Dominic S Ng

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. ncbi request reprint Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    J Biol Chem 277:11715-20. 2002
  2. ncbi request reprint Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario M5B 1A6, Canada
    J Biol Chem 279:7636-42. 2004
  3. ncbi request reprint Treating low HDL--from bench to bedside
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Clin Biochem 37:649-59. 2004
  4. pmc A novel in vivo lecithin-cholesterol acyltransferase (LCAT)-deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy
    Xianghong Zhu
    Department of Medicine, St Michael s Hospital West Annex 2 015, 38 Shuter Street, Toronto, Ontario M5B 1A6 Canada
    Am J Pathol 165:1269-78. 2004
  5. ncbi request reprint Insight into the role of LCAT from mouse models
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Rev Endocr Metab Disord 5:311-8. 2004
  6. doi request reprint Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    Cardiovasc Pathol 17:226-32. 2008
  7. ncbi request reprint The role of statins in oxidative stress and cardiovascular disease
    Dominic S Ng
    St Michael s Hospital West Annex 2 015, 38 Shuter Street, Toronto, Ontario, Canada M5B 1A6
    Curr Drug Targets Cardiovasc Haematol Disord 5:165-75. 2005
  8. pmc Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice
    Lauren Hager
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 287:20755-68. 2012
  9. ncbi request reprint Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism
    Hui Song
    Department of Medicine, St Michael s Hospital, Toronto, ON M5B 1A6, Canada
    Am J Physiol Endocrinol Metab 290:E17-E25. 2006
  10. ncbi request reprint LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling
    Lixin Li
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 293:E587-94. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    J Biol Chem 277:11715-20. 2002
    ..This modulation of oxidative stress may in part contribute to the reduced atherosclerosis seen in the apoE-/- xlcat-/- mice...
  2. ncbi request reprint Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario M5B 1A6, Canada
    J Biol Chem 279:7636-42. 2004
    ..014). Both the HTG and the improved fasting glucose phenotype seen in the dko mice are at least in part attributable to an up-regulation of the hepatic srebp-1c gene...
  3. ncbi request reprint Treating low HDL--from bench to bedside
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Clin Biochem 37:649-59. 2004
    ..We discuss the HDL-C raising effect of a selected number of currently available lipid-modifying drugs and on a selected number of novel HDL-targeted therapeutic strategies under development...
  4. pmc A novel in vivo lecithin-cholesterol acyltransferase (LCAT)-deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy
    Xianghong Zhu
    Department of Medicine, St Michael s Hospital West Annex 2 015, 38 Shuter Street, Toronto, Ontario M5B 1A6 Canada
    Am J Pathol 165:1269-78. 2004
    ....
  5. ncbi request reprint Insight into the role of LCAT from mouse models
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Rev Endocr Metab Disord 5:311-8. 2004
  6. doi request reprint Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    Cardiovasc Pathol 17:226-32. 2008
    ..As paraoxonase-1 has been recently shown to be a lactonase, its functional role remains to be fully elucidated. We explored additional vascular changes in Pon1 knockout mice in the absence of atherogenic diet challenge...
  7. ncbi request reprint The role of statins in oxidative stress and cardiovascular disease
    Dominic S Ng
    St Michael s Hospital West Annex 2 015, 38 Shuter Street, Toronto, Ontario, Canada M5B 1A6
    Curr Drug Targets Cardiovasc Haematol Disord 5:165-75. 2005
    ....
  8. pmc Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice
    Lauren Hager
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 287:20755-68. 2012
    ..Thus, factors influencing the accumulation of ER cholesterol may be important for the development of hepatic insulin resistance...
  9. ncbi request reprint Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism
    Hui Song
    Department of Medicine, St Michael s Hospital, Toronto, ON M5B 1A6, Canada
    Am J Physiol Endocrinol Metab 290:E17-E25. 2006
    ..Some of the phenotypes are not readily explained by known mechanisms and may represent novel regulatory pathways...
  10. ncbi request reprint LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling
    Lixin Li
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 293:E587-94. 2007
    ....
  11. pmc Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways
    Lixin Li
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 286:17809-20. 2011
    ....
  12. doi request reprint Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1
    Adam S Sirek
    Department of Physiology, University of Toronto, Toronto, Canada
    Endocrinology 150:3483-92. 2009
    ..Our observations therefore identify Oct-1 as a transcriptional repressor of ChREBP and suggest that insulin stimulates ChREBP expression via attenuating the repressive effect of Oct-1...
  13. doi request reprint The role of lecithin:cholesterol acyltransferase in the modulation of cardiometabolic risks - a clinical update and emerging insights from animal models
    Dominic S Ng
    Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Canada
    Biochim Biophys Acta 1821:654-9. 2012
    ..Further studies to explore the role of LCAT in the modulation of cardiometabolic disorders and the underlying mechanisms are warranted...
  14. doi request reprint Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones
    Philip W Connelly
    Department of Medicine, University of Toronto, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Biochim Biophys Acta 1811:39-45. 2011
    ..In contrast, medium-chain length fatty acid lactones are stable in mouse serum in the absence of PON1, suggesting that PON1 plays a specific role in the metabolism of these compounds...
  15. doi request reprint Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis
    Amir Bashiri
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto, Canada Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada
    Biochim Biophys Acta 1861:594-605. 2016
    ..These novel findings provide opportunities for exploring a cellular cholesterol-focused strategy for treatment of NASH. ..
  16. doi request reprint Lecithin cholesterol acyltransferase deficiency protects from diet-induced insulin resistance and obesity--novel insights from mouse models
    Dominic S Ng
    Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Vitam Horm 91:259-70. 2013
    ....
  17. doi request reprint HDL--is it too big to fail?
    Dominic S Ng
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Shuter Wing, Room 3 041, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Nat Rev Endocrinol 9:308-12. 2013
    ..But, while wobbly, the HDL hypothesis is still standing, seemingly too big to fail owing to past intellectual, economic and psychological investments in the idea...