William F N Chan

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits
    William F N Chan
    Department of Surgery, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
    Biol Direct 2:10. 2007
  2. pmc Microchimerism in the human brain: more questions than answers
    William F N Chan
    Department of Biochemistry, University of Alberta, Edmonton, AB Canada
    Chimerism 4:32-3. 2013
  3. pmc Male microchimerism in the human female brain
    William F N Chan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS ONE 7:e45592. 2012
  4. ncbi request reprint Differential susceptibility of allogeneic targets to indirect CD4 immunity generates split tolerance
    William F N Chan
    Department of Medical Microbiology, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 181:4603-12. 2008
  5. ncbi request reprint Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimeras
    William F N Chan
    Department of Medical Microbiology and Immunology, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 180:5177-86. 2008
  6. doi request reprint Nonobese diabetic natural killer cells: a barrier to allogeneic chimerism that can be reduced by rapamycin
    David P Al-Adra
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Transplantation 92:977-84. 2011
  7. pmc Microchimerism in the rheumatoid nodules of patients with rheumatoid arthritis
    William F N Chan
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Arthritis Rheum 64:380-8. 2012
  8. ncbi request reprint Non-myeloablative mixed chimerism approaches and tolerance, a split decision
    Bin Luo
    Department of Surgery, Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Eur J Immunol 37:1233-42. 2007
  9. doi request reprint T cells generated in the absence of a thoracic thymus fail to establish homeostasis
    Christa Smolarchuk
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada
    Eur J Immunol 44:2263-73. 2014

Collaborators

Detail Information

Publications9

  1. pmc The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits
    William F N Chan
    Department of Surgery, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
    Biol Direct 2:10. 2007
    ..We explored the ability of natural tolerance to prevent immune responses to alloantigens, and the reasons for the disparate outcomes of pre-immunocompetence transplants...
  2. pmc Microchimerism in the human brain: more questions than answers
    William F N Chan
    Department of Biochemistry, University of Alberta, Edmonton, AB Canada
    Chimerism 4:32-3. 2013
    ..As further research will be required to clarify this issue, here we discuss some of the questions that could be addressed to improve our understanding. ..
  3. pmc Male microchimerism in the human female brain
    William F N Chan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS ONE 7:e45592. 2012
    ..06) of male microchimerism in the brains of women with Alzheimer's disease than the brains of women without neurologic disease. In conclusion, male microchimerism is frequent and widely distributed in the human female brain...
  4. ncbi request reprint Differential susceptibility of allogeneic targets to indirect CD4 immunity generates split tolerance
    William F N Chan
    Department of Medical Microbiology, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 181:4603-12. 2008
    ..The futility of these responses can convert immunity into tolerance...
  5. ncbi request reprint Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimeras
    William F N Chan
    Department of Medical Microbiology and Immunology, Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 180:5177-86. 2008
    ..In contrast, the possibility of humoral tolerance to multiple donors is potentially beneficial...
  6. doi request reprint Nonobese diabetic natural killer cells: a barrier to allogeneic chimerism that can be reduced by rapamycin
    David P Al-Adra
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Transplantation 92:977-84. 2011
    ..Because NOD NK cells exhibit functional defects, they may not inhibit chimerism generation...
  7. pmc Microchimerism in the rheumatoid nodules of patients with rheumatoid arthritis
    William F N Chan
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Arthritis Rheum 64:380-8. 2012
    ..This study was undertaken to investigate rheumatoid nodules for microchimerism...
  8. ncbi request reprint Non-myeloablative mixed chimerism approaches and tolerance, a split decision
    Bin Luo
    Department of Surgery, Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Eur J Immunol 37:1233-42. 2007
    ..A model of the requirements for split tolerance is presented...
  9. doi request reprint T cells generated in the absence of a thoracic thymus fail to establish homeostasis
    Christa Smolarchuk
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada
    Eur J Immunol 44:2263-73. 2014
    ..Together the data suggests that the cervical thymus can function in the complete absence of the thoracic thymus; however, the T cells generated do not establish homeostasis...