Jonathan Dostrovsky

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Immediate and long-term plasticity in human somatosensory thalamus and its involvement in phantom limbs
    J O Dostrovsky
    Department of Physiology, University of Toronto, Ontario, Canada
    Pain . 1999
  2. ncbi request reprint Microstimulation-induced inhibition of neuronal firing in human globus pallidus
    J O Dostrovsky
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 84:570-4. 2000
  3. ncbi request reprint The globus pallidus, deep brain stimulation, and Parkinson's disease
    Jonathan O Dostrovsky
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Neuroscientist 8:284-90. 2002
  4. ncbi request reprint Mechanisms of deep brain stimulation
    Jonathan O Dostrovsky
    Department of Physiology and Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 17:S63-8. 2002
  5. ncbi request reprint Deep brain stimulation for Parkinson's disease: disrupting the disruption
    Andres M Lozano
    Toronto Western Hospital Research Institute, and Department of Surgery, University of Toronto, ON, Canada
    Lancet Neurol 1:225-31. 2002
  6. ncbi request reprint Eye movement-related responses of neurons in human subthalamic nucleus
    Adrian P Fawcett
    Dept of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Exp Brain Res 162:357-65. 2005
  7. ncbi request reprint Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordings
    William D Hutchison
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
    J Neurosci 24:9240-3. 2004
  8. ncbi request reprint Human anterior cingulate cortex neurons encode cognitive and emotional demands
    Karen D Davis
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:8402-6. 2005
  9. ncbi request reprint Central sensitization induced in thalamic nociceptive neurons by tooth pulp stimulation is dependent on the functional integrity of trigeminal brainstem subnucleus caudalis but not subnucleus oralis
    Soo Joung Park
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, Canada M5G 1G6
    Brain Res 1112:134-45. 2006
  10. ncbi request reprint Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patients
    Joyce K H Tang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Exp Brain Res 166:230-6. 2005

Research Grants

  1. MECHANISMS OF DEEP BRAIN STIMULATION.
    Jonathan Dostrovsky; Fiscal Year: 2003

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Immediate and long-term plasticity in human somatosensory thalamus and its involvement in phantom limbs
    J O Dostrovsky
    Department of Physiology, University of Toronto, Ontario, Canada
    Pain . 1999
    ..Furthermore, in those patients that had a phantom limb, microstimulation in this region induced sensations perceived as originating on the phantom...
  2. ncbi request reprint Microstimulation-induced inhibition of neuronal firing in human globus pallidus
    J O Dostrovsky
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 84:570-4. 2000
    ..These findings suggest that microstimulation within GPi preferentially excites the axon terminals of striatal and/or external pallidal neurons causing release of GABA and inhibition of GPi neurons...
  3. ncbi request reprint The globus pallidus, deep brain stimulation, and Parkinson's disease
    Jonathan O Dostrovsky
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Neuroscientist 8:284-90. 2002
    ....
  4. ncbi request reprint Mechanisms of deep brain stimulation
    Jonathan O Dostrovsky
    Department of Physiology and Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 17:S63-8. 2002
    ....
  5. ncbi request reprint Deep brain stimulation for Parkinson's disease: disrupting the disruption
    Andres M Lozano
    Toronto Western Hospital Research Institute, and Department of Surgery, University of Toronto, ON, Canada
    Lancet Neurol 1:225-31. 2002
    ..Current research is aimed at elucidating how DBS works and using this information to develop better treatments for patients with PD and other neurological disorders...
  6. ncbi request reprint Eye movement-related responses of neurons in human subthalamic nucleus
    Adrian P Fawcett
    Dept of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Exp Brain Res 162:357-65. 2005
    ....
  7. ncbi request reprint Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordings
    William D Hutchison
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
    J Neurosci 24:9240-3. 2004
  8. ncbi request reprint Human anterior cingulate cortex neurons encode cognitive and emotional demands
    Karen D Davis
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:8402-6. 2005
    ....
  9. ncbi request reprint Central sensitization induced in thalamic nociceptive neurons by tooth pulp stimulation is dependent on the functional integrity of trigeminal brainstem subnucleus caudalis but not subnucleus oralis
    Soo Joung Park
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, Canada M5G 1G6
    Brain Res 1112:134-45. 2006
    ..These findings indicate that central sensitization induced in nociceptive neurons within VPM and PO by noxious stimulation of the tooth pulp is dependent upon the functional integrity of Vc but not Vo...
  10. ncbi request reprint Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patients
    Joyce K H Tang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Exp Brain Res 166:230-6. 2005
    ..Furthermore, the findings did reveal a difference between firing patterns in the HD and PD groups, thereby supporting the role of altered firing patterns in the pathophysiology of these diseases...
  11. ncbi request reprint Bursting activity of neurons in the human anterior thalamic nucleus
    Mojgan Hodaie
    Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada
    Brain Res 1115:1-8. 2006
    ..This study describes for the first time the properties of this nucleus in humans and may be important in furthering our knowledge of thalamic mechanisms of epileptogenesis...
  12. ncbi request reprint Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
    Moran Weinberger
    Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 96:3248-56. 2006
    ..The study also suggests that LFP beta oscillatory activity is generated largely within the dorsal portion of the STN and can produce synchronous oscillatory activity of the local neuronal population...
  13. ncbi request reprint Dual microelectrode technique for deep brain stereotactic surgery in humans
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Neurosurgery 60:277-83; discussion 283-4. 2007
    ..To improve functional stereotactic microelectrode localization of small deep brain structures by developing and evaluating a recording system with two closely separated independently controlled microelectrodes...
  14. ncbi request reprint Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease
    Panida Piboolnurak
    Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 22:990-7. 2007
    ..1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years...
  15. ncbi request reprint Activation of the 5-HT1B/D receptor reduces hindlimb neurogenic inflammation caused by sensory nerve stimulation and capsaicin
    Nicole M E Carmichael
    University of Toronto, Department of Physiology, Medical Science Building, Rm 3305, 1 King s College Circle, Toronto, Ont, Canada M5S1A8
    Pain 134:97-105. 2008
    ..5-HT(1B/D) receptor agonists may be useful for the treatment of non-trigeminal pain conditions involving NI...
  16. ncbi request reprint Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease
    Joyce K H Tang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:720-9. 2007
    ..These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders...
  17. ncbi request reprint Nerve resection and re-location may relieve causalgia: a case report
    C Peter N Watson
    Department of Medicine, University of Toronto, Canada
    Pain 132:211-7. 2007
    ..Therefore, in selected patients with causalgia this nerve re-location technique may help in symptom resolution and improve quality of life...
  18. ncbi request reprint Neuronal activity in the globus pallidus of multiple system atrophy patients
    Luiz C M Pereira
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1485-92. 2004
    ....
  19. ncbi request reprint Subthalamic nucleus deep brain stimulation for parkinson's disease after successful pallidotomy: clinical and electrophysiological observations
    Galit Kleiner-Fisman
    Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1209-14. 2004
    ..017, 0.005). There were no side-to-side differences clinically or in the STN neuronal firing rates and patterns. Bilateral STN DBS is safe and efficacious in improving motor symptoms in patients with prior pallidotomy...
  20. ncbi request reprint Very fast oscillations evoked by median nerve stimulation in the human thalamus and subthalamic nucleus
    Ritsuko Hanajima
    Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada
    J Neurophysiol 92:3171-82. 2004
    ..The VFOs from STN probably represent volume conduction, possibly from the medial lemniscus. We conclude that the thalamic VFOs are generated within Vc and that they induce time-locked firing in a network of neurons...
  21. ncbi request reprint Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
    ..These results also suggest that overt neuronal synchronization, which may be attributable to an increase in direct synaptic connections or common collateral afferent inputs, is not present in the basal ganglia of patients with PD...
  22. ncbi request reprint Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Brain 125:1196-209. 2002
    ....
  23. ncbi request reprint Chronic anterior thalamus stimulation for intractable epilepsy
    Mojgan Hodaie
    Division of Neurosurgery, University of Toronto, ON, Canada
    Epilepsia 43:603-8. 2002
    ..We investigated neuromodulation of the anterior thalamus by using deep-brain stimulation (DBS) in patients with intractable seizures...
  24. ncbi request reprint Localization of clinically effective stimulating electrodes in the human subthalamic nucleus on magnetic resonance imaging
    Jean A Saint-Cyr
    Department of Surgery, Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Neurosurg 97:1152-66. 2002
    ..The authors sought to determine the location of deep brain stimulation (DBS) electrodes that were most effective in treating Parkinson disease (PD)...
  25. ncbi request reprint Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease
    Aviva Abosch
    Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
    J Neurosurg 97:1167-72. 2002
    ..The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields...
  26. ncbi request reprint Pallidal neuronal activity: implications for models of dystonia
    William D Hutchison
    Department of Surgery, Division of Neurosurgery and Toronto Western Research Institute, Toronto Western Hospital and Faculty of Medicine, University of Toronto, Ontario, Canada
    Ann Neurol 53:480-8. 2003
    ..The widely accepted pathophysiological models of dystonia that propose global decreases in basal ganglia output need to be viewed with caution in light of these findings...
  27. ncbi request reprint Somatosensory evoked potentials (SEPs) recorded from deep brain stimulation (DBS) electrodes in the thalamus and subthalamic nucleus (STN)
    Ritsuko Hanajima
    Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst St, Toronto, ON M5T 2S8, Canada
    Clin Neurophysiol 115:424-34. 2004
    ..To examine the location of deep brain stimulation (DBS) electrode somatosensory evoked potentials (SEPs) and determine the generators of the median nerve SEPs recorded in thalamus and subthalamic nucleus (STN)...
  28. doi request reprint Pedunculopontine nucleus microelectrode recordings in movement disorder patients
    Moran Weinberger
    Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
    Exp Brain Res 188:165-74. 2008
    ..It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy...
  29. ncbi request reprint Tremor cells in the human thalamus: differences among neurological disorders
    Jason A Brodkey
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    J Neurosurg 101:43-7. 2004
    ....
  30. ncbi request reprint Histological analysis of the location of effective thalamic stimulation for tremor. Case report
    Robert E Gross
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosurg 100:547-52. 2004
    ....
  31. ncbi request reprint Cingulotomy for psychiatric disease: microelectrode guidance, a callosal reference system for documenting lesion location, and clinical results
    Erich O Richter
    Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
    Neurosurgery 54:622-28; discussion 628-30. 2004
    ....
  32. ncbi request reprint Stimulation-induced inhibition of neuronal firing in human subthalamic nucleus
    Mohammed Filali
    Department of Physiology, Rm 3305 Medical Sciences Building, University of Toronto, University Health Network, 1 King s College Circle, M5S 1A8, Toronto, Ontario, Canada
    Exp Brain Res 156:274-81. 2004
    ..Therefore, the overall effects of DBS stimulation in STN are likely to be inhibition of intrinsic and synaptically mediated activity, and its replacement by regular high-frequency firing...
  33. ncbi request reprint P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralis
    Bo Hu
    Faculty of Dentistry, University of Toronto, Ontario M5G 1G6, Canada
    J Neurophysiol 88:1614-24. 2002
    ..These results suggest that P2X(3) and possibly also the P2X(2/3) receptor subtypes in Vc may play a role in the initiation and maintenance of central sensitization in Vo nociceptive neurons induced by MO application to the pulp...
  34. ncbi request reprint Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia
    Joyce K H Tang
    Department of Physiology, Med Sci Bldg 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Exp Neurol 204:845-8. 2007
    ..These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia...
  35. ncbi request reprint The motor thalamus in neurosurgery
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 58:146-58; discussion 146-58. 2006
    ..The aim of the present article is to briefly review the major anatomic and physiological aspects of the motor thalamus as well as the electrophysiological findings described in humans undergoing surgical procedures...
  36. pmc Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada
    Sleep 30:823-7. 2007
    ..We sought to identify and characterize human PGO waves...
  37. ncbi request reprint Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn
    Chen Yu Chiang
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    J Neurosci 27:9068-76. 2007
    ..These findings suggest that the astroglial glutamate-glutamine shuttle is essential for the initiation of inflammation-induced central sensitization but that inhibition of astroglial function may not affect normal nociceptive processing...
  38. ncbi request reprint Dissociation of thalamic high frequency oscillations and slow component of sensory evoked potentials following damage to ascending pathways
    Ritsuko Hanajima
    Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, ONT Canada
    Clin Neurophysiol 117:906-11. 2006
    ..In this study, we examined how lesions in the sensory afferent pathway affect these components...
  39. ncbi request reprint Deep brain stimulation for chronic neuropathic pain: long-term outcome and the incidence of insertional effect
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ont, Canada
    Pain 125:188-96. 2006
    ..The relatively low efficacy of DBS for the treatment of neuropathic pain stresses the need for further investigation and the exploration of new surgical targets...

Research Grants1

  1. MECHANISMS OF DEEP BRAIN STIMULATION.
    Jonathan Dostrovsky; Fiscal Year: 2003
    ..abstract_text> ..