Steven A Narod

Summary

Affiliation: Sunnybrook and Women's College Health Sciences Centre
Country: Canada

Publications

  1. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
  2. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
  3. pmc A common missense variant in BRCA2 predisposes to early onset breast cancer
    Bohdan Gorski
    Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland
    Breast Cancer Res 7:R1023-7. 2005
  4. ncbi request reprint Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study
    Steven A Narod
    Centre for Research on Women s Health, University of Toronto, Ontario, Canada
    Lancet Oncol 7:402-6. 2006
  5. doi request reprint Screening of women at high familial risk of breast cancer
    Steven A Narod
    Women s College Research Institute, University of Toronto, Toronto, ON M5G 1N8, Canada
    Womens Health (Lond) 6:509-10. 2010
  6. doi request reprint Clinical implications of the breast cancer susceptibility genes BRCA1 and BRCA2
    Steven A Narod
    Sunnybrook and Women s College Health Sciences Center, Center for Research in Women s Health, 790 Bay Street, Toronto Ontario, M5G 1N8, Canada
    Womens Health (Lond) 1:27-34. 2005
  7. ncbi request reprint BRCA1 and BRCA2: 1994 and beyond
    Steven A Narod
    Centre for Research on Women s Health, Sunnybrook and Womens College Health Sciences Center, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada
    Nat Rev Cancer 4:665-76. 2004
  8. ncbi request reprint Prevention and management of hereditary breast cancer
    Steven A Narod
    Centre for Research in Women s Health, University of Toronto, 790 Bay St, Toronto, Ontario M5G 1N8, Canada
    J Clin Oncol 23:1656-63. 2005
  9. ncbi request reprint A comparison of bilateral breast cancers in BRCA carriers
    Jeffrey N Weitzel
    The Centre for Research in Women s Health, 790 Bay Street, Toronto, Ontario, Canada M5G 1N8
    Cancer Epidemiol Biomarkers Prev 14:1534-8. 2005
  10. doi request reprint Clinical impact of unclassified variants of the BRCA1 and BRCA2 genes
    Mohammad R Akbari
    Women s College Research Institute, University of Toronto, Toronto, ON, Canada
    J Med Genet 48:783-6. 2011

Detail Information

Publications140 found, 100 shown here

  1. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
    ....
  2. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
    ..In this study, we investigate the association of variants in genes involved in IGF signaling and risk of breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations...
  3. pmc A common missense variant in BRCA2 predisposes to early onset breast cancer
    Bohdan Gorski
    Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland
    Breast Cancer Res 7:R1023-7. 2005
    ..For a deleterious variant, one would expect a greater allele frequency in breast cancer cases than in ethnic-matched controls. In contrast, neutral polymorphic variants should be equally frequent in the two groups...
  4. ncbi request reprint Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study
    Steven A Narod
    Centre for Research on Women s Health, University of Toronto, Ontario, Canada
    Lancet Oncol 7:402-6. 2006
    ..We aimed to assess whether exposure to ionising radiation through mammography screening was associated with risk of breast cancer in BRCA1 or BRCA2 mutation carriers...
  5. doi request reprint Screening of women at high familial risk of breast cancer
    Steven A Narod
    Women s College Research Institute, University of Toronto, Toronto, ON M5G 1N8, Canada
    Womens Health (Lond) 6:509-10. 2010
    ..There were no interval cancers. This data suggests that MRI screening can be used to downstage breast cancers, but larger studies with longer follow-up periods are required to confirm these findings...
  6. doi request reprint Clinical implications of the breast cancer susceptibility genes BRCA1 and BRCA2
    Steven A Narod
    Sunnybrook and Women s College Health Sciences Center, Center for Research in Women s Health, 790 Bay Street, Toronto Ontario, M5G 1N8, Canada
    Womens Health (Lond) 1:27-34. 2005
    ..This article explores what is known about assessing genetic risk and the evidence supporting a range of preventive strategies...
  7. ncbi request reprint BRCA1 and BRCA2: 1994 and beyond
    Steven A Narod
    Centre for Research on Women s Health, Sunnybrook and Womens College Health Sciences Center, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada
    Nat Rev Cancer 4:665-76. 2004
    ..The ability to translate this knowledge into novel treatments, however, remains elusive...
  8. ncbi request reprint Prevention and management of hereditary breast cancer
    Steven A Narod
    Centre for Research in Women s Health, University of Toronto, 790 Bay St, Toronto, Ontario M5G 1N8, Canada
    J Clin Oncol 23:1656-63. 2005
  9. ncbi request reprint A comparison of bilateral breast cancers in BRCA carriers
    Jeffrey N Weitzel
    The Centre for Research in Women s Health, 790 Bay Street, Toronto, Ontario, Canada M5G 1N8
    Cancer Epidemiol Biomarkers Prev 14:1534-8. 2005
    ..It is generally believed that the two cancers represent independent events. However, the extent of concordance between the first and second tumors with respect to hormone receptor expression and other pathologic features is unknown...
  10. doi request reprint Clinical impact of unclassified variants of the BRCA1 and BRCA2 genes
    Mohammad R Akbari
    Women s College Research Institute, University of Toronto, Toronto, ON, Canada
    J Med Genet 48:783-6. 2011
    ..In this sample, only Align Grantham Variation Grantham Deviation appeared to predict penetrance based on first-degree relatives...
  11. doi request reprint Family history of cancer and cancer risks in women with BRCA1 or BRCA2 mutations
    Kelly Metcalfe
    Women s College Research Institute, Toronto, ON, Canada
    J Natl Cancer Inst 102:1874-8. 2010
    ..61; 95% CI = 1.21 to 2.14). Among women with a BRCA2 mutation, the risk of breast cancer increased by 1.7-fold for each first-degree relative younger than 50 years with breast cancer (HR = 1.67; 95% CI = 1.04 to 2.07)...
  12. doi request reprint Germline RAP80 mutations and susceptibility to breast cancer
    Mohammad Reza Akbari
    Women s College Research Institute, University of Toronto, 790 Bay Street, 7th Floor, Toronto, ON, Canada
    Breast Cancer Res Treat 113:377-81. 2009
    ..A novel RAP80 haplotype or rare missense mutations may be associated with a modest increased risk of breast cancer, but this observation needs to be confirmed by additional studies...
  13. pmc Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1
    Ian Harley
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, ON, Canada
    Gynecol Oncol 109:384-7. 2008
    ..We sought to establish whether or not this polymorphic variant also predisposes to ovarian cancer...
  14. doi request reprint Risk factors for carcinoma of the fallopian tube in women with and without a germline BRCA mutation
    Danielle Vicus
    Women s College Research Institute, 790 Bay Street, Toronto, Ontario, Canada
    Gynecol Oncol 118:155-9. 2010
    ..The purpose of this study was to identify risk factors for fallopian tube cancer in women with and without a BRCA mutation...
  15. ncbi request reprint Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study
    Andrea Eisen
    Toronto Sunnybrook Regional Cancer Center, Toronto, ON, Canada
    J Clin Oncol 23:7491-6. 2005
    ....
  16. doi request reprint Utility of incorporating genetic variants for the early detection of prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, Department of Radiation Oncology, Sunnybrook Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 15:1787-93. 2009
    ..Several single nucleotide polymorphisms (SNP) have been associated with the risk of prostate cancer. The clinical utility of using SNPs in the early detection of prostate cancer has not been evaluated...
  17. pmc International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers
    Kelly A Metcalfe
    Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada
    Int J Cancer 122:2017-22. 2008
    ..Approximately one-half of women at risk for breast cancer rely on screening alone...
  18. ncbi request reprint The risk of ovarian cancer after breast cancer in BRCA1 and BRCA2 carriers
    Kelly A Metcalfe
    Faculty of Nursing, University of Toronto, 50 St George Street, Toronto, ON, Canada, M5S 3H4
    Gynecol Oncol 96:222-6. 2005
    ..To estimate the risk of ovarian cancer after a primary diagnosis of breast cancer among women with a BRCA1 or BRCA2 mutation and to identify host and treatment-related factors that might modify the risk...
  19. doi request reprint Predictors of contralateral prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation: the Hereditary Breast Cancer Clinical Study Group
    Kelly A Metcalfe
    Lawrence Bloomberg Faculty of Nursing, University of Toronto, Canada
    J Clin Oncol 26:1093-7. 2008
    ..To evaluate the rate of prophylactic contralateral mastectomy in an international cohort of women with hereditary breast cancer and to evaluate the predictors of uptake of preventive surgery...
  20. pmc International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers
    John Semple
    Women s College Research Institute, Toronto, ON, Canada
    Ann Surg Oncol 20:3817-22. 2013
    ..We report on the uptake of breast reconstruction after prophylactic mastectomy in women with BRCA mutations from eight countries...
  21. pmc Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis
    Kelly Metcalfe
    Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Canada
    BMJ 348:g226. 2014
    ..To compare the survival rates of women with BRCA associated breast cancer who did and did not undergo mastectomy of the contralateral breast...
  22. pmc Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers
    Andrea Eisen
    Sunnybrook Regional Cancer Center, Toronto, Ontario, Canada
    J Natl Cancer Inst 100:1361-7. 2008
    ....
  23. doi request reprint The incidence of endometrial cancer in women with BRCA1 and BRCA2 mutations: an international prospective cohort study
    Yakir Segev
    Women s College Research Institute, Familial Breast Cancer Research, 790 Bay Street, Toronto, Ontario, M5G 1N8, Canada
    Gynecol Oncol 130:127-31. 2013
    ..To evaluate the risk of endometrial cancer in women who carry a mutation in the BRCA1 or the BRCA2 gene...
  24. ncbi request reprint Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Steven A Narod
    The Centre for Research on Women s Health, University of Toronto, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada
    J Natl Cancer Inst 94:1773-9. 2002
    ..We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2...
  25. ncbi request reprint Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, Women s College Hospital, University of Toronto, Room 750, 790 Bay Street, 7th Floor, Toronto, ON M5G 1N8, Canada
    Breast Cancer Res Treat 105:221-8. 2007
    ..Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective...
  26. pmc Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Women s College Research Institute, University of Toronto, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 21:1089-96. 2012
    ..To evaluate the effect of the cumulative number of ovulatory cycles and its contributing components on the risk of breast cancer among BRCA mutation carriers...
  27. doi request reprint Anthropometric measures and risk of ovarian cancer among BRCA1 and BRCA2 mutation carriers
    Jacob McGee
    Women s College Research Institute, Toronto, Ontario, Canada
    Obesity (Silver Spring) 20:1288-92. 2012
    ..28). The results from this study suggest that height, weight, or weight gain do not influence the risk of ovarian cancer among carriers of a BRCA1 or BRCA2 mutation...
  28. ncbi request reprint Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, University of Toronto, Women s College Hospital, 790 Bay Street, 7th Floor, Totonto, Ontario M5G 1N8, Canada
    Cancer Causes Control 16:667-74. 2005
    ..46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation...
  29. doi request reprint Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case-control study
    Joanne Kotsopoulos
    Women s College Research Institute, Women s College Hospital, University of Toronto, Toronto, ON, Canada
    Cancer Causes Control 19:1111-9. 2008
    ..It is important to evaluate whether or not infertility per se or exposure to fertility medications increase the risk of breast cancer in genetically predisposed women...
  30. doi request reprint Risk of ipsilateral breast cancer in BRCA1 and BRCA2 mutation carriers
    Kelly Metcalfe
    Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada
    Breast Cancer Res Treat 127:287-96. 2011
    ..2% per year. For women treated with chemotherapy, radiation therapy or oophorectomy the risk is low, compared to women who did not receive any of these treatments...
  31. ncbi request reprint The use of genetic markers to determine risk for prostate cancer at prostate biopsy
    Robert K Nam
    Division of Urology and Department of Pathology, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Clin Cancer Res 11:8391-7. 2005
    ..We examined a panel of 13 polymorphisms in 13 different genes to determine whether specific genotypes can help predict prostate cancer at the time of biopsy among men prescreened with prostate-specific antigen and digital rectal exam...
  32. ncbi request reprint Risk factors for non-invasive lesions of the fallopian tube in BRCA mutation carriers
    Danielle Vicus
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Gynecol Oncol 118:295-8. 2010
    ..To identify risk factors for the presence of a non-invasive lesion of the fallopian tube in women with a BRCA1 or BRCA2 mutation...
  33. doi request reprint Prevalence of BRCA1 and BRCA2 germ line mutations among women with carcinoma of the fallopian tube
    Danielle Vicus
    Women s College Research Institute, Toronto, ON, Canada
    Gynecol Oncol 118:299-302. 2010
    ..The purpose of this study is to determine the prevalence of BRCA1 and BRCA2 mutations among a large series of women with carcinoma of the fallopian tube...
  34. ncbi request reprint Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy
    Robert K Nam
    Division of Urology Department of Pathology, Sunnybrook Health Sciences Centre, University Health Network, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Clin Cancer Res 12:6452-8. 2006
    ..We examined five variants of the KLK2 gene to further define its relevance to prostate cancer susceptibility and hK2 levels...
  35. doi request reprint BRCA1 and BRCA2 families and the risk of skin cancer
    Ophira M Ginsburg
    Department of Medicine, Division of Medical Oncology, University of Toronto, Toronto, ON, Canada
    Fam Cancer 9:489-93. 2010
    ..10; P = 0.02). The odds ratio for basal cell carcinoma was higher (OR = 3.8; 95% CI 1.5-9.4; P = 0.002). BRCA2 mutation carriers are at increased risk for skin cancer, compared with BRCA1 carriers, in particular for basal cell carcinoma...
  36. pmc Long-term ovarian cancer survival associated with mutation in BRCA1 or BRCA2
    John R McLaughlin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    J Natl Cancer Inst 105:141-8. 2013
    ..We sought to evaluate the impact of carrying a BRCA1 or BRCA2 mutation on long-term survival of women after a diagnosis of invasive ovarian cancer...
  37. doi request reprint Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer
    Shiyu Zhang
    Women s College Research Institute, University of Toronto, 790 Bay Street, 7th Floor, Toronto, ON, Canada M5G 1N8
    Gynecol Oncol 121:353-7. 2011
    ..It is important to have an accurate estimate of the proportion of ovarian cancer patients who carry a mutation and the specific factors which predict the presence of a mutation...
  38. ncbi request reprint Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study
    John R McLaughlin
    Samuel Lunenfeld Research Institute, Toronto, ON, Canada
    Lancet Oncol 8:26-34. 2007
    ..We aimed to assess the effect of these three risk factors, and of tubal ligation, on the risk of ovarian cancer in women who carry a mutation in the BRCA1 or BRCA2 genes...
  39. ncbi request reprint Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 12:1429-37. 2003
    ..The GST-T1 and IGF-I polymorphisms demonstrated modest associations with prostate cancer risk. IGF-I levels were not helpful in identifying patients with prostate cancer at the time of biopsy...
  40. ncbi request reprint Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, 790 Bay Street, 7th Floor, Women s College Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1N8
    Gynecol Oncol 100:83-8. 2006
    ..This association has not been evaluated in BRCA1 or BRCA2 mutation carriers who face very high lifetime risks of both breast and ovarian cancers...
  41. doi request reprint PPM1D mutations in circulating white blood cells and the risk for ovarian cancer
    Mohammad R Akbari
    Affiliations of authors Womens College Research Institute, Womens College Hospital MRA, San, Dalla Lana School of Public Health MRA, JM, San, Samuel Lunenfeld Research Institute JM, University of Toronto, Toronto, Canada Genome Quebec Innovation Centre, McGill University, Montreal, Canada PL Department of Gynecology Oncology BR, and Department of Medical Oncology MM, Princess Margaret Hospital, Toronto, Canada Department of Epidemiology and Public Health, School of Public Health, School of Medicine, Yale University, New Haven, CT HR
    J Natl Cancer Inst 106:djt323. 2014
    ..These observations suggest PPM1D mutations in the mosaic state predispose women to breast and ovarian cancer in the absence of a family history of cancer. ..
  42. ncbi request reprint Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation
    Amy Finch
    Centre for Research in Women s Health, Toronto Sunnybrook Regional Cancer Center, Toronto, Ontario, Canada
    JAMA 296:185-92. 2006
    ..Women with BRCA1 or BRCA2 mutation are often advised to undergo preventive oophorectomy. The effectiveness of this intervention has not been prospectively evaluated in a large cohort...
  43. doi request reprint The impact of prophylactic salpingo-oophorectomy on quality of life and psychological distress in women with a BRCA mutation
    Amy Finch
    Women s College Research Institute, Women s College Hospital, Toronto, ON, Canada
    Psychooncology 22:212-9. 2013
    ..The objective of this study was to measure the impact of prophylactic salpingo-oophorectomy on health-related quality of life and psychological distress in women...
  44. pmc Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, Women s College Hospital, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res 7:R833-43. 2005
    ..We asked whether there is an association between changes in body weight and the risk of breast cancer in women who carry a mutation in either breast cancer susceptibility gene, BRCA1 or BRCA2...
  45. doi request reprint Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer
    Joanne Kotsopoulos
    Women s College Research Institute, Women s College Hospital, University of Toronto, Toronto, Canada
    Breast Cancer Res Treat 112:585-93. 2008
    ..Individual variation in the genes involved in the transport of folate, or its metabolism, may affect risk, or may modify the association between folate and breast cancer risk...
  46. ncbi request reprint Association between CYP3A4 genotype and risk of endometrial cancer following tamoxifen use
    William Chu
    Department of Radiation Oncology, Princess Margaret Hospital University Health Network, Toronto, Ontario, Canada
    Carcinogenesis 28:2139-42. 2007
    ..004). These findings suggest that a subgroup of breast cancer patients who carry the CYP3A4*1B allele and take tamoxifen may be at increased risk of developing endometrial cancer...
  47. ncbi request reprint Serum insulin-like growth factor-I levels and prostatic intraepithelial neoplasia: a clue to the relationship between IGF-I physiology and prostate cancer risk
    Robert K Nam
    Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, MG 406 Toronto, Ontario, Canada, M4N 3M5
    Cancer Epidemiol Biomarkers Prev 14:1270-3. 2005
    ..Larger studies will be required to confirm this relationship...
  48. ncbi request reprint The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, Women s College Hospital, University of Toronto, Canada
    Cancer Epidemiol Biomarkers Prev 16:912-6. 2007
    ..This study suggests that caffeine protects against breast cancer in women with a BRCA1 mutation and illustrates the importance of integrating individual genetic variability when assessing diet-disease associations...
  49. doi request reprint Improvement in DCIS detection rates by MRI over time in a high-risk breast screening study
    Ellen Warner
    Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Breast J 17:9-17. 2011
    ..MRI-guided biopsy capability is essential for a high-risk screening program. In experienced centers the increased sensitivity of MRI relative to mammography is at least as high for DCIS as it is for invasive breast cancer...
  50. pmc Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers
    Danielle Vicus
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Gynecol Oncol 115:135-7. 2009
    ..Our objective is to assess if tamoxifen treatment is associated with an increase in the subsequent risk of ovarian cancer among women with a BRCA1 mutation...
  51. doi request reprint Incidence of complications other than urinary incontinence or erectile dysfunction after radical prostatectomy or radiotherapy for prostate cancer: a population-based cohort study
    Robert K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada Electronic address
    Lancet Oncol 15:223-31. 2014
    ..We aimed to assess other important complications associated with these treatments for prostate cancer...
  52. ncbi request reprint The risk of endometrial cancer in women with BRCA1 and BRCA2 mutations. A prospective study
    Mario E Beiner
    Centre for Research in Women s Health, 790 Bay Street, Toronto, ON, Canada M5G 1N8
    Gynecol Oncol 104:7-10. 2007
    ..To evaluate the risk of endometrial cancer in women who carry a deleterious mutation in the BRCA1 or BRCA2 genes...
  53. pmc Contribution of BRCA1 and BRCA2 mutations to breast and ovarian cancer in Pakistan
    Alexander Liede
    University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Am J Hum Genet 71:595-606. 2002
    ..7; 95% CI 1.5-4.9; P=.0008) and case subjects with ovarian cancer (OR=2.4; 95% CI 1.4-4.2; P=.002). These results suggest that recessively inherited genes may contribute to breast and ovarian cancer risk in Pakistan...
  54. doi request reprint Prospective multi-institutional study evaluating the performance of prostate cancer risk calculators
    Robert K Nam
    Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Room MG 406, Toronto, Ontario, Canada
    J Clin Oncol 29:2959-64. 2011
    ..Prostate cancer risk calculators incorporate many factors to evaluate an individual's risk for prostate cancer. We validated two common North American-based, prostate cancer risk calculators...
  55. doi request reprint Is mammography adequate for screening women with inherited BRCA mutations and low breast density?
    Rachel Z Bigenwald
    Division of Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 17:706-11. 2008
    ..We sought to determine the extent to which the low sensitivity of mammography is due to greater breast density...
  56. pmc Uptake of clinical genetic testing for ovarian cancer in Ontario: a population-based study
    Kelly A Metcalfe
    Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada
    Gynecol Oncol 112:68-72. 2009
    ..It is unknown what proportion of women with ovarian cancer receive genetic testing as a result of this recommendation...
  57. pmc Smoking and the risk of breast cancer in BRCA1 and BRCA2 carriers: an update
    Ophira Ginsburg
    The Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital, Toronto, ON, Canada
    Breast Cancer Res Treat 114:127-35. 2009
    ..There is a possibility of an increased risk of breast cancer among BRCA1 carriers associated with past smoking. There may be different effects of carcinogens in BRCA mutation carriers, depending upon the timing of exposure...
  58. ncbi request reprint Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
    Kelly Metcalfe
    Centre for Research on Women s Health, Women s College Hospital, Toronto, Ontario, Canada
    J Clin Oncol 22:2328-35. 2004
    ..To estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers after diagnosis and to determine which factors are predictive of the risk of a second primary breast cancer...
  59. doi request reprint Should all BRCA1 mutation carriers with stage I breast cancer receive chemotherapy?
    Steven A Narod
    Women s College Research Institute, 790 Bay Street, Room 750, Toronto M5G 1N8, Canada
    Breast Cancer Res Treat 138:273-9. 2013
    ..The difference cannot be explained by other prognostic factors. All women with invasive breast cancer and a BRCA1 mutation should be considered to be candidates for chemotherapy...
  60. doi request reprint Mutations of the MYH gene do not substantially contribute to the risk of breast cancer
    Mario E Beiner
    Women s College Research Institute, Women s College Hospital, 790 Bay Street, 7th Floor, Toronto, ON, Canada M5G 1N8
    Breast Cancer Res Treat 114:575-8. 2009
    ..To explore whether or not there is an association between the presence of either of the germline mutations in the MutY human homologue (MYH) gene (Y165C and G382D) and the risk of breast cancer...
  61. ncbi request reprint Assessing individual risk for prostate cancer
    Robert K Nam
    Division of Urology, Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Clin Oncol 25:3582-8. 2007
    ..To construct a clinical nomogram instrument to estimate individual risk for having prostate cancer (PC) for patients undergoing prostate specific antigen (PSA) screening, using all risk factors known for PC...
  62. pmc Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer
    Yaakov Bentov
    Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
    PLoS ONE 4:e5918. 2009
    ..These were considered to be candidate genes in the present study...
  63. doi request reprint Patterns of recurrence in the basal and non-basal subtypes of triple-negative breast cancers
    Sharon Nofech-Mozes
    Department of Pathology, Sunnybrook Health Sciences Center and University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 118:131-7. 2009
    ..The prognosis of these women may be superior to that of basal-like breast cancers but firm conclusions cannot be made...
  64. ncbi request reprint Making sense of prostate specific antigen: improving its predictive value in patients undergoing prostate biopsy
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Urol 175:489-94. 2006
    ..The clinical usefulness of PSA for prostate cancer screening is unclear, although the test remains in common use. New methods to interpret PSA are needed...
  65. doi request reprint Effect of Oophorectomy on Survival After Breast Cancer in BRCA1 and BRCA2 Mutation Carriers
    Kelly Metcalfe
    Women s College Research Institute, Toronto, Ontario, Canada2Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada
    JAMA Oncol 1:306-13. 2015
    ....
  66. pmc The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation
    Adriana Valentini
    Women s College Research Institute, Toronto, ON, Canada
    Breast Cancer Res Treat 142:177-85. 2013
    ..76; 95 % CI 0.31-1.91; p = 0.56). Pregnancy concurrent with or after a diagnosis of breast cancer does not appear to adversely affect survival among BRCA1/2 mutation carriers...
  67. pmc Risk factors for ovarian cancers with and without microsatellite instability
    Yakir Segev
    Familial Breast Cancer Research, Women s College Research Institute, Toronto, Ontario, Canada
    Int J Gynecol Cancer 23:1010-5. 2013
    ....
  68. doi request reprint Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Urol 189:S12-7; discussion S17-8. 2013
    ..Transrectal ultrasound guided prostate biopsy is widely used to confirm the diagnosis of prostate cancer. The technique has been associated with significant morbidity in a small proportion of patients...
  69. ncbi request reprint [Genetic predisposition for breast cancer: BRCA1 and BRCA2 genes]
    Steven A Narod
    Women s College Research Institute, University of Toronto, Toronto, Canada
    Salud Publica Mex 53:420-9. 2011
    ..In the present paper we explore the criteria to decide when to run the testing for the genes, as well as the implications for the treatment of patients who are identified with them...
  70. pmc New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, University of Toronto, ON, Canada
    Cancer Biol Ther 12:997-1004. 2011
    ..To identify and examine polymorphisms of genes associated with aggressive and clinical significant forms of prostate cancer among a screening cohort...
  71. ncbi request reprint Nomogram prediction for prostate cancer and aggressive prostate cancer at time of biopsy: utilizing all risk factors and tumor markers for prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Can J Urol 13:2-10. 2006
    ..There is a large amount of confusion in interpreting prostate specific antigen (PSA) values for prostate cancer. More precise risk assessments for prostate cancer detection are needed for men faced with an abnormal PSA...
  72. pmc Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations
    Louise Bordeleau
    Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Cancer 117:1812-8. 2011
    ..Hyperinsulinemia and the metabolic syndrome are both risk factors for breast cancer. It is not clear if diabetes is associated with the risk of breast cancer in women with a BRCA1 or BRCA2 mutation...
  73. doi request reprint Time to disease recurrence in basal-type breast cancers: effects of tumor size and lymph node status
    Rebecca Dent
    Department of Medical Oncology, Odette Cancer Center, Sunnybrook Health Sciences Center and University of Toronto, Toronto, Ontario, Canada
    Cancer 115:4917-23. 2009
    ..This class of tumors has an unusually aggressive course, and it is not clear whether conventional prognostic factors for breast cancers also predict outcome for patients who have the basal phenotype...
  74. doi request reprint Association between germline HOXB13 G84E mutation and risk of prostate cancer
    Mohammad R Akbari
    Women s College Research Institute, Women s College Hospital, Toronto, ON, Canada
    J Natl Cancer Inst 104:1260-2. 2012
    ..7%] vs 2 of 1757 [0.1%], P = .01) and was associated with an increased risk of prostate cancer (unadjusted odds ratio = 5.8, 95% confidence interval = 1.3 to 26.5, P = .01)...
  75. doi request reprint Changes in psychosocial functioning 1 year after mastectomy alone, delayed breast reconstruction, or immediate breast reconstruction
    Kelly A Metcalfe
    Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada
    Ann Surg Oncol 19:233-41. 2012
    ....
  76. ncbi request reprint Breast tissue organochlorine levels and metabolic genotypes in relation to breast cancer risk Canada
    David McCready
    Department of Surgery, University Health Network, Toronto, Ontario, Canada
    Cancer Causes Control 15:399-418. 2004
    ..2; 95% CI = 1.1-4.4). However, multiple comparisons were made and generally our data do not support the hypothesis that organochlorines increase the risk of breast cancer among subgroups of women with specific metabolic genotypes...
  77. ncbi request reprint A polymorphic locus in the promoter region of the IGFBP3 gene is related to mammographic breast density
    Joe H Lai
    Centre for Research in Women s Health, University of Toronto, 8790 Bay Street, Toronto, Ontario, M5G 1N8 Canada
    Cancer Epidemiol Biomarkers Prev 13:573-82. 2004
    ....
  78. ncbi request reprint Satisfaction with breast reconstruction in women with bilateral prophylactic mastectomy: a descriptive study
    Kelly A Metcalfe
    Faculty of Nursing, University of Toronto, Ontario, Canada
    Plast Reconstr Surg 114:360-6. 2004
    ..Correcting overestimation of breast cancer risk in women who have prophylactic mastectomy may improve satisfaction with reconstruction following prophylactic mastectomy...
  79. doi request reprint The prevalence of germ-line TP53 mutations in women diagnosed with breast cancer before age 30
    Ophira M Ginsburg
    Department of Medicine, Division of Medical Oncology, University of Toronto, Toronto, Canada
    Fam Cancer 8:563-7. 2009
    ..No TP53 mutation was found. This study does not support a policy that TP53 testing should be offered routinely to unselected women with early-onset breast cancer in the absence of a family history of cancer...
  80. ncbi request reprint A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families
    Catherine M Phelan
    Center for Research in Women s Health, Toronto, Ontario, Canada
    Hum Mutat 20:352-7. 2002
    ..Non-founder BRCA1 mutations are rare in Ashkenazi Jewish breast/ovarian cancer families...
  81. doi request reprint Quality of life and health status after prophylactic salpingo-oophorectomy in women who carry a BRCA mutation: A review
    Amy Finch
    Women s College Research Institute, Women s College Hospital, Toronto, ON, Canada
    Maturitas 70:261-5. 2011
    ..Studies of the long term health and quality of life after salpingo-oophorectomy in women who carry a BRCA mutation have not yet been published...
  82. ncbi request reprint Variation in patterns of practice in diagnosing screen-detected prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    BJU Int 94:1239-44. 2004
    ....
  83. doi request reprint Pattern of metastatic spread in triple-negative breast cancer
    Rebecca Dent
    Department of Medical Oncology, Sunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 115:423-8. 2009
    ..It is proposed that the underlying difference in recurrence rates may be explained in part by different routes of metastatic spread...
  84. pmc Effect of Prior Bilateral Oophorectomy on the Presentation of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers
    Kelly A Metcalfe
    The Centre for Research in Women s Health, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Hered Cancer Clin Pract 3:53-7. 2005
    ..To compare the presentation of invasive breast cancer in BRCA1 and BRCA2 mutation carriers with and without prior bilateral oophorectomy...
  85. ncbi request reprint Triple-negative breast cancer: clinical features and patterns of recurrence
    Rebecca Dent
    Department of Medical Oncology, Sunnybrook Health Sciences Center, University of Toronto, Ontario, Canada
    Clin Cancer Res 13:4429-34. 2007
    ..To compare the clinical features, natural history, and outcomes for women with "triple-negative" breast cancer with women with other types of breast cancer...
  86. doi request reprint Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women
    Kelly A Metcalfe
    Lawrence S Bloomberg, Faculty of Nursing and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 28:387-91. 2010
    ..To date, population screening in this population has not been suggested. However, this may be rational. Little is known about the appropriateness of testing guidelines for the Jewish population or the level of interest in testing...
  87. pmc The prevalence of BRCA1 mutations among young women with triple-negative breast cancer
    S R Young
    Women s College Research Institute, Department of Public Health, The University of Toronto, Toronto, Canada
    BMC Cancer 9:86. 2009
    ....
  88. ncbi request reprint A novel serum marker, total prostate secretory protein of 94 amino acids, improves prostate cancer detection and helps identify high grade cancers at diagnosis
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre and University Health Network, Toronto, Ontario, Canada
    J Urol 175:1291-7. 2006
    ..New biomarkers for prostate cancer are needed. We determined whether a novel serum marker, total PSP94 can be used to accomplish these goals...
  89. ncbi request reprint Increased rates of chromosome breakage in BRCA1 carriers are normalized by oral selenium supplementation
    Elzbieta Kowalska
    Centre for Research in Women s Health, 790 Bay Street, Toronto, Ontario, Canada, M5G 1N8
    Cancer Epidemiol Biomarkers Prev 14:1302-6. 2005
    ..40 versus 0.39). Oral selenium is a good candidate for chemoprevention in women who carry a mutation in the BRCA1 gene...
  90. ncbi request reprint Clinical and pathologic findings of prophylactic salpingo-oophorectomies in 159 BRCA1 and BRCA2 carriers
    Amy Finch
    The Centre for Research in Women s Health, 790 Bay Street, 7th Floor, Toronto, ON, Canada M5G 1N8
    Gynecol Oncol 100:58-64. 2006
    ..To estimate the likelihood of occult cancer diagnosis at prophylactic oophorectomy in BRCA1 and BRCA2 carriers in different age groups and to determine the histopathology of these lesions...
  91. ncbi request reprint Psychosocial functioning in women who have undergone bilateral prophylactic mastectomy
    Kelly A Metcalfe
    Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada
    Psychooncology 13:14-25. 2004
    ....
  92. ncbi request reprint A BRCA1 mutation in Native North American families
    Alexander Liede
    University of Toronto and Sunnybrook and Women s College, Health Sciences Centre, Toronto, Canada
    Hum Mutat 19:460. 2002
    ..The families represent two aboriginal Canadian tribes (Cree and Ojibwe), although a common ancestral origin is likely. This is the first evidence of a BRCA1 mutation specific to aboriginal peoples of North America...
  93. ncbi request reprint Prophylactic bilateral mastectomy: patterns of practice
    Kelly A Metcalfe
    The Centre for Research in Women s Health, Toronto, Ontario, Canada
    Cancer 95:236-42. 2002
    ..We conducted a population-based study to review the indications for, and patterns of practice of prophylactic mastectomy in Ontario, Canada, since 1991...
  94. ncbi request reprint Modifiers of risk of hereditary breast and ovarian cancer
    Steven A Narod
    Centre for Research on Women s Health, Women s College Hospital, 790 Bay Street, Room 750, University of Toronto, Toronto, Canada M5G 1N8
    Nat Rev Cancer 2:113-23. 2002
    ..Genetic risk can be modified by external factors, but what are these factors, and how might our knowledge of them help us to better define the risks for individual women and to develop strategies for cancer prevention?..
  95. ncbi request reprint Current understanding of the epidemiology and clinical implications of BRCA1 and BRCA2 mutations for ovarian cancer
    Steven A Narod
    The Centre for Research on Women s Health, Women s College Hospital, University of Toronto, Toronto, Canada
    Curr Opin Obstet Gynecol 14:19-26. 2002
    ..Strategies for prevention of ovarian cancer among carriers include oral contraceptives, tubal ligation and prophylactic oophorectomy...
  96. ncbi request reprint Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination
    Ellen Warner
    Division of Medical Oncology, Department of Medicine, Sunnybrook and Women s College Health Sciences Centre and University of Toronto, Ontario, Canada
    JAMA 292:1317-25. 2004
    ..Magnetic resonance imaging (MRI) and ultrasound may improve the ability to detect breast cancer at an early stage...
  97. ncbi request reprint Breast cancer risk perception among women who have undergone prophylactic bilateral mastectomy
    Kelly A Metcalfe
    The Centre for Research in Women s Health, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    J Natl Cancer Inst 94:1564-9. 2002
    ..We compared the perceptions of breast cancer risk among women who had previously undergone prophylactic bilateral mastectomy with objective estimates of their breast cancer risk...
  98. doi request reprint Toenail selenium status and DNA repair capacity among female BRCA1 mutation carriers
    Joanne Kotsopoulos
    Women s College Research Institute, 790 Bay Street, Toronto, Ontario, Canada
    Cancer Causes Control 21:679-87. 2010
    ..These results provide evidence for a possible protective effect of selenium against BRCA1-associated breast cancers...
  99. ncbi request reprint Hereditary breast and ovarian cancer in Asia: genetic epidemiology of BRCA1 and BRCA2
    Alexander Liede
    Centre for Research in Women s Health, University of Toronto, Toronto, Ontario, Canada
    Hum Mutat 20:413-24. 2002
    ..Studies conducted on the Asian populations described here have expanded our current knowledge of genetic susceptibility and its contribution to breast and ovarian cancer rates in Asian populations...
  100. ncbi request reprint Towards a dietary prevention of hereditary breast cancer
    Joanne Kotsopoulos
    Centre for Research in Women s Health, Toronto, Ontario, Canada
    Cancer Causes Control 16:125-38. 2005
    ..The prevention of hereditary breast cancer through diet is an attractive complement to current management strategies and deserves exploration...
  101. doi request reprint A BRCA1 mutation is not associated with increased indicators of oxidative stress
    Joanne Kotsopoulos
    Women s College Research Institute, Women s College Hospital, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Clin Breast Cancer 8:506-10. 2008
    ..It is possible that individuals with a BRCA1 mutation might be susceptible to the effects of oxidative stress. The aim of this study was to evaluate whether women with a BRCA1 mutation exhibit increased indicators of oxidative stress...