H O Coxson
Affiliation: University of British Columbia
- DNAH5 is associated with total lung capacity in chronic obstructive pulmonary diseaseJin Hwa Lee
Channing Division of Network Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston 02115, MA, USA
Respir Res 15:97. 2014..Total lung capacity (TLC) is an indicator of hyperinflation particularly in subjects with moderate-to-severe airflow obstruction. The aim of our study was to identify genetic variants associated with TLC in COPD...
- Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitusCraig P Hersh
Channing Division of Network Medicine, Boston, MA, USA
BMC Pulm Med 14:164. 2014..However, the broader distinction between airway-predominant and emphysema-predominant COPD may be clinically relevant. The objective was to define clinical features of emphysema-predominant and non-emphysematous COPD patients...
- The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE studyHarvey O Coxson
Department of Radiology, University of British Columbia, Vancouver, Canada Electronic address
Lancet Respir Med 1:129-36. 2013..We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density...
- Sources of variation in quantitative computed tomography of the lungHarvey O Coxson
Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada
J Thorac Imaging 28:272-9. 2013....
- Quantification of lung surface area using computed tomographyRen Yuan
University of British Columbia James Hogg Research Centre and the Heart and Lung Institute, St Paul s Hospital, Burrard Street, Vancouver, Canada
Respir Res 11:153. 2010..To incorporate both regional lung density measured by CT and cluster analysis of low attenuation areas for comparison with histological measurement of surface area per unit lung volume...
- Characterisation of COPD heterogeneity in the ECLIPSE cohortAlvar Agusti
Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
Respir Res 11:122. 2010..Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE)...
- Quantitative computed tomography assessment of airway wall dimensions: current status and potential applications for phenotyping chronic obstructive pulmonary diseaseHarvey O Coxson
Department of Radiology Vancouver General Hospital, 855 West 12th Ave, Room 3350 JPN, Vancouver, BC, V5Z 1M9 Canada
Proc Am Thorac Soc 5:940-5. 2008..Therefore, these new imaging techniques are very likely to play a front-line role in the study of COPD and will, hopefully, allow clinicians to phenotype individuals, thereby personalizing their treatment...
- Quantitative assessment of the airway wall using computed tomography and optical coherence tomographyHarvey O Coxson
Department of Radiology, Vancouver General Hospital, and Department of Medicine, University of British Columbia, 855 West 12th Ave, Room 3350 JPN, Vancouver, BC, V5Z 1M9 Canada
Proc Am Thorac Soc 6:439-43. 2009....
- Computed tomography assessment of lung volume changes after bronchial valve treatmentH O Coxson
Department of Radiology, Vancouver General Hospital, 855 West 12th Ave, Room 3350 JPN, Vancouver, BC, V5Z 1M9, Canada
Eur Respir J 32:1443-50. 2008..The significant health status improvements reported by subjects following bilateral bronchial valve treatment are associated with regional lung volume changes and interlobar shift measured using computed tomography...
- Quantitative computed tomography of chronic obstructive pulmonary diseaseHarvey O Coxson
Department of Radiology and James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada V5Z 1M9
Acad Radiol 12:1457-63. 2005..This review describes some of these CT techniques for quantitative assessment of lung structure...
- Airway wall thickness assessed using computed tomography and optical coherence tomographyHarvey O Coxson
Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
Am J Respir Crit Care Med 177:1201-6. 2008..Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less...
- Amplification of inflammation in emphysema and its association with latent adenoviral infectionI Retamales
University of British Columbia McDonald Research Laboratories, St. Paul's Hospital, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 164:469-73. 2001..We conclude that cigarette smoke-induced lung inflammation is amplified in severe emphysema and that latent expression of the adenoviral E1A protein expressed by alveolar epithelial cells influenced this amplification process...
- Prediction of the rate of decline in FEV(1) in smokers using quantitative Computed TomographyR Yuan
University of British Columbia James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research and the Providence Heart Lung Institute, St Paul s Hospital, British Columbia, Canada
Thorax 64:944-9. 2009....
- Pulmonary embolism: comparison of gadolinium-enhanced MR angiography with contrast-enhanced spiral CT in a porcine modelP Reittner
Department of Radiology, Vancouver Hospital and Health Sciences Centre, British Columbia, Canada
Acad Radiol 8:343-50. 2001..CONCLUSION: MR angiography is as sensitive as CT for the detection of small PE in a porcine model...
- CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbitsC M Doerschuk
University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, Canada
J Immunol 144:2327-33. 1990..However, PMN adherence in the pulmonary circulation may occur by either CD18-dependent or -independent mechanisms that are specific to the inciting stimulus...
- Early emphysema in patients with anorexia nervosaHarvey O Coxson
Department of Radiology, Vancouver Coastal Health Research Institute Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada
Am J Respir Crit Care Med 170:748-52. 2004..These data demonstrate that emphysema-like changes are present in the lungs of patients who are chronically malnourished...
- Sex differences in emphysema and airway disease in smokersPat G Camp
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Chest 136:1480-8. 2009..The purpose of this study was to test for sex differences in COPD phenotypes by using high-resolution CT (HRCT) scanning in male and female smokers with and without COPD...
- Bronchiolitis obliterans following lung transplantation: early detection using computed tomographic scanningP A de Jong
Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Thorax 61:799-804. 2006....
- New and current clinical imaging techniques to study chronic obstructive pulmonary diseaseHarvey O Coxson
Providence Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 180:588-97. 2009..In this article, we provide an overview of these imaging modalities in the context of COPD and discuss their strengths as well as their limitations for providing quantitative COPD phenotypes...
- New concepts in the radiological assessment of COPDHarvey O Coxson
Department of Radiology, University of British Columbia, Vanvouver General Hospital, 855 W 12th Avenue, Vancouver, BC, Canada V5Z 1M9
Semin Respir Crit Care Med 26:211-20. 2005....
- Micro-computed tomography measurements of peripheral lung pathology in chronic obstructive pulmonary diseaseJames C Hogg
Emeritus Lab Medicine, iCAPTURE Center, St Paul s Hospital, Vancouver, BC V6Z 1Y6, Canada
Proc Am Thorac Soc 6:546-9. 2009..The smaller airways, < 2 mm in diameter, offer little resistance in normal lungs, but become the major site of obstruction in chronic obstructive pulmonary disease (COPD)...
- The nature of small-airway obstruction in chronic obstructive pulmonary diseaseJames C Hogg
University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
N Engl J Med 350:2645-53. 2004..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
- Selection of patients for lung volume reduction surgery using a power law analysis of the computed tomographic scanH O Coxson
University of British Columbia, McDonald Research Laboratories, St Paul s Hospital, Vancouver, BC, Canada V6Z 1Y6
Thorax 58:510-4. 2003..A study was undertaken to test the hypothesis that patients respond better to lung volume reduction surgery (LVRS) if their emphysema is confluent and predominantly located in the upper lobes...
- Bullae, bronchiectasis and nutritional emphysema in severe anorexia nervosaV J Cook
Respiratory Division, Department of Medicine, St Paul's Hospital, University of British Columbia, Vancouver, British Columbia
Can Respir J 8:361-5. 2001..Malnutrition has been associated with emphysematous changes in animals and may be the primary insult in the development of emphysema, bullae and bronchiectasis in the present patient...
- Tomographic comparison of ventilation techniques for CT-guided thoracoscopic staple excision of subcentimeter lung nodulesHumberto Lara-Guerra
Department of Surgery, Division of Thoracic Surgery, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada
J Invest Surg 19:185-91. 2006..Thus, although total lung capacity produces the highest confidence level, all three of the ventilatory techniques examined have similar detection of subcentimeter pulmonary nodules using computed tomography scans...
- Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathologyJames C Hogg
University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Am J Respir Crit Care Med 176:454-9. 2007..COPD is associated with reduced life expectancy...
- Lung density is not altered following intense normobaric hypoxic interval training in competitive female cyclistsJordan A Guenette
Health and Integrative Physiology Laboratory, University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
J Appl Physiol (1985) 103:875-82. 2007..Mean lung density did not change from pre (0.138 +/- 0.014 g/ml)- to postexercise (0.137 +/- 0.011 g/ml). These findings suggest that pulmonary edema does not occur in highly trained females following intense normobaric hypoxic exercise...
- The effects of radiation dose and CT manufacturer on measurements of lung densitometryRen Yuan
Department of Radiology, Vancouver General Hospital, 855 West Twelfth Ave, Room 3350 JPN, Vancouver, BC, Canada
Chest 132:617-23. 2007..To evaluate the effect of radiation dose and scanner manufacturer on quantitative CT scan measurements of lung morphology in smokers...
- Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokersA William Sheel
School of Human Kinetics, University of British Columbia, BC, Canada
J Appl Physiol (1985) 107:1622-8. 2009..In males and females matched for lung size women had significantly smaller airway luminal areas. The larger conducting airways in females are significantly smaller than those of males even after controlling for lung size...
- CT-Directed microcoil localization of small peripheral lung nodules: a feasibility study in pigsDalbhir Jangra
Department of Surgery, Vancouver Hospital and University of British Columbia, Vancouver, British Columbia, Canada
J Invest Surg 18:265-72. 2005..Platinum microcoils can be safely and easily deployed into the lung parenchyma with minimal complication risk, and can be used to guide subsequent thoracoscopic wedge resection...
- Diagnosis of subsegmental pulmonary emboli: a multi-center study using a porcine modelHarvey O Coxson
Department of Radiology, Vancouver General Hospital, Vancouver, BC, Canada
J Thorac Imaging 20:24-31. 2005....
- Reduced radiation dose helical chest CT: effect on reader evaluation of structures and lung findingsJohn R Mayo
Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 W 12th Ave, Vancouver, BC, Canada V5Z 1M9
Radiology 232:749-56. 2004..To assess, by using computer simulation, the effect of the use of reduced computed tomographic (CT) tube current on reader evaluation of structures and lung findings on images obtained at clinically indicated chest CT examinations...
- Detection of lung perfusion abnormalities using computed tomography in a porcine model of pulmonary embolismNicholas J Screaton
Department of Radiology Vancouver General Hospital, Vancouver, British Columbia, Canada
J Thorac Imaging 18:14-20. 2003..5 and 9 ml/s. A linear relationship exists (r = 0.88) between injection rate and change in maximal attenuation. In conclusion, perfusion defects of the lung are seen using computer-manipulated CT images...
- Conventional high-resolution CT versus contiguous multidetector CT in the detection of bronchiolitis obliterans syndrome in lung transplant recipientsJonathan D Dodd
Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada
J Thorac Imaging 23:235-43. 2008....
- Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysemaAlison M Wallace
University of British Columbia UBC James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, BC, Canada
COPD 5:13-23. 2008..Furthermore, these data provide evidence to support the concept that multiple proteinases, causing both elastin and collagen degradation, are important in the pathogenesis of pulmonary emphysema...
- Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary diseaseBipen D Patel
Department of Medicine, University of Cambridge, Cambridge, UK
Am J Respir Crit Care Med 178:500-5. 2008..It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families...
- Use of CT morphometry to detect changes in lung weight and gas volumeAndrew Perez
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Chest 128:2471-7. 2005..CT estimates of lung density have been used to estimate the extent and severity of emphysema. The present study was designed to test the hypothesis that quantitative CT can track the changes that occur in diffuse lung disease...
- High-resolution computed tomography imaging of airway disease in infants with cystic fibrosisTanya M Martínez
Department of Pediatrics, Section of Pediatric Pulmonology, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, Room 4270, Indianapolis, IN 46202, USA
Am J Respir Crit Care Med 172:1133-8. 2005..The development of early lung disease in patients with cystic fibrosis (CF) remains poorly defined...
- The prediction of small airway dimensions using computed tomographyYasutaka Nakano
Department of Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
Am J Respir Crit Care Med 171:142-6. 2005..01). We conclude that CT measurements of airways with a Pi of 0.75 cm or more could be used to estimate the dimensions of the small conducting airways, which are the site of airway obstruction in chronic obstructive pulmonary disease...
- The association between small airway obstruction and emphysema phenotypes in COPDWon Dong Kim
Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
Chest 131:1372-8. 2007..This study compares the severity of small airway obstruction in both forms of emphysema and determines its relationship with FEV(1)...
- Airway and parenchymal disease in chronic obstructive pulmonary disease are distinct phenotypesBip Patel
Institute of Public Health and Department of Medicine, University of Cambridge, Cambridge, UK
Proc Am Thorac Soc 3:533. 2006
- Antielastin autoimmunity in tobacco smoking-induced emphysemaSeung Hyo Lee
Department of Medicine, Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Med 13:567-9. 2007..These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers...
- Estimation of cancer mortality associated with repetitive computed tomography scanningPim A de Jong
Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
Am J Respir Crit Care Med 173:199-203. 2006..Low-dose radiation from computed tomography (CT) may increase the risk of certain cancers, especially in children...
- New 133Xe gas trapping index for quantifying severe emphysema before partial lung volume reductionJeffrey J Mathews
Nuclear Medicine, Department of Radiology, Temple University School of Medicine and Hospital, Philadelphia, Pennsylvania 19140, USA
J Nucl Med 49:771-5. 2008..The purpose of this study was to investigate the potential of using a new quantitative gas trapping index (GTI) derived from a (133)Xe ventilation scan to assess the severity of emphysema...
- Changes in airway dimensions on computed tomography scans of children with cystic fibrosisPim A de Jong
Erasmus MC, Sophia Children s Hospital, Department of Pediatric Pulmonology, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
Am J Respir Crit Care Med 172:218-24. 2005..Objectives: To quantify airway wall thickening and lumen dilatation in children with CF over a 2-year interval...
- Computed tomography in the evaluation of cystic fibrosis lung diseaseAlan S Brody
Department of Radiology, MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
Am J Respir Crit Care Med 172:1246-52. 2005..Second is the need for more sensitive outcome measures to assess new therapies. This had led to new interest and a series of important publications. The goal of this article is to present the current status of CT scanning in CF...
- Relationship between pathologic characteristics of peripheral airways and outcome after lung volume reduction surgery in severe chronic obstructive pulmonary diseaseFrank C Sciurba
Division of Pulmonary and Critical Care Medicine, Emphysema Research Center, University of Pittsburgh, Suite 1211, 3471 Fifth Avenue, PA 15213, USA
Proc Am Thorac Soc 3:533-4. 2006