Norman D Rosenblum

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint The path ahead for MD/PhD programs in Canada Commentary on Jones et al
    Norman D Rosenblum
    Clin Invest Med 39:E140-1. 2016
  2. doi request reprint Deletions in 16q24.2 are associated with autism spectrum disorder, intellectual disability and congenital renal malformation
    Gregory Ryan Handrigan
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G1X8
    J Med Genet 50:163-73. 2013
  3. ncbi request reprint Developmental biology of the human kidney
    Norman D Rosenblum
    The Hospital for Sick Children, Division of Nephrology and Program in Developmental and Stem Cell Biology, 555 University Avenue, Toronto, Ontario, Canada
    Semin Fetal Neonatal Med 13:125-32. 2008
  4. pmc Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner
    Lijun Chi
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e65448. 2013
  5. ncbi request reprint GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
    Ming Chang Hu
    Program in Developmental Biology, Hospital for Sick Children, University of Toronto, Canada
    Development 133:569-78. 2006
  6. pmc GLI3 repressor controls functional development of the mouse ureter
    Jason E Cain
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Invest 121:1199-206. 2011
  7. ncbi request reprint Shh controls epithelial proliferation via independent pathways that converge on N-Myc
    Pleasantine Mill
    Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 9:293-303. 2005
  8. pmc Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis
    Chungyee Leung-Hagesteijn
    Cancer Research Program, Research Institute, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Mol Cell Biol 25:3648-57. 2005
  9. pmc GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, Toronto, Ontario, Canada
    PLoS ONE 4:e7313. 2009
  10. pmc Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor
    Joshua Blake
    Program in Developmental and Stem Cell Biology, Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Hum Mol Genet 25:437-47. 2016

Collaborators

Detail Information

Publications46

  1. ncbi request reprint The path ahead for MD/PhD programs in Canada Commentary on Jones et al
    Norman D Rosenblum
    Clin Invest Med 39:E140-1. 2016
    ..The authors are to be commended for their efforts and productivity. ..
  2. doi request reprint Deletions in 16q24.2 are associated with autism spectrum disorder, intellectual disability and congenital renal malformation
    Gregory Ryan Handrigan
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G1X8
    J Med Genet 50:163-73. 2013
    ..The disease associations of deletions in the intervening region, 16q24.2, have only been defined to a limited extent...
  3. ncbi request reprint Developmental biology of the human kidney
    Norman D Rosenblum
    The Hospital for Sick Children, Division of Nephrology and Program in Developmental and Stem Cell Biology, 555 University Avenue, Toronto, Ontario, Canada
    Semin Fetal Neonatal Med 13:125-32. 2008
    ..These models reveal mechanisms by which cell lineages are established in the embryonic kidney and the genetic pathways that are involved in their establishment and maintenance...
  4. pmc Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner
    Lijun Chi
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e65448. 2013
    ..Together, our data demonstrate that Kif3a controls nephron number via distinct cell lineage-specific mechanisms...
  5. ncbi request reprint GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
    Ming Chang Hu
    Program in Developmental Biology, Hospital for Sick Children, University of Toronto, Canada
    Development 133:569-78. 2006
    ..Together, these results demonstrate that SHH-SMO signaling controls renal morphogenesis via transcriptional control of Gli, renal patterning and cell cycle regulator genes in a manner that is opposed by GLI3...
  6. pmc GLI3 repressor controls functional development of the mouse ureter
    Jason E Cain
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Invest 121:1199-206. 2011
    ..Together, these data demonstrate that Hh signaling controls Kit and Hcn3 expression and ureter peristalsis...
  7. ncbi request reprint Shh controls epithelial proliferation via independent pathways that converge on N-Myc
    Pleasantine Mill
    Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 9:293-303. 2005
    ..These findings demonstrate that Shh signaling controls the rapid and patterned expansion of epithelial progenitors through convergent Gli-mediated regulation...
  8. pmc Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis
    Chungyee Leung-Hagesteijn
    Cancer Research Program, Research Institute, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Mol Cell Biol 25:3648-57. 2005
    ..We conclude that ILK functions in a BMP7/p38(MAPK)/ATF-2 signaling pathway and stimulates epithelial cell morphogenesis...
  9. pmc GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, Toronto, Ontario, Canada
    PLoS ONE 4:e7313. 2009
    ..Thus, GLI3 repressor controls nephron number by regulating ureteric tip cell expression of Wnt11 and Ret...
  10. pmc Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor
    Joshua Blake
    Program in Developmental and Stem Cell Biology, Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Hum Mol Genet 25:437-47. 2016
    ..We conclude that the urogenital system phenotypes observed in PHS are caused by GLI3R-dependent perturbations in nephric duct patterning, renal branching morphogenesis and nephrogenic progenitor self-renewal...
  11. doi request reprint Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor
    Jinny J Kim
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:1825-36. 2011
    ..Together, our data demonstrate that SuFu controls cerebellar patterning and cell differentiation in a GLI3 repressor-dependent manner...
  12. ncbi request reprint Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription
    Ming Chang Hu
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Development 132:215-25. 2005
    ..These results provide novel insights into mechanisms by which interacting signaling pathways control transcription during the genesis of renal dysplasia...
  13. pmc β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    J Am Soc Nephrol 22:718-31. 2011
    ..Together, these results demonstrate that elevation of β-catenin levels during kidney development causes dysplasia...
  14. doi request reprint β-Catenin overexpression in the metanephric mesenchyme leads to renal dysplasia genesis via cell-autonomous and non-cell-autonomous mechanisms
    Sanjay Sarin
    Program in Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 184:1395-410. 2014
    ..Together, these data support a model in which the elevation of β-catenin in the metanephric mesenchyme results in cell-autonomous and non-cell-autonomous events that lead to the genesis of renal dysplasia. ..
  15. pmc Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development
    Joanna Smeeton
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Development 137:3233-43. 2010
    ..p38 MAPK activation was not dependent on the kinase activity of ILK. Thus, we conclude that ILK plays a crucial role in activating p38 MAPK, which regulates cell cycle arrest of epithelial cells in renal tubulogenesis...
  16. ncbi request reprint Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo
    Sunny Hartwig
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada
    Mech Dev 122:928-38. 2005
    ..These results demonstrate that BMP2-SMAD signaling, modulated by GPC3, inhibits renal branching morphogenesis in vivo...
  17. doi request reprint Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    Pediatr Res 68:91-8. 2010
    ..Here, we review current knowledge regarding the genetic contributions to renal hypoplasia with particular emphasis on the mechanisms that control nephron endowment in humans and mice...
  18. ncbi request reprint p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1
    Ming Chang Hu
    Division of Nephrology, Program in Developmental Biology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 279:12051-9. 2004
    ..We conclude that BMP7 stimulates renal epithelial cell morphogenesis via p38(MAPK) and that p38(MAPK) activity is negatively regulated by Smad1...
  19. doi request reprint Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm
    Valeria Di Giovanni
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 138:2717-27. 2011
    ..Together, these results demonstrate a requirement for Alk3 in distinct progenitor cell populations derived from the intermediate mesoderm...
  20. doi request reprint Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..Together, these data demonstrate that beta-catenin performs essential functions during renal branching morphogenesis via control of a hierarchy of genes that control ureteric branching...
  21. doi request reprint Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Nephrol 24:1611-9. 2009
    ..We also highlight new knowledge related to both established and novel signaling systems that are important for stimulating and inhibiting branching morphogenesis...
  22. ncbi request reprint Control of murine kidney development by sonic hedgehog and its GLI effectors
    Paul S Gill
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Canada
    Cell Cycle 5:1426-30. 2006
    ..Further, we highlight the roles of BMP, WNT and FGF signaling during renal development and discuss possible interactions of these pathways with SHH signaling...
  23. ncbi request reprint Hypercalciuria in Beckwith-Wiedemann syndrome
    Michael Goldman
    Division of Nephrology and the Program in Developmental Biology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Pediatr 142:206-8. 2003
    ..Serum calcium was normal in all patients with HC. Because we found that an increased prevalence in the occurrence of HC and its complications in a group of children with BWS, any child with BWS should be evaluated for HC...
  24. doi request reprint Tubulointerstitial nephritis as an extraintestinal manifestation of Crohn's disease
    Aoife M Waters
    Hospital for Sick Children, Toronto, ON, Canada
    Nat Clin Pract Nephrol 4:693-7. 2008
    ..A second case of tubulointerstitial nephritis in a patient with Crohn's disease, is also presented...
  25. pmc Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8
    Joanna Smeeton
    Program in Developmental and Stem Cell Biology, and Departments of Paediatrics, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Nephrol 27:1465-77. 2016
    ..Together, these data demonstrate that Ilk controls branching morphogenesis by regulating the expression of DUSP8, which inhibits p38MAPK activity and decreases branching morphogenesis. ..
  26. pmc Insights into the renal pathogenesis in Schimke immuno-osseous dysplasia: A renal histological characterization and expression analysis
    Sanjay Sarin
    Program in Pathology and Molecular Medicine, McMaster University, Hamilton, Canada SS, AJ, FB, IA, BS, SC, DL, DB Department of Biochemistry and Molecular Biology ABH, CFB, University of British Columbia, Vancouver, CanadaDepartment of Medical Genetics CFB, University of British Columbia, Vancouver, CanadaDepartment of Pediatrics, Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Canada NDR
    J Histochem Cytochem 63:32-44. 2015
    ..Our results highlight the cells that may contribute to the renal pathogenesis in SIOD. Further, we suggest that disruptions in genomic integrity during fetal kidney development contribute to the pathogenesis of FSGS in SIOD patients. ..
  27. pmc BMP receptor ALK3 controls collecting system development
    Sunny Hartwig
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Am Soc Nephrol 19:117-24. 2008
    ..In summary, normal kidney development requires ALK3-dependent BMP signaling, which controls ureteric bud branching...
  28. doi request reprint Bone morphogenetic protein signaling in the developing kidney: present and future
    Jason E Cain
    Program in Developmental and Stem Cell Biology The Hospital for Sick Children, Toronto, ON, Canada
    Differentiation 76:831-42. 2008
    ..We highlight major gaps in our knowledge of the roles of BMP signaling in the development of the normal and abnormal kidney and identify areas and techniques likely to improve our understanding...
  29. ncbi request reprint Genetic regulation of branching morphogenesis: lessons learned from loss-of-function phenotypes
    Ming Chang Hu
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Res 54:433-8. 2003
    ..This review summarizes current knowledge regarding the molecular control of branching morphogenesis in vivo with particular emphasis on the genetic contribution to perturbed branching morphogenesis in mice and humans...
  30. doi request reprint Going beyond Kirkpatrick in evaluating a clinician scientist program: it's not "if it works" but "how it works"
    Kathryn Parker
    Holland Bloorview Kids Rehabilitation Hospital, and Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Acad Med 86:1389-96. 2011
    ..To explore how the Canadian Child Health Clinician Scientist Program (CCHCSP) works to achieve prearticulated and emergent outcomes...
  31. ncbi request reprint The molecular control of renal branching morphogenesis: current knowledge and emerging insights
    Tino D Piscione
    Program in Development Biology, Division of Nephrology, The Hospital for Sick Children, University of Toronto, 555 University Ave, Ontario, M5G1X8, Canada
    Differentiation 70:227-46. 2002
    ..In addition, in vivo and in vitro evidence regarding the functions of several other gene families are considered, rendering new insight into emerging regulatory roles for these molecules in renal branching morphogenesis...
  32. ncbi request reprint Elevated SMAD1/beta-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice
    Ming Chang Hu
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Development 130:2753-66. 2003
    ..Our work provides novel insights into the role that crucial developmental signaling pathways may play during the genesis of malformed renal tissue elements...
  33. doi request reprint Renal involvement and the role of Notch signalling in Alagille syndrome
    Binita M Kamath
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Nat Rev Nephrol 9:409-18. 2013
    ..Increased awareness of Alagille syndrome amongst nephrologists may lead to more diagnoses of Alagille syndrome in patients with apparently isolated renal disease...
  34. ncbi request reprint Performance of a career development and compensation program at an academic health science center
    Hugh O'Brodovich
    Department of Pediatrics, University of Toronto, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Pediatrics 119:e791-7. 2007
    ..The objective of this study was to determine whether the principles of the Career Development and Compensation Program were sustained during the initial 7 years of its implementation...
  35. pmc Hepatocyte growth factor-mediated renal epithelial branching morphogenesis is regulated by glypican-4 expression
    Anil Karihaloo
    Division of Nephrology, Program in Development Biology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Mol Cell Biol 24:8745-52. 2004
    ..These results demonstrate that both signaling and phenotypic responses to HGF can be regulated by specific Gpc expression patterns...
  36. ncbi request reprint Outcome of isolated antenatal hydronephrosis: a systematic review and meta-analysis
    Gagan Sidhu
    Division of Nephrology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Pediatr Nephrol 21:218-24. 2006
    ..Further studies are needed to define outcomes, particularly in more severe forms of IAHN...
  37. doi request reprint Control of mammalian kidney development by the Hedgehog signaling pathway
    Jason E Cain
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    Pediatr Nephrol 26:1365-71. 2011
    ..Furthermore, we propose mechanisms by which Hedgehog signaling contributes to both normal and abnormal renal development...
  38. doi request reprint Renal branching morphogenesis: morphogenetic and signaling mechanisms
    Joshua Blake
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Canada Department of Physiology, University of Toronto, Canada
    Semin Cell Dev Biol 36:2-12. 2014
    ..We also highlight salient molecular signaling pathways that govern these processes, and the investigative techniques used to interrogate them. ..
  39. doi request reprint Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks
    Xuewen Song
    Division of Nephrology, University Health Network, McMaster University, Hamilton, Ontario, Canada
    Hum Mol Genet 18:2328-43. 2009
    ..Pharmacological modulation of some of these signaling pathways may provide a potential therapeutic strategy for ADPKD...
  40. doi request reprint A translational approach to congenital non-obstructive hydronephrosis
    Robyn P Thom
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Towers, 101 College Street, Toronto, Ontario, Canada, M5G 1 L7
    Pediatr Nephrol 28:1757-61. 2013
    ..Here, we review the pathobiology and clinical management of non-obstructive hydronephrosis and describe how inhibitors of GLI3 repressor formation may serve as novel therapies for this disorder. ..
  41. doi request reprint Developmental origins and functions of stromal cells in the normal and diseased mammalian kidney
    Winny Li
    Institute of Medical Science, University of Toronto, Toronto, Canada Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Dev Dyn 243:853-63. 2014
    ..Gaps in our current understanding of renal stromal cells and future directions needed to advance this expanding field of study are highlighted...
  42. ncbi request reprint Neonatal renal venous thrombosis: clinical outcomes and prevalence of prothrombotic disorders
    Stephen D Marks
    Division of Nephrology, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Ontario, Canada
    J Pediatr 146:811-6. 2005
    ..To determine clinical outcomes and the prevalence of prothrombotic conditions in patients who had neonatal renal venous thrombosis (RVT)...
  43. ncbi request reprint Outcome of isolated antenatal hydronephrosis
    Adam M Cheng
    Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario
    Arch Pediatr Adolesc Med 158:38-40. 2004
    ..To define the clinical outcome in isolated antenatal hydronephrosis (ANH), defined as pelviectasis without vesicoureteral reflux or urinary tract obstruction...
  44. ncbi request reprint Renal abnormalities in beckwith-wiedemann syndrome are associated with 11p15.5 uniparental disomy
    Michael Goldman
    Divisions of Nephrology and Clinical and Metabolic Genetics, Program in Developmental Biology, Research Institute, and Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Soc Nephrol 13:2077-84. 2002
    ..5 in BWS was associated with a higher incidence of renal abnormalities, mutations at CDKN1C and KvDMR1 imprinting defects were not, suggesting that imprinted genes on 11p15.5 other than CDKN1C are critical for renal development...
  45. ncbi request reprint Favorable outcome in patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis
    Athimalaipet V Ramanan
    Department of Pediatrics, Health Policy Management and Evaluation, and Public Health Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 31:2068-70. 2004
    ..In 2 recently reported case series of MAS in SoJRA, renal involvement appeared to be associated with poor prognosis. We describe 3 children with SoJRA who had renal involvement complicating MAS and had a favorable outcome...
  46. doi request reprint Defects in ciliary localization of Nek8 is associated with cystogenesis
    Melissa L Trapp
    Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr, Burnaby, BC V5A1S6, Canada
    Pediatr Nephrol 23:377-87. 2008
    ..These data indicate that the ciliary localization of Nek8 in a subset of ureteric-bud-derived kidney tubules is essential for maintaining the integrity of those tubules in the mammalian kidney...