Jason R B Dyck

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi Effects of adenosine on myocardial glucose and palmitate metabolism after transient ischemia: role of 5'-AMP-activated protein kinase
    Jagdip S Jaswal
    Dept of Pharmacology, Faculty of Medicine and Dentistry, Univ of Alberta, Edmonton, AB, Canada
    Am J Physiol Heart Circ Physiol 291:H1883-92. 2006
  2. pmc The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study
    Justin A Ezekowitz
    Mazankowski Alberta Heart Institute, 2C2 WMC, 8440 112 Street, Edmonton, AB, Canada
    BMC Cardiovasc Disord 14:91. 2014
  3. pmc Adiponectin gene therapy ameliorates high-fat, high-sucrose diet-induced metabolic perturbations in mice
    A D Kandasamy
    Departments of Pediatrics and Pharmacology, Cardiovascular Research Centre, University of Alberta, Edmonton, Canada
    Nutr Diabetes 2:e45. 2012
  4. ncbi Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation
    Jason R B Dyck
    Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, 474 Heritage Medical Research Centre, The University of Alberta, Edmonton, Alberta, T6G 2S2 Canada
    Circ Res 94:e78-84. 2004
  5. doi Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat
    Vernon W Dolinsky
    458 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Hypertension 56:412-21. 2010
  6. ncbi Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury
    Jason R B Dyck
    Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2
    Circulation 114:1721-8. 2006
  7. ncbi Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization
    Jagdip S Jaswal
    Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Alberta T6G 2H7, Canada
    Am J Physiol Heart Circ Physiol 293:H1107-14. 2007
  8. ncbi Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus
    Bernard Thebaud
    Vascular Biology Group, University of Alberta, Edmonton, Alberta, Canada
    Circulation 110:1372-9. 2004
  9. doi Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension
    Gopinath Sutendra
    Pulmonary Hypertension Program, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    Sci Transl Med 2:44ra58. 2010
  10. pmc Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt
    Anita Y M Chan
    Cardiovascular Research Group and the Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 283:24194-201. 2008

Detail Information

Publications95

  1. ncbi Effects of adenosine on myocardial glucose and palmitate metabolism after transient ischemia: role of 5'-AMP-activated protein kinase
    Jagdip S Jaswal
    Dept of Pharmacology, Faculty of Medicine and Dentistry, Univ of Alberta, Edmonton, AB, Canada
    Am J Physiol Heart Circ Physiol 291:H1883-92. 2006
    ..Rather, activation of AMPK alters partitioning of glucose away from glycogen synthesis; the increase in glycolysis may in part contribute to loss of adenosine-induced cardioprotection in hearts subjected to transient ischemia...
  2. pmc The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study
    Justin A Ezekowitz
    Mazankowski Alberta Heart Institute, 2C2 WMC, 8440 112 Street, Edmonton, AB, Canada
    BMC Cardiovasc Disord 14:91. 2014
    ..The current one-year mortality rate after diagnosis of heart failure remains high at >25%. Consequently, new therapeutic strategies need to be developed for this debilitating condition...
  3. pmc Adiponectin gene therapy ameliorates high-fat, high-sucrose diet-induced metabolic perturbations in mice
    A D Kandasamy
    Departments of Pediatrics and Pharmacology, Cardiovascular Research Centre, University of Alberta, Edmonton, Canada
    Nutr Diabetes 2:e45. 2012
    ....
  4. ncbi Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation
    Jason R B Dyck
    Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, 474 Heritage Medical Research Centre, The University of Alberta, Edmonton, Alberta, T6G 2S2 Canada
    Circ Res 94:e78-84. 2004
    ..This switch in energy substrate preference improves cardiac function during and after ischemia, suggesting that pharmacological inhibition of MCD may be a novel approach to treating ischemic heart disease...
  5. doi Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat
    Vernon W Dolinsky
    458 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Hypertension 56:412-21. 2010
    ..As a result, CR may serve as an effective nonpharmacological treatment of hypertension, and targeting the adiponectin/AMPK/eNOS pathway may improve treatment of hypertension...
  6. ncbi Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury
    Jason R B Dyck
    Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2
    Circulation 114:1721-8. 2006
    ..However, it is unknown whether chronic inhibition of MCD results in altered cardiac function, energy metabolism, or ischemic cardioprotection...
  7. ncbi Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization
    Jagdip S Jaswal
    Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Alberta T6G 2H7, Canada
    Am J Physiol Heart Circ Physiol 293:H1107-14. 2007
    ..0.30 +/- 0.15, n = 8, P < 0.05). These data indicate that inhibition of p38 MAPK abolishes subsequent phosphorylation of AMPK and improves the coupling of glucose metabolism, thereby restoring adenosine-induced cardioprotection...
  8. ncbi Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus
    Bernard Thebaud
    Vascular Biology Group, University of Alberta, Edmonton, Alberta, Canada
    Circulation 110:1372-9. 2004
    ..We hypothesized that the basis for impaired O2 constriction in preterm DA is reduced expression and function of O2-sensitive, voltage-gated (Kv) channels...
  9. doi Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension
    Gopinath Sutendra
    Pulmonary Hypertension Program, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    Sci Transl Med 2:44ra58. 2010
    ....
  10. pmc Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt
    Anita Y M Chan
    Cardiovascular Research Group and the Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 283:24194-201. 2008
    ..Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt, thus suppressing protein synthesis and gene transcription...
  11. ncbi In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats
    Zlatko I Pozeg
    Vascular Biology Group, Cardiology, University of Alberta, Edmonton, Canada
    Circulation 107:2037-44. 2003
    ..CH decreases Kv channel current/expression and depolarizes and causes Ca2+ overload in PASMCs. We hypothesize that Kv gene transfer would normalize the pulmonary circulation (restore HPV and reduce CH-PHT), despite ongoing hypoxia...
  12. pmc Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy
    Thomas Pulinilkunnil
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 62:1464-77. 2013
    ....
  13. pmc Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance
    Debby P Y Koonen
    Department of Pediatrics, Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 59:1366-75. 2010
    ..Therefore, we sought to investigate how middle age impacts skeletal muscle fatty acid handling and to determine how this contributes to the development of diet-induced insulin resistance...
  14. pmc Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Mol Cell Biol 32:740-50. 2012
    ..Overall, this study shows that ATGL overexpression is sufficient to alter myocardial energy metabolism and improve cardiac function...
  15. ncbi Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    M Sean McMurtry
    Department of Medicine and Pediatrics, University of Alberta, Edmonton, Canada
    Circ Res 95:830-40. 2004
    ..5 in the media. We identify mitochondria-dependent apoptosis as a potential target for therapy and DCA as an effective and selective treatment for PAH...
  16. ncbi The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes
    Karalyn D Folmes
    Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, 474 Heritage Medical Research Centre, Edmonton, Alberta, Canada
    Am J Physiol Heart Circ Physiol 293:H3456-64. 2007
    ....
  17. ncbi p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase
    Jagdip S Jaswal
    Departments of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Heart Circ Physiol 292:H1978-85. 2007
    ..The ability of p38 MAPK inhibitors to relieve the inhibition of glycogen synthesis and to inhibit glycolysis and proton production suggests that these agents may restore adenosine-induced cardioprotection in stressed hearts...
  18. ncbi CD36 expression contributes to age-induced cardiomyopathy in mice
    Debby P Y Koonen
    Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Circulation 116:2139-47. 2007
    ..Although vascular abnormalities associated with aging contribute to the age-related decline in cardiac function, myocardium-specific events may also be involved...
  19. ncbi Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice
    Teresa A Hopkins
    Departments of Pharmacology and Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am J Physiol Heart Circ Physiol 285:H270-6. 2003
    ....
  20. pmc Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice
    Vernon W Dolinsky
    Cardiovascular Research Center, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Endocrinol Metab 305:E243-53. 2013
    ..Our findings have important implications for protecting patients against DOX-associated cardiac injury. ..
  21. ncbi Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy
    Anna A Noga
    Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine and Dentistry, Univ of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Heart Circ Physiol 292:H1460-9. 2007
    ..Together, our data show that increased LKB1 activity in the cardiac myocyte can decrease hypertrophy-induced protein synthesis and suggest that LKB1 activation may be a method for the prevention of pathological cardiac hypertrophy...
  22. doi A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted
    Jayan Nagendran
    Pulmonary Hypertension Program, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 136:168-78, 178.e1-3. 2008
    ..We hypothesized that the poor performance of the hypertrophied right ventricle is caused, at least in part, by a suboptimal mitochondrial/metabolic remodeling...
  23. ncbi Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
    Debby P Y Koonen
    Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 56:2863-71. 2007
    ....
  24. doi Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice
    Jeevan Nagendran
    University of Alberta, Edmonton, Alberta, Canada
    Heart 99:1041-7. 2013
    ....
  25. ncbi Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
    Anita Y M Chan
    Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 279:32771-9. 2004
    ..Together, our data suggest that the inhibition of protein synthesis by pharmacological activation of AMPK may be a key regulatory mechanism by which hypertrophic growth can be controlled...
  26. doi Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1
    Vernon W Dolinsky
    Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G2S2, Canada
    Circulation 119:1643-52. 2009
    ....
  27. pmc Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted
    Vernon W Dolinsky
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    Diabetes 60:2274-84. 2011
    ..Since resveratrol (Resv), the polyphenol produced by plants, exerts insulin-sensitizing effects, we tested whether Resv could prevent deleterious metabolic effects of being born IUGR...
  28. ncbi Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity
    Carrie Lynn M Soltys
    Cardiovascular Research Group, Department of Pediatrics, 474 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Am J Physiol Heart Circ Physiol 290:H2472-9. 2006
    ..Taken together, our data show that activation of Akt1 is able to prevent activation of cardiac AMPK by LKB1 and at least one other AMPKK, likely by prior phosphorylation of AMPKalpha(1)/alpha(2) at Ser(485/491)...
  29. doi Synergistic effects of prenatal hypoxia and postnatal high-fat diet in the development of cardiovascular pathology in young rats
    Christian F Rueda-Clausen
    Department of Physiology, University of Alberta, Edmonton, Canada
    Am J Physiol Regul Integr Comp Physiol 303:R418-26. 2012
    ....
  30. ncbi Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia
    Michael Kuang
    Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 109:1550-7. 2004
    ..In this report we assessed the contribution of FAT/CD36 to overall fatty acid oxidation rates in the intact heart and determined the effect of FAT/CD36 on energy metabolism during reperfusion of ischemic hearts...
  31. doi Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction
    Miranda M Y Sung
    Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    J Mol Med (Berl) 89:459-69. 2011
    ..Overall, we suggest that inhibition of CD36-mediated fatty acid uptake may prevent obesity-related cardiomyopathies in the middle-aged population...
  32. doi Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery
    Jeevan Nagendran
    Cardiovascular Research Centre, Department of Pediatrics, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Division of Cardiac Surgery, Department of Surgery, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    J Mol Cell Cardiol 63:180-8. 2013
    ..As such, targeting cardiomyocyte FA uptake and FAO via inhibition of CD36 in the adult myocardium may provide therapeutic benefit during ischemia-reperfusion. ..
  33. pmc Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome
    Christian F Rueda-Clausen
    Department of Physiology, University of Alberta, Edmonton, Canada
    Diabetes 60:507-16. 2011
    ..Thus, we hypothesized that offspring born with IUGR exhibit permanent metabolic changes that make them more susceptible to HF diet-induced MetS...
  34. pmc Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Cardiovasc Res 99:442-51. 2013
    ..However, whether ATGL deficiency specifically in adult cardiomyocytes contributes to impaired PPARα activity, cardiac function, and metabolism is not known...
  35. doi Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury
    John R Ussher
    Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
    Cardiovasc Res 94:359-69. 2012
    ..However, the effects of such interventions on the evolution of myocardial infarction are unknown. The purpose of this study was to determine whether infarct size is decreased in response to increased glucose oxidation...
  36. doi Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling
    Brent A McLean
    Department of Physiology, Department of Medicine, University of Alberta, Edmonton, Canada
    J Mol Cell Cardiol 54:9-18. 2013
    ..We then investigated parallel signaling pathways, and found that mitogen-activated protein kinase signaling was increased in PI3KαDN hearts, possibly through the inhibition of negative feedback loops downstream of PI3Kα...
  37. doi Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- Mice
    Laura K Cole
    Molecular and Cell Biology of Lipids and Department of Biochemistry, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
    Circ Res 108:686-94. 2011
    ..PEMT is required for normal secretion of very-low-density lipoproteins from the liver. We hypothesized that lack of PEMT would attenuate atherosclerosis and improve myocardial function...
  38. ncbi Role of AMP-activated protein kinase in healthy and diseased hearts
    Vernon W Dolinsky
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am J Physiol Heart Circ Physiol 291:H2557-69. 2006
    ..The consequences of alterations in AMPK activity and subsequent cardiac energy metabolism in the healthy and the diseased heart will be discussed...
  39. ncbi Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase
    Gary D Lopaschuk
    Cardiovascular Research Group, Department of Pediatrics, University of Alberta, Edmonton, Canada
    Circ Res 93:e33-7. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  40. pmc Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase
    John R Ussher
    Cardiovascular Research Group, University of Alberta, Edmonton, Canada
    Diabetes 58:1766-75. 2009
    ....
  41. doi Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice
    Vernon W Dolinsky
    Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1832:1723-33. 2013
    ..Overall, we show that high dose RESV reduces oxidative stress, improves vascular function, attenuates high BP and prevents cardiac hypertrophy through the preservation of the LKB1-AMPK-eNOS signaling axis. ..
  42. ncbi Malonyl CoA control of fatty acid oxidation in the ischemic heart
    Jason R B Dyck
    Cardiovascular Research Group, Departments of Pediatrics and Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Mol Cell Cardiol 34:1099-109. 2002
    ..This paper will discuss some of the molecular changes that occur in fatty acid oxidation in the ischemic heart and will include a discussion of the important role of malonyl CoA in this process...
  43. doi Improved cardiac metabolism and activation of the RISK pathway contributes to improved post-ischemic recovery in calorie restricted mice
    Miranda M Y Sung
    Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada
    J Mol Med (Berl) 89:291-302. 2011
    ..As such, pre-operative CR may be a clinically relevant strategy for increasing ischemic tolerance of the heart...
  44. doi Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased myocardial glycogen
    Karalyn D Folmes
    Cardiovascular Research Centre, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Circ Cardiovasc Genet 2:457-66. 2009
    ..Although considerable information is known regarding the consequences of harboring the gamma(2)R302Q mutation, little is known about the early signaling events that contribute to the development of this cardiomyopathy...
  45. pmc Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
    Rene L Jacobs
    Group on the Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 285:22403-13. 2010
    ..Thus, de novo synthesis of choline via PEMT has a previously unappreciated role in regulating whole body energy metabolism...
  46. pmc AMPK alterations in cardiac physiology and pathology: enemy or ally?
    Jason R B Dyck
    Cardiovascular Research Group, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Physiol 574:95-112. 2006
    ..Resolving this issue has important implications as to whether therapeutic approaches to protect the ischaemic heart should be developed which either activate or inhibit AMPK...
  47. pmc Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver
    Bernard P C Kok
    Signal Transduction Research Group, University of Alberta, Edmonton, Alberta, Canada
    J Lipid Res 54:1662-77. 2013
    ..Our results identify novel differences in the regulation of lipins, PPARα, and PGC-1α splice variants during fasting in heart versus liver, even though the ultimate outcome in both tissues is to increase FA turnover and oxidation...
  48. pmc Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion
    Kevin S C Hamming
    Department of Pharmacology, Alberta Diabetes Institute and Cardiovascular Research Centre, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 59:1686-93. 2010
    ..3 and -1.7 in beta-cells. As pharmacological inhibitors of NCX1 splice variants are in development, the pharmacological profile of beta-cell NCX1.3 and -1.7 and the cellular effects of NCX1 inhibition were investigated...
  49. doi AMPK signalling and the control of substrate use in the heart
    Jeevan Nagendran
    Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Mol Cell Endocrinol 366:180-93. 2013
    ..The work reviewed herein also emphasizes areas that require further investigation for the purpose of eventually translating this information into improved patient care...
  50. pmc Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats
    Vernon W Dolinsky
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    J Physiol 590:2783-99. 2012
    ..Overall, our findings provide evidence that the capacity for fatty acid oxidation is augmented by the addition of RESV to the diet during ET, and that this may contribute to the improved physical performance of rats following ET...
  51. pmc Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice
    Bernard P C Kok
    Signal Transduction Research Group, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    J Lipid Res 53:105-18. 2012
    ..However, lipin-1 deficiency increases the accumulation of newly synthesized phosphatidate and induces aberrant cell signaling...
  52. ncbi Prolonged repolarization and triggered activity induced by adenoviral expression of HERG N629D in cardiomyocytes derived from stem cells
    GuoQi Teng
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Cardiovasc Res 61:268-77. 2004
    ..Heterologous co-expression of N629D and the wildtype HERG resulted in a relative loss of the selectivity of K+ over Na+, but its physiologic relevance has not been assessed in cardiac myocytes...
  53. doi Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure
    Enhui Wei
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    Cell Metab 11:183-93. 2010
    ..Tgh(-/-) mice have smaller sized pancreatic islets but maintain normal glucose-stimulated insulin secretion. These studies demonstrate the potential of TGH as a therapeutic target for lowering blood lipid levels...
  54. ncbi Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy
    Anita Y M Chan
    Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, AB, Canada
    Can J Physiol Pharmacol 83:24-8. 2005
    ..Recent advances linking AMPK and the energy status of the cell to the regulation of protein synthesis and (or) cardiac myocyte hypertrophy will be discussed...
  55. ncbi Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation
    Rene L Jacobs
    Canadian Institutes of Health Research Group on the Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 282:4516-23. 2007
    ..However, unlike cholesterol and triacylglycerol biosynthesis, PC production is not regulated by AMPK...
  56. ncbi Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart
    Arzu Onay-Besikci
    Department of Pharmacology, University of Alberta, Edmonton, Canada T6G 2S2
    Am J Physiol Heart Circ Physiol 284:H283-9. 2003
    ..Our data suggest that a decrease in malonyl CoA control of CPT-1 is primarily responsible for the increase in fatty acid oxidation seen in the newborn heart...
  57. doi Myocardial triacylglycerol metabolism
    Petra C Kienesberger
    Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
    J Mol Cell Cardiol 55:101-10. 2013
    ..This article is part of a Special Issue entitled "Focus on Cardiac Metabolism"...
  58. ncbi Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique
    Nandakumar Sambandam
    Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
    Eur J Biochem 271:2831-40. 2004
    ..7 kDa isoform of MCD protein in the mitochondria. This differential regulation of MCD expression and activity in the mitochondria by AMPK may potentially regulate malonyl-CoA levels at sites nearby CPT-I on the mitochondria...
  59. ncbi Phosphorylation of cardiac protein kinase B is regulated by palmitate
    Carrie Lynn M Soltys
    Cardiovascular Research Group, Departments of Pediatrics and Pharmacology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am J Physiol Heart Circ Physiol 283:H1056-64. 2002
    ..Taken together, these experiments show the control of PKB phosphorylation by palmitate is independent of ceramide and suggest that this signaling event may be an important regulator of myocardial glucose uptake and oxidation...
  60. ncbi A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with hig
    Fiona M Campbell
    Department of Pharmacology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 277:4098-103. 2002
    ..This study demonstrates that PPARalpha is an important regulator of fatty acid oxidation in the heart and that this regulation of fatty acid oxidation may in part occur due to the transcriptional control of malonyl-CoA decarboxylase...
  61. pmc Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs
    Michael J Riedel
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    EMBO J 25:4605-14. 2006
    ..Additionally, our findings have broad implications for the coupling of Ca(2+) homeostasis to fat metabolism in a variety of tissues...
  62. pmc Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression
    Nikole J Byrne
    Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
    Cardiovasc Res 110:249-57. 2016
    ....
  63. ncbi Metabolic effects of insulin on cardiomyocytes from control and diabetic db/db mouse hearts
    Rogayah Carroll
    Department of Pharmacology and Therapeutics, Faculty of Medicine, Univ of Calgary, 3330 Hospital Dr N W, Calgary, Alberta, T2N 4N1, Canada
    Am J Physiol Endocrinol Metab 288:E900-6. 2005
    ..Insulin resistance in db/db cardiomyocytes is manifested by reduced insulin-stimulated deoxyglucose uptake...
  64. doi Resveratrol prevents pathological but not physiological cardiac hypertrophy
    Vernon W Dolinsky
    Cardiovascular Research Centre, Faculty of Medicine and Dentistry, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada
    J Mol Med (Berl) 93:413-25. 2015
    ..This has important clinical implications as our findings support the concept that resveratrol may be useful in the selective treatment of pathological LVH...
  65. doi AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation
    Beshay N M Zordoky
    From the Department of Pediatrics, Faculty of Medicine and Dentistry, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada B N M Z, J N, T P, P C K, G M, T J W, J R B D Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, Melbourne, Victoria, Australia B E K and Division of Endocrinology and Metabolism, Department of Medicine and Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada G R S
    Circ Res 115:518-24. 2014
    ..However, studies supporting this have not directly assessed whether the maintenance of FAO rates and subsequent cardiac function requires AMPK-dependent inhibitory phosphorylation of ACC...
  66. ncbi Malonyl-CoA decarboxylase is a major regulator of myocardial fatty acid oxidation
    Karalyn D Cuthbert
    Department of Pediatrics, 474 Heritage Medical Research Centre, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2
    Curr Hypertens Rep 7:407-11. 2005
    ....
  67. doi Carbonic anhydrase II promotes cardiomyocyte hypertrophy
    Brittany F Brown
    Membrane Protein Disease Research Group, Department of Biochemistry, School of Translational Medicine, University of Alberta, Edmonton, AB, Canada
    Can J Physiol Pharmacol 90:1599-610. 2012
    ..Moreover, cardiomyocytes from Car2 mice do not respond to prohypertrophic stimulation. Together, these findings support a role of CAII in promoting CH...
  68. pmc Calreticulin induces dilated cardiomyopathy
    Dukgyu Lee
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e56387. 2013
    ..After birth, the calreticulin gene is sharply down regulated in the heart, and thus, adult hearts have negligible levels of calreticulin. In this study we tested the role of calreticulin in the adult heart...
  69. doi Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization
    David N Brindley
    Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, AB, Canada
    Am J Physiol Endocrinol Metab 298:E897-908. 2010
    ....
  70. doi Age-related cardiovascular disease and the beneficial effects of calorie restriction
    Miranda M Y Sung
    Department of Pediatrics, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada
    Heart Fail Rev 17:707-19. 2012
    ....
  71. ncbi O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor
    Evangelos D Michelakis
    Cardiology Division and the Vascular Biology Group, Department of Medicine, University of Alberta, Alberta, Canada
    Circ Res 91:478-86. 2002
    ..We conclude that O2 controls human DA tone by modulating the function of the mitochondrial ETC thereby varying DeltaPsim and the production of H2O2, which regulates DASMC Kv channel activity and DA tone...
  72. ncbi Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes
    Peter E Light
    Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Circulation 107:1962-5. 2003
    ..Some PRKAG2 mutations in the human gene encoding for the gamma-subunit of the adenosine monophosphate-activated protein kinase (AMPK) recently have been shown to cause rhythm disturbances (often fatal) in affected patients...
  73. doi Calorie restriction and resveratrol in cardiovascular health and disease
    Vernon W Dolinsky
    Department of Pediatrics, Cardiovascular Resaerch Center, Mazankoaski Alberta Heart Institute, University of Alberta, Edmonton, Canada
    Biochim Biophys Acta 1812:1477-89. 2011
    ..While accumulating data demonstrate the health benefits of calorie restriction and resveratrol in experimental animal models, whether these interventions translate to patients with cardiovascular disease remains to be determined...
  74. ncbi Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
    Jayan Nagendran
    Pulmonary Hypertension Program, Department of Medicine, University of Alberta, Edmonton, Canada T6G 2B7
    Circulation 116:238-48. 2007
    ....
  75. ncbi Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels
    Evangelos D Michelakis
    Department of Medicine, University of Alberta, Edmonton, Canada
    Circulation 105:244-50. 2002
    ..We hypothesized that dichloroacetate (DCA), a metabolic modulator that can shift redox balance toward an oxidized state and increase Kv current in myocardial cells, would reverse CH-PHT...
  76. doi Activation of Akt protects alveoli from neonatal oxygen-induced lung injury
    Rajesh S Alphonse
    Department of Pediatrics, Women and Children Health Research Institute, University of Alberta, Edmonton, Canada
    Am J Respir Cell Mol Biol 44:146-54. 2011
    ..We speculate that the modulation of apoptosis may have therapeutic potential in lung diseases characterized by alveolar damage...
  77. ncbi AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts
    Yi Xu
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2R7
    Am J Physiol Heart Circ Physiol 282:H1206-15. 2002
    ..Other groups (except CHA) did not improve recovery. The results suggest that, in isolated working hearts, AT(2)R plays a significant role in ischemia-reperfusion and AT(2)R blockade induces increased AT(2)R protein and cardioprotection...
  78. ncbi Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury
    Wenjie Wang
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Circulation 106:1543-9. 2002
    ..The acute contractile defect of the heart after ischemia-reperfusion may involve the proteolytic degradation of the thin filament protein troponin I; however, the protease responsible for this remains obscure...
  79. ncbi Regulation of malonyl-CoA concentration and turnover in the normal heart
    Aneta E Reszko
    Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 279:34298-301. 2004
    ..Our data show that, in the absence of enzyme inhibitors, the rate of acetyl-CoA carboxylation is the main determinant of the malonyl-CoA concentration in the heart...
  80. ncbi Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
    Suzanne Kovacic
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 2256, USA
    J Biol Chem 278:39422-7. 2003
    ..In addition, our data suggest that the ability of insulin to inhibit AMPK may be controlled via an Akt-mediated mechanism...
  81. ncbi Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power
    Kristen L King
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 289:H1033-7. 2005
    ....
  82. doi Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    Timothy R Koves
    Sarah W Stedman Nutrition and Metabolism Center, Department of Medicine, Duke University, Durham, NC 27710, USA
    Cell Metab 7:45-56. 2008
    ..These findings reveal a strong connection between skeletal muscle insulin resistance and lipid-induced mitochondrial stress...
  83. ncbi Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression
    Molly S Bray
    US Department of Agriculture, Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 294:H1036-47. 2008
    ..These studies suggest that the cardiomyocyte circadian clock influences myocardial contractile function, metabolism, and gene expression...
  84. ncbi Circadian rhythms in myocardial metabolism and contractile function: influence of workload and oleate
    David J Durgan
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Houston, Texas, USA
    Am J Physiol Heart Circ Physiol 293:H2385-93. 2007
    ..In conclusion, these studies expose marked circadian rhythmicities in myocardial oxidative and nonoxidative metabolism as well as responsiveness of the rat heart to changes in workload and fatty acid availability...
  85. ncbi Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy
    Maya Khairallah
    Montreal Heart Institute and University of Montreal, 5000 Belanger St, Montreal, Quebec, Canada H1T 1C8
    J Mol Cell Cardiol 43:119-29. 2007
    ..They also suggest the presence of a "sub-clinical" defect in the NO/cGMP pathway, which in vivo, at an early age, may be compensated by enhanced anf gene expression...
  86. pmc A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
    Min Xie
    Center for Cardiovascular Development, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17378-83. 2006
    ..Thus, by disrupting the endogenous TAK1 locus, we prove a pivotal role for TAK1 in the LKB1/AMPK signaling axis, an essential governor of cell metabolism...
  87. doi Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms
    Ramesh Saeedi
    Department of Pathology and Laboratory Medicine, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia Saint Paul s Hospital, Canada
    Am J Physiol Heart Circ Physiol 294:H2497-506. 2008
    ..Thus the metabolic actions of metformin in the heart muscle can occur independent of changes in AMPK activity and may be mediated by p38 MAPK- and PKC-dependent mechanisms...
  88. ncbi Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents
    Jie Fei Cheng
    Department of Chemistry, Chugai Pharma USA, LLC, 6275 Nancy Ridge Drive, San Diego, California 92121, USA
    J Med Chem 49:4055-8. 2006
    ..Compound 5 improved the cardiac efficiency and function in a rat heart global ischemia/reperfusion model, suggesting MCD inhibitors may be useful for the treatment of ischemic heart diseases...
  89. ncbi Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors
    Jie Fei Cheng
    Department of Chemistry and Discovery Biology, Chugai Pharma LLC, 6275 Nancy Ridge Dr, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 16:3484-8. 2006
    ..Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts...
  90. ncbi Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors
    Jie Fei Cheng
    Department of Chemistry, Chugai Pharma USA, LLC, 6225 Nancy Ridge Drive, San Diego, California 92121, USA
    J Med Chem 49:1517-25. 2006
    ....
  91. ncbi Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin
    David J Durgan
    USDA ARS Children s Nutrition Research Center, Baylor College of Medicine, Department of Pediatrics, 1100 Bates Street, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 290:H2480-97. 2006
    ..Our data expose differential regulation of acsl isoforms and cte1 in the heart, where acsl1 and cte1 are PPARalpha-regulated genes, whereas acsl6 is an insulin-regulated gene...
  92. ncbi Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia
    William C Stanley
    Dept of Physiology and Biophysics, School of Medicine, Case Western Reserve Univ, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 289:H2304-9. 2005
    ..Thus modulation of MCD activity is an effective means of regulating myocardial fatty acid oxidation under normal and ischemic conditions and reducing lactate production during demand-induced ischemia...
  93. ncbi The ischemic heart: starving to stimulate the adiponectin-AMPK signaling axis
    Jason R B Dyck
    Circulation 116:2779-81. 2007
  94. ncbi Expression, purification, and characterization of human malonyl-CoA decarboxylase
    Demin Zhou
    Department of Discovery Biology, Chugai Pharma USA, LLC, 6275 Nancy Ridge Drive, San Diego, CA 92121, USA
    Protein Expr Purif 34:261-9. 2004
    ..5. Our results showed that the N-terminal region of hMCD has no effect on the catalytic activity of the enzyme but plays a role in the folding process and conformation stability of hMCD...
  95. ncbi Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
    Renaud Dentin
    Departement d Endocrinologie, Institut Cochin, Métabolisme et Cancer, 24 rue du Faubourg St Jacques, Paris 75014, France
    Diabetes 55:2159-70. 2006
    ..Taken together, our results demonstrate that ChREBP is central for the regulation of lipogenesis in vivo and plays a determinant role in the development of the hepatic steatosis and of insulin resistance in ob/ob mice...