Andrew J Baker

Summary

Affiliation: St. Michael's Hospital
Country: Canada

Publications

  1. doi request reprint Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats
    Gregory M T Hare
    Departments of Anesthesia and Critical Care, Cara Phelan Centre for Trauma Research, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, M5B 1W8, Canada
    Intensive Care Med 35:1925-33. 2009
  2. ncbi request reprint Management of the severely head injured patient
    A J Baker
    Department of Anaesthesia, University of Toronto, ON
    Can J Anaesth 46:R35-45. 1999
  3. doi request reprint Effects of resuscitation fluid on neurologic physiology after cerebral trauma and hemorrhage
    Andrew J Baker
    Cara Phelan Center for Trauma Research, Department of Anaesthesia, St Michael s Hospital, Toronto, Ontario, Canada
    J Trauma 64:348-57. 2008
  4. ncbi request reprint Number of deaths by neurological criteria, and organ and tissue donation rates at three critical care centres in Canada
    Andrew Baker
    Department of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Can J Anaesth 53:722-6. 2006
  5. doi request reprint Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients
    Andrew J Baker
    Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 26:1227-40. 2009
  6. ncbi request reprint Attenuation of the electrophysiological function of the corpus callosum after fluid percussion injury in the rat
    A J Baker
    Department of Anaesthesia, University of Toronto, Toronto, Canada
    J Neurotrauma 19:587-99. 2002
  7. doi request reprint The Toronto prehospital hypertonic resuscitation--head injury and multiorgan dysfunction trial: feasibility study of a randomized controlled trial
    Laurie J Morrison
    Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Ontario, Canada
    J Crit Care 26:363-72. 2011
  8. ncbi request reprint Increased cerebral tissue oxygen tension after extensive hemodilution with a hemoglobin-based oxygen carrier
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesth Analg 99:528-35, table of contents. 2004
  9. pmc Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients
    Shawn G Rhind
    Defence Research and Development Canada, Toronto, Canada
    J Neuroinflammation 7:5. 2010
  10. ncbi request reprint Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    J Appl Physiol (1985) 103:1021-9. 2007

Collaborators

Detail Information

Publications52

  1. doi request reprint Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats
    Gregory M T Hare
    Departments of Anesthesia and Critical Care, Cara Phelan Centre for Trauma Research, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, M5B 1W8, Canada
    Intensive Care Med 35:1925-33. 2009
    ..To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101)...
  2. ncbi request reprint Management of the severely head injured patient
    A J Baker
    Department of Anaesthesia, University of Toronto, ON
    Can J Anaesth 46:R35-45. 1999
    ..Careful attention to post-operative care will also affect outcome. Recognizing that the outcome may not be determined solely at the time of impact is an important concept for all who take care of these patients...
  3. doi request reprint Effects of resuscitation fluid on neurologic physiology after cerebral trauma and hemorrhage
    Andrew J Baker
    Cara Phelan Center for Trauma Research, Department of Anaesthesia, St Michael s Hospital, Toronto, Ontario, Canada
    J Trauma 64:348-57. 2008
    ..Guidelines for the choice of fluid resuscitation and the use of red blood cell transfusions are not yet clear in the context of brain injury...
  4. ncbi request reprint Number of deaths by neurological criteria, and organ and tissue donation rates at three critical care centres in Canada
    Andrew Baker
    Department of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Can J Anaesth 53:722-6. 2006
    ..We sought to measure directly the number of deaths by neurological criteria, the associated donation rates, and the reasons for the differences...
  5. doi request reprint Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients
    Andrew J Baker
    Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 26:1227-40. 2009
    ..Pre-hospital resuscitation with HSD is associated with a reduction in serum S100B, NSE, and MBP concentrations, which are correlated with better outcome after severe TBI...
  6. ncbi request reprint Attenuation of the electrophysiological function of the corpus callosum after fluid percussion injury in the rat
    A J Baker
    Department of Anaesthesia, University of Toronto, Toronto, Canada
    J Neurotrauma 19:587-99. 2002
    ..They also indicated a greater degree of attenuation than predicted by APP expression changes alone...
  7. doi request reprint The Toronto prehospital hypertonic resuscitation--head injury and multiorgan dysfunction trial: feasibility study of a randomized controlled trial
    Laurie J Morrison
    Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Ontario, Canada
    J Crit Care 26:363-72. 2011
    ..The aim of the study was to evaluate the feasibility of a prehospital trial comparing hypertonic saline and dextran (HSD) with normal saline (NS) in blunt head injury patients...
  8. ncbi request reprint Increased cerebral tissue oxygen tension after extensive hemodilution with a hemoglobin-based oxygen carrier
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesth Analg 99:528-35, table of contents. 2004
    ..These data suggest that transfusion with hemoglobin raffimer may help to maintain cerebral oxygenation during severe anemia...
  9. pmc Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients
    Shawn G Rhind
    Defence Research and Development Canada, Toronto, Canada
    J Neuroinflammation 7:5. 2010
    ..This study examined the impact of hypertonic fluids on inflammatory/coagulation cascades in isolated head injury...
  10. ncbi request reprint Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma
    Gregory M T Hare
    Department of Anesthesia, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    J Appl Physiol (1985) 103:1021-9. 2007
    ..05 for both). Hemodilutional anemia reduced cerebral Pbr(O(2)) and oxygen extraction and increased cell death following TBI. These results support our hypothesis that acute anemia accentuated hypoxic cerebral injury after neurotrauma...
  11. pmc Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury
    Wolfgang G Junger
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School and Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria Defence Research and Development Canada, Toronto Research Centre and Departments of Surgery and Critical Care Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington Brain Injury Laboratory, Cara Phelan Centre for Trauma Research Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada and American College of Surgeons, Department of Surgery, University of California, Irvine, California
    Shock 40:366-74. 2013
    ..Since hypertonic fluids can inhibit PMN activation, we studied whether hypertonic fluid resuscitation can reduce excessive PMN activation in TBI patients...
  12. ncbi request reprint Effect of oxygen affinity and molecular weight of HBOCs on cerebral oxygenation and blood pressure in rats
    Gregory M T Hare
    Department of Anesthesia, St Michael s Hospital, Canada
    Can J Anaesth 53:1030-8. 2006
    ....
  13. doi request reprint The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury
    Jane Topolovec-Vranic
    Trauma and Neurosurgery Program, St Michael s Hospital, Toronto, Canada
    J Trauma 71:S478-86. 2011
    ..To determine, using a civilian model of mild traumatic brain injury (TBI), the added value of biomarker sampling upon prognostication of outcome at 1 week and 6 weeks postinjury...
  14. pmc Traumatic brain injury: can the consequences be stopped?
    Eugene Park
    Cara Phelan Centre for Trauma Research, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ont
    CMAJ 178:1163-70. 2008
    ..In this review we discuss new insights into the subcellular mechanisms of secondary injury that have highlighted numerous potential targets for intervention...
  15. doi request reprint Cerebral cortical gene expression in acutely anemic rats: a microarray analysis
    Francoise Briet
    Department of Anaesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Can J Anaesth 56:921-34. 2009
    ..This study assesses whether hemodilutional anemia up-regulated inflammatory cerebral gene expression (microarray) to help define the mechanism...
  16. doi request reprint An analysis of regional microvascular loss and recovery following two grades of fluid percussion trauma: a role for hypoxia-inducible factors in traumatic brain injury
    Eugene Park
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Cara Phelan Centre for Trauma Research, Ontario, Canada
    J Cereb Blood Flow Metab 29:575-84. 2009
    ..Collectively, the results indicate diffuse and heterogeneous microvascular alterations as well as endogenous expression of neuroprotective and neovascularization pathways after TBI...
  17. doi request reprint A model of low-level primary blast brain trauma results in cytoskeletal proteolysis and chronic functional impairment in the absence of lung barotrauma
    Eugene Park
    Cara Phelan Centre for Trauma Research, Keenan Research Centre in the Li Ka Shing Knowledge Institute at St Michael s Hospital, Toronto, Ontario, Canada
    J Neurotrauma 28:343-57. 2011
    ..Despite anatomical and scaling differences in rats compared to humans, the results suggest the potential for undiagnosed traumatic brain pathologies occurring in combat veterans following shock-wave exposure...
  18. ncbi request reprint Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats
    Anya T McLaren
    Department of Anesthesia, Cara Phelan Trauma Research Centre, University of Toronto, St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R403-14. 2007
    ..nNOS and VEGF protein levels were also increased within the cerebral cortex of anemic rats at clinically relevant hemoglobin concentrations...
  19. ncbi request reprint Hypercapnia increases cerebral tissue oxygen tension in anesthetized rats
    Gregory M T Hare
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Anaesth 50:1061-8. 2003
    ..To test the hypotheses that deliberate elevation of PaCO(2) increases cerebral tissue oxygen tension (PBrO(2)) by augmenting PaO(2) and regional cerebral blood flow (rCBF)...
  20. ncbi request reprint Heavy neurofilament accumulation and alpha-spectrin degradation accompany cerebellar white matter functional deficits following forebrain fluid percussion injury
    Eugene Park
    Cara Phelan Center for Trauma Research, St Michael s Hospital, 7082 Bond Wing, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Exp Neurol 204:49-57. 2007
    ..This study demonstrates the electrophysiological consequences of cerebellar white matter injury and a temporal profile of NF200 and spectrin degradation following forebrain FPI...
  21. pmc Sympathoadrenal Activation is Associated with Acute Traumatic Coagulopathy and Endotheliopathy in Isolated Brain Injury
    Alex P Di Battista
    Defence Research and Development Canada, Toronto Research Centre, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada Department of Critical Care, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Department of Anesthesia and Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada Keenan Research Centre for Biomedical Science, St Michael s Hospital, Toronto, Ontario, Canada Division of Trauma and Critical Care, University of Southern California, Los Angeles, California LA County and USC Medical Center, Los Angeles, California Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada Canadian Forces Health Services, The 1 Canadian Field Hospital, Petawawa, Ontario, and the Trauma Program, McGill University Health Centre, Montreal, Quebec, Canada
    Shock 46:96-103. 2016
    ..Acute coagulopathy after traumatic brain injury (TBI) involves a complex multifactorial hemostatic response that is poorly characterized...
  22. pmc Bone marrow-derived endothelial progenitor cells protect postischemic axons after traumatic brain injury
    Katya J Park
    Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 34:357-66. 2014
    ..The results indicate that EPCs are important for the protection of the white matter after trauma and represent a potential avenue for therapy. ..
  23. doi request reprint Electrophysiological white matter dysfunction and association with neurobehavioral deficits following low-level primary blast trauma
    Eugene Park
    Keenan Research Centre in the Li Ka Shing Knowledge Institute at St Michael s Hospital, Toronto, ON, Canada
    Neurobiol Dis 52:150-9. 2013
    ..Collectively, our results indicate that subclinical blast exposure can result in persistent neurological changes in cerebral white matter occurring in parallel with detectable neurobehavioral deficits...
  24. ncbi request reprint Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury
    Jinglu Ai
    Traumatic Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 24:960-78. 2007
    ..Multiple drug administrations may be necessary for achieving a persisting effectiveness of this compound...
  25. ncbi request reprint Structural and functional alterations of cerebellum following fluid percussion injury in rats
    Jinglu Ai
    Traumatic Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8
    Exp Brain Res 177:95-112. 2007
    ..These observations provide a basis for future mechanistic investigations aiming to realize neuroprotection from cerebellar neuronal death and loss of cerebellar functionality...
  26. doi request reprint Controlled blast exposure during forced explosive entry training and mild traumatic brain injury
    Andrew J Baker
    Interdepartmental Division of Critical Care Medicine, Department of Anesthesia, University of Toronto, Toronto, Canada
    J Trauma 71:S472-7. 2011
    ..The purpose of this investigation was to test the feasibility of implementing a research protocol in the context of a forced explosive entry training course...
  27. pmc Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis
    Matthew J Delano
    Department of Surgery, Division of Acute Care Surgery, University of Michigan, Ann Arbor, Michigan American College of Surgeons, Department of Surgery, University of California, Irvine, California Department of Surgery and Critical Care Medicine, St Michael s Hospital, and Defence Research and Development Canada Toronto, University of Toronto, Toronto, Ontario, Canada Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts Brain Injury Laboratory, Cara Phelan Centre for Trauma Research Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada and US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas
    Shock 44:25-31. 2015
    ....
  28. doi request reprint Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats
    Tina Hu
    Department of Anesthesia, Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond St, Toronto, ON M5B 1W8, Canada
    Anesth Analg 116:649-62. 2013
    ..We expanded on these findings by testing the hypothesis that acute β-blockade with a highly β(1)-specific antagonist (nebivolol) causes dose-dependent cerebral hypoxia during hemodilution...
  29. pmc The Toronto prehospital hypertonic resuscitation-head injury and multi organ dysfunction trial (TOPHR HIT)--methods and data collection tools
    Laurie J Morrison
    Rescu, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond St, Toronto Ontario, Canada
    Trials 10:105. 2009
    ..We describe a feasibility study of randomizing head injured patients to hypertonic saline and dextran vs. normal saline administration in the out of hospital setting...
  30. ncbi request reprint Cerebellar injury: clinical relevance and potential in traumatic brain injury research
    Eugene Park
    St Michael s Hospital, Trauma Research, and University of Toronto, Institute of Medical Sciences, Toronto, ON, M5S 1A, Canada
    Prog Brain Res 161:327-38. 2007
    ..This review highlights some of the recent findings in cerebellar trauma and builds an argument for including the cerebellum as a model to assess mechanisms of secondary injury and its potential contribution to the pathology of TBI...
  31. ncbi request reprint Mild in vitro trauma induces rapid Glur2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells
    Joshua D Bell
    Cara Phelan Center for Trauma Research, St Michaels Hospital, Toronto, Ontario, Canada
    Brain 130:2528-42. 2007
    ..Prevention of GluR2 endocytosis may be critical in the development of pharmacotherapies aimed at mild, seemingly inconsequential trauma, to avoid ensuing secondary damage...
  32. doi request reprint A Model of Excitotoxic Brain Injury in Larval Zebrafish: Potential Application for High-Throughput Drug Evaluation to Treat Traumatic Brain Injury
    Victoria McCutcheon
    1 Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    Zebrafish 13:161-9. 2016
    ..This system has potential to be applied as a high-throughput drug screening model to quickly identify candidate lead compounds for further evaluation. ..
  33. pmc Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury
    Alex P Di Battista
    Defence Research and Development Canada, Toronto Research Centre, Toronto, ON, Canada
    J Neuroinflammation 13:40. 2016
    ....
  34. doi request reprint Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A
    Ishita Siddiq
    Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 29:2647-59. 2012
    ..Collectively, the results provide supportive evidence for the concept of acute and delayed treatment following TBI using VEGF-ZFP to induce angiogenesis, reduce cell death, and enhance functional recovery...
  35. doi request reprint Abnormal coagulation tests are associated with progression of traumatic intracranial hemorrhage
    Christopher B Allard
    Department of Surgery and or Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Trauma 67:959-67. 2009
    ..ICH commonly increases in size and coagulopathy has been implicated in such progression. We investigated the association between coagulopathy diagnosed by routine laboratory tests and ICH progression...
  36. pmc Altered Blood Biomarker Profiles in Athletes with a History of Repetitive Head Impacts
    Alex P Di Battista
    Institute of Medical Science, University of Toronto, Toronto ON, Canada
    PLoS ONE 11:e0159929. 2016
    ..However, further validation is needed to correlate systemic biomarkers to repetitive brain impacts, as opposed to the extracranial effects common to an athletic population such as exercise and muscle damage. ..
  37. ncbi request reprint Case report: profound hypotension associated with labetalol therapy in a patient with cerebral aneurysms and subarachnoid hemorrhage
    Sana Jivraj
    Department of Anesthesia, St Michael s Hospital, University of Toronto, Ontario, Canada
    Can J Anaesth 53:678-83. 2006
    ..We present a case of profound hypotension, refractory to inotropic and vasopressor therapy following an iv infusion of labetalol...
  38. ncbi request reprint Protective effect of high glucose against ischemia-induced synaptic transmission damage in rat hippocampal slices
    Guo Feng Tian
    Traumatic Brain Injury Laboratory, Cara Phelan Centre for Trauma Research and Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronto, Ontario M5B 1W8 Canada
    J Neurophysiol 88:236-48. 2002
    ..These results indicate that high glucose in ACSF during the period before and after ischemia significantly protects CA1 synaptic transmission against in vitro ischemia-induced damage through postponing the occurrence of ID...
  39. ncbi request reprint Trauma and tribulation: the experiences and attitudes of operating room nurses working with organ donors
    Cheryl Regehr
    Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada
    J Clin Nurs 13:430-7. 2004
    ..It has been suggested that the attitudes of medical personnel towards organ retrieval is a key success factor in improving organ donation. Yet there is evidence that those closest to the process of procurement are the most negative...
  40. ncbi request reprint A novel model of traumatic brain injury in adult zebrafish demonstrates response to injury and treatment comparable with mammalian models
    Victoria McCutcheon
    Keenan Research Centre in the Li Ka Shing Knowledge Institute at St Michael s Hospital, Trauma Research, 30 Bond St, Toronto, Ontario, Canada, M5B 1W8
    J Neurotrauma . 2016
    ..Together, results indicate that the zebrafish exhibits responses to injury and intervention similar to mammalian TBI pathophysiology and suggest the potential for use to rapidly evaluate therapeutic compounds with high efficiency...
  41. ncbi request reprint The Impact of Red Blood Cell Transfusion on Cerebral Tissue Oxygen Saturation in Severe Traumatic Brain Injury
    Victoria A McCredie
    Department of Critical Care Medicine, Sunnybrook Health Sciences Center, 2075 Bayview Ave, Room D108, Toronto, ON, M4N 3M5, Canada
    Neurocrit Care . 2016
    ..The aim of this study was to examine the influence of red blood cell transfusions on cerebral tissue oxygenation (SctO2) in critically ill TBI patients...
  42. doi request reprint Biomarkers of Glycocalyx Injury are Associated with Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage: A Case Series Supporting a New Hypothesis
    Josh D Bell
    Clinician Investigator Program, Department of Anesthesia, University of Toronto, Toronto, ON, Canada
    Neurocrit Care . 2016
    ..The vascular endothelial glycocalyx mediates platelet aggregation and endothelial cell-leukocyte interactions and may play an important role in DCI pathogenesis...
  43. doi request reprint Patient satisfaction and documentation of pain assessments and management after implementing the adult nonverbal pain scale
    Jane Topolovec-Vranic
    St Michael s Hospital in Toronto, Ontario, Canada
    Am J Crit Care 19:345-54; quiz 355. 2010
    ..Accurate assessment and management of pain in critically ill patients who are nonverbal or cognitively impaired is challenging. No widely accepted assessment tool is currently in place for assessing pain in these patients...
  44. ncbi request reprint Purkinje cell vulnerability to mild and severe forebrain head trauma
    Eugene Park
    Cara Phelan Center for Trauma Research, St Michael s Hospital, Toronto, Ontario, Canada
    J Neuropathol Exp Neurol 65:226-34. 2006
    ..Expression of calbindin-28k increased in regions of greatest PN loss, suggesting that the surviving PNs possess higher calcium-buffering capacities, which may account for their survival...
  45. doi request reprint Transcranial Doppler monitoring in subarachnoid hemorrhage: a critical tool in critical care
    Andrea Rigamonti
    Department of Anaesthesia, St Michael s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Can J Anaesth 55:112-23. 2008
    ..To review the literature regarding the use of transcranial Doppler ultrasonography (TCD) for monitoring cerebral vasospasm following subarachnoid hemorrhage (SAH)...
  46. pmc Application of blood-based biomarkers in human mild traumatic brain injury
    Alex P Di Battista
    Faculty of Medicine, Institute of Medical Science, University of Toronto Toronto, ON, Canada
    Front Neurol 4:44. 2013
    ..The purpose of this review is to highlight a number of current experimental peripheral blood biomarkers of mTBI, as well as comment on the issues surrounding their clinical application and utility...
  47. ncbi request reprint Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression
    Gregory M T Hare
    Department of Anaesthesia, University of Toronto, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Appl Physiol (1985) 94:2058-67. 2003
    ..Hemodilutional anemia caused an acute reduction in Pbr(O(2)) and an increase in cerebral cortical nNOS mRNA, supporting a role for nNOS in the physiological response to acute anemia...
  48. pmc Awareness during anesthesia
    Beverley A Orser
    Department of Anesthesia, University of Toronto, Toronto, Ont
    CMAJ 178:185-8. 2008
  49. ncbi request reprint Family perceptions of end-of-life care in an urban ICU
    Maria Kjerulf
    Faculty of Nursing, McMaster University
    Dynamics 16:22-5. 2005
    ..The researchers sought to determine levels of satisfaction with care, visitation, support, comfort and pain measures...
  50. pmc Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential
    Sam D Shemie
    Division of Pediatric Critical Care, Montreal Children s Hospital, McGill University Health Centre, Montreal, Que
    CMAJ 174:S13-32. 2006
  51. ncbi request reprint Neuroprotection following fluid percussion brain trauma: a pilot study using quercetin
    Elisabeth Schultke
    Departments of Anatomy and Cell Biology, and Surgery, Division of Neurosurgery, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada
    J Neurotrauma 22:1475-84. 2005
    ..Quercetin significantly prevented decrease of glutathione levels and decreased myeloperoxidase activity. We conclude that this dietary flavonoid has therapeutic potential following brain trauma...
  52. pmc National recommendations for donation after cardiocirculatory death in Canada: Donation after cardiocirculatory death in Canada
    Sam D Shemie
    Division of Pediatric Critical Care, Montreal Children s Hospital, McGill University Health Centre, Montreal, Canada
    CMAJ 175:S1. 2006
    ..The impact of DCD, including pre-and post-mortem interventions, on donor family experiences, organ availability, graft function and recipient survival should be carefully documented and studied...