Mary Corey

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Power considerations for studies of lung function in cystic fibrosis
    Mary Corey
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada
    Proc Am Thorac Soc 4:334-7. 2007
  2. doi request reprint Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis
    Ruslan Dorfman
    Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 46:385-92. 2011
  3. doi request reprint Does extensive genotyping and nasal potential difference testing clarify the diagnosis of cystic fibrosis among patients with single-organ manifestations of cystic fibrosis?
    Chee Y Ooi
    Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada
    Thorax 69:254-60. 2014
  4. doi request reprint Field testing of the 2006 World Health Organization growth charts from birth to 2 years: assessment of hospital undernutrition and overnutrition rates and the usefulness of BMI
    Andrea Nash
    Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    JPEN J Parenter Enteral Nutr 32:145-53. 2008
  5. doi request reprint Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis
    Chee Y Ooi
    Physiology and Experimental Medicine, The Research Institute, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Gastroenterology 140:153-61. 2011
  6. ncbi request reprint Enteric-coated pancreatic enzyme with bicarbonate is equal to standard enteric-coated enzyme in treating malabsorption in cystic fibrosis
    Daina Kalnins
    Division of Respiratory Medicine, Department of Pediatrics, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 42:256-61. 2006
  7. ncbi request reprint Mapping of genetic factors influencing the weight of cystic fibrosis knockout mice
    Christina K Haston
    Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Mamm Genome 13:614-8. 2002
  8. pmc Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis
    Lei Sun
    Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 44:562-9. 2012
  9. pmc Mutations in the cystic fibrosis transmembrane regulator gene and in vivo transepithelial potentials
    Michael Wilschanski
    The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Am J Respir Crit Care Med 174:787-94. 2006
  10. doi request reprint Socioeconomic status and risk of hospitalization among individuals with cystic fibrosis in Ontario, Canada
    Anne Stephenson
    Adult CF Program, St Michael s Hospital, Toronto, Ontario, Canada
    Pediatr Pulmonol 46:376-84. 2011

Detail Information

Publications50

  1. ncbi request reprint Power considerations for studies of lung function in cystic fibrosis
    Mary Corey
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada
    Proc Am Thorac Soc 4:334-7. 2007
    ..Computerized algorithms can provide objective scores, but it will be an ongoing challenge to confirm the validity of candidate measures and their relationship to CF lung disease...
  2. doi request reprint Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis
    Ruslan Dorfman
    Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 46:385-92. 2011
    ....
  3. doi request reprint Does extensive genotyping and nasal potential difference testing clarify the diagnosis of cystic fibrosis among patients with single-organ manifestations of cystic fibrosis?
    Chee Y Ooi
    Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada
    Thorax 69:254-60. 2014
    ..However, the diagnostic yield of extensive genotyping and NPD and the concordance between NPD and the sweat test have not been carefully evaluated...
  4. doi request reprint Field testing of the 2006 World Health Organization growth charts from birth to 2 years: assessment of hospital undernutrition and overnutrition rates and the usefulness of BMI
    Andrea Nash
    Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    JPEN J Parenter Enteral Nutr 32:145-53. 2008
    ..The interchangeability of the WHO weight-for-length and WHO BMI percentiles was also assessed...
  5. doi request reprint Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis
    Chee Y Ooi
    Physiology and Experimental Medicine, The Research Institute, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Gastroenterology 140:153-61. 2011
    ..We investigated whether CFTR genotypes determine the risk of pancreatitis in patients with cystic fibrosis (CF)...
  6. ncbi request reprint Enteric-coated pancreatic enzyme with bicarbonate is equal to standard enteric-coated enzyme in treating malabsorption in cystic fibrosis
    Daina Kalnins
    Division of Respiratory Medicine, Department of Pediatrics, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 42:256-61. 2006
    ..5 mEq of bicarbonate per capsule with a conventional enteric-coated enzyme (EC-PE) capsule in cystic fibrosis patients with signs or symptoms of moderate to severe malabsorption...
  7. ncbi request reprint Mapping of genetic factors influencing the weight of cystic fibrosis knockout mice
    Christina K Haston
    Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Mamm Genome 13:614-8. 2002
    ..Further study of these putative CF body weight modifiers may provide insight on the pathogenesis of cystic fibrosis...
  8. pmc Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis
    Lei Sun
    Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 44:562-9. 2012
    ..0002; testing of 155 apical membrane genes jointly and in replication, P = 0.022). These findings suggest that modulating activities of apical membrane constituents could complement current therapeutic paradigms for cystic fibrosis...
  9. pmc Mutations in the cystic fibrosis transmembrane regulator gene and in vivo transepithelial potentials
    Michael Wilschanski
    The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Am J Respir Crit Care Med 174:787-94. 2006
    ..To examine the relationship between cystic fibrosis transmembrane regulator gene mutations (CFTR) and in vivo transepithelial potentials...
  10. doi request reprint Socioeconomic status and risk of hospitalization among individuals with cystic fibrosis in Ontario, Canada
    Anne Stephenson
    Adult CF Program, St Michael s Hospital, Toronto, Ontario, Canada
    Pediatr Pulmonol 46:376-84. 2011
    ..The objective of this study was to assess the effect of SES on annual hospitalization rates in a large cohort of pediatric and adult CF subjects under a universal health care system...
  11. ncbi request reprint Cholecalciferol significantly increases 25-hydroxyvitamin D concentrations in adults with cystic fibrosis
    Anne Stephenson
    Toronto Adult Cystic Fibrosis Centre, St Michael s Hospital, Toronto, Canada
    Am J Clin Nutr 85:1307-11. 2007
    ..Vitamin D deficiency is increasingly being recognized and treated in patients with cystic fibrosis, although the treatment guidelines are not proven and the effectiveness of vitamin D preparations is untested...
  12. pmc Complex two-gene modulation of lung disease severity in children with cystic fibrosis
    Ruslan Dorfman
    Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Invest 118:1040-9. 2008
    ....
  13. ncbi request reprint Failure of conventional strategies to improve nutritional status in malnourished adolescents and adults with cystic fibrosis
    Daina Kalnins
    Division of Respiratory Medicine, and Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 147:399-401. 2005
    ..1 years) with cystic fibrosis. Energy intake and nutritional status were evaluated over 3 months. There was no significant change in energy intake or percent ideal body weight in either group...
  14. ncbi request reprint Amiloride-insensitive nasal potential difference varies with the menstrual cycle in cystic fibrosis
    Neil B Sweezey
    Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 42:519-24. 2007
    ..One potential explanation is that gender hormones (sex steroids) may modulate the severity of CF lung disease, the principal cause of mortality in CF, by altering respiratory transepithelial ion transport...
  15. doi request reprint Higher risk of hospitalization among females with cystic fibrosis
    Anne Stephenson
    Adult CF Program, St Michael s Hospital, Toronto, ON, Canada
    J Cyst Fibros 10:93-9. 2011
    ..The objective was to assess sex-specific differences in hospitalization rates after adjusting for clinically important factors within a universal health care system...
  16. ncbi request reprint Glucose intolerance in children with cystic fibrosis
    Melinda P Solomon
    Departments of Genetics and Population Health Sciences, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Pediatr 142:128-32. 2003
    ..To evaluate the relations among glucose intolerance, genotype, and exocrine pancreatic status in patients with cystic fibrosis (CF)...
  17. doi request reprint Pattern of growth of very low birth weight preterm infants, assessed using the WHO Growth Standards, is associated with neurodevelopment
    Andrea Nash
    Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada
    Appl Physiol Nutr Metab 36:562-9. 2011
    ..In conclusion, a decelerated pattern of weight gain, determined with the WHO-GS, but not the CDC-GRC, is associated with poorer neurodevelopment scores on the BSID-III than a pattern of sustained growth...
  18. ncbi request reprint Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis
    Satti Beharry
    Program in Integrative Biology, The Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G839-48. 2007
    ..The potential therapeutic benefits of DHA in severe CF-associated liver disease remain to be explored...
  19. pmc A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis genetic modifier studies
    Chelsea Taylor
    Child Health Evaluative Sciences Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 46:857-69. 2011
    ..This approach will facilitate large-scale genetic and environmental epidemiological studies which will provide targeted therapeutic pathways for the clinical benefit of patients with CF...
  20. pmc Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results
    Ruslan Dorfman
    Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada
    Hum Genet 126:763-78. 2009
    ..002), warranting further follow-up studies. Our linkage approach was used to direct our fine-mapping studies, which uncovered two potential modifier genes worthy of follow-up...
  21. ncbi request reprint Prevalence of vertebral fractures in adults with cystic fibrosis and their relationship to bone mineral density
    Anne Stephenson
    Department of Respirology, University of Toronto, ON, Canada
    Chest 130:539-44. 2006
    ..The objectives of this study were to determine the prevalence of morphometric vertebral fractures in a large cohort of adult cystic fibrosis (CF) patients, and to examine the association between fractures and bone mineral density (BMD)...
  22. ncbi request reprint Comparison of spirometric reference values
    Padmaja Subbarao
    Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Pediatr Pulmonol 37:515-22. 2004
    ..Extrapolating reference equations beyond the age range of subjects used to generate then is not recommended...
  23. ncbi request reprint Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice
    Christina K Haston
    Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Mamm Genome 13:605-13. 2002
    ..Most of these putative loci are specific to the sex of the animals. These results suggest that multiple genes can influence the severity of CF lung disease in mice...
  24. ncbi request reprint Growth assessment in infants and toddlers using three different reference charts
    Andrea Nash
    Department of Newborn and Developmental Paediatrics, Sunnybrook and Women s College Health Science Centre, 76 Grenville Street, Toronto, Canada
    J Pediatr Gastroenterol Nutr 40:283-8. 2005
    ....
  25. ncbi request reprint Cystic fibrosis birth rates in Canada: a decreasing trend since the onset of genetic testing
    Annie Dupuis
    The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Pediatr 147:312-5. 2005
    ....
  26. doi request reprint Longitudinal relationship between physical activity and lung health in patients with cystic fibrosis
    Jane E Schneiderman
    The Hospital for Sick Children, Toronto
    Eur Respir J 43:817-23. 2014
    ....
  27. pmc Recursive partitioning models for linkage in COGA data
    Wei Xu
    Genetics and Genomic Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Genet 6:S38. 2005
    ..However, using the RP model, several suggestive regions were found on chromosomes 2, 4, 6, 14, and 20, with detection of associated covariates such as sex and age at onset...
  28. ncbi request reprint Combining unprotected pancreatic enzymes with pH-sensitive enteric-coated microspheres does not improve nutrient digestion in patients with cystic fibrosis
    Daina Kalnins
    Division of Respiratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    J Pediatr 146:489-93. 2005
    ..To assess the efficacy of combining unprotected powder enzymes and oral enteric-coated microsphere (ECM) and to ECM alone in treating nutrient maldigestion in patients with cystic fibrosis...
  29. ncbi request reprint The repeatability of forced expiratory volume measurements in adults with cystic fibrosis
    Matthew B Stanbrook
    Adult Cystic Fibrosis Program, St Michael s Hospital, Toronto, ON, Canada
    Chest 125:150-5. 2004
    ..To determine the repeatability of measurements of FEV(1) in adults with lung disease due to cystic fibrosis (CF)...
  30. ncbi request reprint Increased vitamin A and E levels in adult cystic fibrosis patients after lung transplantation
    Anne Stephenson
    Toronto Adult CF Centre, St Michael s Hospital, Toronto, ON, Canada
    Transplantation 79:613-5. 2005
    ..Although the etiology of this novel finding is unclear, possibilities include altered absorption, drug interactions, impaired retinol metabolism, or increased hepatic synthesis of retinol binding protein...
  31. ncbi request reprint Disease severity in siblings with cystic fibrosis
    Sherri L Katz
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 37:407-12. 2004
    ..The apparent finding of younger age at first isolation of pathogens from respiratory cultures in younger siblings is likely because many older siblings were already infected with these organisms at time of diagnosis...
  32. doi request reprint Non-tuberculous mycobacteria in children with cystic fibrosis: isolation, prevalence, and predictors
    Dhenuka K Radhakrishnan
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Pediatr Pulmonol 44:1100-6. 2009
    ..Additionally, we compared two different sputum decontamination methods before mycobacterial culture...
  33. ncbi request reprint Determination of maximal voluntary ventilation in children with cystic fibrosis
    Richard Stein
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 35:467-71. 2003
    ..Whenever possible, we recommend MVV be determined by the sprint method in accordance with ATS guidelines. If this is not feasible, we recommend considering the new prediction equation...
  34. ncbi request reprint Evaluation of the ambulatory and home care record: Agreement between self-reports and administrative data
    Denise N Guerriere
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario M5T 3M6, Canada
    Int J Technol Assess Health Care 22:203-10. 2006
    ..This study evaluated a newly developed tool, the Ambulatory and Home Care Record (AHCR), which comprehensively evaluates costs incurred by the health system and care recipients and their unpaid caregivers...
  35. ncbi request reprint Towards the ideal quantitative pancreatic function test: analysis of test variables that influence validity
    Susanne Schibli
    Department of Gastroenterology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Gastroenterol Hepatol 4:90-7. 2006
    ..Although pancreatic stimulation tests quantify acinar and ductal exocrine pancreatic function, no standard methodology exists. We evaluated the impact of several variables on test accuracy...
  36. doi request reprint Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients
    Yvonne C W Yau
    Division of Microbiology, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada Electronic address
    J Cyst Fibros 14:262-6. 2015
    ..Biofilm antimicrobial susceptibility testing did not lead to improved microbiological or clinical outcomes compared to conventional methods in the treatment of pulmonary exacerbations in CF patients with chronic P. aeruginosa...
  37. pmc The genetics of cross-sectional and longitudinal body mass index
    Lisa Strug
    University of Toronto, Public Health Sciences, 12 Queen s Park Crescent West, Toronto, Ontario, Canada
    BMC Genet 4:S14. 2003
    ..77 at GATA8A05. Our analysis shows how omitting the decline phase of BMI in the definition of obesity phenotypes can result in evidence for linkage which might have been otherwise overlooked...
  38. ncbi request reprint Evaluation of bronchial constriction in children with cystic fibrosis after inhaling two different preparations of tobramycin
    Ghassan A Alothman
    Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, ON, Canada
    Chest 122:930-4. 2002
    ....
  39. ncbi request reprint Confidence intervals for candidate gene effects and environmental factors in population-based association studies of families
    Janey Shin
    Eli Lilly Canada, Toronto, Canada
    Ann Hum Genet 71:421-32. 2007
    ..Although the bootstrap approach was more computationally demanding, it outperformed the GEE in terms of confidence interval coverage probabilities for all sample sizes considered...
  40. ncbi request reprint Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis
    Carol Durno
    Programmes in Integrative Biology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Gastroenterology 123:1857-64. 2002
    ..Pancreatitis is known to occur in some patients with cystic fibrosis (CF), but the prevalence, natural history, and genotypic basis are unclear. We examined a well-defined cohort of patients with CF to answer these questions...
  41. ncbi request reprint Alpha 1-antitrypsin deficiency alleles in cystic fibrosis lung disease
    Despina D Frangolias
    McDonald Research Laboratories iCAPTURE Centre, Division of Biochemical Diseases, Department of Pediatrics, University of British Columbia, B C Children s Hospital, Vancouver, Canada
    Am J Respir Cell Mol Biol 29:390-6. 2003
    ..Body mass index was a significant predictor of alpha1-AT levels during exacerbations. alpha1-AT genotype is not a major contributor to the variability of pulmonary disease severity in CF...
  42. ncbi request reprint How useful is fecal pancreatic elastase 1 as a marker of exocrine pancreatic disease?
    Satti Beharry
    Department of Pediatrics, The University of Toronto, Ontario, Canada
    J Pediatr 141:84-90. 2002
    ..To evaluate the role of fecal elastase 1 (E1) as a marker of exocrine pancreatic insufficiency (PI)...
  43. pmc Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada
    David P Speert
    University of British Columbia and Children s and Women s Health Centre of British Columbia, Vancouver, Canada
    Emerg Infect Dis 8:181-7. 2002
    ..cepacia complex from genomovar III are the most potentially transmissible and that the B. cepacia epidemic strain marker is a robust marker for transmissibility...
  44. ncbi request reprint Clinical manifestations of cystic fibrosis among patients with diagnosis in adulthood
    Marita Gilljam
    Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Chest 126:1215-24. 2004
    ..To define the clinical characteristics and diagnostic parameters of patients with cystic fibrosis (CF) diagnosed in adulthood...
  45. ncbi request reprint High-dose ibuprofen in cystic fibrosis: Canadian safety and effectiveness trial
    Larry C Lands
    Department of Pediatrics, Montreal Children s Hospital McGill University Health Center, Montreal, Quebec, Canada
    J Pediatr 151:249-54. 2007
    ..To assess the effectiveness and safety of high-dose ibuprofen when used as part of routine therapy in patients with cystic fibrosis (CF)...
  46. ncbi request reprint Realities of expectorated sputum collection in the pediatric cystic fibrosis clinic
    Dhenuka K Radhakrishnan
    Department of Pediatrics, University of Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 161:603-6. 2007
    ..To determine the proportion of pediatric patients with cystic fibrosis who do not produce expectorated sputum during routine ambulatory clinic visits and to identify clinical predictors of these patients...
  47. ncbi request reprint The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitis
    Michele D Bishop
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard School of Medicine, Boston, MA, USA
    Hum Genet 118:372-81. 2005
    ..We concluded that extensive genotyping and ion channel testing are useful to confirm or exclude the diagnosis of CF in the majority of patients with idiopathic pancreatitis...
  48. ncbi request reprint Genetic and physiologic correlates of longitudinal immunoreactive trypsinogen decline in infants with cystic fibrosis identified through newborn screening
    Marci K Sontag
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Pediatr 149:650-657. 2006
    ..To characterize the time course and physiologic significance of decline in serum immunoreactive trypsinogen (IRT) levels in infants with cystic fibrosis (CF) by mode of diagnosis and genotype, and to examine IRT heritability...
  49. ncbi request reprint Genetic modifiers of lung disease in cystic fibrosis
    Mitchell L Drumm
    Department of Pediatrics, Case Western Reserve University, Cleveland, USA
    N Engl J Med 353:1443-53. 2005
    ..Polymorphisms in genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene may modify the severity of pulmonary disease in patients with cystic fibrosis...
  50. doi request reprint Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review
    Virginia A Stallings
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, 3535 Market St, Philadelphia, PA 19104, USA
    J Am Diet Assoc 108:832-9. 2008
    ..These Registry data-based recommendations are presented...