Andrew N Redington

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Assumed oxygen consumption in the determination of cardiac output in children after cardiac surgery
    Jia Li
    J Thorac Cardiovasc Surg 131:251; author reply 252. 2006
  2. ncbi request reprint Noninvasive analysis of myocardial function using high-resolution Doppler tissue echocardiography in rats
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 18:461-7. 2005
  3. ncbi request reprint Determinants and assessment of pulmonary regurgitation in tetralogy of Fallot: practice and pitfalls
    Andrew N Redington
    Division of Cardiology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Cardiol Clin 24:631-9, vii. 2006
  4. ncbi request reprint Protecting the heart and other organs after cardiac surgery: old problems, new solutions?
    Andrew N Redington
    Division of Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cardiol Young 14:182-91. 2004
  5. ncbi request reprint Right ventricular function
    Andrew N Redington
    University of Toronto, Division of Cardiology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Cardiol Clin 20:341-9, v. 2002
  6. doi request reprint Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors
    Kathrine L Redington
    Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, M5G1X8, Canada
    J Physiol Sci 63:219-23. 2013
  7. pmc Delayed onset of tricuspid valve flow in repaired tetralogy of Fallot: an additional mechanism of diastolic dysfunction and interventricular dyssynchrony
    Ai Min Sun
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, M5G1X8, Canada
    J Cardiovasc Magn Reson 13:43. 2011
  8. ncbi request reprint Comparison of the profiles of postoperative systemic hemodynamics and oxygen transport in neonates after the hybrid or the Norwood procedure: a pilot study
    Jia Li
    Division of Cardiology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8
    Circulation 116:I179-87. 2007
  9. ncbi request reprint Profiles of hemodynamics and oxygen transport derived by using continuous measured oxygen consumption after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 133:441-8. 2007
  10. ncbi request reprint Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery
    Sara Arab
    Richard Lewar Centre of Excellence, Toronto General Hospital, University of Toronto, Toronto, Canada
    J Thorac Cardiovasc Surg 134:74-81, 81.e1-2. 2007

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Assumed oxygen consumption in the determination of cardiac output in children after cardiac surgery
    Jia Li
    J Thorac Cardiovasc Surg 131:251; author reply 252. 2006
  2. ncbi request reprint Noninvasive analysis of myocardial function using high-resolution Doppler tissue echocardiography in rats
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 18:461-7. 2005
  3. ncbi request reprint Determinants and assessment of pulmonary regurgitation in tetralogy of Fallot: practice and pitfalls
    Andrew N Redington
    Division of Cardiology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Cardiol Clin 24:631-9, vii. 2006
    ..This article describe the primary determinants of pulmonary regurgitation after the repair of tetralogy of Fallot. Furthermore, the methods by which pulmonary regurgitation is measured and some of the pitfalls therein are highlighted...
  4. ncbi request reprint Protecting the heart and other organs after cardiac surgery: old problems, new solutions?
    Andrew N Redington
    Division of Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cardiol Young 14:182-91. 2004
  5. ncbi request reprint Right ventricular function
    Andrew N Redington
    University of Toronto, Division of Cardiology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Cardiol Clin 20:341-9, v. 2002
    ....
  6. doi request reprint Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors
    Kathrine L Redington
    Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, M5G1X8, Canada
    J Physiol Sci 63:219-23. 2013
    ..These results suggest that EA recapitulates the cardioprotection achieved by remote preconditioning, by similarly leading to release of circulating cardioprotective factors...
  7. pmc Delayed onset of tricuspid valve flow in repaired tetralogy of Fallot: an additional mechanism of diastolic dysfunction and interventricular dyssynchrony
    Ai Min Sun
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, M5G1X8, Canada
    J Cardiovasc Magn Reson 13:43. 2011
    ..The present study sought to assess the prevalence and mechanism of early diastolic dysfunction of the RV defined as delayed onset of the tricuspid valve (TV) flow after TOF repair...
  8. ncbi request reprint Comparison of the profiles of postoperative systemic hemodynamics and oxygen transport in neonates after the hybrid or the Norwood procedure: a pilot study
    Jia Li
    Division of Cardiology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8
    Circulation 116:I179-87. 2007
    ....
  9. ncbi request reprint Profiles of hemodynamics and oxygen transport derived by using continuous measured oxygen consumption after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 133:441-8. 2007
    ..We used measured oxygen consumption to characterize hemodynamics and oxygen transport after the classic Norwood procedure...
  10. ncbi request reprint Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery
    Sara Arab
    Richard Lewar Centre of Excellence, Toronto General Hospital, University of Toronto, Toronto, Canada
    J Thorac Cardiovasc Surg 134:74-81, 81.e1-2. 2007
    ..We tested the hypothesis that intraoperative ischemia-reperfusion under conditions of blood cardioplegic arrest would induce a unique myocardial genomic profile indicative of a cardioprotective response...
  11. ncbi request reprint Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans
    Michael M H Cheung
    Division of Cardiology and Cardiovascular Surgery, Hospital for Sick Children, Toronto, Canada
    J Am Coll Cardiol 47:2277-82. 2006
    ..We conducted a randomized controlled trial of the effects of remote ischemic preconditioning (RIPC) in children undergoing repair of congenital heart defects...
  12. ncbi request reprint Initial experience with hybrid palliation for neonates with single-ventricle physiology
    Christopher A Caldarone
    Division of Cardiovascular Surgery, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 84:1294-300. 2007
    ..Hybrid palliation consisting of bilateral pulmonary artery banding and ductal stenting (PAB/DS) is an emerging method to palliate neonates with functional single ventricles...
  13. doi request reprint Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload
    Christian Apitz
    Division of Cardiology, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 144:1494-501. 2012
    ..Although aortic constriction has been shown to improve systolic function in acute RV failure, its effect on RV responses to chronic pressure overload is unknown...
  14. doi request reprint Effect of inhaled hydrogen sulfide on metabolic responses in anesthetized, paralyzed, and mechanically ventilated piglets
    Jia Li
    Cardiac Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Crit Care Med 9:110-2. 2008
    ..We conducted a preclinical study to explore the potential effect of H2S on metabolic rate in large mammals...
  15. doi request reprint Surgical repair of the mitral valve in children with dilated cardiomyopathy and mitral regurgitation
    Mark A Walsh
    Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 85:2085-8. 2008
    ..Significant mitral regurgitation is known to exacerbate left ventricular dysfunction in dilated cardiomyopathy. Although intervention on the regurgitant mitral valve is frequently described in adults, there is little pediatric data...
  16. ncbi request reprint Doppler tissue imaging in the assessment of atrioventricular conduction time: validation of a novel technique and comparison with electrophysiologic and pulsed wave Doppler-derived equivalents in an animal model
    Masaki Nii
    Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 19:314-21. 2006
    ..05). Pre-ejection period prolonged with faster HR (P < .001), unlike electromechanical delay. In conclusion, DTI allows more accurate measurement of AVCT over a wider HR range than does PD...
  17. ncbi request reprint Evidence for a significant myocardial contribution to total metabolic burden during hypothermic cardiopulmonary bypass: a study of continuously measured oxygen consumption and arterial lactate levels in pigs
    Jia Li
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    Perfusion 20:277-83. 2005
    ..We assessed the causes of imbalance of oxygen transport by continuously measuring oxygen consumption (VO2) during hypothermic cardiopulmonary bypass (CPB) in pigs...
  18. ncbi request reprint Disruption of the ventricular myocardial force-frequency relationship after cardiac surgery in children: noninvasive assessment by means of tissue Doppler imaging
    Michael M H Cheung
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 131:625-31. 2006
    ....
  19. doi request reprint The influence of systemic hemodynamics and oxygen transport on cerebral oxygen saturation in neonates after the Norwood procedure
    Jia Li
    Heart Center, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 135:83-90, 90.e1-2. 2008
    ..Ischemic brain injury is an important morbidity in neonates after the Norwood procedure. Its relationship to systemic hemodynamic oxygen transport is poorly understood...
  20. doi request reprint Carbon dioxide--a complex gas in a complex circulation: its effects on systemic hemodynamics and oxygen transport, cerebral, and splanchnic circulation in neonates after the Norwood procedure
    Jia Li
    The Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 136:1207-14. 2008
    ..We sought to quantitatively define the effects of stepwise increases in arterial carbon dioxide tension on systemic oxygen transport and cerebral and splanchnic circulation after the Norwood procedure...
  21. ncbi request reprint Adverse effects of dopamine on systemic hemodynamic status and oxygen transport in neonates after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 48:1859-64. 2006
    ..The purpose of this study was to evaluate the effects of dopamine on hemodynamic status and oxygen transport in neonates after the Norwood procedure...
  22. doi request reprint Assessment of vascular remodeling after the Fontan procedure using a novel very high resolution ultrasound method: arterial wall thinning and venous thickening in late follow-up
    Taisto Sarkola
    Division of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Heart Vessels 28:66-75. 2013
    ..These novel data may be of clinical importance in the circulatory management as well as the understanding of the early pathogenesis of vasculopathy in patients after the Fontan procedure...
  23. doi request reprint Refining the assessment of pulmonary regurgitation in adults after tetralogy of Fallot repair: should we be measuring regurgitant fraction or regurgitant volume?
    Rachel M Wald
    Department of Cardiology, Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto General Hospital, North Wing, 5N 517, 585 University Avenue, Toronto, Ontario, Canada M5G 2C4
    Eur Heart J 30:356-61. 2009
    ..We hypothesized that a volumetric expression of PR would be a better measure of ventricular preload and a more accurate reflection of degree of insufficiency...
  24. ncbi request reprint The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium
    Igor E Konstantinov
    Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1326-32. 2005
    ..We tested the hypothesis that remote ischemic preconditioning modifies myocardial gene expression immediately after the remote ischemic preconditioning stimulus (early phase) and 24 hours later (late phase)...
  25. ncbi request reprint Anatomical and functional evaluation of pulmonary veins in children by magnetic resonance imaging
    Lars Grosse-Wortmann
    Section of Cardiac Imaging, Department of Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, Toronto, Canada
    J Am Coll Cardiol 49:993-1002. 2007
    ....
  26. ncbi request reprint An analysis of oxygen consumption and oxygen delivery in euthermic infants after cardiopulmonary bypass with modified ultrafiltration
    Jia Li
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 78:1389-96. 2004
    ..We sought to assess VO2 and DO2 and their relationship with proinflammatory cytokines after CPB with the use of modified ultrafiltration (MUF) in infants...
  27. doi request reprint Remote preconditioning improves maximal performance in highly trained athletes
    Emilie Jean-St-Michel
    The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Med Sci Sports Exerc 43:1280-6. 2011
    ..Exercise performance in highly trained athletes is limited by tissue hypoxemia and acidosis, which may therefore represent a type of ischemia-reperfusion stress modifiable by RIPC...
  28. ncbi request reprint Hemodynamic evaluation of the peripheral pulmonary circulation by cine phase-contrast magnetic resonance imaging
    Christian J Kellenberger
    Department of Diagnostic Imaging, Hospital for Sick Children, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada
    J Magn Reson Imaging 22:780-7. 2005
    ..To describe the normal flow patterns in peripheral pulmonary vessels with phase-contrast (PC) magnetic resonance imaging (MRI)...
  29. doi request reprint Isovolumic acceleration at rest and during exercise in children normal values for the left ventricle and first noninvasive demonstration of exercise-induced force-frequency relationships
    Susan Lucy Roche
    The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 57:1100-7. 2011
    ....
  30. doi request reprint Energy expenditure and caloric and protein intake in infants following the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Crit Care Med 9:55-61. 2008
    ..Energy requirements of these patients have not been well studied. We assessed energy expenditure and caloric and protein intake during the first 3 days following the Norwood procedure...
  31. doi request reprint Airway pressure release ventilation improves pulmonary blood flow in infants after cardiac surgery
    Mark A Walsh
    Division of Cardiology, The Hospital for Sick Children and the University of Toronto, Toronto, Canada
    Crit Care Med 39:2599-604. 2011
    ....
  32. doi request reprint Anatomical factors determining surgical decision-making in patients with transposition of the great arteries with left ventricular outflow tract obstruction
    Osami Honjo
    The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Eur J Cardiothorac Surg 44:1085-94; discussion 1094. 2013
    ..We sought to identify pre- and intraoperative factors that determine the timing of repair, procedure type and subsequent LVOT outcome...
  33. doi request reprint Transcutaneous electrical nerve stimulation as a novel method of remote preconditioning: in vitro validation in an animal model and first human observations
    Anthony C Merlocco
    The Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G1X8, Canada
    Basic Res Cardiol 109:406. 2014
    ..TENS is a novel method for inducing cardioprotection and may provide an alternative to the limb ischemia stimulus for induction of rIPC clinically. ..
  34. ncbi request reprint Assessment of the evolution of normal fetal diastolic function during mid and late gestation by spectral Doppler tissue echocardiography
    Masaki Nii
    Division of Cardiology, The Hospital for Sick Children, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 19:1431-7. 2006
    ..To establish gestational age-specific reference values in healthy singleton fetuses, we prospectively assessed the evolution of diastolic longitudinal wall-motion velocities by spectral Doppler tissue imaging...
  35. doi request reprint The left heart after pulmonary valve replacement in adults late after tetralogy of Fallot repair
    Daniel Tobler
    Division of Cardiology and Cardiovascular Surgery, Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, Toronto, Ontario, Canada
    Int J Cardiol 160:165-70. 2012
    ..Adverse ventricular-ventricular interactions have been recognized in those with repaired tetralogy of Fallot (TOF) and severe pulmonary regurgitation...
  36. doi request reprint Genetic determinants of right-ventricular remodeling after tetralogy of Fallot repair
    Aamir Jeewa
    Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Res 72:407-13. 2012
    ..Hypoxia-inducible factor (HIF1A) regulates the myocardial response to hypoxia and hemodynamic load. We investigated the association of HIF1A variants with right-ventricular (RV) remodeling after tetralogy of Fallot (TOF) repair...
  37. doi request reprint Assessment of vascular phenotype using a novel very-high-resolution ultrasound technique in adolescents after aortic coarctation repair and/or stent implantation: relationship to central haemodynamics and left ventricular mass
    Taisto Sarkola
    Labatt Family Heart Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Heart 97:1788-93. 2011
    ..The objective was to determine the severity of residual cardiovascular abnormalities in youths after CoA repair and their relation to regional BP...
  38. doi request reprint Atrioventricular valve repair in patients with functional single-ventricle physiology: impact of ventricular and valve function and morphology on survival and reintervention
    Osami Honjo
    The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 142:326-35.e2. 2011
    ..This study was to determine whether atrioventricular valve repair modifies natural history of single-ventricle patients with atrioventricular valve insufficiency and to identify factors predicting survival and reintervention...
  39. ncbi request reprint The effects of changes in loading conditions and modulation of inotropic state on the myocardial performance index: comparison with conductance catheter measurements
    Michael M H Cheung
    Division of Cardiology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada, M5G 1X8
    Eur Heart J 25:2238-42. 2004
    ..The purpose of this study was therefore to study formally the effect of clinically relevant changes in these parameters in an animal model...
  40. doi request reprint Tetralogy of Fallot
    Christian Apitz
    Division of Cardiology, Labatt Family Heart Centre, Hospital for Sick Children, Toronto, ON, Canada
    Lancet 374:1462-71. 2009
    ....
  41. doi request reprint Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Ontario, Canada
    J Surg Res 158:155-61. 2010
    ..The goal of the current study was to determine if the observed changes in gene expression lead to functional changes in neutrophils...
  42. doi request reprint Exercise induces biventricular mechanical dyssynchrony in children with repaired tetralogy of Fallot
    S Lucy Roche
    The Labatt Family Heart Center, The Hospital for Sick Children, Toronto, Ontario, Canada
    Heart 96:2010-5. 2010
    ..This study investigated biventricular dyssynchrony in children with TOF and its relationship to exercise, QRS duration (QRSd) and ventricular mechanics...
  43. doi request reprint Adverse left ventricular mechanics in adults with repaired tetralogy of Fallot
    Nikolaos Tzemos
    Toronto Congenital Cardiac Centre for Adults and Echocardiography Laboratory, Division of Cardiology, University Health Network, University of Toronto, Toronto General Hospital, Toronto, Canada
    Am J Cardiol 103:420-5. 2009
    ..It was possible that abnormal LV mechanics in combination with RV dysfunction may explain the relation between QRS duration and adverse cardiac outcomes...
  44. ncbi request reprint Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism
    Igor E Konstantinov
    Division of Cardiovascular Surgery, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Transplantation 79:1691-5. 2005
    ....
  45. pmc Remote ischemic preconditioning in children undergoing cardiac surgery with cardiopulmonary bypass: a single-center double-blinded randomized trial
    Brian W McCrindle
    Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada B W M C, N A C, S K, H M H, C M, S M S, C A C, J G C, G S V A, A N R Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada B W M C, A N R
    J Am Heart Assoc 3:. 2014
    ..We sought to determine the impact of RIPC on clinical outcomes and physiological markers related to ischemia-reperfusion injury and inflammatory activation after cardiac surgery in children...
  46. doi request reprint Right ventricular diastolic performance in children with pulmonary arterial hypertension associated with congenital heart disease: correlation of echocardiographic parameters with invasive reference standards by high-fidelity micromanometer catheter
    Kenichi Okumura
    From the Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Circ Cardiovasc Imaging 7:491-501. 2014
    ..We investigated echocardiographic parameters of right ventricular diastolic function in children with PAH in relation to simultaneously measured invasive reference measures...
  47. doi request reprint Remote cardioprotection by direct peripheral nerve stimulation and topical capsaicin is mediated by circulating humoral factors
    Kathrine L Redington
    Division of Cardiology, Labatt Family Heart Center, Hospital for Sick Children, Toronto, ON, Canada
    Basic Res Cardiol 107:241. 2012
    ..Direct electrical or peripheral neural stimulation evokes the release of cardioprotective substances into the bloodstream, with comparable effects to that of rIPC induced by limb ischemia...
  48. doi request reprint The impact of changing medical therapy on transplantation-free survival in pediatric dilated cardiomyopathy
    Paul F Kantor
    Cardiomyopathy and Heart Function Program, Labatt Family Heart Centre, University of Toronto Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 55:1377-84. 2010
    ..We sought to determine whether the introduction of these agents had altered the outcome of dilated cardiomyopathy (DC) in childhood...
  49. ncbi request reprint Inclusion of oxygen consumption improves the accuracy of arterial and venous oxygen saturation interpretation after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 131:1099-107. 2006
    ..We sought to examine the correlation of the indirect indicators to VO2-derived measures of oxygen transport...
  50. doi request reprint Arterial complications associated with cardiac catheterization in pediatric patients with a previous history of Kawasaki disease
    Rebecca C Gurofsky
    Department of Pediatrics, Division of Cardiology, Labatt Family Heart Centre, University of Toronto, The Hospital for Sick Children, Toronto, Canada
    Catheter Cardiovasc Interv 73:809-13. 2009
    ....
  51. doi request reprint Renin-angiotensin-aldosterone system genotype and serum BNP in a contemporary cohort of adults late after Fontan palliation
    Luke J Burchill
    Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada
    Int J Cardiol 197:209-15. 2015
    ..This study evaluated associations between RAAS genotype, ventricular mass and function in a contemporary cohort of adults with a Fontan circulation...
  52. doi request reprint Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin
    Jing Li
    Division of Cardiology, Labatt Family Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
    Clin Sci (Lond) 120:451-62. 2011
    ....
  53. doi request reprint Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protection
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Toronto, Canada
    Clin Sci (Lond) 117:191-200. 2009
    ..This cardioprotection is transferable across species, independent of local neurogenic activity, and requires opioid receptor activation...
  54. ncbi request reprint Late complications of repair of tetralogy of Fallot and indications for pulmonary valve replacement
    Michael M H Cheung
    Division of Cardiology, Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8 Ontario, Canada
    Semin Thorac Cardiovasc Surg 17:155-9. 2005
    ..In this article we review the existing literature regarding the deleterious effects of chronic PR in these patients and the current data regarding the timing and mode of intervention...
  55. ncbi request reprint Isovolumic but not ejection phase Doppler tissue indices detect left ventricular dysfunction caused by coronary stenosis
    Mikiko Shimizu
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 18:1241-6. 2005
    ..IVA also has the ability to describe the force-frequency relationship during incremental atrial pacing in vivo...
  56. doi request reprint Left Ventricular Myocardial and Hemodynamic Response to Exercise in Young Patients after Endovascular Stenting for Aortic Coarctation
    Ching Kit Chen
    Department of Pediatrics, Division of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 29:237-46. 2016
    ..The aim of this study was to characterize the LV myocardial and hemodynamic response to exercise in young patients who underwent endovascular stenting for CoA during childhood using semisupine bicycle exercise stress echocardiography...
  57. doi request reprint Exercise echocardiography demonstrates biventricular systolic dysfunction and reveals decreased left ventricular contractile reserve in children after tetralogy of Fallot repair
    S Lucy Roche
    The Labatt Family Heart Center in the Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada Electronic address
    J Am Soc Echocardiogr 28:294-301. 2015
    ..A need exists for early indices of both left ventricular (LV) and right ventricular (RV) compromise in this population...
  58. doi request reprint Medical errors: the performance gap in hypoplastic left heart syndrome and physiologic equivalents?
    Frederic Jacques
    Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 145:1465-73; discussion 1473-5. 2013
    ..The frequency and impact of medical errors during staged palliation are unknown...
  59. doi request reprint Transcutaneous very-high resolution ultrasound for the quantification of carotid arterial intima-media thickness in children - feasibility and comparison with conventional high resolution vascular ultrasound imaging
    Taisto Sarkola
    Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Atherosclerosis 224:102-7. 2012
    ....
  60. ncbi request reprint Images in cardiovascular medicine. Recovery of left ventricular systolic function after biventricular resynchronization pacing in a child with repaired tetralogy of Fallot and severe biventricular dysfunction
    Joel A Kirsh
    Division of Cardiology, Hospital for Sick Children, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Circulation 113:e691-2. 2006
  61. ncbi request reprint Insulin-like growth factor 1 improves the relationship between systemic oxygen consumption and delivery in piglets after cardiopulmonary bypass
    Jia Li
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 127:1436-41. 2004
    ..We sought to assess the effects of insulin-like growth factor 1 on the balance between systemic oxygen consumption and oxygen delivery after cardiopulmonary bypass in piglets...
  62. ncbi request reprint Assessment of vascular phenotype using a novel very high resolution ultrasound technique in adolescents after aortic coarctation repair and/or stent implantation: relationship to central haemodynamics and left ventricular mass
    Taisto Sarkola
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Heart 97:1870-5. 2011
    ..The more pronounced cardiovascular abnormalities after CoA stent implantation are likely related to the older patient age at the time of intervention...
  63. doi request reprint Insulin resistance and inflammation are a cause of hyperglycemia after pediatric cardiopulmonary bypass surgery
    Alejandro A Floh
    Department of Critical Care Medicine, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Canada Electronic address
    J Thorac Cardiovasc Surg 150:498-504.e1. 2015
    ..We examined the role of CPB-induced inflammation on postoperative plasma glucose, insulin, and the glucose-to-insulin ratio, which was used as a marker of insulin resistance; a decrease in the ratio reflects increased resistance...
  64. pmc Acute, delayed and chronic remote ischemic conditioning is associated with downregulation of mTOR and enhanced autophagy signaling
    Sagar Rohailla
    Division of Cardiology, Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Ontario, Canada
    PLoS ONE 9:e111291. 2014
    ..In this study we examine the effect of RIC on pro-autophagy signaling as a possible mechanism of benefit...
  65. ncbi request reprint The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans
    Igor E Konstantinov
    Division of Cardiovascular Surgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Physiol Genomics 19:143-50. 2004
    ..This is the first study of human gene expression following rIPC stimulus. rIPC stimulus suppressed proinflammatory gene transcription in human leukocytes...
  66. doi request reprint Remote ischemic per-conditioning: a novel therapy for acute stroke?
    Cecil D Hahn
    Division of Neurology, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Stroke 42:2960-2. 2011
    ..This study evaluated whether remote ischemic per-conditioning may provide neuroprotection in a clinically relevant rat model of acute ischemic stroke...
  67. doi request reprint Pathophysiology and management of heart failure in repaired congenital heart disease
    Paul F Kantor
    Division of Cardiology, University of Toronto, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Heart Fail Clin 6:497-506, ix. 2010
    ..Together, these factors result in progressive heart failure in certain high-risk patients with congenital heart disease. Understanding this sequence leads to a logical application of treatments at the various stages of disease...
  68. ncbi request reprint Continuous measurement of oxygen consumption during cardiopulmonary bypass: description of the method and in vivo observations
    Jia Li
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 77:1671-7. 2004
    ..We aimed to develop a noninvasive method to continuously measure oxygen consumption using respiratory mass spectrometry during hypothermic cardiopulmonary bypass in pigs...
  69. ncbi request reprint Effect of carbon dioxide on systemic oxygenation, oxygen consumption, and blood lactate levels after bidirectional superior cavopulmonary anastomosis
    Jia Li
    Division of Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Crit Care Med 33:984-9. 2005
    ..We sought to assess the effects of four different CO2 tensions on systemic oxygenation, oxygen consumption, and arterial blood lactate levels early after bidirectional superior cavopulmonary anastomosis...
  70. pmc Patterns of cardiac and extracardiac anomalies in adults with tetralogy of fallot
    Sara Piran
    Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Division of Cardiology, University of Toronto, Toronto, Canada
    Am Heart J 161:131-7. 2011
    ..Of the few known causes, 22q11.2 deletion syndrome (22q11DS) is the most common. We sought to define other clinical subgroups by focusing on cardiac and extracardiac features...
  71. doi request reprint Pharmacokinetic and hemodynamic responses to oral sildenafil during invasive testing in children with pulmonary hypertension
    Christian Apitz
    Division of Cardiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 55:1456-62. 2010
    ..The purpose of our study was to characterize the hemodynamic and corresponding pharmacokinetic responses to a single dose of oral sildenafil by children with pulmonary arterial hypertension (PAH) undergoing invasive testing...
  72. pmc Transition to adult health care for adolescents and young adults with congenital heart disease: perspectives of the patient, parent and health care provider
    Nadia A Clarizia
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Labbatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Can J Cardiol 25:e317-22. 2009
    ..Pediatric institutions play a large role in preparing young adults with congenital heart disease to transition to adult care...
  73. ncbi request reprint How is pulmonary arterial blood flow affected by pulmonary venous obstruction in children? A phase-contrast magnetic resonance study
    Kevin S Roman
    Diagnostic Imaging and Radiology, Hospital for Sick Children, Toronto, ON, Canada
    Pediatr Radiol 35:580-6. 2005
    ..Hemodynamic changes within a stenosed pulmonary vein might not reflect the severity of the obstruction if redistribution of pulmonary artery flow occurs...
  74. doi request reprint Inferior sinus venosus defect: echocardiographic diagnosis and surgical approach
    Matthew A Crystal
    Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 137:1349-55. 2009
    ..We sought to define the inferior sinus venosus defect anatomically and document successful surgical approaches...
  75. ncbi request reprint Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model
    Conan L McCaul
    The Lung Biology Program, The Research Institute, University of Toronto, Toronto, Ontario, Canada
    Anesth Analg 102:542-8. 2006
    ..001) without systolic dysfunction. Epinephrine appears to be harmful in the setting of brief cardiac arrest after asphyxia...
  76. ncbi request reprint Doppler tissue echocardiography: can transesophageal echocardiography be used to acquire functional data?
    Michael M H Cheung
    Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 16:732-7. 2003
    ..To date there is no direct comparison of transesophageal and transthoracic Doppler tissue data in patients with cardiac malposition. We compared data acquired from both methods in an animal model...
  77. pmc Pulmonary regurgitation in congenital heart disease
    Rajiv R Chaturvedi
    Division of Cardiology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Heart 93:880-9. 2007
  78. ncbi request reprint Differential regurgitation in branch pulmonary arteries after repair of tetralogy of Fallot: a phase-contrast cine magnetic resonance study
    I Seok Kang
    Department of Diagnostic Imaging, The University of Toronto School of Medicine, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 107:2938-43. 2003
    ..This phase-contrast cine magnetic resonance (PC MR) study was performed to evaluate the relative contribution of each lung to total regurgitant volume...
  79. ncbi request reprint Assessment of myocardial ventricular function in donor hearts: is isovolumic acceleration measured by tissue Doppler the Holy Grail?
    Michael M H Cheung
    Division of Cardiology, Hospital for Sick Children, Toronto M5G 1X8, Ontario, Canada
    J Heart Lung Transplant 23:S253-6. 2004
  80. pmc Tbx5-dependent pathway regulating diastolic function in congenital heart disease
    Yonghong Zhu
    Programme in Developmental and Stem Cell Biology, Division of Cardiology and Labatt Family Heart Centre, Programme in Physiology and Experimental Medicine, and Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 105:5519-24. 2008
    ..These results reveal a direct genetic pathway that regulates cardiac diastolic function, implying that patients with structural CHDs may have clinically important underlying anomalies in heart function that merit treatment...
  81. doi request reprint Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning
    Ping Xin
    Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Am J Physiol Heart Circ Physiol 298:H1819-31. 2010
    ..However, combined PostC+PerC may result in complementary effects on kinase signaling to recapitulate the effects of local IPC. Finally, combined PostC+PerC is not additive to IPC, suggesting that each works via a common pathway...
  82. ncbi request reprint Remote preconditioning reduces ischemic injury in the explanted heart by a KATP channel-dependent mechanism
    Steen B Kristiansen
    Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
    Am J Physiol Heart Circ Physiol 288:H1252-6. 2005
    ..In conclusion, the protective effect of remote preconditioning is memorized in the explanted heart by a mechanism that involves mitochondrial K(ATP) channels...
  83. ncbi request reprint The energy metabolism in the right and left ventricles of human donor hearts across transplantation
    Serban C Stoica
    Department of Transplantation, Papworth Hospital, Cambridge CB3 8RE, UK
    Eur J Cardiothorac Surg 23:503-12. 2003
    ..We aimed to describe the time-dependent variation in high energy phosphate (HEP) metabolism of the two ventricles, and the relationship with endothelial activation and postoperative functional recovery...
  84. ncbi request reprint Measured versus estimated oxygen consumption in ventilated patients with congenital heart disease: the validity of predictive equations
    Jia Li
    Department of Cardiology, Great Ormond Street Hospital, London, UK
    Crit Care Med 31:1235-40. 2003
    ..To determine the validity of predictive equations in calculating oxygen consumption (Vo(2)) in ventilated patients with congenital heart disease...
  85. ncbi request reprint Noninvasive assessment of left ventricular force-frequency relationships using tissue Doppler-derived isovolumic acceleration: validation in an animal model
    Michael Vogel
    Cardiothoracic Unit, Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Circulation 107:1647-52. 2003
    ..In this study, we assessed the usefulness of IVA to measure left ventricular (LV) contractile function and force-frequency relationships in an experimental preparation...
  86. ncbi request reprint Validation of myocardial acceleration during isovolumic contraction as a novel noninvasive index of right ventricular contractility: comparison with ventricular pressure-volume relations in an animal model
    Michael Vogel
    Cardiothoracic Unit, Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Circulation 105:1693-9. 2002
    ..In this study, we assessed the utility of IVA to measure right ventricular (RV) contractile function...
  87. ncbi request reprint Brain death leads to abnormal contractile properties of the human donor right ventricle
    Serban C Stoica
    Papworth Hospital, Cambridge, United Kingdom
    J Thorac Cardiovasc Surg 132:116-23. 2006
    ..Experimental and clinical data suggest that brain death predominantly affects the right ventricle. We aimed to investigate right ventricle function after brain death and during clinical transplantation with load-independent methods...
  88. ncbi request reprint Reduction of QRS duration following pulmonary valve replacement in tetralogy of Fallot: implications for arrhythmia reduction?
    Elizabeth A Stephenson
    Eur Heart J 26:863-4. 2005
  89. ncbi request reprint The endothelin antagonist BQ123 reduces pulmonary vascular resistance after surgical intervention for congenital heart disease
    Ingram Schulze-Neick
    Cardiac Intensive Care Unit, Department of Vascular Biology and Pharmacology, and Cardiothoracic Unit, Great Ormond Street Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 124:435-41. 2002
    ....
  90. ncbi request reprint Systemic ventricular function in patients with transposition of the great arteries after atrial repair: a tissue Doppler and conductance catheter study
    Michael Vogel
    GUCH Unit Heart Hospital, London, United Kingdom
    J Am Coll Cardiol 43:100-6. 2004
    ..The aim of this study was to assess the utility of tissue Doppler echocardiography in the setting of repaired transposition of the great arteries when the right ventricle (RV) functions as the systemic ventricle...
  91. ncbi request reprint Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease
    Ingram Schulze-Neick
    Abteilung für Angeborene Herzfehler, Deutsches Herzzentrum Berlin, Berlin, Germany
    Circulation 108:II167-73. 2003
    ..This study compares the effects of inhaled NO before and after the specific inhibition of the PDE-5 by intravenous sildenafil (Viagra) in pre- and postoperative children with increased PVR because of CHD...
  92. ncbi request reprint Letter regarding article by Lyseggen et al, "Myocardial acceleration during isovolumic contraction: relationship to contractility"
    Michael M H Cheung
    Circulation 112:e135; author reply e135-6. 2005
  93. ncbi request reprint Optimal timing of the Ross procedure in the management of chronic aortic incompetence in the young
    Michael M H Cheung
    Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Cardiol Young 13:253-7. 2003
    ..We retrospectively analysed case notes, and measured pre- and postoperative echocardiographic indexes of left ventricular function, in patients who had undergone the Ross procedure for chronic aortic incompetence...
  94. ncbi request reprint Noradrenaline use in the human donor and relationship with load-independent right ventricular contractility
    Serban C Stoica
    Transplant Unit, Papworth Hospital, Cambridge CB3 8RE, United Kingdom
    Transplantation 78:1193-7. 2004
    ..We aimed to describe the relationship between empirical noradrenaline treatment and donor heart function, described for the first time with load-independent indices of right ventricular contractility...
  95. ncbi request reprint Endothelial activation in the transplanted human heart from organ retrieval to 3 months after transplantation: an observational study
    Serban C Stoica
    Transplant Unit, Papworth Hospital, Cambridge, United Kingdom
    J Heart Lung Transplant 24:593-601. 2005
    ..We aimed to characterize the time course of endothelial activation in right ventricle (RV) and left ventricle (LV) during the acute phase of clinical transplantation...
  96. ncbi request reprint Images in cardiovascular medicine. Rupture of aneurysm of the right sinus of Valsalva into the right ventricular outflow tract: treatment with Amplatzer atrial septal occluder
    Seamus Cullen
    Grown Up Congenital Heart Department, Middlesex Hospital, London, UK
    Circulation 105:E1-2. 2002
  97. ncbi request reprint Left ventricular volume measurement in mice by conductance catheter: evaluation and optimization of calibration
    Jan Møller Nielsen
    Department of Cardiology B, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark
    Am J Physiol Heart Circ Physiol 293:H534-40. 2007
    ..Although V(CC) may be underestimated compared with MRI, optimized calibration techniques enable reliable volume estimation with the CC in mice...
  98. ncbi request reprint Percutaneous left ventricular "vent" insertion for left heart decompression during extracorporeal membrane oxygenation
    Michael M H Cheung
    Cardiothoracic Unit, Great Ormond Street Hospital, London, UK
    Pediatr Crit Care Med 4:447-9. 2003
    ..Description of a novel method of left ventricular decompression by a percutaneous technique under transthoracic echocardiographic guidance...
  99. ncbi request reprint From mesothelioma to cardiovascular protection via the phosphoinositide-3 kinase pathway: a new vista in cardiothoracic surgery
    Igor E Konstantinov
    J Thorac Cardiovasc Surg 131:509-10; author reply 510. 2006
  100. ncbi request reprint Transposition complexes in the adult: a changing perspective
    Tim S Hornung
    Green Lane Hospital, Green Lane West, Auckland 3, New Zealand
    Cardiol Clin 20:405-20. 2002
    ..It is vital that this evolving group of adult patients, as with most patients emerging from a childhood with other congenital heart malformations, is managed by cardiologists fully trained in congenital heart disease...
  101. ncbi request reprint Linking gene expression, nuclear factor kappa B, remote ischemic preconditioning, and transplantation: a quest for an elusive Holy Grail or a road to an amazing discovery?
    Igor E Konstantinov
    J Thorac Cardiovasc Surg 131:507-9. 2006