Jean Carruthers

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Combination therapy with BOTOX and fillers: the new rejuvnation paradigm
    Kiersten R Coleman
    Department of Dermatology, Louisiana State University Health Sciences Center, New Orleans, USA
    Dermatol Ther 19:177-88. 2006
  2. ncbi request reprint Safety and efficacy of nonanimal stabilized hyaluronic acid for improvement of mouth corners
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia
    Dermatol Surg 31:276-80. 2005
  3. doi request reprint Anatomic guidelines for augmentation of the cheek and infraorbital hollow
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 38:1223-33. 2012
  4. doi request reprint Validated assessment scales for the mid face
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 38:320-32. 2012
  5. ncbi request reprint Botulinum toxin (botox) chemodenervation for facial rejuvenation
    J Carruthers
    Division of Dermatologic Surgery, University of British Columbia, Vancounver, British Columbia, Canada
    Facial Plast Surg Clin North Am 9:197-204, vii. 2001
  6. ncbi request reprint Botox: beyond wrinkles
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia School of Medicine, Vancouver, British Columbia, Canada
    Clin Dermatol 22:89-93. 2004
  7. ncbi request reprint Facial sculpting and tissue augmentation
    Jean D A Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:1604-12. 2005
  8. ncbi request reprint Botulinum toxin A in the mid and lower face and neck
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, 943 West Broadway, Suite 720, Vancouver, BC V5M 4E1, Canada
    Dermatol Clin 22:151-8. 2004
  9. doi request reprint Volumizing with a 20-mg/mL smooth, highly cohesive, viscous hyaluronic acid filler and its role in facial rejuvenation therapy
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 36:1886-92. 2010
  10. ncbi request reprint Two-center Canadian report on the safety and effectiveness of Evolence Breeze
    Jean Carruthers
    Department of Ophthalmology andVisual Sciences, University of British Columbia
    J Drugs Dermatol 8:830-4. 2009

Detail Information

Publications85

  1. ncbi request reprint Combination therapy with BOTOX and fillers: the new rejuvnation paradigm
    Kiersten R Coleman
    Department of Dermatology, Louisiana State University Health Sciences Center, New Orleans, USA
    Dermatol Ther 19:177-88. 2006
    ..As with any of the new technological innovations currently available, understanding of the differing properties of the agents used and education in optimal technique is essential to clinical and esthetic success...
  2. ncbi request reprint Safety and efficacy of nonanimal stabilized hyaluronic acid for improvement of mouth corners
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia
    Dermatol Surg 31:276-80. 2005
    ..A new technique to offer structural support using the recently approved filler nonanimal stabilized hyaluronic acid (NASHA; Restylane, Q-med Inc., Uppsala, Sweden) is described...
  3. doi request reprint Anatomic guidelines for augmentation of the cheek and infraorbital hollow
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 38:1223-33. 2012
    ..Mid-face reflation requires a sophisticated knowledge of bony and soft tissue anatomy...
  4. doi request reprint Validated assessment scales for the mid face
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 38:320-32. 2012
    ..The improvement of aesthetic treatment options for age-related mid face changes, such as volume loss, and the increase in patient expectations necessitates the development of more-complex and globally accepted assessment tools...
  5. ncbi request reprint Botulinum toxin (botox) chemodenervation for facial rejuvenation
    J Carruthers
    Division of Dermatologic Surgery, University of British Columbia, Vancounver, British Columbia, Canada
    Facial Plast Surg Clin North Am 9:197-204, vii. 2001
    ..A mere increase in years is no longer enough reason for "ageism." Botulinum Toxin (Botox) aesthetic treatments, because of their outstanding effectiveness and safety, can continue to play a positive role in the rebuttal of "ageism."..
  6. ncbi request reprint Botox: beyond wrinkles
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia School of Medicine, Vancouver, British Columbia, Canada
    Clin Dermatol 22:89-93. 2004
    ..Moreover, other conditions-notably some pain and gastrointestinal disorders-have responded to BTX injections...
  7. ncbi request reprint Facial sculpting and tissue augmentation
    Jean D A Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:1604-12. 2005
    ....
  8. ncbi request reprint Botulinum toxin A in the mid and lower face and neck
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, 943 West Broadway, Suite 720, Vancouver, BC V5M 4E1, Canada
    Dermatol Clin 22:151-8. 2004
    ..In addition to its use as primary procedure, botulinum toxin is also an effective adjunct to other cosmetic procedures, enhancing and prolonging the benefits of surgery, soft tissue augmentation, and laser resurfacing...
  9. doi request reprint Volumizing with a 20-mg/mL smooth, highly cohesive, viscous hyaluronic acid filler and its role in facial rejuvenation therapy
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 36:1886-92. 2010
    ..OBJECTIVE Evaluate clinical experience with 20 mg/mL HA dermal filler to date and comment on its current and potential uses within the facial rejuvenation treatment paradigm...
  10. ncbi request reprint Two-center Canadian report on the safety and effectiveness of Evolence Breeze
    Jean Carruthers
    Department of Ophthalmology andVisual Sciences, University of British Columbia
    J Drugs Dermatol 8:830-4. 2009
    ..This represents our initial experience with both subject satisfaction and product safety during this one year period approximately 1.5 years after Health Canada product approval...
  11. ncbi request reprint The effect of full-face broadband light treatments alone and in combination with bilateral crow's feet Botulinum toxin type A chemodenervation
    Jean Carruthers
    Opthalmology, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 30:355-66; discussion 366. 2004
    ..Irvine, CA) treatment of the lateral periocular region relaxes the vertical fibers of the orbicularis oculi and results in softening of the lateral orbital crow's feet rhytides and widening of the palpebral aperture...
  12. doi request reprint Multicenter, randomized, parallel-group study of onabotulinumtoxinA and hyaluronic acid dermal fillers (24-mg/ml smooth, cohesive gel) alone and in combination for lower facial rejuvenation: satisfaction and patient-reported outcomes
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 36:2135-45. 2010
    ..Patient-reported outcomes (PROs) are important assessment benchmarks after aesthetic procedures. Systematic studies of PROs have not been conducted in the lower face...
  13. ncbi request reprint The evolution of botulinum neurotoxin type A for cosmetic applications
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    J Cosmet Laser Ther 9:186-92. 2007
    ..Although BOTOX is the most clinically substantiated and published of the BoNTA preparations, other BoNTA products, as well as a BoNT type B product, are available in some parts of the world, and others are in development...
  14. ncbi request reprint Hyaluronic acid gel in skin rejuvenation
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Canada
    J Drugs Dermatol 5:959-64. 2006
    ..The more viscous agents are very helpful in the treatment of facial lipoatrophy particularly in the region of the cheeks and chin...
  15. ncbi request reprint Complications of botulinum toxin type A
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, V5Z 4E1, Canada
    Facial Plast Surg Clin North Am 15:51-4, vi. 2007
    ..Complications can occur, particularly when used by the inexperienced injectors. Through knowledge of its mechanism of action and effect and careful attention to dosing and technique can minimize the risk of more serious adverse events...
  16. doi request reprint Botulinum toxin in facial rejuvenation: an update
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, 943 West Broadway, Suite 740, Vancouver, BC, Canada
    Dermatol Clin 27:417-25, v. 2009
    ..Although recent reports have questioned the safety of BTX, 25 years of therapeutic and over 20 years of cosmetic use has demonstrated an impressive record of safety and efficacy when used appropriately by experienced injectors...
  17. ncbi request reprint Aesthetic botulinum A toxin in the mid and lower face and neck
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Dermatol Surg 29:468-76. 2003
    ..Botulinum toxin type A (BOTOX formulation) is used extensively for smoothing hyperkinetic lines in the upper face. The use of botulinum toxin for aesthetic indications in the mid and lower face and neck is now becoming increasingly popular...
  18. ncbi request reprint Deep resting glabellar rhytides respond to BTX-A and Hylan B
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 29:539-44. 2003
    ..BTX-A is the standard treatment for glabellar furrows. However, some individuals have resting glabellar rhytides that are sufficiently deep that they respond poorly to BTX-A alone...
  19. ncbi request reprint A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox) and nonanimal sourced hyaluronic acid (NASHA, Restylane) in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: trea
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 29:802-9. 2003
    ..Over the past 15 years, BTX-A has become the standard treatment for dynamic glabellar furrowing. Some individuals have resting glabellar rhytides that are sufficiently deep that they respond poorly to BTX-A alone...
  20. doi request reprint Advances in facial rejuvenation: botulinum toxin type a, hyaluronic acid dermal fillers, and combination therapies--consensus recommendations
    Jean D A Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Plast Reconstr Surg 121:5S-30S; quiz 31S-36S. 2008
    ..Clinicians can benefit from ongoing guidance on products, tailoring treatments to individual patients, treating multiple facial areas, and using combinations of products and ways to optimize outcomes...
  21. doi request reprint A validated grading scale for crow's feet
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S173-8. 2008
    ..To develop the Crow's Feet Grading Scale for objective quantification of the severity of lateral canthal lines and to establish the reliability of this photonumeric scale for clinical research and practice...
  22. doi request reprint A validated grading scale for marionette lines
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S167-72. 2008
    ..Melomental folds, or marionette lines, are one of the consequences of facial aging. The curvilinear wrinkles formed because of facial movements and the aging process extend downward from the oral commissures...
  23. doi request reprint A validated grading scale for forehead lines
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S155-60. 2008
    ..As with other facial wrinkles, the gradual loss and disorganization of collagen fibers and elastin, connective tissues that provide underlying support for skin, cause horizontal forehead rhytides in large part...
  24. doi request reprint A validated lip fullness grading scale
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S161-6. 2008
    ..To develop the Lip Fullness Grading Scale for objective quantification of lip volume for a reliable assessment and to establish the reliability of this photonumeric scale for clinical research and practice...
  25. doi request reprint A validated hand grading scale
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S179-83. 2008
    ..Irregular surface pigmentation, prominence of superficial veins and tendons, thinning of the dermis, and loss of subcutaneous fat typically characterize aging of the hand...
  26. doi request reprint Multicenter, randomized, parallel-group study of the safety and effectiveness of onabotulinumtoxinA and hyaluronic acid dermal fillers (24-mg/ml smooth, cohesive gel) alone and in combination for lower facial rejuvenation
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 36:2121-34. 2010
    ..Combination treatment with toxins and fillers is the standard regimen in facial rejuvenation. Systematic studies of botulinum toxin alone and in combination with hyaluronic acid (HA) have not, however, been conducted in the lower face...
  27. doi request reprint A validated brow positioning grading scale
    Alastair Carruthers
    Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S150-4. 2008
    ..Movement and positioning of the brows are also sex specific. Men may desire a low brow, whereas women may prefer high, arched brows...
  28. ncbi request reprint Adjunctive botulinum toxin type A: fillers and light-based therapies
    Jean Carruthers
    Carruthers Cosmetic Centre, 790 943 West Broadway, Vancouver, British Columbia, Canada V5Z 4E1
    Int Ophthalmol Clin 45:143-51. 2005
  29. ncbi request reprint Development and Validation of a Photonumeric Scale for Evaluation of Static Horizontal Forehead Lines
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut Allergan plc, Irvine, California Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada UC Davis Medical Group, Sacramento, California Division of Dermatology, University of California at Los Angeles, Los Angeles, California Peloton Advantage, LLC, Parsippany, New Jersey
    Dermatol Surg 42:S243-S250. 2016
    ..A validated scale is needed for objective and reproducible comparisons of static forehead lines before and after treatment in practice and clinical studies...
  30. ncbi request reprint Development and Validation of a Photonumeric Scale for Evaluation of Transverse Neck Lines
    Derek Jones
    Division of Dermatology, University of California at Los Angeles, Los Angeles, California Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada Allergan plc, Irvine, California UC Davis Medical Group, Sacramento, California Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Peloton Advantage, LLC, Parsippany, New Jersey
    Dermatol Surg 42:S235-S242. 2016
    ..A validated scale is needed for objective and reproducible comparisons of horizontal neck lines before and after treatment in practice and clinical studies...
  31. ncbi request reprint Development and Validation of a Photonumeric Scale for Evaluation of Facial Fine Lines
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut Allergan plc, Irvine, California Division of Dermatology, University of California, Los Angeles, Los Angeles, California Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada UC Davis Medical Group, Sacramento, California Peloton Advantage, LLC, Parsippany, New Jersey
    Dermatol Surg 42:S227-S234. 2016
    ..A validated scale is needed for objective and reproducible comparisons of facial fine lines before and after treatment in practice and clinical studies...
  32. ncbi request reprint Development and Validation of a Photonumeric Scale for Evaluation of Facial Skin Texture
    Lisa Donofrio
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada Allergan plc, Irvine, California Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Division of Dermatology, University of California at Los Angeles, Los Angeles, California UC Davis Medical Group, Sacramento, California Peloton Advantage, LLC, Parsippany, New Jersey
    Dermatol Surg 42:S219-S226. 2016
    ..A validated scale is needed for objective and reproducible comparisons of facial skin roughness before and after aesthetic treatment in practice and in clinical studies...
  33. ncbi request reprint Development and Validation of a Photonumeric Scale for Evaluation of Infraorbital Hollows
    Lisa Donofrio
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Allergan plc, Irvine, California Division of Dermatology, University of California, Los Angeles, Los Angeles, California UC Davis Medical Group, Sacramento, California Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada Peloton Advantage, LLC, Parsippany, New Jersey
    Dermatol Surg 42:S251-S258. 2016
    ..A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies...
  34. ncbi request reprint Development and Validation of a Photonumeric Scale for Assessment of Chin Retrusion
    Jonathan M Sykes
    Department of Otolaryngology Facial Plastic Surgery, UC Davis Medical Group, Sacramento, California Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada Allergan plc, Irvine, California Division of Dermatology, University of California at Los Angeles, Los Angeles, California Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut Peloton Advantage, LLC, Parsippany, New Jersey
    Dermatol Surg 42:S211-S218. 2016
    ..A validated scale is needed for objective and reproducible comparisons of chin appearance before and after chin augmentation in practice and clinical studies...
  35. ncbi request reprint Development and Validation of a Photonumeric Scale for Evaluation of Volume Deficit of the Temple
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Division of Dermatology, University of California at Los Angeles, Los Angeles, California Allergan plc, Irvine, California Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut UC Davis Medical Group, Sacramento, California Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada Peloton Advantage, LLC, Parsippany, New Jersey
    Dermatol Surg 42:S203-S210. 2016
    ..A validated scale is needed for objective and reproducible comparisons of temple appearance before and after aesthetic treatment in practice and clinical studies...
  36. doi request reprint Radiographic and computed tomographic studies of calcium hydroxylapatite for treatment of HIV-associated facial lipoatrophy and correction of nasolabial folds
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 34:S78-84. 2008
    ..following augmentation to correct the nasolabial folds or facial wasting associated with human immunodeficiency virus lipoatrophy...
  37. ncbi request reprint Botulinum toxin type A for the treatment of glabellar rhytides
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, BC, Canada
    Dermatol Clin 22:137-44. 2004
    ....
  38. ncbi request reprint The use of botulinum toxin type A in the upper face
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, 943 West Broadway, Suite 720, Vancouver, BC V5M 4E1, Canada
    Facial Plast Surg Clin North Am 14:253-60. 2006
  39. ncbi request reprint The science and art of dermal fillers for soft-tissue augmentation
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada
    J Drugs Dermatol 8:335-50. 2009
    ....
  40. ncbi request reprint Consensus recommendations on the use of botulinum toxin type a in facial aesthetics
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Plast Reconstr Surg 114:1S-22S. 2004
    ..Factors unique to each area are presented, and the discussion of each treatment area concludes with a review of key elements that can increase the likelihood of a successful outcome. Summary tables are provided throughout...
  41. ncbi request reprint A single-center dose-comparison study of botulinum neurotoxin type A in females with upper facial rhytids: assessing patients' perception of treatment outcomes
    Alastair Carruthers
    University of British Columbia, Department of Dermatology and Skin Science, Vancouver, BC, Canada
    J Drugs Dermatol 8:924-9. 2009
    ..Few studies evaluate patient-reported outcomes (PROs)...
  42. ncbi request reprint Dilution volume of botulinum toxin type A for the treatment of glabellar rhytides: does it matter?
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:S97-104. 2007
    ..Because well-controlled studies examining the efficacy and safety of various dilutions of botulinum toxin type A (BTX-A) have not been performed, dilutions used in clinical practice are chosen at the discretion of the clinician...
  43. ncbi request reprint Eyebrow height after botulinum toxin type A to the glabella
    Alastair Carruthers
    Department of Dermatology, University of Bristish Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:S26-31. 2007
    ..Numerous reports have cited an associated brow lift with BTX-A injections in the glabellar complex, presumably caused by deactivation of the brow depressor muscles. Few analyses examining this phenomenon more closely exist, however...
  44. ncbi request reprint Botulinum toxin below the eyes
    Jean Carruthers
    Carruthers Cosmetic Centre, 790 943 West Broadway, Vancouver, British Columbia, Canada V5Z 4E1
    Int Ophthalmol Clin 45:133-41. 2005
  45. ncbi request reprint Dose-ranging study of botulinum toxin type A in the treatment of glabellar rhytids in females
    Alastair Carruthers
    University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 31:414-22; discussion 422. 2005
    ..To compare the efficacy, safety, and duration of effect of four doses of botulinum toxin type A in the treatment of glabellar rhytids in females...
  46. ncbi request reprint Botulinum toxin type A treatment of multiple upper facial sites: patient-reported outcomes
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:S10-7. 2007
    ..Aesthetic treatment planning must address subjects' goals and include subject-reported outcomes...
  47. ncbi request reprint Patient-reported outcomes with botulinum neurotoxin type A
    Alastair Carruthers
    Department of Dermatology and Skin Science, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Cosmet Laser Ther 9:32-7. 2007
    ..These outcomes data help in understanding patient objectives and motivations, establishing a treatment plan, and ensuring patient satisfaction. Clinicians can use the SPA measure for all patients to help show the value of treatment...
  48. ncbi request reprint The natural history of polymethylmethacrylate microspheres granulomas
    Allison Gelfer
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 33:614-20. 2007
  49. ncbi request reprint Dose-finding, safety, and tolerability study of botulinum toxin type B for the treatment of hyperfunctional glabellar lines
    Alastair Carruthers
    University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:S60-8. 2007
    ..Previous open-label studies have demonstrated that botulinum toxin type B (BTX-B, Myobloc, Solstice Neurosciences) in doses of up to 3,000 U is safe and effective in the treatment of glabellar wrinkles...
  50. ncbi request reprint Prospective, double-blind, randomized, parallel-group, dose-ranging study of botulinum toxin type A in men with glabellar rhytids
    Alastair Carruthers
    Department of Dermatology, University of British Columbia, 943 West Broadway, Ste 820, Vancouver, British Columbia V5Z 4E1, Canada
    Dermatol Surg 31:1297-303. 2005
    ..The effective dose for treating glabellar lines with botulinum toxin type A in men has not been studied adequately...
  51. doi request reprint Evaluation of injectable calcium hydroxylapatite for the treatment of facial lipoatrophy associated with human immunodeficiency virus
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 34:1486-99. 2008
    ..To evaluate the safety and effectiveness of soft tissue augmentation with calcium hydroxylapatite (CaHA) microspheres in an aqueous gel in patients with facial lipoatrophy (FLA) secondary to human immunodeficiency virus (HIV) disease...
  52. ncbi request reprint A prospective, double-blind, randomized, parallel- group, dose-ranging study of botulinum toxin type a in female subjects with horizontal forehead rhytides
    Alastair Carruthers
    Division of Dermatology, Vancouver, British Columbia, Canada
    Dermatol Surg 29:461-7. 2003
    ..Botulinum toxin type A is used cosmetically to improve facial lines, but it has not been thoroughly investigated for the treatment of horizontal forehead rhytides...
  53. doi request reprint A single-center, dose-comparison, pilot study of botulinum neurotoxin type A in female patients with upper facial rhytids: safety and efficacy
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, 943 W Broadway, Suite 820, Vancouver, British Columbia V5Z 4E1, Canada
    J Am Acad Dermatol 60:972-9. 2009
    ..Treating multiple upper facial rhytids at one time is common, but has not been researched extensively...
  54. ncbi request reprint Development and Validation of a Photonumeric Scale for Evaluation of Volume Deficit of the Hand
    Derek Jones
    Division of Dermatology, University of California at Los Angeles, Los Angeles, California Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut Allergan plc, Irvine, California Departments of Ophthalmology and Visual Sciences, and Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada UC Davis Medical Group, Sacramento, California Peloton Advantage, LLC, Parsippany, New Jersey
    Dermatol Surg 42:S195-S202. 2016
    ..A validated scale is needed for objective and reproducible comparisons of hand appearance before and after treatment in practice and clinical studies...
  55. doi request reprint Efficacy of incobotulinumtoxinA for treatment of glabellar frown lines: a post hoc pooled analysis of 2 randomized, placebo-controlled, phase 3 trials
    Derek Jones
    Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Carruthers Clinical Research, Vancouver, BC, Canada Dermatology Surgery and Laser Center, White Plains, New York Coleman Cosmetic Dermatologic Surgery Center, Metairie, Louisiana Ogilvy 4D, Oxford, United Kingdom Dermatology Research Institute, Coral Gables, Florida AboutSkin Dermatology and DermSurgery, Englewood, Colorado
    Dermatol Surg 40:776-85. 2014
    ..Botulinum neurotoxin type A trials in aesthetic indications have used differing efficacy parameters and responder definitions...
  56. doi request reprint Multicenter, randomized, phase III study of a single dose of incobotulinumtoxinA, free from complexing proteins, in the treatment of glabellar frown lines
    Alastair Carruthers
    Carruthers Clinical Research, Vancouver, British Columbia, Canada
    Dermatol Surg 39:551-8. 2013
    ..IncobotulinumtoxinA (NT 201, Xeomin/Xeomeen/Bocouture, Merz Pharmaceuticals GmbH, Frankfurt, Germany) is a 150-kDa botulinum toxin type A free of complexing proteins...
  57. doi request reprint A validated facial grading scale: the future of facial ageing measurement tools?
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    J Cosmet Laser Ther 12:235-41. 2010
    ..Validation studies show that these scales have good intra- and inter-rater reliability, with intra-class correlation coefficients generally in the range 0.85-0.95, and similar test-retest correlations...
  58. ncbi request reprint Single-center, double-blind, randomized study to evaluate the efficacy of 4% lidocaine cream versus vehicle cream during botulinum toxin type A treatments
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, BC
    Dermatol Surg 31:1655-9. 2005
    ..Botulinum toxin type A (BTX-A) injections are overwhelmingly safe and effective treatment in cosmetic treatment, but some patients are apprehensive about pain associated with injection...
  59. ncbi request reprint Non-animal-based hyaluronic acid fillers: scientific and technical considerations
    Alastair Carruthers
    Department of Dermatology, University of British Columbia, Canada
    Plast Reconstr Surg 120:33S-40S. 2007
    ..Recent advances in the technology and biocompatibility of the hyaluronans in all skin types mean that they are becoming the temporary facial filling agents of choice for many aesthetic physicians and surgeons...
  60. doi request reprint Repeated OnabotulinumtoxinA Treatment of Glabellar Lines at Rest Over Three Treatment Cycles
    Alastair Carruthers
    Departments of Dermatology and Skin Science, and Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Private Practice, Boca Raton, Florida Department of Clinical Development, Allergan plc, Irvine, California Department of Neurology, University of California, Irvine, California
    Dermatol Surg 42:1094-101. 2016
    ..OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at rest; however, less is known regarding the effect of repeat treatment on more severe lines at rest...
  61. doi request reprint A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Repeated OnabotulinumtoxinA Treatments in Subjects With Crow's Feet Lines and Glabellar Lines
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Division of Dermatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut Department of Dermatology, Tulane University School of Medicine, New Orleans, Louisiana Division of Dermatology, University of Toronto, Toronto, Ontario, Canada Allergan, Inc, Irvine, California SCI Scientific Communications and Information, Parsippany, New Jersey C Somogyi and F C Beddingfield are now at Kythera Biopharmaceuticals, Inc, Calabasas, California
    Dermatol Surg 41:702-11. 2015
    ..This is the third study in a Phase 3 program evaluating onabotulinumtoxinA treatment of crow's feet lines (CFL)...
  62. doi request reprint OnabotulinumtoxinA treatment of mild glabellar lines in repose
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 36:2168-71. 2010
    ..OnabotulinumtoxinA is an established treatment for glabellar frown lines, but its effects on lines at repose are less well documented...
  63. ncbi request reprint Introduction to the consensus recommendations
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Plast Reconstr Surg 114:i-iii. 2004
  64. doi request reprint Efficacy and safety of onabotulinumtoxinA for treating crow's feet lines alone or in combination with glabellar lines: a multicenter, randomized, controlled trial
    Marion Moers-Carpi
    Private Clinic, Hautok, Munich, Germany Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada Private Practice, Boca Raton, Florida Department of Dermatology, Tulane University School of Medicine, New Orleans, Louisiana Private Practice, New Orleans, Louisiana Centre de Chirurgie Esthétique du Cap d Antibes, Cap d Antibes, France Division of Dermatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California Allergan, Inc, Irvine, California SCI Scientific Communications and Information, Parsippany, New Jersey Dr Beddingfield and Ms Somogyi are now at Kythera Biopharmaceuticals, Inc, Calabasas, California
    Dermatol Surg 41:102-12. 2015
    ..This was the second study in a Phase 3 program treating crow's feet lines (CFL) with onabotulinumtoxinA...
  65. doi request reprint The convergence of medicine and neurotoxins: a focus on botulinum toxin type A and its application in aesthetic medicine--a global, evidence-based botulinum toxin consensus education initiative: part II: incorporating botulinum toxin into aesthetic clinic
    Jean Carruthers
    University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 39:510-25. 2013
    ..The key to using BoNTA to its best effect is to understand patient-specific factors that will determine the treatment plan and the physician's ability to personalize injection strategies...
  66. ncbi request reprint Shrinking upper and lower eyelid skin with a novel radiofrequency tip
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 33:802-9. 2007
    ..25-cm(2) monopolar radiofrequency tip in a prospective noncomparative study as a novel nonsurgical method to safely tighten upper and lower eyelid skin in subjects of differing ethnicity and sex...
  67. ncbi request reprint Botulinum toxin type A
    Alastair Carruthers
    Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Acad Dermatol 53:284-90. 2005
  68. doi request reprint Introduction to Fillers
    Jean Carruthers
    Vancouver, British Columbia, Canada From the Department of Ophthalmology and Visual Sciences, University of British Columbia and Department of Dermatology and Skin Science, University of British Columbia
    Plast Reconstr Surg 136:120S-131S. 2015
    ..Over the last few years, injectable soft-tissue fillers have become an integral part of cosmetic therapy, with a wide array of products designed to fill lines and folds and revolumize the face...
  69. doi request reprint REFINE-1, a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial With ATX-101, an Injectable Drug for Submental Fat Reduction
    Derek H Jones
    Dermatology Division, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California Department ofDermatology, Howard University College of Medicine, Washington, DC Kythera Biopharmaceuticals, Inc, Westlake Village, California now an affiliate of Allergan plc, Irvine, California Evidence Scientific Solutions, Philadelphia, Pennsylvania
    Dermatol Surg 42:38-49. 2016
    ..ATX-101, an injectable form of deoxycholic acid, is approved in the United States and Canada for submental fat (SMF) reduction...
  70. doi request reprint Clinical Experience With 11,460 mL of a 20-mg/mL, Smooth, Highly Cohesive, Viscous Hyaluronic Acid Filler
    Shannon Humphrey
    Departments of Dermatology and Skin Science, and Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 41:1060-7. 2015
    ..The newest HA formulation is a 20-mg/mL smooth cohesive filler (Juvéderm Voluma [HA-V]) that combines both low- and high-molecular-weight HA for more efficient cross-linking and greater lift capabilities...
  71. doi request reprint Epidemiologic analysis of change in eyelash characteristics with increasing age in a population of healthy women
    Dee A Glaser
    Department of Dermatology, Saint Louis University, St Louis, Missouri Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia Scientific Communications and Information, Parsippany, New Jersey Allergan, Inc, Irvine, California
    Dermatol Surg 40:1208-13. 2014
    ..Observations that eyelashes become thinner, shorter, and lighter, as women age has not been previously quantified...
  72. doi request reprint Injecting botulinum toxin at different depths is not effective for the correction of eyebrow asymmetry
    Jason Sneath
    Departments of Dermatology and Skin Science, and Ophthalmology, University of British Columbia, Vancouver, BC, Canada
    Dermatol Surg 41:S82-7. 2015
    ..Expert consensus is that increased injection depth delivers more BoNT-A to these depressors and causes increased elevation. This technique is applied to the correction of brow height asymmetry...
  73. doi request reprint You want to inject what?
    Alastair Carruthers
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada Department of Ophthalmology and Visual Sciences, University of British Columbia, British Columbia, Vancouver, Canada
    Dermatol Surg 41:S2-8. 2015
    ..This article is a review of the authors' 32 years' experience with botulinum toxin type A (BoNTA), especially its cosmetic use. It includes a review of the relevant literature and pointers to the future...
  74. doi request reprint Cryolipolysis and skin tightening
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada Division Plastic Surgery, Keck School of Medicine, University of Southern California, Marina del Rey, California Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada
    Dermatol Surg 40:S184-9. 2014
    ..Anecdotally, there have been reports of skin tightening after cryolipolysis, but this has not been studied or reported in the literature...
  75. doi request reprint Patient satisfaction and safety with aesthetic onabotulinumtoxinA after at least 5 years: a retrospective cross-sectional analysis of 4,402 glabellar treatments
    Ada Trindade de Almeida
    Hospital do Servidor Publico Municipal, Sao Paulo, Brazil Carruthers Clinical Research, Vancouver, British Columbia, Canada Aesthetic Solutions, Chapel Hill, North Carolina Goldman, Butterwick, Fitzpatrick, Groff and Fabi Cosmetic Laser Dermatology, San Diego, California Allergan, Inc, Irvine, California
    Dermatol Surg 41:S19-28. 2015
    ..Despite extensive clinical experience with onabotulinumtoxinA, few data exist on patient satisfaction or safety with continuous treatment...
  76. ncbi request reprint HIV-associated facial lipoatrophy
    Julia James
    Division of Dermatology and Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 28:979-86. 2002
    ..HIV-infected individuals are living long, healthy lives. They are now concerned with less life-threatening problems, especially lipodystrophy...
  77. doi request reprint Commentary: Long-Term Treatment of Glabellar Rhytides Using OnabotulinumtoxinA
    Alastair Carruthers
    University of British Columbia, Vancouver, British Columbia, Canada
    Dermatol Surg 37:929-30. 2011
    Drs. Alastair and Jean Carruthers are consultants to Allergan, Inc., and have been paid to do research by Allergan, Inc.
  78. ncbi request reprint Botulinum toxin in facial rejuvenation: an update
    Jean Carruthers
    Department of Ophthalmology and Visual Sciences, University of British Columbia, 943 West Broadway, Suite 740, Vancouver, BC, Canada V5Z 4E1
    Obstet Gynecol Clin North Am 37:571-82, ix. 2010
    ..Although recent reports have questioned the safety of BTX, 25 years of therapeutic and over 20 years of cosmetic use has demonstrated an impressive record of safety and efficacy when used appropriately by experienced injectors...
  79. ncbi request reprint Surgical pearl: the use of the Ultra-Fine II short needle 0.3-cc insulin syringe for botulinum toxin injections
    Timothy Corcoran Flynn
    Department of Dermatology, Tulane University Medical School, New Orleans, Louisiana 70112, USA
    J Am Acad Dermatol 46:931-3. 2002
  80. ncbi request reprint Management of injected hyaluronic acid induced Tyndall effects
    Ranella J Hirsch
    Skincare Doctors, Cambridge, Massachusetts 02138, USA
    Lasers Surg Med 38:202-4. 2006
    ..Soft tissue augmentation represents a cosmetic procedure performed with increasing frequency...
  81. ncbi request reprint Botulinum treatment of forehead wrinkles
    Alastair Carruthers
    Plast Reconstr Surg 117:1354; author reply 1355. 2006
  82. ncbi request reprint Botulinum toxin A: its expanding role in dermatology and esthetics
    Samireh Said
    University of California, Irvine, California, USA
    Am J Clin Dermatol 4:609-16. 2003
    ..Botulinum toxin A can provide an alternative treatment of palmar and axillary hyperhidrosis when options such as topical agents (aluminum chloride) and iontophoresis have failed...
  83. ncbi request reprint Monopolar radiofrequency treatment of human eyelids: a prospective, multicenter, efficacy trial
    Brian S Biesman
    Department of Ophthalmology, Otolaryngology, Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Lasers Surg Med 38:890-8. 2006
    ..To evaluate the efficacy of a novel 0.25 cm(2) monopolar radiofrequency (RF) treatment tip for aesthetic rejuvenation of the eyelids...
  84. ncbi request reprint Mad cows, prions, and wrinkles
    Jean Carruthers
    Arch Dermatol 138:667-70. 2002
  85. ncbi request reprint Surgical pearl: accurate documentation of facial lesions using only one landmark
    Alastair Carruthers
    J Am Acad Dermatol 49:359-60. 2003