Affiliation: University of Toronto
- Immediate and long-term plasticity in human somatosensory thalamus and its involvement in phantom limbsJ O Dostrovsky
Department of Physiology, University of Toronto, Ontario, Canada
Pain . 1999..Furthermore, in those patients that had a phantom limb, microstimulation in this region induced sensations perceived as originating on the phantom...
- Microstimulation-induced inhibition of neuronal firing in human globus pallidusJ O Dostrovsky
Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Neurophysiol 84:570-4. 2000..These findings suggest that microstimulation within GPi preferentially excites the axon terminals of striatal and/or external pallidal neurons causing release of GABA and inhibition of GPi neurons...
- The globus pallidus, deep brain stimulation, and Parkinson's diseaseJonathan O Dostrovsky
Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
Neuroscientist 8:284-90. 2002....
- Mechanisms of deep brain stimulationJonathan O Dostrovsky
Department of Physiology and Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
Mov Disord 17:S63-8. 2002....
- Deep brain stimulation for Parkinson's disease: disrupting the disruptionAndres M Lozano
Toronto Western Hospital Research Institute, and Department of Surgery, University of Toronto, ON, Canada
Lancet Neurol 1:225-31. 2002..Current research is aimed at elucidating how DBS works and using this information to develop better treatments for patients with PD and other neurological disorders...
- Eye movement-related responses of neurons in human subthalamic nucleusAdrian P Fawcett
Dept of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Exp Brain Res 162:357-65. 2005....
- Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordingsWilliam D Hutchison
Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
J Neurosci 24:9240-3. 2004
- Human anterior cingulate cortex neurons encode cognitive and emotional demandsKaren D Davis
Toronto Western Research Institute, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
J Neurosci 25:8402-6. 2005....
- Central sensitization induced in thalamic nociceptive neurons by tooth pulp stimulation is dependent on the functional integrity of trigeminal brainstem subnucleus caudalis but not subnucleus oralisSoo Joung Park
Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, Canada M5G 1G6
Brain Res 1112:134-45. 2006..These findings indicate that central sensitization induced in nociceptive neurons within VPM and PO by noxious stimulation of the tooth pulp is dependent upon the functional integrity of Vc but not Vo...
- Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patientsJoyce K H Tang
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
Exp Brain Res 166:230-6. 2005..Furthermore, the findings did reveal a difference between firing patterns in the HD and PD groups, thereby supporting the role of altered firing patterns in the pathophysiology of these diseases...
- Bursting activity of neurons in the human anterior thalamic nucleusMojgan Hodaie
Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada
Brain Res 1115:1-8. 2006..This study describes for the first time the properties of this nucleus in humans and may be important in furthering our knowledge of thalamic mechanisms of epileptogenesis...
- Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's diseaseMoran Weinberger
Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Neurophysiol 96:3248-56. 2006..The study also suggests that LFP beta oscillatory activity is generated largely within the dorsal portion of the STN and can produce synchronous oscillatory activity of the local neuronal population...
- Dual microelectrode technique for deep brain stereotactic surgery in humansRon Levy
Department of Physiology, University of Toronto, Toronto, Canada
Neurosurgery 60:277-83; discussion 283-4. 2007..To improve functional stereotactic microelectrode localization of small deep brain structures by developing and evaluating a recording system with two closely separated independently controlled microelectrodes...
- Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's diseasePanida Piboolnurak
Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
Mov Disord 22:990-7. 2007..1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years...
- Activation of the 5-HT1B/D receptor reduces hindlimb neurogenic inflammation caused by sensory nerve stimulation and capsaicinNicole M E Carmichael
University of Toronto, Department of Physiology, Medical Science Building, Rm 3305, 1 King s College Circle, Toronto, Ont, Canada M5S1A8
Pain 134:97-105. 2008..5-HT(1B/D) receptor agonists may be useful for the treatment of non-trigeminal pain conditions involving NI...
- Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's diseaseJoyce K H Tang
Department of Physiology, University of Toronto, Toronto, ON, Canada
J Neurophysiol 98:720-9. 2007..These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders...
- Nerve resection and re-location may relieve causalgia: a case reportC Peter N Watson
Department of Medicine, University of Toronto, Canada
Pain 132:211-7. 2007..Therefore, in selected patients with causalgia this nerve re-location technique may help in symptom resolution and improve quality of life...
- Neuronal activity in the globus pallidus of multiple system atrophy patientsLuiz C M Pereira
Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
Mov Disord 19:1485-92. 2004....
- Subthalamic nucleus deep brain stimulation for parkinson's disease after successful pallidotomy: clinical and electrophysiological observationsGalit Kleiner-Fisman
Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Mov Disord 19:1209-14. 2004..017, 0.005). There were no side-to-side differences clinically or in the STN neuronal firing rates and patterns. Bilateral STN DBS is safe and efficacious in improving motor symptoms in patients with prior pallidotomy...
- Very fast oscillations evoked by median nerve stimulation in the human thalamus and subthalamic nucleusRitsuko Hanajima
Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada
J Neurophysiol 92:3171-82. 2004..The VFOs from STN probably represent volume conduction, possibly from the medial lemniscus. We conclude that the thalamic VFOs are generated within Vc and that they induce time-locked firing in a network of neurons...
- Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activityRon Levy
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
J Neurosci 22:2855-61. 2002..These results also suggest that overt neuronal synchronization, which may be attributable to an increase in direct synaptic connections or common collateral afferent inputs, is not present in the basal ganglia of patients with PD...
- Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's diseaseRon Levy
Department of Physiology, University of Toronto, Toronto, Canada
Brain 125:1196-209. 2002....
- Chronic anterior thalamus stimulation for intractable epilepsyMojgan Hodaie
Division of Neurosurgery, University of Toronto, ON, Canada
Epilepsia 43:603-8. 2002..We investigated neuromodulation of the anterior thalamus by using deep-brain stimulation (DBS) in patients with intractable seizures...
- Localization of clinically effective stimulating electrodes in the human subthalamic nucleus on magnetic resonance imagingJean A Saint-Cyr
Department of Surgery, Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada
J Neurosurg 97:1152-66. 2002..The authors sought to determine the location of deep brain stimulation (DBS) electrodes that were most effective in treating Parkinson disease (PD)...
- Movement-related neurons of the subthalamic nucleus in patients with Parkinson diseaseAviva Abosch
Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
J Neurosurg 97:1167-72. 2002..The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields...
- Pallidal neuronal activity: implications for models of dystoniaWilliam D Hutchison
Department of Surgery, Division of Neurosurgery and Toronto Western Research Institute, Toronto Western Hospital and Faculty of Medicine, University of Toronto, Ontario, Canada
Ann Neurol 53:480-8. 2003..The widely accepted pathophysiological models of dystonia that propose global decreases in basal ganglia output need to be viewed with caution in light of these findings...
- Somatosensory evoked potentials (SEPs) recorded from deep brain stimulation (DBS) electrodes in the thalamus and subthalamic nucleus (STN)Ritsuko Hanajima
Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst St, Toronto, ON M5T 2S8, Canada
Clin Neurophysiol 115:424-34. 2004..To examine the location of deep brain stimulation (DBS) electrode somatosensory evoked potentials (SEPs) and determine the generators of the median nerve SEPs recorded in thalamus and subthalamic nucleus (STN)...
- Pedunculopontine nucleus microelectrode recordings in movement disorder patientsMoran Weinberger
Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
Exp Brain Res 188:165-74. 2008..It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy...
- Tremor cells in the human thalamus: differences among neurological disordersJason A Brodkey
Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
J Neurosurg 101:43-7. 2004....
- Histological analysis of the location of effective thalamic stimulation for tremor. Case reportRobert E Gross
Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosurg 100:547-52. 2004....
- Cingulotomy for psychiatric disease: microelectrode guidance, a callosal reference system for documenting lesion location, and clinical resultsErich O Richter
Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
Neurosurgery 54:622-28; discussion 628-30. 2004....
- Stimulation-induced inhibition of neuronal firing in human subthalamic nucleusMohammed Filali
Department of Physiology, Rm 3305 Medical Sciences Building, University of Toronto, University Health Network, 1 King s College Circle, M5S 1A8, Toronto, Ontario, Canada
Exp Brain Res 156:274-81. 2004..Therefore, the overall effects of DBS stimulation in STN are likely to be inhibition of intrinsic and synaptically mediated activity, and its replacement by regular high-frequency firing...
- P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralisBo Hu
Faculty of Dentistry, University of Toronto, Ontario M5G 1G6, Canada
J Neurophysiol 88:1614-24. 2002..These results suggest that P2X(3) and possibly also the P2X(2/3) receptor subtypes in Vc may play a role in the initiation and maintenance of central sensitization in Vo nociceptive neurons induced by MO application to the pulp...
- Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystoniaJoyce K H Tang
Department of Physiology, Med Sci Bldg 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Exp Neurol 204:845-8. 2007..These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia...
- The motor thalamus in neurosurgeryClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Neurosurgery 58:146-58; discussion 146-58. 2006..The aim of the present article is to briefly review the major anatomic and physiological aspects of the motor thalamus as well as the electrophysiological findings described in humans undergoing surgical procedures...
- Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human ponsAndrew S Lim
Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada
Sleep 30:823-7. 2007..We sought to identify and characterize human PGO waves...
- Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal hornChen Yu Chiang
Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada M5G 1G6
J Neurosci 27:9068-76. 2007..These findings suggest that the astroglial glutamate-glutamine shuttle is essential for the initiation of inflammation-induced central sensitization but that inhibition of astroglial function may not affect normal nociceptive processing...
- Dissociation of thalamic high frequency oscillations and slow component of sensory evoked potentials following damage to ascending pathwaysRitsuko Hanajima
Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, ONT Canada
Clin Neurophysiol 117:906-11. 2006..In this study, we examined how lesions in the sensory afferent pathway affect these components...
- Deep brain stimulation for chronic neuropathic pain: long-term outcome and the incidence of insertional effectClement Hamani
Division of Neurosurgery, Toronto Western Hospital, Toronto, Ont, Canada
Pain 125:188-96. 2006..The relatively low efficacy of DBS for the treatment of neuropathic pain stresses the need for further investigation and the exploration of new surgical targets...
- MECHANISMS OF DEEP BRAIN STIMULATION.Jonathan Dostrovsky; Fiscal Year: 2003..abstract_text> ..