Affiliation: The Hospital for Sick Children
- Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryosSteffen Biechele
Department of Molecular Genetics, University of Toronto, ON, Canada
Dev Biol 355:275-85. 2011..Taken together, these data confirm the importance of Porcn for Wnt secretion and gastrulation and suggest that disruption of early development underlies the male lethality of human PORCN mutants...
- Zygotic Porcn paternal allele deletion in mice to model human focal dermal hypoplasiaSteffen Biechele
Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 8:e79139. 2013....
- Sox17-mediated XEN cell conversion identifies dynamic networks controlling cell-fate decisions in embryo-derived stem cellsAngela C H McDonald
Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 686 Bay Street, Toronto, ON M5G 0A4, Canada Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada
Cell Rep 9:780-93. 2014..Sox17-mediated XEN conversion helps to explain the regulation of cell-fate changes and reveals GRNs regulating lineage decisions in the mouse embryo. ..