Affiliation: University of Lethbridge
- The aging hippocampus: navigating between rat and human experimentsIra Driscoll
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
Rev Neurosci 16:87-121. 2005..In addition, studies of the aging hippocampus may have a side-effect in leading to a better understanding of the mechanisms that underlie learning and memory in general...
- Virtual navigation in humans: the impact of age, sex, and hormones on place learningIra Driscoll
Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, 4401 University Drive Lethbridge, Alberta, Canada T1H 6P4
Horm Behav 47:326-35. 2005..Our findings indicate that the persistence of male spatial advantage may be related to circulating testosterone, but not cortisol levels, and independent of generalized age-related cognitive decline...
- The aging hippocampus: cognitive, biochemical and structural findingsIra Driscoll
Department of Psychology, The University of New Mexico, Albuquerque, New Mexico 87131, USA
Cereb Cortex 13:1344-51. 2003....
- Damage to the hippocampal formation does not disrupt representational flexibility as measured by a novelty transfer testIra Driscoll
Canadian Centre for Behavioural Neuroscience, Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
Behav Neurosci 118:1427-32. 2004..Eichenbaum, 1992). They are consistent with the view that simple associative processes guide choice behavior in animals with hippocampal damage that are confronted with novel combinations...
- Neurophysiological properties of cells filling the neonatal medial prefrontal cortex lesion cavityIra Driscoll
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
Brain Res 1178:38-43. 2007....
- FGF-2-induced functional improvement from neonatal motor cortex injury via corticospinal projectionsMarie H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
Exp Brain Res 185:453-60. 2008..Our results demonstrate that FGF-2 treatment restores the connectivity of the filled region in neonatal rats. This provides a possible mechanism for FGF-2-induced functional recovery...
- Seahorse wins all races: hippocampus participates in both linear and non-linear visual discrimination learningIra Driscoll
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Alta
Behav Brain Res 164:29-35. 2005....
- Reduced area of the corpus callosum in posttraumatic stress disorderGerardo Villarreal
New Mexico VA Healthcare System, PTSD Program 116A, 1501 San Pedro Drive SE, Albuquerque, NM 87108, USA
Psychiatry Res 131:227-35. 2004..These findings are similar to previous results in children with PTSD and suggest specific changes in the CC...
- Differential contributions of hippocampus, amygdala and perirhinal cortex to recognition of novel objects, contextual stimuli and stimulus relationshipsSandra N Moses
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St, Toronto, Ont, Canada M6A 2E1
Brain Res Bull 67:62-76. 2005..Implications for declarative and conjunctive hippocampal theories are discussed...
- Reduced hippocampal volume and total white matter volume in posttraumatic stress disorderGerardo Villarreal
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, USA
Biol Psychiatry 52:119-25. 2002..The purpose of this study was to assess hippocampal and whole-brain volume in civilian PTSD...
- A quantitative comparison of synaptic density following perfusion versus immersion fixation in the rat cerebral cortexMarie H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada, T1K 3M4
Microsc Res Tech 67:300-4. 2005..Our results suggest that, despite suboptimal qualitative results, fixation by immersion allows for adequate quantification of synapses...
- FGF-2-induced cell proliferation stimulates anatomical, neurophysiological and functional recovery from neonatal motor cortex injuryMarie H Monfils
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
Eur J Neurosci 24:739-49. 2006....
- Enhanced cell death and learning deficits after a mini-stroke in aged hippocampusIra Driscoll
Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada
Neurobiol Aging 29:1847-58. 2008..Overall, our pattern of results suggest that the aged hippocampus is more vulnerable to the same insult that has little or no effect on the young hippocampus...
- Human place learning in a virtual Morris water task: some important constraints on the flexibility of place navigationDerek A Hamilton
Department of Psychology, Logan Hall, The University of New Mexico, Albuquerque, NM 87131, USA
Behav Brain Res 129:159-70. 2002..Oxford, UK: Clarendon Press, 1978). Additionally, the transfer data reported here closely match the data obtained by Sutherland et al. with rats suggesting some generality in the principles involved in place learning...
- Apolipoprotein E and prospective memory in normally aging adultsIra Driscoll
Department of Psychology, University of New Mexico, Albuquerque, NM, USA
Neuropsychology 19:28-34. 2005..The authors found a significant deficit in prospective memory for epsilon4 allele carriers but no effect of association in either group. The results suggest the deficit was due to failure of the prospective component of the task...
- Testosterone and cognition in normal aging and Alzheimer's disease: an updateIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
Curr Alzheimer Res 4:33-45. 2007..In addition, a number of potential explanations of the discrepancy between data obtained in humans and non-human animals are discussed...
- Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderlyIra Driscoll
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Neurol 60:688-95. 2006..We investigated whether cognitive trajectories differ between clinically normal elderly individuals with and without AD neuropathology and how they compare with trajectories of clinically impaired individuals before dementia diagnosis...
- Correlates of virtual navigation performance in older adultsLaura E Korthauer
Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, WI, USA
Neurobiol Aging 39:118-27. 2016..Collectively, these results suggest a pattern of differences in the structural integrity of regions supporting successful navigation even in the absence of longitudinal performance decrements. ..
- Vulnerability of the orbitofrontal cortex to age-associated structural and functional brain changesSusan M Resnick
Intramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224 6825, USA
Ann N Y Acad Sci 1121:562-75. 2007..Future studies using new in vivo imaging probes will help determine whether neuropathologic changes underlie the structural and functional changes...