Affiliation: University of Alberta
- Neuroactive steroids and fatigue severity in patients with primary biliary cirrhosis and hepatitis CS Ahboucha
Neuroscience Research Unit, Universite de Montreal, Montreal, QC, Canada
Neurogastroenterol Motil 20:671-9. 2008..The present preliminary findings suggest that increased inhibition through GABA-A receptors due to the accumulation of neuroinhibitory steroids may represent an important pathophysiological mechanism of fatigue in chronic liver diseases...
- Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosisS Ahboucha
Neuroscience Research Unit, Universite de Montreal, CHUM Hôpital Saint Luc, Montreal, QC, Canada
Neurogastroenterol Motil 20:949-57. 2008..Pharmacological approaches using agents that either reduce neurosteroid synthesis or modulate the neurosteroid site on GABA-A receptor could offer new therapeutic tools for the management and treatment of HE...
- Dehydroepiandrosterone sulphate improves cholestasis-associated fatigue in bile duct ligated ratsR F Butterworth
Neuroscience Research Unit, Hopital Saint Luc, CHUM, Montreal, QC, Canada
Neurogastroenterol Motil 21:1319-25. 2009..Substitutive therapies with DHEAS or DHEA could represent novel approaches in the management of fatigue due to cholestasis-induced liver failure...