N Alfaidy

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy
    Pascale Hoffmann
    Institut National de la Santé et de la Recherche Médicale EMI 01 05, Département réponse et dynamique cellulaires Laboratoire d Angiogenèse, Commissariat a l Energie Atomique Grenoble, France
    Endocrinology 147:1675-84. 2006
  2. ncbi Late gestation increase in 11beta-hydroxysteroid dehydrogenase 1 expression in human fetal membranes: a novel intrauterine source of cortisol
    Nadia Alfaidy
    Canadian Institutes for Health Research CIHR, Institute of Human Development, Child and Youth Health, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 88:5033-8. 2003
  3. ncbi Prostaglandin F2alpha potentiates cortisol production by stimulating 11beta-hydroxysteroid dehydrogenase 1: a novel feedback loop that may contribute to human labor
    N Alfaidy
    CIHR Group in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 86:5585-92. 2001
  4. ncbi Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications
    N Alfaidy
    Department of Physiology, Canadian Institutes for Health Research Group in Development and Fetal Health, University of Toronto Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 87:4797-805. 2002
  5. ncbi Glucocorticoid regulation of human and ovine parturition: the relationship between fetal hypothalamic-pituitary-adrenal axis activation and intrauterine prostaglandin production
    W L Whittle
    MRC Group in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario, Canada M5A 1A8
    Biol Reprod 64:1019-32. 2001
  6. ncbi Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus
    S Gupta
    CIHR Institute of Human Development, Child and Youth Health, Departments of Physiology, and Obstetrics and Gynecology, University of Toronto, Canada M5S 1A8
    J Endocrinol 176:175-84. 2003
  7. ncbi Fetal hypothalamic-pituitary adrenal (HPA) development and activation as a determinant of the timing of birth, and of postnatal disease
    J Challis
    Department of Physiology, University of Toronto, Ontario, Canada
    Endocr Res 26:489-504. 2000
  8. ncbi Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy
    D Giannoulias
    Canadian Institutes of Health Research in Human Development, Department of Physiology, University of Toronto, 1 King s College Circle, Medical Sciences Building Room 3344, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 87:5274-82. 2002
  9. ncbi Understanding preterm labor
    J R Challis
    Department of Physiology, University of Toronto, CIHR Institute of Human Development, Child and Youth Health, Canada
    Ann N Y Acad Sci 943:225-34. 2001
  10. ncbi The fetal placental hypothalamic-pituitary-adrenal (HPA) axis, parturition and post natal health
    J R Challis
    Department of Physiology, University of Toronto, 1 King s College Circle, Med Sciences, Building MSB 3205 7, Toronto, Ontario, Canada M5S 1A8
    Mol Cell Endocrinol 185:135-44. 2001

Collaborators

Detail Information

Publications17

  1. ncbi Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy
    Pascale Hoffmann
    Institut National de la Santé et de la Recherche Médicale EMI 01 05, Département réponse et dynamique cellulaires Laboratoire d Angiogenèse, Commissariat a l Energie Atomique Grenoble, France
    Endocrinology 147:1675-84. 2006
    ..The expression pattern of EG-VEGF, its regulation by oxygen tension, and its complementary localization to that of VEGF suggest that this new factor might also be deregulated in preeclampsia...
  2. ncbi Late gestation increase in 11beta-hydroxysteroid dehydrogenase 1 expression in human fetal membranes: a novel intrauterine source of cortisol
    Nadia Alfaidy
    Canadian Institutes for Health Research CIHR, Institute of Human Development, Child and Youth Health, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 88:5033-8. 2003
    ..This local F production may be involved in different pathways contributing to the regulation of parturition...
  3. ncbi Prostaglandin F2alpha potentiates cortisol production by stimulating 11beta-hydroxysteroid dehydrogenase 1: a novel feedback loop that may contribute to human labor
    N Alfaidy
    CIHR Group in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 86:5585-92. 2001
    ....
  4. ncbi Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications
    N Alfaidy
    Department of Physiology, Canadian Institutes for Health Research Group in Development and Fetal Health, University of Toronto Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 87:4797-805. 2002
    ..3% O(2). No change in 11 beta-HSD1 expression was observed in early pregnancy or in PE. This is the first report to suggest that 11 beta-HSD2 is O(2) dependent in first and third trimester placenta during human gestation...
  5. ncbi Glucocorticoid regulation of human and ovine parturition: the relationship between fetal hypothalamic-pituitary-adrenal axis activation and intrauterine prostaglandin production
    W L Whittle
    MRC Group in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario, Canada M5A 1A8
    Biol Reprod 64:1019-32. 2001
    ....
  6. ncbi Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus
    S Gupta
    CIHR Institute of Human Development, Child and Youth Health, Departments of Physiology, and Obstetrics and Gynecology, University of Toronto, Canada M5S 1A8
    J Endocrinol 176:175-84. 2003
    ..In summary, we found that, in sheep during late gestation, cortisol increased both 11beta-HSD1 and GR in the fetal liver, and these effects were accentuated in the absence of increased E(2)...
  7. ncbi Fetal hypothalamic-pituitary adrenal (HPA) development and activation as a determinant of the timing of birth, and of postnatal disease
    J Challis
    Department of Physiology, University of Toronto, Ontario, Canada
    Endocr Res 26:489-504. 2000
    ..We conclude that the level of fetal HPA activity is crucial not only for determining gestation length, but also predicts pathophysiologic adjustment in later life...
  8. ncbi Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy
    D Giannoulias
    Canadian Institutes of Health Research in Human Development, Department of Physiology, University of Toronto, 1 King s College Circle, Medical Sciences Building Room 3344, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 87:5274-82. 2002
    ..The lack of change in PGES indicates that alterations at other points along the pathway of arachidonic acid metabolism may be of greater importance in affecting local changes in PGE(2)...
  9. ncbi Understanding preterm labor
    J R Challis
    Department of Physiology, University of Toronto, CIHR Institute of Human Development, Child and Youth Health, Canada
    Ann N Y Acad Sci 943:225-34. 2001
    ..These different mechanisms need to be considered in the development of strategies for the detection and management of the patient in preterm labor...
  10. ncbi The fetal placental hypothalamic-pituitary-adrenal (HPA) axis, parturition and post natal health
    J R Challis
    Department of Physiology, University of Toronto, 1 King s College Circle, Med Sciences, Building MSB 3205 7, Toronto, Ontario, Canada M5S 1A8
    Mol Cell Endocrinol 185:135-44. 2001
    ..Thus, the level of fetal HPA activity is crucial not only for determining gestation length, but may also predict pathophysiologic adjustments in later life...
  11. ncbi Prostaglandins and mechanisms of preterm birth
    John R G Challis
    Department of Physiology, CIHR Group in Fetal and Neonatal Health and Development, CIHR Institute of Human Development, Child and Youth Health, University of Toronto, Medical Sciences Building, Suite 3368, Toronto M5S 1A8, Canada
    Reproduction 124:1-17. 2002
    ..In these circumstances, increased concentrations of maternal cortisol may cross into the fetal compartment, contributing to growth restriction and programming later life disease...
  12. ncbi Expression of extracellular matrix metalloproteinase inducer in human placenta and fetal membranes at term labor
    Wei Li
    Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 89:2897-904. 2004
    ....
  13. ncbi Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells
    Marina Premyslova
    Canadian Institute of Health Research, Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 88:6040-7. 2003
    ..However, multiple mechanisms, which apparently are inductor- and cell-type-specific, exist for the regulation of these enzymes...
  14. ncbi Expression of membrane prostaglandin E synthase in human placenta and fetal membranes and effect of labor
    Nadia Alfaidy
    Canadian Institutes of Health Research in Human Development, Child and Youth Health, Department of Physiology, University of Toronto, Toronto, Canada
    Endocrine 20:219-25. 2003
    ..The differences in expression found among placenta, chorion, and amnion before and after labor would indicate that this enzyme is differentially regulated in these tissues at this time...
  15. ncbi Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in human placenta and fetal membranes in relation to preterm and term labor
    Ping Xu
    CIHR Group in Fetal and Neonatal Health and Development and Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 87:1353-61. 2002
    ..An increase in MMP-9 expression may contribute to degradation of the ECM in the FM and PL, thereby facilitating FM rupture and PL detachment from the maternal uterus at labor, both preterm and term...
  16. ncbi Effects of dexamethasone and sulfasalazine on prostaglandin E2 output by human placental cells in vitro
    Nasser Mirazi
    Canadian Institutes for Health Research, Group in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario, Canada
    J Soc Gynecol Investig 11:22-6. 2004
    ....
  17. ncbi Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway
    Jason C Choi
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 178:1598-607. 2007
    ..We propose that phosphatase-mediated suppression of IFN-gamma signaling in TBCs contributes to fetal maintenance by inhibiting expression of genes that could be detrimental to successful pregnancy...