Jacques Turgeon

Summary

Country: Canada

Publications

  1. ncbi The pharmacokinetics of ezetimibe
    Chantale Simard
    Universite de Montreal, Quebec
    Can J Clin Pharmacol 10:13A-20A. 2003
  2. doi Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal Heart Institute, Montreal, QC, Canada
    Ann Pharmacother 42:925-32. 2008
  3. ncbi Assessment of competitive and mechanism-based inhibition by clarithromycin: use of domperidone as a CYP3A probe-drug substrate and various enzymatic sources including a new cell-based assay with freshly isolated human hepatocytes
    Veronique Michaud
    CRCHUM, Centre Hospitalier de l Université de Montréal and Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Drug Metab Lett 4:69-76. 2010
  4. pmc Understanding clopidogrel efficacy in the presence of cytochrome P450 polymorphism
    Jacques Turgeon
    Faculte de Pharmacie, Universite de Montreal, Montreal, Que
    CMAJ 174:1729. 2006
  5. doi Lengthening of cardiac repolarization in isolated guinea pigs hearts by sequential or concomitant administration of two IKr blockers
    Raymond Hreiche
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Pharm Sci 100:2469-81. 2011
  6. doi Gender-related differences in drug-induced prolongation of cardiac repolarization in prepubertal guinea pigs
    Raymond Hreiche
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol Ther 14:28-37. 2009
  7. doi Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, Research Center, Department of Pharmacy, Hopital du Sacre Coeur de Montreal, 5400, Boulevard Gouin Ouest Montréal, Quebec, Canada H4J 1C5
    Int J Cardiol 143:43-50. 2010
  8. doi PRKCB is associated with calcineurin inhibitor-induced renal dysfunction in heart transplant recipients
    Kim Lachance
    University of Montreal, Quebec, Canada
    Pharmacogenet Genomics 22:336-43. 2012
  9. doi Week-long high-maintenance dose clopidogrel regimen achieves better platelet aggregation inhibition than a standard loading dose before percutaneous coronary intervention: results of a double-blind, randomized clinical trial
    Thuy Anh Nguyen
    Faculties of Pharmacy, Universite de Montreal, Montreal, Canada
    J Interv Cardiol 22:368-77. 2009
  10. doi Genetic determinants of response to aspirin: appraisal of 4 candidate genes
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada
    Thromb Res 128:47-53. 2011

Collaborators

Detail Information

Publications39

  1. ncbi The pharmacokinetics of ezetimibe
    Chantale Simard
    Universite de Montreal, Quebec
    Can J Clin Pharmacol 10:13A-20A. 2003
    ..5- to 2-fold. So far, no drug interaction study has been associated with major changes in either the pharmokinetics of ezetimibe or coadministered drugs...
  2. doi Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal Heart Institute, Montreal, QC, Canada
    Ann Pharmacother 42:925-32. 2008
    ..It is currently impossible to determine which patient will benefit from the addition of an ARB...
  3. ncbi Assessment of competitive and mechanism-based inhibition by clarithromycin: use of domperidone as a CYP3A probe-drug substrate and various enzymatic sources including a new cell-based assay with freshly isolated human hepatocytes
    Veronique Michaud
    CRCHUM, Centre Hospitalier de l Université de Montréal and Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Drug Metab Lett 4:69-76. 2010
    ..Drug interactions between clarithromycin and several CYP3A substrates are predicted to be insidious; the risk of severe adverse events should increase over time and persist for a few days after cessation of the drug...
  4. pmc Understanding clopidogrel efficacy in the presence of cytochrome P450 polymorphism
    Jacques Turgeon
    Faculte de Pharmacie, Universite de Montreal, Montreal, Que
    CMAJ 174:1729. 2006
  5. doi Lengthening of cardiac repolarization in isolated guinea pigs hearts by sequential or concomitant administration of two IKr blockers
    Raymond Hreiche
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Pharm Sci 100:2469-81. 2011
    ..Furthermore, order of administration of two I(Kr) blockers together may be an important factor in drug-induced long QT syndrome...
  6. doi Gender-related differences in drug-induced prolongation of cardiac repolarization in prepubertal guinea pigs
    Raymond Hreiche
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol Ther 14:28-37. 2009
    ....
  7. doi Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, Research Center, Department of Pharmacy, Hopital du Sacre Coeur de Montreal, 5400, Boulevard Gouin Ouest Montréal, Quebec, Canada H4J 1C5
    Int J Cardiol 143:43-50. 2010
    ..Additionally, we sought to investigate whether individual pre-selected demographic, hematological or biochemical parameters further increased the risk of inadequate platelet response to aspirin...
  8. doi PRKCB is associated with calcineurin inhibitor-induced renal dysfunction in heart transplant recipients
    Kim Lachance
    University of Montreal, Quebec, Canada
    Pharmacogenet Genomics 22:336-43. 2012
    ..The secondary objective was to investigate the effect of candidate genes related to the RAAS, natriuretic peptides, and other elements involved in the intracellular signaling of these pathways...
  9. doi Week-long high-maintenance dose clopidogrel regimen achieves better platelet aggregation inhibition than a standard loading dose before percutaneous coronary intervention: results of a double-blind, randomized clinical trial
    Thuy Anh Nguyen
    Faculties of Pharmacy, Universite de Montreal, Montreal, Canada
    J Interv Cardiol 22:368-77. 2009
    ..This study evaluated the effect on platelet aggregation of four different dosing regimens of clopidogrel given before elective PCI in a randomized, prospective, double-blind, and placebo-controlled design...
  10. doi Genetic determinants of response to aspirin: appraisal of 4 candidate genes
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada
    Thromb Res 128:47-53. 2011
    ....
  11. doi Association between renal function and CYP3A5 genotype in heart transplant recipients treated with calcineurin inhibitors
    Simon de Denus
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Heart Lung Transplant 30:326-31. 2011
    ..The aim of this study was to evaluate the association between polymorphisms of the genes encoding these proteins and the long-term renal function of heart transplant recipients treated with calcineurin inhibitors...
  12. doi Prevalence and risk of potential cytochrome P450-mediated drug-drug interactions in older hospitalized patients with polypharmacy
    Julie Doan
    Sir Mortimer B Davis Jewish General Hospital, Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Ann Pharmacother 47:324-32. 2013
    ..As rates of polypharmacy rise and medication regimens become more complex, the risk of potential cytochrome P450 (CYP)-mediated drug-drug interactions (DDIs) is a growing clinical concern for older adults...
  13. doi Rosuvastatin blocks hERG current and prolongs cardiac repolarization
    Isabelle Plante
    CRCHUM, Research Center, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada H2W 1T7
    J Pharm Sci 101:868-78. 2012
    ..Genetic polymorphisms observed for BCRP, MDR1, and OATP2B1, and IC(50) determined for hERG blocking lead us to propose that some patients may be at risk of rosuvastatin-induced LQTS...
  14. doi CKM and LILRB5 are associated with serum levels of creatine kinase
    Marie Pierre Dube
    From the Montreal Heart Institute, Montreal, Quebec, Canada M P D, R Z, A B, A M K B, I M, V N, N L, G A, Y F Z, S P, S d D, E R, M S P, J C T Université de Montréal, Montreal, Quebec, Canada M P D, R Z, A B, R D, S d D, J T, E R, M S P, J C T Beaulieu Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada M P D, R Z, A B, I M, A M K B V N, UK
    Circ Cardiovasc Genet 7:880-6. 2014
    ..Creatine kinase (CK) is a commonly used biomarker to assist in the diagnosis of statin-induced myotoxicity but the normal range of CK concentrations is wide, which limits its use as a diagnostic biomarker...
  15. doi The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition
    Veronique Michaud
    McGill University AIDS Centre, Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine Rd, Montreal, Quebec, H3T 1E2, Canada
    Pharmacol Rev 64:803-33. 2012
    ....
  16. doi Combined administration of quinidine and propafenone for atrial fibrillation: the CAQ-PAF study
    Gilles E O'Hara
    Institut Universitaire de Cardiologie et de Pneumologie, Quebec, Quebec, CanadaFaculty of Medicine, Universite Laval, QuébecCRCHUM, Centre Hospitalier de l Université de Montréal and Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, CanadaCentre Hospitalier Région de l Amiante, Thetford Mines, Quebec, Canada
    J Clin Pharmacol 52:171-9. 2012
    ..0001). Thus, chronic inhibition of CYP2D6 is achievable with low-dose quinidine in humans. Increased plasma levels of propafenone may be highly beneficial to prevent recurrence of atrial fibrillation. ..
  17. pmc Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism
    Veronique Michaud
    Research Centre of the University of Montreal Hospital Centre CRCHUM, Centre Hospitalier de l Université de Montréal and Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 5:e15666. 2010
    ..The overall objective of our study was to determine in a large cohort of samples, mRNA levels and CYP450 activity expressed in the human heart...
  18. doi Detection and prevention of drug-drug interactions in the hospitalized elderly: utility of new cytochrome p450-based software
    Hubert Zakrzewski-Jakubiak
    Universite de Montreal, Quebec, Canada
    Am J Geriatr Pharmacother 9:461-70. 2011
    ..Polypharmacy increases the risk of cytochrome P450-based drug-drug interactions (CYP450-DDIs), leading to decreased therapeutic efficacy or increased drug toxicity...
  19. doi An evaluation of pharmacists' expectations towards pharmacogenomics
    Simon de Denus
    Universite de Montreal, Montreal, Canada
    Pharmacogenomics 14:165-75. 2013
    ..However, little is known about the opinions of pharmacists towards pharmacogenomics or their willingness to integrate this new field in their practice...
  20. doi Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors
    Yoanna Skrobik
    Maisonneuve Rosemont Hospital and Université de Montréal, Intensive Care Unit, Montreal, Quebec, Canada
    Crit Care Med 41:999-1008. 2013
    ..Both may be associated with sedative or opiate doses and pharmacokinetic or pharmacogenetic variables, such as drug plasma levels (exposure), drug metabolism, and/or their transport across the blood-brain barrier...
  21. doi Increased risk of myocardial infarction associated with angiotensin-converting enzyme gene polymorphism is age dependent
    Bettina A Hamelin
    Quebec Heart Institute, Quebec, Canada
    J Clin Pharmacol 51:1286-92. 2011
    ..05). Similar observations were obtained versus the healthy elderly men (P < .05). The ACE-I/D polymorphism seems to be a genetic risk factor for MI in young men and becomes an important modulator of MI risk at a young age...
  22. doi Evaluation of Limited Sampling Methods for Oral Busulfan Pharmacokinetic Monitoring in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation
    Philippe Bouchard
    Department of Pharmacy, Hôpital Maisonneuve Rosemont Faculty of Pharmacy, Université de Montréal CRCHUM, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    Ther Drug Monit 38:414-8. 2016
    ..Monitoring busulfan area under the plasma concentration-time curve (AUC) to establish the dose regimen for stem cell transplantation desirable to achieve efficacy while avoiding toxicity...
  23. doi Highly sensitive LC-MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human
    Alexia Grangeon
    Faculty of Pharmacy, University of Montreal, 2940 Chemin de la polytechnique, Montreal, Quebec H3T 1J4, Canada CRCHUM, Centre de recherche du Centre Hospitalier de l Universite de Montreal, 900 Saint Denis Street, Montreal, Quebec H2X 0A9, Canada Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 1040:144-158. 2016
    ..So far, our CYP450 cocktail assays have been successfully applied to phenotype CYP450 activities in patients...
  24. doi Development of a sensitive method for the determination of oxycodone and its major metabolites noroxycodone and oxymorphone in human plasma by liquid chromatography-tandem mass spectrometry
    Fleur Gaudette
    CRCHUM, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 1008:174-80. 2016
    ....
  25. doi Impact of glucose concentration on cardiac ventricular repolarization under I Kr/I Ks blocking agents
    Raymond Hreiche
    Faculte de Pharmacie, Universite de Montreal, Montreal QC, Canada
    J Mol Cell Cardiol 47:210-20. 2009
    ..P-glycoprotein drug extrusion efficacy appears as a key determinant of dofetilide's I(Kr)-blocking effect. This efficacy appears to be affected by glucose concentration, particularly hyperglycemia...
  26. doi Validation of warfarin pharmacogenetic algorithms in clinical practice
    Mélina Marin-Leblanc
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    Pharmacogenomics 13:21-9. 2012
    ..Michaud et al., Wadelius et al. and the International Warfarin Pharmacogenetics Consortium algorithm...
  27. ncbi A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Eur Heart J 28:1702-8. 2007
    ..We sought to compare the results obtained from six major platelet function tests in the assessment of the prevalence of aspirin resistance in patients with stable coronary artery disease...
  28. doi Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy
    Kaitlyn Shaw
    Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia Pharmaceutical Outcomes Programme, British Columbia Children s Hospital Child and Family Research Institute, Vancouver, British Columbia, Canada Institute of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, Switzerland Division of Clinical Pharmacology, Department of Medicine, Western University, London, Ontario, Canada Department of Pharmaceutics, University of Florida, Orlando CRCHUM, Centre Hospitalier de l Université de Montréal and Faculty of Pharmacy, Universite de Montreal, Québec Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver and Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Ther Drug Monit 37:428-36. 2015
    ..reduce adverse effects? (2) Are there subgroups of patients who may benefit more from genetic testing compared with others? (3) How should patients with an indication for warfarin therapy be managed based on their genetic test results?..
  29. doi Effects of β-blockers and tricyclic antidepressants on the activity of human organic anion transporting polypeptide 1A2 (OATP1A2)
    Jennifer Lu
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Quebec, Canada J L, V M, L G G M, F G, Y H L, J T and Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada J L, V M, L G G M, Y H L, J T
    J Pharmacol Exp Ther 352:552-8. 2015
    ..On the other hand, tricyclic compounds with a short aliphatic amine chain inhibited OATP1A2-mediated rosuvastatin transport. Our data suggest that these drugs may modulate the transport of OATP1A2 substrates and may affect drug actions. ..
  30. doi Drug-induced long QT syndrome in women: review of current evidence and remaining gaps
    Raymond Hreiche
    Faculty of Pharmacy, Université de Montréal and Research Center, CHUM, Montreal, Quebec, Canada
    Gend Med 5:124-35. 2008
    ..This major cardiac adverse effect may lead to malignant polymorphic ventricular tachycardias, termed torsades de pointes, which may degenerate into ventricular fibrillation and cause sudden death...
  31. ncbi An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies
    Veronique Michaud
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 852:611-6. 2007
    ..The assay allows estimation of enzymatic parameters (K(m) and V(max)) of domperidone for the formation of its various metabolites and sensitivity is sufficient for the conduct of inhibition studies with potent CYP3A inhibitors...
  32. ncbi Modulatory role of verapamil treatment on the cardiac electrophysiological effects of cisapride
    Pierre Morissette
    Faculty of Pharmacy, Universite de Montreal, C P 6128 Succursale Centre Ville, Montreal, QC H3C 3J7, Canada
    Can J Physiol Pharmacol 84:1285-90. 2006
    ....
  33. doi The impact of a multidisciplinary information technology-supported program on blood pressure control in primary care
    Stephane Rinfret
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Circ Cardiovasc Qual Outcomes 2:170-7. 2009
    ..Effective programs to address this problem are lacking. We hypothesized that an information technology-supported management program could help improve blood pressure (BP) control...
  34. pmc Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure
    Marcin Zakrzewski-Jakubiak
    Universite de Montreal, Montreal, Canada
    Br J Clin Pharmacol 65:742-51. 2008
    ..It is also acknowledged that the genotype frequency of certain gene polymorphisms varies across different ethnic groups and that a difference in gene polymorphism frequencies between healthy and heart failure patients seems to exist...
  35. ncbi Inhibitory effects of propafenone on the pharmacokinetics of caffeine in humans
    Veronique Michaud
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Ther Drug Monit 28:779-83. 2006
    ..Caffeine has intrinsic proarrhythmic effects; thus, its coadministration with an antiarrhythmic agent such as propafenone should be used with caution, especially in patients with poor CYP2D6 activity...
  36. pmc Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination
    Frederique Fenneteau
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    Theor Biol Med Model 6:2. 2009
    ..This work aims to improve our understanding of the impact of P-gp activity modulation on tissue distribution of P-gp substrate...
  37. doi Performance of different population pharmacokinetic algorithms
    Philippe Colucci
    Faculte de Pharmacie, University of Montreal, Montreal, Canada
    Ther Drug Monit 33:583-91. 2011
    ..This increased interest has given rise to additional algorithms...
  38. pmc The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension
    Jean Lefebvre
    Hypertension Research Unit, CHUL Research Center, Faculty of Pharmacy, Laval University, Quebec, Canada
    Br J Clin Pharmacol 63:575-82. 2007
    ..The metabolism of the third-generation beta(1)-receptor antagonist nebivolol has been shown to be highly dependent on cytochrome P450 2D6 enzymatic activity in preclinical studies...
  39. ncbi Effects of ciprofloxacin on the stereoselective disposition of mexiletine in man
    Line Labbe
    Quebec Heart Institute, Hopital Laval, Ste Foy, Quebec G1V 4G5, Canada
    Ther Drug Monit 26:492-8. 2004
    ..Nevertheless, results obtained in this study suggest that no major drug interaction is to be expected during the concomitant administration of ciprofloxacin and mexiletine in patients...