Philip N Ainslie

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Breathing and sleep at high altitude
    Philip N Ainslie
    Centre of Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, British Columbia, Canada Electronic address
    Respir Physiol Neurobiol 188:233-56. 2013
  2. doi request reprint Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans
    P N Ainslie
    Dept of Human Kinetics, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada
    J Appl Physiol (1985) 113:1058-67. 2012
  3. pmc The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study
    Judith Bellapart
    Department of Intensive Care, Royal Brisbane and Women s Hospital, Butterfield Street, Herston 4029, QLD, Australia
    BMC Anesthesiol 11:4. 2011
  4. doi request reprint Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance
    Philip N Ainslie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
    Exp Physiol 95:251-62. 2010
  5. pmc Cerebral pressure-flow relationship in lowlanders and natives at high altitude
    Jonathan D Smirl
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Science, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 34:248-57. 2014
  6. doi request reprint Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, Development, University of British Columbia, Kelowna, British Columbia, Canada
    Am J Physiol Regul Integr Comp Physiol 304:R147-54. 2013
  7. doi request reprint Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow
    Anthony R Bain
    Center for Heart, Lung, and Vascular Health, University of British Columbia, Okanagan, British Columbia, Canada
    J Appl Physiol (1985) 115:653-9. 2013
  8. pmc Cerebral oxidative metabolism is decreased with extreme apnoea in humans; impact of hypercapnia
    Anthony R Bain
    Centre for Heart Lung and Vascular Health, University of British Columbia, Kelowna, BC, Canada
    J Physiol 594:5317-28. 2016
  9. pmc Role of cerebral blood flow in extreme breath holding
    Anthony R Bain
    Centre for Heart Lung and Vascular Health, University of British Columbia, Kelowna, BC, Canada
    Transl Neurosci 7:12-16. 2016
  10. doi request reprint Beta 1-blockade increases maximal apnea duration in elite breath hold divers
    Ryan L Hoiland
    University of British Columbia, Okanagan Campus
    J Appl Physiol (1985) . 2016

Collaborators

Detail Information

Publications52

  1. doi request reprint Breathing and sleep at high altitude
    Philip N Ainslie
    Centre of Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, British Columbia, Canada Electronic address
    Respir Physiol Neurobiol 188:233-56. 2013
    ..Finally, we suggest avenues for future research, and discuss implications for understanding sleep pathology...
  2. doi request reprint Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans
    P N Ainslie
    Dept of Human Kinetics, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada
    J Appl Physiol (1985) 113:1058-67. 2012
    ..These findings have implications for our understanding of CBF function in the context of pathologies associated with sympathoexcitation and hypoxemia...
  3. pmc The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study
    Judith Bellapart
    Department of Intensive Care, Royal Brisbane and Women s Hospital, Butterfield Street, Herston 4029, QLD, Australia
    BMC Anesthesiol 11:4. 2011
    ..This study sought to determine the impact of ventricular assist devices on the dynamic relationship between arterial blood pressure and cerebral blood flow velocity...
  4. doi request reprint Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance
    Philip N Ainslie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
    Exp Physiol 95:251-62. 2010
    ..The associated implications of these hypoxia-induced integrative alterations for the regulation of CBF are discussed, and future avenues for research are proposed...
  5. pmc Cerebral pressure-flow relationship in lowlanders and natives at high altitude
    Jonathan D Smirl
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Science, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 34:248-57. 2014
    ..Our findings indicate that spontaneous changes in TFA metrics do not necessarily reflect physiologically important alterations in the capacity of the brain to regulate BP. ..
  6. doi request reprint Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, Development, University of British Columbia, Kelowna, British Columbia, Canada
    Am J Physiol Regul Integr Comp Physiol 304:R147-54. 2013
    ..Although the development of IOH is not influenced by the α(1)-adrenergic receptor pathway, this pathway is critical in the recovery from IOH to prevent cerebral hypoperfusion and ultimately syncope...
  7. doi request reprint Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow
    Anthony R Bain
    Center for Heart, Lung, and Vascular Health, University of British Columbia, Okanagan, British Columbia, Canada
    J Appl Physiol (1985) 115:653-9. 2013
    ....
  8. pmc Cerebral oxidative metabolism is decreased with extreme apnoea in humans; impact of hypercapnia
    Anthony R Bain
    Centre for Heart Lung and Vascular Health, University of British Columbia, Kelowna, BC, Canada
    J Physiol 594:5317-28. 2016
    ..A hypercapnia-induced oxygen-conserving response may protect the brain against severe oxygen deprivation associated with prolonged apnoea...
  9. pmc Role of cerebral blood flow in extreme breath holding
    Anthony R Bain
    Centre for Heart Lung and Vascular Health, University of British Columbia, Kelowna, BC, Canada
    Transl Neurosci 7:12-16. 2016
    ..01). These findings indicate that the impact of CBF on maximal BH time is likely attributable to its influence on cerebral H+ washout, and therefore central chemoreceptive drive to breathe, rather than to CDO2...
  10. doi request reprint Beta 1-blockade increases maximal apnea duration in elite breath hold divers
    Ryan L Hoiland
    University of British Columbia, Okanagan Campus
    J Appl Physiol (1985) . 2016
    ....
  11. pmc Peripheral chemoreflex inhibition with low-dose dopamine: new insight into mechanisms of extreme apnea
    Anthony R Bain
    Center for Heart Lung and Vascular Health, University of British Columbia, Kelowna, British Columbia, Canada
    Am J Physiol Regul Integr Comp Physiol 309:R1162-71. 2015
    ..At least in elite apnea divers, the small increase in apnea time and similar PaO2 at breakpoint (∼31 mmHg) suggest the apnea breakpoint is more related to PaO2 , rather than peripheral chemoreflex drive to breathe. ..
  12. pmc Hypoxia, not pulmonary vascular pressure, induces blood flow through intrapulmonary arteriovenous anastomoses
    Joshua C Tremblay
    Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia, Kelowna, BC, Canada
    J Physiol 593:723-37. 2015
    ....
  13. pmc The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 35:873-81. 2015
    ..4) At SL hypoxia increased CBF, and restoration of oxygen at HA reduced CBF, but neither had any effect on cerebral metabolism. Acclimatization resets the cerebrovasculature to chronic hypocapnia...
  14. doi request reprint Elevated aerobic fitness sustained throughout the adult lifespan is associated with improved cerebral hemodynamics
    Damian M Bailey
    From the Neurovascular Research Laboratory, University of South Wales, UK D M B, C J M, J V B, D H, K J N the Department of Biomedical Engineering, Toyo University, Kawagoe shi, Saitama, Japan S O and the School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada P N A
    Stroke 44:3235-8. 2013
    ..The present study examined to what extent cerebral hemodynamics are improved when training is sustained throughout the adult lifespan...
  15. doi request reprint Dynamic cerebral autoregulation during and following acute hypoxia: role of carbon dioxide
    Jordan S Querido
    Faculty of Medicine, University of British Columbia Vancouver, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 114:1183-90. 2013
    ..05). Our results demonstrate that dCA impairment in isocapnic hypoxia can be prevented with hypocapnia, and highlight the integrated nature of hypoxic cerebrovascular control, which is under strong CO2 influence...
  16. doi request reprint The effect of α1 -adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea level and high altitude
    Michael M Tymko
    Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia, Kelowna, Canada
    J Physiol . 2016
    ..The current study helps to elucidate the physiological mechanisms associated with high-altitude acclimatization, and provides insight into the relationship between sympathetic nervous activity and vascular endothelial function...
  17. doi request reprint Hypercapnia is essential to reduce the cerebral oxidative metabolism during extreme apnea in humans
    Anthony R Bain
    1 Centre for Heart Lung and Vascular Health, University of British Columbia, Kelowna, BC, Canada
    J Cereb Blood Flow Metab . 2017
    ..05). These novel data support hypercapnia/pH as a key mechanism mediating reductions in CMRO2 during apnea, and show that severe hypoxemia stimulates lactate release from the brain...
  18. pmc Indomethacin-induced impairment of regional cerebrovascular reactivity: implications for respiratory control
    Ryan L Hoiland
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada
    J Physiol 593:1291-306. 2015
    ..No relationships were apparent with anterior CVR. As higher posterior, but not anterior, CVR was linked to HVD, our study highlights the importance of measuring flow in posterior vessels to investigate CBF and ventilatory integration...
  19. pmc Impact of hypocapnia and cerebral perfusion on orthostatic tolerance
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, University of British Columbia, Okanagan, Canada
    J Physiol 592:5203-19. 2014
    ..In summary, cerebral hypoperfusion either at rest or induced by hypocapnia at pre-syncope does not impact OT, probably due to a compensatory increase in oxygen extraction. ..
  20. pmc Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride
    Aaron A Phillips
    1 Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, British Columbia, Canada 2 Experimental Medicine Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 3 Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna, British Columbia, Canada 4 International Collaboration on Repair Discoveries ICORD, Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, and GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, British Columbia, Canada
    J Cereb Blood Flow Metab 34:794-801. 2014
    ..05). Improvements in BP were related to improved cognitive function in those with SCI (r(2)=0.52; P<0.05). Impaired NVC, secondary to low BP, may partially mediate reduced cognitive function in individuals with high-level SCI...
  21. doi request reprint Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia
    Philip N Ainslie
    School of Health and Exercise Sciences, University of British Columbia, British Columbia, Canada
    Clin Sci (Lond) 126:661-70. 2014
    ..As such, cerebral metabolism is still supported almost exclusively by carbohydrate oxidation during severe levels of hypoxaemia. ..
  22. pmc Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas
    Glen E Foster
    School of Health and Exercise Science, Faculty of Health and Social Development, University of British Columbia Okanagan, 3333 University Way, Kelowna, BC, V1V 1V7 Canada
    J Physiol 592:1397-409. 2014
    ..Despite elevated pulmonary pressures and profound hypoxaemia, IPAVA blood flow in all subjects at HA was lower than expected compared to acute normobaric hypoxia...
  23. doi request reprint Adenosine receptor dependent signaling is not obligatory for normobaric and hypobaric hypoxia-induced cerebral vasodilation in humans
    Ryan L Hoiland
    University of British Columbia, Okanagan Campus
    J Appl Physiol (1985) . 2017
    ..05). We conclude that adenosine receptor dependent signaling is not obligatory for cerebral hypoxic vasodilation in humans...
  24. pmc Changes in cerebral vascular reactivity and structure following prolonged exposure to high altitude in humans
    Glen E Foster
    Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia, Kelowna, Canada School of Kinesiology, University of British Columbia, Vancouver, Canada
    Physiol Rep 3:. 2015
    ..These changes were the result of improvement and/or reversal of negative CVR to positive CVR in these regions. Three weeks of high-altitude exposure is reflected in loss of gray matter volume and improvements in negative CVR. ..
  25. pmc Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: a role for prostaglandins?
    Ryan L Hoiland
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, Kelowna, BC, Canada
    J Physiol 594:3463-81. 2016
    ....
  26. doi request reprint Impact of transient hypotension on regional cerebral blood flow in humans
    Nia C S Lewis
    Centre of Heart, Lung and Vascular Health, University of British Columbia, Kelowna, Canada
    Clin Sci (Lond) 129:169-78. 2015
    ..Additionally, our findings suggest TCD measures of blood flow velocity may modestly underestimate changes in CBF during hypotension with and without hypocapnia, particularly in the posterior circulation...
  27. pmc Relationship between blood pressure and cerebral blood flow during supine cycling: influence of aging
    Jonathan D Smirl
    Centre for Heart, Lung and Vascular Health School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, Canada
    J Appl Physiol (1985) 120:552-63. 2016
    ..It is speculated that these age-related changes in the TFA metrics are mediated by alterations in vasoactive factors, sympathetic tone, or the mechanical buffering of the compliance vessels. ..
  28. doi request reprint Relationship between cerebral blood flow and blood pressure in long-term heart transplant recipients
    Jonathan D Smirl
    From the Department of Health and Social Development, Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, British Columbia, Canada J D S, K R M, P N A Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta and Mazankowki Alberta Heart Institute, Edmonton, Canada M J H Cedars Sinai Heart Institute, Los Angeles, CA M D N Department of Surgery and Anaesthesia, Cardiovascular Systems Laboratory, Centre for Translational Physiology, University of Otago, Wellington, New Zealand Y C T and Department of Sport and Exercise Science, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK H J
    Hypertension 64:1314-20. 2014
    ..Thus, in contrast to our hypothesis, the increased risk of cerebrovascular complication after heart transplantation does not seem to be related to alterations in cerebral pressure-flow dynamics. Future research is, therefore, warranted. ..
  29. doi request reprint Maintained cerebrovascular function during post-exercise hypotension
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, 3333 University Way, Okanagan, Kelowna, BC, Canada
    Eur J Appl Physiol 113:1597-604. 2013
    ..05). These data indicate that cerebrovascular regulation remains intact following a moderate bout of aerobic exercise...
  30. doi request reprint Cerebrovascular reactivity and dynamic autoregulation in tetraplegia
    Luke C Wilson
    Department of Physiology, University of British Columbia Okanagan, Kelowna, BC V1X, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R1035-42. 2010
    ..Changes are evident in coherence at baseline and MCAv PI during baseline and hypercapnic states in chronic Tetra, which may be indicative of cerebrovascular adaptation...
  31. ncbi request reprint Influence of posture on the regulation of cerebral perfusion
    Jinelle C Geinas
    School of Health and Exercises Sciences, Faculty of Health and Social Development, University of British Columbia, Okanagan Campus, BC, Canada
    Aviat Space Environ Med 83:751-7. 2012
    ..Posture has a major influence on cerebral blood flow (CBF). Unlike head-up tilt (HUT), less is known about how CBF is regulated during head-down tilt (HDT). We hypothesized that CBF would be elevated during HDT and decreased during HUT...
  32. ncbi request reprint Evidence for Shear Stress-Mediated Dilation of the Internal Carotid Artery in Humans
    Howard H Carter
    From the School of Sport Science, Exercise and Health, University of Western Australia, Perth, Australia H H C, C L A, I H A H, A H, E R, K J S, R L H, D J G Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark H H C Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, Canada K J S, P N A, R L H and Research Institute for Sport and Exercise Science, Liverpool John Moores University, United Kingdom H H C, C L A, D J G
    Hypertension 68:1217-1224. 2016
    ....
  33. pmc Hypoxemia, oxygen content, and the regulation of cerebral blood flow
    Ryan L Hoiland
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan Campus, Kelowna, British Columbia, Canada and
    Am J Physiol Regul Integr Comp Physiol 310:R398-413. 2016
    ..Clinical implications (e.g., disorders associated with anemia and polycythemia) and future study directions are considered. ..
  34. doi request reprint Cerebral Blood Flow Responses to Autonomic Dysreflexia in Humans with Spinal Cord Injury
    Aaron A Phillips
    1 Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurotrauma 33:315-8. 2016
    ..74 ± 4 cm · sec(-1)) and end-tidal partial pressure of carbon dioxide (PETCO2) (35 ± 1 vs. 34 ± 3 mm Hg) were maintained. These preliminary data indicate that the brain may effectively buffer moderate episodes of AD...
  35. doi request reprint End tidal-to-arterial CO2 and O2 gas gradients at low- and high-altitude during dynamic end-tidal forcing
    Michael M Tymko
    Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia, Kelowna, Canada and
    Am J Physiol Regul Integr Comp Physiol 308:R895-906. 2015
    ..Future research is needed to validate these prediction algorithms and determine the implications of end-tidal-to-arterial gradients in the assessment of ventilatory and/or vascular reactivity...
  36. pmc Regulation of brain blood flow and oxygen delivery in elite breath-hold divers
    Christopher K Willie
    Centre for Heart, Lung, and Vascular Health, School of Health and Exercise, Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 35:66-73. 2015
    ..Termination of apnea was not determined by reduced cerebral oxygen delivery; despite 40% to 50% reductions in arterial oxygen content, oxygen delivery was maintained by commensurately increased CBF...
  37. doi request reprint Increased central arterial stiffness explains baroreflex dysfunction in spinal cord injury
    Aaron A Phillips
    1 Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, Canada
    J Neurotrauma 31:1122-8. 2014
    ..55; p<0.05), but not in able-bodied persons. Normalizing BP did not improve BRS or CCA stiffness. This study clearly shows that reduced BRS is closely related to increased arterial stiffness in the population with SCI...
  38. doi request reprint Regulation of cerebral blood flow after spinal cord injury
    Aaron A Phillips
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, Canada
    J Neurotrauma 30:1551-63. 2013
    ....
  39. pmc Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, University of British Columbia, Okanagan Campus, School of Health and Exercise Sciences 111 Health Science Centre 1088 Discovery Avenue, Kelowna, British Columbia, Canada
    J Physiol 592:1009-24. 2014
    ..Although a lifetime of high-altitude exposure neither intensifies nor attenuates the impairments seen with short-term exposure, chronic high-altitude exposure appears to be associated with arterial remodelling...
  40. pmc Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine
    Aaron A Phillips
    Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 116:645-53. 2014
    ..4 ± 2% decline; P < 0.05), and a 59% improvement in orthostatic tolerance (P < 0.01). The vertebrobasilar region may be particularly susceptible to hypoperfusion in SCI, leading to increased orthostatic intolerance...
  41. doi request reprint The effect of time-of-day and sympathetic α1-blockade on orthostatic tolerance
    Nina C S Lewis
    School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada
    Chronobiol Int 29:882-90. 2012
    ..04). These findings highlight an important role of α(1)-sympathetic vasoconstrictor activity in acutely regulating blood pressure and offsetting syncope, especially in the early morning...
  42. doi request reprint Lessons from the laboratory; integrated regulation of cerebral blood flow during hypoxia
    Philip N Ainslie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan Campus, Kelowna, British Columbia, Canada
    Exp Physiol . 2016
    ..The molecular mechanisms of CBF regulation in hypoxia are also briefly discussed and future directions proposed. This article is protected by copyright. All rights reserved...
  43. pmc Neurovascular coupling in humans: Physiology, methodological advances and clinical implications
    Aaron A Phillips
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada International Collaboration on Repair Discoveries ICORD, UBC, Vancouver, Canada Experimental Medicine Program, Faculty of Medicine, UBC, Vancouver, Canada
    J Cereb Blood Flow Metab 36:647-64. 2016
    ....
  44. pmc Methodological comparison of active- and passive-driven oscillations in blood pressure; implications for the assessment of cerebral pressure-flow relationships
    Jonathan D Smirl
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, British Columbia, Canada and
    J Appl Physiol (1985) 119:487-501. 2015
    ..8%) at 0.05 and 0.10 Hz, respectively, were considered biologically acceptable for reproducibility. These findings have important implications for the reliable assessment and interpretation of cerebral pressure-flow dynamics in humans. ..
  45. pmc Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, University of British Columbia, Kelowna, British Columbia, Canada
    J Appl Physiol (1985) 116:1189-96. 2014
    ....
  46. pmc Integrative regulation of human brain blood flow
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada V1V 1V7
    J Physiol 592:841-59. 2014
    ..Finally, we summarize the state of our knowledge with respect to these areas, outline important gaps in the literature and suggest avenues for future research. ..
  47. doi request reprint Oscillatory shear stress, flow-mediated dilatation, and circulating microparticles at sea level and high altitude
    Joshua C Tremblay
    Centre for Heart, Lung, and Vascular Health School of Health and Exercise Science, University of British Columbia, Kelowna, Canada Electronic address
    Atherosclerosis . 2016
    ..We examined the effects of acute manipulation of oscillatory shear stress on endothelial function and circulating MPs at sea level (SL) and high altitude (HA)...
  48. doi request reprint Cerebral Vascular Control and Metabolism in Heat Stress
    Anthony R Bain
    Centre for Heart Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, Kelowna, Canada
    Compr Physiol 5:1345-80. 2015
    ....
  49. pmc Influence of age on syncope following prolonged exercise: differential responses but similar orthostatic intolerance
    Carissa Murrell
    Department of Human Kinetics, University of British Columbia Okanagan, Kelowna, Canada
    J Physiol 587:5959-69. 2009
    ..The similar MCAv at pre-syncope indicates there is an age-independent critical cerebral blood flow threshold at which syncope occurs...
  50. doi request reprint Influence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2 and breathing stability: the influence of PCO2 gradients
    Jui Lin Fan
    Department of Physiology, Otago School of Medical Science, University of Otago, Dunedin, New Zealand
    Am J Physiol Regul Integr Comp Physiol 298:R1648-58. 2010
    ....
  51. doi request reprint Influence of changes in blood pressure on cerebral perfusion and oxygenation
    Samuel J E Lucas
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Hypertension 55:698-705. 2010
    ..Thus, a finite slope of the plateau region does not necessarily imply a defective CA. Moreover, with progressive hypotension and hypertension there are differential changes in cerebral oxygenation and MCAv(mean)...