William F N Chan
Affiliation: University of Alberta
- The ability of natural tolerance to be applied to allogeneic tissue: determinants and limitsWilliam F N Chan
Department of Surgery, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
Biol Direct 2:10. 2007..We explored the ability of natural tolerance to prevent immune responses to alloantigens, and the reasons for the disparate outcomes of pre-immunocompetence transplants...
- Microchimerism in the human brain: more questions than answersWilliam F N Chan
Department of Biochemistry, University of Alberta, Edmonton, AB Canada
Chimerism 4:32-3. 2013..As further research will be required to clarify this issue, here we discuss some of the questions that could be addressed to improve our understanding. ..
- Male microchimerism in the human female brainWilliam F N Chan
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
PLoS ONE 7:e45592. 2012..06) of male microchimerism in the brains of women with Alzheimer's disease than the brains of women without neurologic disease. In conclusion, male microchimerism is frequent and widely distributed in the human female brain...
- Differential susceptibility of allogeneic targets to indirect CD4 immunity generates split toleranceWilliam F N Chan
Department of Medical Microbiology, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
J Immunol 181:4603-12. 2008..The futility of these responses can convert immunity into tolerance...
- Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimerasWilliam F N Chan
Department of Medical Microbiology and Immunology, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
J Immunol 180:5177-86. 2008..In contrast, the possibility of humoral tolerance to multiple donors is potentially beneficial...
- Nonobese diabetic natural killer cells: a barrier to allogeneic chimerism that can be reduced by rapamycinDavid P Al-Adra
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Transplantation 92:977-84. 2011..Because NOD NK cells exhibit functional defects, they may not inhibit chimerism generation...
- Microchimerism in the rheumatoid nodules of patients with rheumatoid arthritisWilliam F N Chan
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Arthritis Rheum 64:380-8. 2012..This study was undertaken to investigate rheumatoid nodules for microchimerism...
- Non-myeloablative mixed chimerism approaches and tolerance, a split decisionBin Luo
Department of Surgery, Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
Eur J Immunol 37:1233-42. 2007..A model of the requirements for split tolerance is presented...
- T cells generated in the absence of a thoracic thymus fail to establish homeostasisChrista Smolarchuk
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada
Eur J Immunol 44:2263-73. 2014..Together the data suggests that the cervical thymus can function in the complete absence of the thoracic thymus; however, the T cells generated do not establish homeostasis...