Adam Burgener

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. pmc A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression
    Adam Burgener
    University of Manitoba, Department of Medical Microbiology, Winnipeg, Manitoba, Canada
    J Virol 87:5141-50. 2013
  2. ncbi Salivary basic proline-rich proteins are elevated in HIV-exposed seronegative men who have sex with men
    Adam Burgener
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    AIDS 26:1857-67. 2012
  3. doi Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers
    A Burgener
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    J Proteome Res 10:5139-49. 2011
  4. doi Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers
    Adam Burgener
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    J Proteome Res 7:4446-54. 2008
  5. doi Mucosal serpin A1 and A3 levels in HIV highly exposed sero-negative women are affected by the menstrual cycle and hormonal contraceptives but are independent of epidemiological confounders
    Syeda Rahman
    Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    Am J Reprod Immunol 69:64-72. 2013
  6. pmc Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility
    Kenzie Birse
    National Lab for HIV Immunology, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 89:8793-805. 2015
  7. pmc Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers
    Kenzie D M Birse
    Proteomics Unit, National Laboratory for HIV Immunology, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 10:e0130404. 2015
  8. pmc Unbiased proteomics analysis demonstrates significant variability in mucosal immune factor expression depending on the site and method of collection
    Kenzie M Birse
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Proteomics Group, National Lab for HIV Immunology, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 8:e79505. 2013
  9. doi Proteomics as a novel HIV immune monitoring tool
    Derek R Stein
    University of Manitoba, Department of Medical Microbiology bImmunology, Winnipeg, Manitoba, Canada
    Curr Opin HIV AIDS 8:140-6. 2013
  10. pmc Microbial translocation and microbiome dysbiosis in HIV-associated immune activation
    Alexander S Zevin
    aDepartment of Pharmaceutics, University of Washington bWashington National Primate Research Center, Seattle, Washington, USA cCentre for the AIDS Programme of Research CAPRISA, Durban, South Africa dDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba eNational Laboratory for HIV Immunology, JC Wilt Infectious Disease Research Center, Public Health Agency of Canada, Winnipeg, Manitoba, Canada fDepartment of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska, Sweden
    Curr Opin HIV AIDS 11:182-90. 2016

Collaborators

Detail Information

Publications14

  1. pmc A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression
    Adam Burgener
    University of Manitoba, Department of Medical Microbiology, Winnipeg, Manitoba, Canada
    J Virol 87:5141-50. 2013
    ..This may have important implications for early events in HIV transmission and site-specific susceptibility to HIV in the FGT...
  2. ncbi Salivary basic proline-rich proteins are elevated in HIV-exposed seronegative men who have sex with men
    Adam Burgener
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    AIDS 26:1857-67. 2012
    ..We performed proteomic analysis of saliva from a cohort of HESN MSM who have regular unprotected oral receptive intercourse with their HIV-infected partner...
  3. doi Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers
    A Burgener
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    J Proteome Res 10:5139-49. 2011
    ..This comprehensive systems biology approach identifies mucosal serpins and cystatins as novel correlates of HIV-1-resistance. This represents the first study characterizing these factors in the female genital tract...
  4. doi Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers
    Adam Burgener
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    J Proteome Res 7:4446-54. 2008
    ..Validation of these results on a larger sample of individuals will provide further evidence these biomarkers are associated with HIV-1 resistance and could help aid in the development of effective microbicides against HIV-1...
  5. doi Mucosal serpin A1 and A3 levels in HIV highly exposed sero-negative women are affected by the menstrual cycle and hormonal contraceptives but are independent of epidemiological confounders
    Syeda Rahman
    Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    Am J Reprod Immunol 69:64-72. 2013
    ..Here, we characterized mucosal serpin expression in the genital tract of HIV highly exposed sero-negative (HESN) women meeting our epidemiological definition of HIV resistance in relation to epidemiological variables...
  6. pmc Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility
    Kenzie Birse
    National Lab for HIV Immunology, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 89:8793-805. 2015
    ....
  7. pmc Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers
    Kenzie D M Birse
    Proteomics Unit, National Laboratory for HIV Immunology, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 10:e0130404. 2015
    ..We here aimed to define additional antiviral factors that are over-expressed in CVS from female sex workers at high risk of infection...
  8. pmc Unbiased proteomics analysis demonstrates significant variability in mucosal immune factor expression depending on the site and method of collection
    Kenzie M Birse
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Proteomics Group, National Lab for HIV Immunology, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 8:e79505. 2013
    ....
  9. doi Proteomics as a novel HIV immune monitoring tool
    Derek R Stein
    University of Manitoba, Department of Medical Microbiology bImmunology, Winnipeg, Manitoba, Canada
    Curr Opin HIV AIDS 8:140-6. 2013
    ....
  10. pmc Microbial translocation and microbiome dysbiosis in HIV-associated immune activation
    Alexander S Zevin
    aDepartment of Pharmaceutics, University of Washington bWashington National Primate Research Center, Seattle, Washington, USA cCentre for the AIDS Programme of Research CAPRISA, Durban, South Africa dDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba eNational Laboratory for HIV Immunology, JC Wilt Infectious Disease Research Center, Public Health Agency of Canada, Winnipeg, Manitoba, Canada fDepartment of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska, Sweden
    Curr Opin HIV AIDS 11:182-90. 2016
    ..This article describes the mechanisms and consequences of both microbial translocation and microbial dysbiosis in HIV infection...
  11. pmc Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression
    Laura Romas
    1 National HIV and Retrovirology Laboratory, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, Canada
    AIDS Res Hum Retroviruses 32:1005-1015. 2016
    ..Further assessment of more extended use of TFV-gel is recommended to validate these initial associations...
  12. doi The role of serpin and cystatin antiproteases in mucosal innate immunity and their defense against HIV
    Lindsay Aboud
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Reprod Immunol 71:12-23. 2014
    ..Their potential as therapeutic interventions to combat HIV is also discussed...
  13. doi Profiling cervical lavage fluid by SELDI-TOF mass spectrometry
    Adam Burgener
    National Laboratory for HIV Immunology, Public Health Agency of Canada, Winnipeg, MB, Canada
    Methods Mol Biol 818:143-52. 2012
    ..This chapter will outline detailed methods to profile cervical mucosal samples by SELDI-TOF and can serve as a guideline for other types of mucosal samples...
  14. doi Systems biology-based approaches to understand HIV-exposed uninfected women
    Adam Burgener
    National Laboratory for HIV Immunology, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba, Canada
    Curr HIV/AIDS Rep 7:53-9. 2010
    ..Herein we report developments in discovery-based systems biology approaches in EU women and how this broadens our understanding of natural protection against HIV-1...