Christoph Licht

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. doi Remission of resistant MPGN type I with mycophenolate mofetil and steroids
    Sudarsana De
    Division of Nephrology, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 24:597-600. 2009
  2. pmc The global aHUS registry: methodology and initial patient characteristics
    Christoph Licht
    Division of Nephrology and Program in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    BMC Nephrol 16:207. 2015
  3. pmc The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome
    Neesha Hussain
    Division of Nephrology, The Hospital for Sick Children, and University of Toronto, Dalla Lana School of Public Health, 555 University Avenue, M5G 1X8, Toronto, ON, Canada
    BMC Nephrol 14:25. 2013
  4. ncbi Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis
    Christoph Licht
    The Hospital for Sick Children, Division of Nephrology, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8
    Thromb Haemost 101:271-8. 2009
  5. doi Platelet-associated complement factor H in healthy persons and patients with atypical HUS
    Christoph Licht
    Department of Paediatrics, Division of Nephrology, Program in Cell Biology, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada
    Blood 114:4538-45. 2009
  6. doi Genetics of proteinuria: an overview of gene mutations associated with nonsyndromic proteinuric glomerulopathies
    Tino D Piscione
    Division of Nephrology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada
    Adv Chronic Kidney Dis 18:273-89. 2011
  7. doi C3 Glomerulopathy and post-infectious glomerulonephritis define a disease spectrum
    Badria Al-Ghaithi
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 31:2079-86. 2016
  8. pmc NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways
    Joshua Yuen
    Cell Biology Program, The Hospital for Sick Children Research Institute, Toronto, ON, Canada Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Front Immunol 7:137. 2016
  9. doi Successful treatment of DEAP-HUS with eculizumab
    Damien Noone
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 29:841-51. 2014
  10. doi The alternative pathway of complement and the thrombotic microangiopathies
    Chia Wei Teoh
    Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada Research Institute, Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Transfus Apher Sci 54:220-31. 2016

Collaborators

  • Walter H A Kahr
  • Nades Palaniyar
  • Veronique Fremeaux-Bacchi
  • Peter F Zipfel
  • Gianluigi Ardissino
  • Sally Johnson
  • Chantal Loirat
  • Giuseppe Remuzzi
  • Ling Li
  • Yahsou Delmas
  • Magdalena Riedl
  • Damien Noone
  • Tino D Piscione
  • Fred G Pluthero
  • Paul Thorner
  • Chia Wei Teoh
  • Joshua Yuen
  • Damien G Noone
  • Badria Al-Ghaithi
  • Wesley Hayes
  • Michael Kirschfink
  • Diane Hebert
  • Neesha Hussain
  • Swasti Chaturvedi
  • Sudarsana De
  • Rahul Chanchlani
  • Ulrich Budde
  • Yi Quan
  • Marina Ulanova
  • Paula James
  • Lily Lu
  • M Kathryn Liszewski
  • Sonja Schneppenheim
  • Reinhard Schneppenheim
  • Ahmed Cherry
  • Mackenzie L Bowman
  • John P Atkinson
  • David N Douda
  • Steve Balgobin
  • Simon C Ling
  • Janusz Feber
  • Sibylle Tschumi
  • Denis F Geary
  • Aoife Waters
  • Viral P Patel
  • Rulan S Parekh
  • Jovanka Vasilevska-Ristovska
  • J Anastasia Zello
  • Christopher D Battiston
  • Tonny M Banh
  • Pranali Patel
  • Valerie Langlois
  • Daniel Cattran
  • Dana Al-Nabhani

Detail Information

Publications16

  1. doi Remission of resistant MPGN type I with mycophenolate mofetil and steroids
    Sudarsana De
    Division of Nephrology, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 24:597-600. 2009
    ..In summary, this case suggests that there may be potential benefit for use of MMF in children with refractory MPGN I, which supports the rationale for prospectively evaluating MMF treatment in a treatment trial of refractory MPGN I...
  2. pmc The global aHUS registry: methodology and initial patient characteristics
    Christoph Licht
    Division of Nephrology and Program in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    BMC Nephrol 16:207. 2015
    ....
  3. pmc The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome
    Neesha Hussain
    Division of Nephrology, The Hospital for Sick Children, and University of Toronto, Dalla Lana School of Public Health, 555 University Avenue, M5G 1X8, Toronto, ON, Canada
    BMC Nephrol 14:25. 2013
    ....
  4. ncbi Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis
    Christoph Licht
    The Hospital for Sick Children, Division of Nephrology, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8
    Thromb Haemost 101:271-8. 2009
    ..A better understanding of the pathogenesis of MPGN is crucial for the development of novel, specific treatment strategies...
  5. doi Platelet-associated complement factor H in healthy persons and patients with atypical HUS
    Christoph Licht
    Department of Paediatrics, Division of Nephrology, Program in Cell Biology, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada
    Blood 114:4538-45. 2009
    ..This CFH-dependent response did not involve P-selectin mobilization, indicating a complement-induced platelet response distinct from alpha-granule secretion...
  6. doi Genetics of proteinuria: an overview of gene mutations associated with nonsyndromic proteinuric glomerulopathies
    Tino D Piscione
    Division of Nephrology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada
    Adv Chronic Kidney Dis 18:273-89. 2011
    ..This review summarizes gene mutations which are known to be associated with proteinuric glomerulopathies in children and adults...
  7. doi C3 Glomerulopathy and post-infectious glomerulonephritis define a disease spectrum
    Badria Al-Ghaithi
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 31:2079-86. 2016
    ..We hypothesized that PIGN and C3G define a disease spectrum, and that in the past there may be some children with C3G who were misclassified with PIGN before C3G was described as a separate disease entity...
  8. pmc NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways
    Joshua Yuen
    Cell Biology Program, The Hospital for Sick Children Research Institute, Toronto, ON, Canada Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Front Immunol 7:137. 2016
    ..This unique mechanism may play important roles in host defense and help to explain specific roles of complement activation in NET-related diseases. ..
  9. doi Successful treatment of DEAP-HUS with eculizumab
    Damien Noone
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 29:841-51. 2014
    ..CFH autoantibodies are found in 10-15 % of aHUS patients and occur--so far unexplained--almost exclusively in the background of CFHR1 or CFHR3/CFHR1 deletions...
  10. doi The alternative pathway of complement and the thrombotic microangiopathies
    Chia Wei Teoh
    Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada Research Institute, Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Transfus Apher Sci 54:220-31. 2016
    ....
  11. ncbi Pathogenesis and treatment of ANCA-associated vasculitis-a role for complement
    Damien Noone
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol . 2016
    ..Targeting the activation of neutrophils by the anaphylatoxin C5a may serve as an additional therapeutic strategy, however the results of clinical studies are awaited...
  12. doi Von Willebrand factor regulates complement on endothelial cells
    Damien G Noone
    Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Kidney Int 90:123-34. 2016
    ..However, our findings also identify VWF as a new complement regulator on vascular endothelial cells and suggest that VWF has a protective effect on endothelial cells and complement-mediated injury. ..
  13. ncbi C3 Glomerulopathy
    Magdalena Riedl
    Cell Biology Program of the Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 32:43-57. 2017
    ..The new classification not only marks significant advancement in the pathogenic understanding of this rare disease, but also opens doors towards more specific treatment with the potential for improved outcomes...
  14. pmc Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies
    Christoph Licht
    Division of Nephrology and Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Kidney Int 87:1061-73. 2015
    ..Eculizumab was well tolerated, with no new safety concerns or meningococcal infections. Thus, a 2-year analysis found that the earlier clinical benefits achieved by eculizumab treatment of aHUS were maintained at 2 years of follow-up. ..
  15. doi Eculizumab hepatotoxicity in pediatric aHUS
    Wesley Hayes
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 30:775-81. 2015
    ..Eculizumab is a humanized anti-C5 antibody approved for the treatment of atypical hemolytic uremic syndrome (aHUS). Its use is increasing in children following reports of its safety and efficacy...
  16. doi Hemolytic uremic syndrome caused by Bordetella pertussis infection
    Swasti Chaturvedi
    Department of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Nephrol 25:1361-4. 2010
    ..Despite negative results in this case, in-depth workup of the complement system may be important to guide treatment efforts and strategies...