Genomes and Genes
C Thomas G Appleton
Affiliation: University of Western Ontario
- Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritisC Thomas G Appleton
CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
Arthritis Res Ther 9:R13. 2007..The time course of OA progression can be modulated through the use of forced mobilization...
- Molecular and histological analysis of a new rat model of experimental knee osteoarthritisC Thomas G Appleton
CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario, London, Ontario, Canada
Ann N Y Acad Sci 1117:165-74. 2007..Identified candidate genes including genes involved in chemokine, endothelin, and transforming growth factor-alpha signaling are discussed in the context of articular cartilage degeneration in early OA...
- Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritisC Thomas G Appleton
University of Western Ontario, London, Ontario, Canada
Arthritis Rheum 56:3693-705. 2007..To define the roles of transforming growth factor alpha (TGFalpha) in cartilage degradation...
- Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradationC Thomas G Appleton
CIHR Group in Skeletal Development and Remodeling, London, ON, Canada
Lab Invest 90:20-30. 2010..These data suggest that TGFalpha is a strong stimulator of cartilage degradation and that Rho/ROCK and MEK/ERK signaling have critical roles in mediating these effects...
- Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiationC Thomas G Appleton
CIHR Group in Skeletal Development and Remodeling, Ontario, London, Ontario, Canada
J Cell Physiol 207:735-45. 2006..The identification of Rgs genes as novel regulators of chondrogenesis will contribute to a better understanding of both normal cartilage development and the etiology of chondrodysplasias and osteoarthritis...
- Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritisShirine E Usmani
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
J Orthop Res 30:1391-7. 2012..Thus, TGFα may be a therapeutic target upstream of ET(A)R in OA...
- Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritisC Thomas G Appleton
Western University Schulich School of Medicine and Dentistry, London, Ontario, Canada
Arthritis Rheumatol 67:2691-701. 2015..This study was undertaken to test whether TGFα and CCL2 cooperate to promote cartilage degradation and whether inhibiting either reduces disease progression in a rat model of posttraumatic OA...
- Vascular smooth muscle cells as a valvular interstitial cell surrogate in heart valve tissue engineeringAndrew J E Appleton
Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
Tissue Eng Part A 15:3889-97. 2009....
- Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophyClaudine G James
CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario N6A 5C1, Canada
Mol Biol Cell 16:5316-33. 2005..Collectively, these analyses provide novel information on the temporal expression of molecules regulating endochondral bone development...