Eleanor Pullenayegum

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Longitudinal data subject to irregular observation: A review of methods with a focus on visit processes, assumptions, and study design
    Eleanor M Pullenayegum
    Child Health Evaluative Sciences, Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto
    Stat Methods Med Res 25:2992-3014. 2016
  2. ncbi request reprint Handling Regional Variation in Health State Preferences within a Country: A Methodological Framework
    Eleanor M Pullenayegum
    Hospital for Sick Children, Toronto, ON, Canada EP University of Toronto Dalla Lana School of Public Health, Toronto, ON, Canada KS University of Alberta School of Public Health, Edmonton, Alberta, Canada JJ McMaster University, Hamilton, ON, Canada FX
    Med Decis Making . 2016
  3. doi request reprint Quantifying Parameter Uncertainty in EQ-5D-3L Value Sets and Its Impact on Studies That Use the EQ-5D-3L to Measure Health Utility: A Bayesian Approach
    Eleanor M Pullenayegum
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada EMP Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada EMP Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada KKWC Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada FX Program for Health Economics and Outcome Measures, Hamilton, Ontario, Canada FX
    Med Decis Making 36:223-33. 2016
  4. doi request reprint Between-country heterogeneity in EQ-5D-3L scoring algorithms: how much is due to differences in health state selection?
    Eleanor M Pullenayegum
    Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, ON, Canada
    Eur J Health Econ 16:847-55. 2015
  5. pmc Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial
    Emma C Goodall
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Infect Dis 14:273. 2014
  6. doi request reprint A population-based cohort study of breastfeeding according to gestational age at term delivery
    Olha Lutsiv
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Ontario, Canada
    J Pediatr 163:1283-8. 2013
  7. doi request reprint How different are composite and traditional TTO valuations of severe EQ-5D-5L states?
    Feng Xie
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Qual Life Res 25:2101-8. 2016
  8. doi request reprint Determinants of time trade-off valuations for EQ-5D-5L health states: data from the Canadian EQ-5D-5L valuation study
    Fatima Al Sayah
    2 040 Li Ka Shing Centre for Health Research Innovation, School of Public Health, University of Alberta, Edmonton, AB, T6G 2E1, Canada
    Qual Life Res 25:1679-85. 2016
  9. doi request reprint Comparing EQ-5D valuation studies: a systematic review and methodological reporting checklist
    Feng Xie
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada FX, KP, Bd, EP
    Med Decis Making 34:8-20. 2014
  10. doi request reprint Scoring the 5-level EQ-5D: can latent utilities derived from a discrete choice model be transformed to health utilities derived from time tradeoff tasks?
    Eleanor Pullenayegum
    St Joseph s Healthcare Hamilton, Hamilton, ON, Canada
    Med Decis Making 33:567-78. 2013

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Longitudinal data subject to irregular observation: A review of methods with a focus on visit processes, assumptions, and study design
    Eleanor M Pullenayegum
    Child Health Evaluative Sciences, Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto
    Stat Methods Med Res 25:2992-3014. 2016
    ..Moreover, there are some commonly encountered visit scenarios that are not handled well by any method, and we make recommendations with regard to study design that would minimize the chances of these problematic visit scenarios arising...
  2. ncbi request reprint Handling Regional Variation in Health State Preferences within a Country: A Methodological Framework
    Eleanor M Pullenayegum
    Hospital for Sick Children, Toronto, ON, Canada EP University of Toronto Dalla Lana School of Public Health, Toronto, ON, Canada KS University of Alberta School of Public Health, Edmonton, Alberta, Canada JJ McMaster University, Hamilton, ON, Canada FX
    Med Decis Making . 2016
    ..When decisions are made at the regional level, regional variation in health state preferences may be important. We propose that shrinkage analysis and Bland-Altman plots can be a helpful way to investigate regional variation...
  3. doi request reprint Quantifying Parameter Uncertainty in EQ-5D-3L Value Sets and Its Impact on Studies That Use the EQ-5D-3L to Measure Health Utility: A Bayesian Approach
    Eleanor M Pullenayegum
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada EMP Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada EMP Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada KKWC Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada FX Program for Health Economics and Outcome Measures, Hamilton, Ontario, Canada FX
    Med Decis Making 36:223-33. 2016
    ..We hypothesize that this latter source is the major contributor to parameter uncertainty in the value sets...
  4. doi request reprint Between-country heterogeneity in EQ-5D-3L scoring algorithms: how much is due to differences in health state selection?
    Eleanor M Pullenayegum
    Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, ON, Canada
    Eur J Health Econ 16:847-55. 2015
    ..It is unclear how much of this variation is due to differences in health state selection, the relative frequencies with which health states were valued, and model diagnostics, rather than to genuine differences in population preferences...
  5. pmc Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial
    Emma C Goodall
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Infect Dis 14:273. 2014
    ....
  6. doi request reprint A population-based cohort study of breastfeeding according to gestational age at term delivery
    Olha Lutsiv
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Ontario, Canada
    J Pediatr 163:1283-8. 2013
    ..Because breastfeeding is the optimal form of infant feeding, this study was conducted to determine the effect of gestational age on breastfeeding in term infants...
  7. doi request reprint How different are composite and traditional TTO valuations of severe EQ-5D-5L states?
    Feng Xie
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Qual Life Res 25:2101-8. 2016
    ..We compared composite TTO (cTTO) with traditional TTO (tTTO) in valuing severe EQ-5D-5L health states...
  8. doi request reprint Determinants of time trade-off valuations for EQ-5D-5L health states: data from the Canadian EQ-5D-5L valuation study
    Fatima Al Sayah
    2 040 Li Ka Shing Centre for Health Research Innovation, School of Public Health, University of Alberta, Edmonton, AB, T6G 2E1, Canada
    Qual Life Res 25:1679-85. 2016
    ..Previous studies suggest that population subgroups have different perceptions of health, as well as different preferences for hypothetical health states...
  9. doi request reprint Comparing EQ-5D valuation studies: a systematic review and methodological reporting checklist
    Feng Xie
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada FX, KP, Bd, EP
    Med Decis Making 34:8-20. 2014
    ....
  10. doi request reprint Scoring the 5-level EQ-5D: can latent utilities derived from a discrete choice model be transformed to health utilities derived from time tradeoff tasks?
    Eleanor Pullenayegum
    St Joseph s Healthcare Hamilton, Hamilton, ON, Canada
    Med Decis Making 33:567-78. 2013
    ..Latent utilities must therefore be transformed to health utilities. This pilot study investigated the feasibility of performing such a transformation...
  11. pmc The reporting of observational clinical functional magnetic resonance imaging studies: a systematic review
    Qing Guo
    Department of Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada Biostatistics Unit, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    PLoS ONE 9:e94412. 2014
    ..The reporting quality of observational functional magnetic resonance imaging (fMRI) studies involving clinical participants is unclear...
  12. doi request reprint Patients' willingness-to-pay for an Alzheimer's disease medication in Canada
    Mark Oremus
    Department of Clinical Epidemiology and Biostatistics, McMaster University DTC, 50 Main Street East, 3rd Floor, Hamilton, ON, L8N 1E9, Canada
    Patient 6:161-8. 2013
    ..Alzheimer's disease (AD) is a neurodegenerative disorder highlighted by progressive declines in cognition and function...
  13. doi request reprint Caregivers' willingness-to-pay for Alzheimer's disease medications in Canada
    Mark Oremus
    McMaster University, Canada
    Dementia (London) 14:63-79. 2015
    ..Support for out-of-pocket payment and specific dollar amounts were highest when the medication did not involve adverse effects. Caregivers placed more value on the absence of adverse effects than on drug efficacy...
  14. pmc Can the general public use vignettes to discriminate between Alzheimer's disease health states?
    Mark Oremus
    School of Public Health and Health Systems, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada
    BMC Geriatr 16:36. 2016
    ..To help assess whether the general public can serve as an alternate source of proxy HRQoL estimates in AD, we examined whether the general public can use vignettes to discriminate between AD health states...
  15. pmc Impact of including or excluding both-armed zero-event studies on using standard meta-analysis methods for rare event outcome: a simulation study
    Ji Cheng
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    BMJ Open 6:e010983. 2016
    ..Our objective is to evaluate the impact of including or excluding both-armed zero-event (BA0E) studies in meta-analysis of RCTs with rare outcome events through a simulation study...
  16. doi request reprint Validation of Accelerometer Prediction Equations in Children with Chronic Disease
    Samantha Stephens
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Exerc Sci 28:117-32. 2016
    ..62-.88) (SE 0.45-0.78). In conclusion, poor agreement was demonstrated using current prediction equations in children with chronic conditions. Disease-specific equations and cut points were developed. ..
  17. ncbi request reprint Underestimation of Variance of Predicted Health Utilities Derived from Multiattribute Utility Instruments: The Use of Multiple Imputation as a Potential Solution
    Kelvin K W Chan
    Sunnybrook Health Sciences Centre, Division of Medical Oncology, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada KKWC Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada KKWC, ARW, EP Canadian Centre for Applied Research in Cancer Control, Canada KKWC Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada FX Father Sean O Sullivan Research Centre, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada FX Program for Health Economics and Outcome Measures, Hamilton, Ontario, Canada FX Ontario Child Health Support Unit, SickKids Research Institute, Toronto, Ontario, Canada ARW Program in Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada EP
    Med Decis Making . 2016
    ..The aim of this study is to examine the use of multiple imputation as a method to account for this uncertainty of MAUI scoring algorithms...
  18. doi request reprint What do Canadians think about physician-pharmaceutical industry interactions?
    Anne Holbrook
    Division of Clinical Pharmacology and Therapeutics, Department of Medicine, McMaster University, Canada Centre for Evaluation of Medicines, St Joseph s Healthcare Hamilton, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Canada Electronic address
    Health Policy 112:255-63. 2013
    ..Many health professional and regulatory groups have guidelines for identifying, disclosing and managing potential conflicts of interest (COI). The opinions of the Canadian public regarding what constitutes COI are unknown...
  19. pmc Impact of tuberculosis on mortality among HIV-infected patients receiving antiretroviral therapy in Uganda: a prospective cohort analysis
    Rong Chu
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    AIDS Res Ther 10:19. 2013
    ..Tuberculosis (TB) disease affects survival among HIV co-infected patients on antiretroviral therapy (ART). Yet, the magnitude of TB disease on mortality is poorly understood...
  20. doi request reprint A systematic review of the reporting of sample size calculations and corresponding data components in observational functional magnetic resonance imaging studies
    Qing Guo
    Department of Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada Biostatistics Unit, St Joseph s Healthcare Hamilton, Hamilton, ON, Canada Electronic address
    Neuroimage 86:172-81. 2014
    ..We suggest routine reporting of these quantities, and recommend strategies for reducing bias in their reported values. ..
  21. pmc A Time Trade-off-derived Value Set of the EQ-5D-5L for Canada
    Feng Xie
    Department of Clinical Epidemiology and Biostatistics, McMaster University Program for Health Economics and Outcome Measures PHENOM Father Sean O Sullivan Research Centre, St Joseph s Healthcare, Hamilton Child Health Evaluative Sciences Group, Hospital for Sick Kids, Toronto, ON School of Population and Public Health, University of British Columbia, Vancouver, BC School of Public Health, University of Alberta, Edmonton, AB School of Medicine, Universite de Montreal, Montreal, QC, Canada
    Med Care 54:98-105. 2016
    ..The 5-level version of the EQ-5D (EQ-5D-5L) was recently developed. A number of preference-based scoring systems are being developed for several countries around the world...
  22. doi request reprint Shared electronic vascular risk decision support in primary care: Computerization of Medical Practices for the Enhancement of Therapeutic Effectiveness (COMPETE III) randomized trial
    Anne Holbrook
    Division of Clinical Pharmacology and Therapeutics, 105 Main Street E, Hamilton, Ontario, Canada
    Arch Intern Med 171:1736-44. 2011
    ..However, very few high-quality studies are set in routine, community-based clinical care, and no consistent evidence of an effect on patient outcomes has been found...
  23. doi request reprint Estimation of the impact of diabetes-related complications on health utilities for patients with type 2 diabetes in Ontario, Canada
    Daria J O'Reilly
    Programs for Assessment of Technology in Health Research Institute, St Joseph s Healthcare, 25 Main Street West, Suite 2000, Hamilton, ON, L8P 1H1, Canada
    Qual Life Res 20:939-43. 2011
    ..The goal of this study was to analyze health-related quality of life (HRQL) data from a Canadian population with type 2 diabetes in order to estimate the disutility associated with experiencing a diabetes-related complication...
  24. doi request reprint Eliciting preferences to the EQ-5D-5L health states: discrete choice experiment or multiprofile case of best-worst scaling?
    Feng Xie
    Centre for Evaluation of Medicines, St Joseph s Healthcare, Hamilton, ON, Canada
    Eur J Health Econ 15:281-8. 2014
    ..The DCE is more feasible and reliable than the BWS in valuing the EQ-5D-5L. Future studies could focus on comparing the consistency and accuracy of these techniques in predicting the health utilities of the EQ-5D-5L...
  25. doi request reprint Cardiovascular and cerebrovascular outcomes of long-term angiotensin receptor blockade: meta-analyses of trials in essential hypertension
    Leo Akioyamen
    Faculty of Medicine, University of Toronto, Toronto, ON, Canada School of Nursing, McMaster University, Hamilton, ON, Canada
    J Am Soc Hypertens 10:55-69.e1. 2016
    ..Long-term ARB treatment may also confer enhanced protection against stroke but not other cardiovascular outcomes relative to placebo...
  26. ncbi request reprint EQ-5D-derived health utilities and minimally important differences for chronic health conditions: 2011 Commonwealth Fund Survey of Sicker Adults in Canada
    Kate Tsiplova
    Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    Qual Life Res 25:3009-3016. 2016
    ....
  27. doi request reprint Transforming Latent Utilities to Health Utilities: East Does Not Meet West
    Feng Xie
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Health Econ . 2016
    ..While a global transformation function is not recommended, results suggest that regional transformation functions could potentially be used to derive health utilities from DCE data. Copyright © 2016 John Wiley & Sons, Ltd...
  28. pmc Knowledge translation tool to improve pregnant women's awareness of gestational weight gain goals and risks of gaining outside recommendations: a non-randomized intervention study
    Sarah D McDonald
    Department of Obstetrics and Gynecology, McMaster University, 1280 Main St West, Hamilton, ON, L8S 4L8, Canada
    BMC Pregnancy Childbirth 15:105. 2015
    ..We piloted the tool on the impact on women's knowledge of gestational weight gain (GWG) goals, and evaluated its potential in promoting appropriate knowledge about GWG within the 2009 Institute of Medicine guidelines...
  29. doi request reprint Acute rehabilitation practices in critically ill children: a multicenter study
    Karen Choong
    1Department of Pediatrics, Critical Care, Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada 2Department of Clinical Epidemiology and Biostatistics, McMaster University and Biostatistics Unit, St Joseph s Healthcare, Hamilton, ON, Canada 3Department of Pediatrics and Critical Care, Children s Hospital, London Health Sciences Centre, London, ON, Canada 4Department of Pediatrics and Critical Care, The Hospital for Sick Children, Toronto, ON, Canada 5Department of Pediatrics and Critical Care, Stollery Children s Hospital, University of Alberta, Edmonton, AB, Canada 6Department of Pediatrics, CHU Ste Justine, Montreal, QC, Canada 7Department of Pediatrics, Epidemiology and Biostatistics, Children s Hospital of Eastern Ontario, Ottawa, ON, Canada 8Child Health Evaluative Sciences, Hospital for Sick Children and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada 9Children s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
    Pediatr Crit Care Med 15:e270-9. 2014
    ..To evaluate acute rehabilitation practices in pediatric critical care units across Canada...
  30. pmc Closing the personalized medicine information gap: HER2 test documentation practice
    Ilia L Ferrusi
    Centre for Evaluation of Medicines, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    Am J Manag Care 19:838-44. 2013
    ..Pathologists routinely perform HER2 assessment for all tumors > 1 cm, and pathology is reported centrally to the provincial cancer registry...
  31. doi request reprint Prevalence and predictors of exclusive breastfeeding at hospital discharge
    Sarah D McDonald
    Department of Obstetrics and Gynecology, McMaster University, Canada
    Obstet Gynecol 119:1171-9. 2012
    ..To estimate the population-based prevalence and predictors of exclusive breastfeeding at hospital discharge in singleton and twin term newborns...
  32. pmc An empirical comparison of methods for analyzing correlated data from a discrete choice survey to elicit patient preference for colorectal cancer screening
    Ji Cheng
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    BMC Med Res Methodol 12:15. 2012
    ....
  33. pmc How does the canadian general public rate moderate Alzheimer's disease?
    Jean Eric Tarride
    Programs for Assessment of Technology in Health PATH Research Institute, St Joseph s Healthcare Hamilton, 25 Main Street West, Suite 2000, Hamilton, ON, Canada L8P 1H1
    J Aging Res 2011:682470. 2011
    ..Conclusion. Members of the general public may serve as an alternative to patients and caregivers in the elicitation of health-related quality of life in AD...
  34. pmc The relative efficacy of nine osteoporosis medications for reducing the rate of fractures in post-menopausal women
    Robert B Hopkins
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 12:209. 2011
    ..The purpose was to estimate the relative efficacy of reduction of fractures in post-menopausal women, and to assess robustness of the results...
  35. doi request reprint Underestimation of uncertainties in health utilities derived from mapping algorithms involving health-related quality-of-life measures: statistical explanations and potential remedies
    Kelvin K W Chan
    Sunnybrook Health Sciences Centre, Division of Medical Oncology, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada KKWC Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada KKWC, ARW Department of Surgery, McMaster University, Hamilton, Ontario, Canada MG Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada EP
    Med Decis Making 34:863-72. 2014
    ..However, the variances of the mapping-derived HUs are observed to be smaller than those of the actual HUs...