Nick Daneman

Summary

Affiliation: Sunnybrook Health Sciences Centre
Country: Canada

Publications

  1. pmc Influences on the start, selection and duration of treatment with antibiotics in long-term care facilities.
    Nick Daneman
    CMAJ 189:E851-E860. 2017
  2. pmc Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial
    Nick Daneman
    Division of Infectious Diseases and Clinical Epidemiology, Sunnybrook Health Sciences Centre, University of Toronto and Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada
    Trials 16:173. 2015
  3. doi request reprint Prolonged antibiotic treatment in long-term care: role of the prescriber
    Nick Daneman
    Division of Infectious Diseases, Department of Medicine, SunnybrookHealth Sciences Centre, University of Toronto, Toronto, Canada
    JAMA Intern Med 173:673-82. 2013
  4. doi request reprint Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis
    Nick Daneman
    Trauma, Emergency, and Critical Care Program, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada
    Lancet Infect Dis 13:328-41. 2013
  5. pmc Reduction in Clostridium difficile infection rates after mandatory hospital public reporting: findings from a longitudinal cohort study in Canada
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS Med 9:e1001268. 2012
  6. doi request reprint Validation of administrative population-based data sets for the detection of cesarean delivery surgical site infection
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 32:1213-5. 2011
  7. doi request reprint Antibiotic use in long-term care facilities
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Antimicrob Chemother 66:2856-63. 2011
  8. pmc Duration of hospital admission and the need for empirical antipseudomonal therapy
    N Daneman
    Sunnybrook Health Sciences Centre, Department of Microbiology and Division of Infectious Diseases, Toronto, Ontario, Canada
    J Clin Microbiol 50:2695-701. 2012
  9. doi request reprint How long should peripherally inserted central catheterization be delayed in the context of recently documented bloodstream infection?
    Nick Daneman
    Division of Infectious Diseases and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Vasc Interv Radiol 23:123-5. 2012
  10. doi request reprint Antibiotic treatment duration for bloodstream infections in critically ill patients: a national survey of Canadian infectious diseases and critical care specialists
    Nick Daneman
    University of Toronto, Department of Medicine, Toronto, ON, Canada
    Int J Antimicrob Agents 38:480-5. 2011

Detail Information

Publications58

  1. pmc Influences on the start, selection and duration of treatment with antibiotics in long-term care facilities.
    Nick Daneman
    CMAJ 189:E851-E860. 2017
    ..Prescriber audit and feedback may be a promising tool to optimize antibiotic use in long-term care facilities...
  2. pmc Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial
    Nick Daneman
    Division of Infectious Diseases and Clinical Epidemiology, Sunnybrook Health Sciences Centre, University of Toronto and Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada
    Trials 16:173. 2015
    ..Bacteremia is a leading cause of mortality and morbidity in critically ill adults. No previous randomized controlled trials have directly compared shorter versus longer durations of antimicrobial treatment in these patients...
  3. doi request reprint Prolonged antibiotic treatment in long-term care: role of the prescriber
    Nick Daneman
    Division of Infectious Diseases, Department of Medicine, SunnybrookHealth Sciences Centre, University of Toronto, Toronto, Canada
    JAMA Intern Med 173:673-82. 2013
    ..Given that most common bacterial infections can be treated with antibiotic courses of 7 or fewer days, reducing standard antibiotic treatment durations may be an avenue to curtailing antibiotic overuse in long-term care...
  4. doi request reprint Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis
    Nick Daneman
    Trauma, Emergency, and Critical Care Program, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada
    Lancet Infect Dis 13:328-41. 2013
    ..We aimed to assess the effect of SDD and SOD on antimicrobial resistance rates in patients in ICUs...
  5. pmc Reduction in Clostridium difficile infection rates after mandatory hospital public reporting: findings from a longitudinal cohort study in Canada
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    PLoS Med 9:e1001268. 2012
    ..Our objective was to determine whether mandatory public reporting by hospitals is associated with a reduction in hospital rates of Clostridium difficile infection...
  6. doi request reprint Validation of administrative population-based data sets for the detection of cesarean delivery surgical site infection
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 32:1213-5. 2011
    ..Although these data sets are highly specific and could be used to define research cohorts, their low sensitivity and positive predictive value make them inadequate for use as quality indicators...
  7. doi request reprint Antibiotic use in long-term care facilities
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Antimicrob Chemother 66:2856-63. 2011
    ..Our goal was to examine the prevalence of antibiotic use among long-term care facility residents and the extent of variability across these institutions...
  8. pmc Duration of hospital admission and the need for empirical antipseudomonal therapy
    N Daneman
    Sunnybrook Health Sciences Centre, Department of Microbiology and Division of Infectious Diseases, Toronto, Ontario, Canada
    J Clin Microbiol 50:2695-701. 2012
    ..aeruginosa isolation. Any guidelines which distinguish early from late hospital-acquired infection must consider the implications of time point selection on the likelihood of inadequate P. aeruginosa empirical coverage...
  9. doi request reprint How long should peripherally inserted central catheterization be delayed in the context of recently documented bloodstream infection?
    Nick Daneman
    Division of Infectious Diseases and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Vasc Interv Radiol 23:123-5. 2012
    ..The relapse risk was higher when PICCs were inserted within 2 days (two of 31; 6.5%) versus at least 3 days (one of 317; 0.3%) after documentation of bacteremia (P = .02)...
  10. doi request reprint Antibiotic treatment duration for bloodstream infections in critically ill patients: a national survey of Canadian infectious diseases and critical care specialists
    Nick Daneman
    University of Toronto, Department of Medicine, Toronto, ON, Canada
    Int J Antimicrob Agents 38:480-5. 2011
    ..There is equipoise for a randomised trial comparing shorter versus longer courses of antibiotics for most bacteraemic syndromes and pathogens...
  11. doi request reprint Discharge after discharge: predicting surgical site infections after patients leave hospital
    N Daneman
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Hosp Infect 75:188-94. 2010
    ..Post-discharge SSIs are frequent, severe, scattered over time and location, and hard to predict using common risk indices. They represent an important hidden burden in our healthcare system...
  12. doi request reprint Statin use and the risk of surgical site infections in elderly patients undergoing elective surgery
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, G Wing Room 106, Toronto, ON M4N 3M5, Canada
    Arch Surg 144:938-45. 2009
    ..To examine whether preoperative statin use is associated with a reduced risk of surgical site infections...
  13. doi request reprint Validation of a modified version of the national nosocomial infections surveillance system risk index for health services research
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 30:563-9. 2009
    ..To validate the National Nosocomial Infections Surveillance system risk index through administrative data to predict surgical site infections...
  14. doi request reprint Impact of hospital length of stay on the distribution of Gram negative bacteria and likelihood of isolating a resistant organism in a Canadian burn center
    Marsail Wanis
    University of Toronto, Leslie L Dan Faculty of Pharmacy, Toronto, Ontario, Canada
    Burns 42:104-11. 2016
    ..Knowledge of causative pathogens is important in guiding empiric antibiotic therapy...
  15. pmc Pathogens and antimicrobial susceptibility profiles in critically ill patients with bloodstream infections: a descriptive study
    Rachel D Savage
    Dalla Lana School of Public Health Savage, University of Toronto Sunnybrook Health Sciences Centre Savage, Fowler, Rishu, Daneman, Toronto, Ont Division of Critical Care Medicine Fowler, Department of Medicine Institute of Health Policy, Management and Evaluation Fowler, Daneman, University of Toronto, Toronto, Ont Division of Critical Care Medicine Bagshaw, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta Departments of Medicine and Clinical Epidemiology and Biostatistics Cook, McMaster University, Hamilton, Ont Division of Critical Care Medicine Dodek, Reynolds, Department of Medicine, University of British Columbia Center for Health Evaluation and Outcome Sciences Dodek, St Paul s Hospital, Vancouver, BC Department of Critical Care Medicine Hall, Faculty of Medicine, Dalhousie University Nova Scotia Health Authority Hall, Halifax, NS Section of Critical Care Medicine Kumar, Department of Medicine Departments of Medical Microbiology and of Pharmacology and Therapeutics Kumar, University of Manitoba, Winnipeg, Man Centre de recherche du Centre hospitalier universitaire de Sherbrooke Lamontagne, Sherbrooke, Que Service de médecine interne Lamontagne, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que Axe Santé des populations et pratiques optimales en santé Lauzier, Germany
    CMAJ Open 4:E569-E577. 2016
    ..Collating and reporting routine data on clinical isolate testing may offer more timely information about resistance patterns than traditional surveillance network methods...
  16. doi request reprint The co-seasonality of pneumonia and influenza with Clostridium difficile infection in the United States, 1993-2008
    Kevin A Brown
    Dalla Lana School of Public Health, University of Toronto, Ontario, Canada
    Am J Epidemiol 178:118-25. 2013
    ..073, 1.153). Future research could seek to understand which mediating pathways, including changes in broad-spectrum antibiotic prescribing and hospital crowding, are most responsible for the associated changes in incidence. ..
  17. doi request reprint Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients
    Nick Daneman
    1Division of Infectious Diseases, Department of Medicine and Clinical Epidemiology, Sunnybrook Health Sciences Centre, University of Toronto and Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 2Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 3Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada 4Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St Paul s Hospital and University of British Columbia, Vancouver, BC, Canada 5Department of Critical Care Medicine, Dalhousie University and the Capital District, Health Authority, Halifax, NS, Canada 6Sections of Critical Care Medicine and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada 7Department of Medicine, Centre de recherche du CHU de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC, Canada 8Centre de recherche du CHU de Québec, Axe Santé des populations et pratiques optimales en santé, Division de soins intensifs adultes, départements de médecine et d anesthésiologie, Universite Laval, Quebec, QC, Canada 9Departments of Surgery and Critical Care Medicine
    Crit Care Med 44:256-64. 2016
    ....
  18. doi request reprint Derivation and Validation of the Surgical Site Infections Risk Model Using Health Administrative Data
    Carl van Walraven
    1University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Infect Control Hosp Epidemiol 37:455-65. 2016
    ..Records of higher-risk patients can be reviewed to confirm SSI status...
  19. doi request reprint The Economic Burden of Hospital-Acquired Clostridium difficile Infection: A Population-Based Matched Cohort Study
    Natasha Nanwa
    1Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Infect Control Hosp Epidemiol 37:1068-78. 2016
    ..To the best of our knowledge, this study is the first CDI costing study to present longitudinal costs. New strategies may be warranted to mitigate this costly infectious disease. Infect Control Hosp Epidemiol 2016;37:1068-1078. ..
  20. pmc The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study
    Rachel D Savage
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 11:e0154944. 2016
    ..Further research is warranted to improve early diagnostic and risk prediction methods in candidemic patients. ..
  21. pmc The economic burden of patient safety targets in acute care: a systematic review
    Nicole Mittmann
    Health Outcomes and Pharmaco Economics HOPE Research Centre, Division of Clinical Pharmacology, Toronto, ON, Canada
    Drug Healthc Patient Saf 4:141-65. 2012
    ..Our objective was to determine the quality of literature in costing of the economic burden of patient safety...
  22. pmc Delirium after elective surgery among elderly patients taking statins
    Donald A Redelmeier
    Department of Medicine, University of Toronto, Ontario, Toronto, Canada
    CMAJ 179:645-52. 2008
    ..We sought to determine whether the use of statin medications was associated with a higher risk of postoperative delirium than other medications that do not alter microvascular autoregulation...
  23. doi request reprint Inhaled Long-acting Anticholinergics and Urinary Tract Infection in Individuals with COPD
    Andrea S Gershon
    a Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    COPD 14:105-112. 2017
    ..In conclusion, older men with COPD newly started on LAA are at increased risk of UTI. Men considering an inhaled LAA should be informed of this risk and, if they decide to take it, be provided with appropriate monitoring...
  24. doi request reprint Variability in Antibiotic Use Across Nursing Homes and the Risk of Antibiotic-Related Adverse Outcomes for Individual Residents
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada2Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada3Institute of Health Policy, Management and Eva
    JAMA Intern Med 175:1331-9. 2015
    ..Antibiotics are frequently and often inappropriately prescribed to patients in nursing homes. These antibiotics pose direct risks to recipients and indirect risks to others residing in the home...
  25. doi request reprint Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study
    Janine R Hutson
    Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Drugs Aging 29:205-11. 2012
    ..Donepezil is metabolized by the cytochrome P450 isozyme 3A4 (CYP3A4). Clarithromycin is a potent inhibitor of CYP3A4, and patients taking both of these drugs may be at increased risk of cardiac adverse events...
  26. doi request reprint Point prevalence survey of antimicrobial utilization in a Canadian tertiary-care teaching hospital
    Colin Lee
    Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Leslie L Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    J Epidemiol Glob Health 5:143-50. 2015
    ..The primary objective was to identify the prevalence of antimicrobial use at a tertiary care teaching hospital with both acute and long-term care patients...
  27. doi request reprint Identification of predictors of early infection in acute burn patients
    Laura Schultz
    Sunnybrook Health Sciences Centre, Department of Pharmacy, Canada
    Burns 39:1355-66. 2013
    ..05). This pilot project identified significant predictors of early infection and sepsis in acute burns and will be validated in a prospective study...
  28. doi request reprint Audit and feedback to reduce broad-spectrum antibiotic use among intensive care unit patients: a controlled interrupted time series analysis
    Marion Elligsen
    Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 33:354-61. 2012
    ..We aimed to rigorously evaluate the impact of prospective audit and feedback on broad-spectrum antimicrobial use among critical care patients...
  29. doi request reprint Postoperative pneumonia in elderly patients receiving acid suppressants: a retrospective cohort analysis
    Donald A Redelmeier
    Department of Medicine, University of Toronto, Toronto, Canada
    BMJ 340:c2608. 2010
    ..To test whether gastric acid suppressants are associated with an increased risk of postoperative pneumonia in patients undergoing elective surgery...
  30. doi request reprint Introducing a methodology for estimating duration of surgery in health services research
    Donald A Redelmeier
    Department of Medicine, Infectious Disease, and Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 61:882-9. 2008
    ..We introduce a new methodology for assessing the duration of surgery based on anesthesiology billing records, along with reviewing its fundamental logic and limitations...
  31. doi request reprint Lessons from audit and feedback of hospitalized patients with bacteriuria
    Jerome A Leis
    Division of Infectious Diseases, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada Centre for Quality Improvement and Patient Safety, University of Toronto, Toronto, ON, Canada Electronic address
    Am J Infect Control 42:1136-7. 2014
    ..This study highlights the limitations of educational initiatives in overcoming engrained beliefs about bacteriuria even when advice is provided in real time...
  32. pmc Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection
    Kevin A Brown
    Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    Antimicrob Agents Chemother 57:2326-32. 2013
    ..Avoidance of high-risk antibiotics (such as clindamycin, CMCs, and fluoroquinolones) in favor of lower-risk antibiotics (such as penicillins, macrolides, and tetracyclines) may help reduce the incidence of CDI...
  33. doi request reprint Impact of antimicrobial stewardship in critical care: a systematic review
    Reham Kaki
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Antimicrob Chemother 66:1223-30. 2011
    ..To evaluate the current state of evidence for antimicrobial stewardship interventions in the critical care unit...
  34. pmc The impact of infection on population health: results of the Ontario burden of infectious diseases study
    Jeffrey C Kwong
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    PLoS ONE 7:e44103. 2012
    ..We sought to quantify the contribution of a wide range of infectious diseases to the overall infectious disease burden in a high-income setting...
  35. doi request reprint Variability in antibiotic use across Ontario acute care hospitals
    Charlie Tan
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Antimicrob Chemother 72:554-563. 2017
    ..We sought to examine the variability, and risk-adjusted variability, in antibiotic use across acute care hospitals in Ontario, Canada's most populous province...
  36. doi request reprint The economic impact of Clostridium difficile infection: a systematic review
    Natasha Nanwa
    1 Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada 2 Toronto Health Economics and Technology Assessment Collaborative, Toronto, Ontario, Canada
    Am J Gastroenterol 110:511-9. 2015
    ..With Clostridium difficile infection (CDI) on the rise, knowledge of the current economic burden of CDI can inform decisions on interventions related to CDI. We systematically reviewed CDI cost-of-illness (COI) studies...
  37. pmc The magnitude and duration of Clostridium difficile infection risk associated with antibiotic therapy: a hospital cohort study
    Kevin A Brown
    Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 9:e105454. 2014
    ..These findings are consistent with studies showing higher risk associated with longer antibiotic use in hospitalized patients, but suggest that the duration of increased risk is shorter than previously thought. ..
  38. doi request reprint Determination of tobramycin pharmacokinetics in burn patients to evaluate the potential utility of once-daily dosing in this population
    Diane Vella
    From the Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Leslie L Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada Department of Microbiology and Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada and Faculty of Medicine, University of Toronto, Ontario, Canada
    J Burn Care Res 35:e240-9. 2014
    ..Variability in pharmacokinetics in this population and change in pharmacokinetics with time postburn injury necessitate monitoring of tobramycin levels to ensure targets are met and maintained. ..
  39. pmc Reducing the risk of severe complications among patients with Clostridium difficile infection
    Kamran Manek
    Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Can J Gastroenterol 25:368-72. 2011
    ..The incidence and severity of Clostridium difficile infections are increasing, and there is a need to optimize the prevention of complicated disease...
  40. ncbi request reprint Surveillance for hospital outbreaks of invasive group a streptococcal infections in Ontario, Canada, 1992 to 2000
    Nick Daneman
    University of Toronto, Mount Sinai Hospital, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Ann Intern Med 147:234-41. 2007
    ..Streptococcus pyogenes can cause severe disease in the individual patient and dramatic hospital outbreaks...
  41. pmc Validating hospital antibiotic purchasing data as a metric of inpatient antibiotic use
    Charlie Tan
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Antimicrob Chemother 71:547-53. 2016
    ..Antibiotic purchasing data are a widely used, but unsubstantiated, measure of antibiotic consumption. To validate this source, we compared purchasing data from hospitals and external medical databases with patient-level dispensing data...
  42. doi request reprint Administrative data measured surgical site infection probability within 30 days of surgery in elderly patients
    Carl van Walraven
    Ottawa Hospital Research Institute, University of Ottawa, ASB1 003 1053, Carling Ave, Ottawa, Ontario K1Y 4E9, Canada Institute for Clinical Evaluative Sciences, 2075 Bayview Ave, Toronto, Ontario M4N 3M5, Canada Electronic address
    J Clin Epidemiol 77:112-117. 2016
    ..This study derived and internally validated a model that used routinely collected health administrative data to measure the probability of SSI in elderly patients within 30 days of surgery...
  43. doi request reprint Use of a structured panel process to define quality metrics for antimicrobial stewardship programs
    Andrew M Morris
    Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada
    Infect Control Hosp Epidemiol 33:500-6. 2012
    ..There is no standardized approach to evaluate the impact of these programs...
  44. pmc Patient Characteristics and Outcomes of Outpatient Parenteral Antimicrobial Therapy: A Retrospective Study
    Marie Yan
    Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, Canada M5S 1A8
    Can J Infect Dis Med Microbiol 2016:8435257. 2016
    ..These results suggest that many OPAT patients have unplanned health care encounters because of issues related to their infection or treatment, and the creation of a formal OPAT clinic may help improve outcomes. ..
  45. doi request reprint Impact of Reported Beta-Lactam Allergy on Inpatient Outcomes: A Multicenter Prospective Cohort Study
    Derek R MacFadden
    Division of Infectious Diseases, Department of Medicine
    Clin Infect Dis 63:904-10. 2016
    ..Reported allergy to beta-lactam antibiotics is common and often leads to unnecessary avoidance in patients who could tolerate these antibiotics. We prospectively evaluated the impact of these reported allergies on clinical outcomes...
  46. doi request reprint A passage from India: Association between air traffic and reported cases of New Delhi Metallo-beta-lactamase 1 from 2007 to 2012
    Derek R MacFadden
    Division of Infectious Diseases, University of Toronto, Toronto, Ontario, Canada Electronic address
    Travel Med Infect Dis 13:295-9. 2015
    ..The New Delhi Metallo-beta-lactamase 1 gene is hypothesized to have originated in India, with subsequent dissemination by colonized or infected travelers...
  47. doi request reprint A National Survey of Critical Care Physicians' Knowledge, Attitudes, and Perceptions of Antimicrobial Stewardship Programs
    Marilyn Steinberg
    Mount Sinai Hospital, Toronto, Canada
    J Intensive Care Med 31:61-5. 2016
    ..We administered a survey to critical care physicians across Canada to better understand their knowledge, attitudes, and perceptions on the utility of ASPs in improving patient care...
  48. pmc Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada Sunnybrook Research Institute, Toronto, Ontario, Canada
    BMJ Open 5:e010077. 2015
    ....
  49. pmc Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis
    Thomas C Havey
    Department of Medicine, University of Toronto, 1 Kings College Circle, O, M5S 1A8, Canada
    Crit Care 15:R267. 2011
    ....
  50. doi request reprint At the threshold: defining clinically meaningful resistance thresholds for antibiotic choice in community-acquired pneumonia
    Nick Daneman
    Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, USA
    Clin Infect Dis 46:1131-8. 2008
    ..Guidelines suggest a 25% rate of high-level macrolide resistance in the community as the threshold beyond which macrolides should not be used. We evaluated the implications of this threshold for clinical failure rates...
  51. doi request reprint Staphylococcus aureus decolonization as a prevention strategy
    Andrew E Simor
    Department of Medicine, University of Toronto, Toronto, ON, Canada M4N 3M5
    Infect Dis Clin North Am 23:133-51. 2009
    ..This article reviews available data regarding various proposed treatment regimens for eradicating staphylococcal carriage and the effectiveness of decolonization for infection prevention and as an infection control measure...
  52. pmc Sending repeat cultures: is there a role in the management of bacteremic episodes? (SCRIBE study)
    J Brad Wiggers
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Infect Dis 16:286. 2016
    ..However, blood cultures are costly and it is likely unnecessary to repeat them for many patients. We assessed predictors of persistent bacteremia that should prompt repeat blood cultures...
  53. ncbi request reprint Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial
    Waleed Alhazzani
    Dr Waleed Alhazzani, Critical Care Medicine, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada, T 1905 522 1155 ext 32800, F 1905 521 6068 ORCID http orcid org 0000 0001 8076 9626
    Ann Saudi Med 36:427-433. 2016
    ..The aim of this multicenter pilot trial is to determine the feasibility of performing a large RCT to investigate the efficacy and safety of withholding intravenous pantoprazole...
  54. doi request reprint Accuracy of administrative data for identification of patients with infective endocarditis
    Charlie Tan
    Sunnybrook Research Institute, Toronto, Canada
    Int J Cardiol 224:162-164. 2016
    ..Research to improve outcomes for these patients is limited by the rarity of this condition. Therefore, we sought to validate administrative database codes for the diagnosis of infective endocarditis...
  55. doi request reprint Hospital ward antibiotic prescribing and the risks of Clostridium difficile infection
    Kevin Brown
    Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    JAMA Intern Med 175:626-33. 2015
    ..Contact with patients taking antibiotics within the same hospital ward may be a transmission risk factor for C difficile infection, but this hypothesis has never been tested...
  56. doi request reprint Predictive utility of prior positive urine cultures
    Derek R MacFadden
    Department of Medicine, University of Toronto
    Clin Infect Dis 59:1265-71. 2014
    ..We sought to evaluate how well previous urine cultures predict the identity and susceptibility of organisms in a patient's subsequent urine cultures...
  57. doi request reprint Reducing antimicrobial therapy for asymptomatic bacteriuria among noncatheterized inpatients: a proof-of-concept study
    Jerome A Leis
    Division of Infectious Diseases, Department of Medicine, University of Toronto
    Clin Infect Dis 58:980-3. 2014
    ..Larger studies are needed to confirm the generalizability, safety, and sustainability of this model of care. ..
  58. doi request reprint Comparative economic analyses of patient safety improvement strategies in acute care: a systematic review
    Edward Etchells
    University of Toronto Centre for Patient Safety, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    BMJ Qual Saf 21:448-56. 2012
    ..The objective was to systematically review comparative economic analyses of patient safety improvements in the acute care setting...