9. doi request reprint Insights into the activity, differential expression, mutual regulation, and functions of matrix metalloproteinases and a disintegrin and metalloproteinases in hypertension and cardiac disease
    Evan Berry
    Department of Biochemistry, School of Translational Medicine, University of Alberta, Edmonton, Alta, Canada
    J Vasc Res 50:52-68. 2013
    ..The emerging links between metalloproteinases and lipids are intriguing and suggest new therapeutic targets in hypertensive cardiac disease...
  10. doi request reprint Mitochondrial dysfunction in the hypertensive rat brain: respiratory complexes exhibit assembly defects in hypertension
    Ana Lopez-Campistrous
    Department of Biochemistry, Institute for Biomolecular Design, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 51:412-9. 2008
    ..This mitochondrial dysfunction localizes to the brain stem and is, therefore, likely to contribute to the development, as well as to pathophysiological complications, of hypertension...
  11. doi request reprint MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells
    Xiang Wang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    FEBS Lett 589:490-6. 2015
    ..Furthermore, MMP-2 overexpression renders Hepa1-c1c7 cells resistant to PCSK9-induced LDLR degradation. The data suggest that pathological MMP-2 overexpression may protect the LDLR from PCSK-9-induced degradation. ..
  12. ncbi request reprint Therapeutic potential of the epidermal growth factor receptor transactivation in hypertension: a convergent signaling pathway of vascular tone, oxidative stress, and hypertrophic growth downstream of vasoactive G-protein-coupled receptors?
    Carlos Fernandez-Patron
    Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada
    Can J Physiol Pharmacol 85:97-104. 2007
    ..If this hypothesis is proven generally correct, then transactivation blockers have general therapeutic potential in hypertension regardless of the causative agonist...
  13. ncbi request reprint Vascular responses to alpha1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species
    Li Hao
    Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Arterioscler Thromb Vasc Biol 26:819-25. 2006
    ..Focusing on adrenoceptors, we examined whether the MMP-dependent signaling pathway depends on reactive oxygen species (ROS)...
  14. pmc Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism
    Samuel Hernandez-Anzaldo
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Am Heart Assoc 5:. 2016
    ..Matrix metalloproteinases (MMPs) are dysregulated in patients and animal models with atherosclerosis. Whether systemic MMP activity influences cholesterol metabolism is unknown...
  15. doi request reprint ADAMs family and relatives in cardiovascular physiology and pathology
    Pu Zhang
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada
    J Mol Cell Cardiol 93:186-99. 2016
    ..Here, we review what is currently known about the structure and function of ADAMs and ADAM-TSs, and their roles in development, physiology and pathology of the cardiovascular system. ..
  16. doi request reprint Proteomic analysis of brain mitochondrial proteome and mitochondrial complexes
    Ana Lopez-Campistrous
    Department of Biochemistry, Institute for Biomolecular Design, University of Alberta, Edmonton, AB, Canada
    Methods Mol Biol 1005:129-41. 2013
    ..This approach allows for a comprehensive identification of mitochondrial proteomic differences between health and disease conditions...
  17. doi request reprint A Disintegrin and Metalloprotease-17 Regulates Pressure Overload-Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1
    Dong Fan
    From the Departments of Physiology D F, A T, M S, X W, Z K, Biochemistry C F P, Medicine, Faculty of Medicine and Dentistry R B, V P, G Y O, and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada V S, J M S and Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Edmonton, Canada D F, A T, M S, V S, R B, V P, X W, C F P, J M S, G Y O, Z K
    Hypertension 68:937-48. 2016
    ..This function of ADAM17 is selective for pressure overload-induced myocardial hypertrophy and dysfunction, and not agonist-induced hypertrophy. ..
  18. doi request reprint Modulation of Systemic Metabolism by MMP-2: From MMP-2 Deficiency in Mice to MMP-2 Deficiency in Patients
    Carlos Fernandez-Patron
    Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Compr Physiol 6:1935-1949. 2016
    ..The possible existence of tissue-specific MMP/cytokine/PLA2 signaling systems is discussed. © 2016 American Physiological Society. Compr Physiol 6:1935-1949, 2016...
  19. pmc A novel PKD2L1 C-terminal domain critical for trimerization and channel function
    Wang Zheng
    Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, T6G 2H7, Edmonton, AB, Canada
    Sci Rep 5:9460. 2015
    ..Thus, our study identified C1 as the first PKD2L1 domain essential for both PKD2L1 trimerization and channel function, and suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process. ..