Arya M Sharma

Summary

Country: Canada

Publications

  1. pmc Parents as agents of change (PAC) in pediatric weight management: the protocol for the PAC randomized clinical trial
    Geoff D C Ball
    8B, Pediatric Centre for Weight and Health, Edmonton General Continuing Care Centre, 11111 Jasper Ave, Edmonton, AB, Canada, T5K0L4
    BMC Pediatr 12:114. 2012
  2. pmc Should I stay or should I go? Understanding families' decisions regarding initiating, continuing, and terminating health services for managing pediatric obesity: the protocol for a multi-center, qualitative study
    Geoff D C Ball
    Pediatric Centre for Weight and Health, Edmonton General Continuing Care Centre, Edmonton, AB, Canada
    BMC Health Serv Res 12:486. 2012
  3. pmc Differential changes in serum uric acid concentrations in sibutramine promoted weight loss in diabetes: results from four weeks of the lead-in period of the SCOUT trial
    Charlotte Andersson
    Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark
    Nutr Metab (Lond) 6:42. 2009
  4. pmc The weight lowering effect of sibutramine and its impact on serum lipids in cardiovascular high risk patients with and without type 2 diabetes mellitus - an analysis from the SCOUT lead-in period
    Peter Weeke
    Department of Cardiology, Gentofte Hospital, University of Copenhagen, Denmark
    BMC Endocr Disord 10:3. 2010
  5. pmc Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study
    Arya M Sharma
    McMaster University, Hamilton, ON, Canada
    Cardiovasc Diabetol 6:28. 2007
  6. doi request reprint Blood pressure changes associated with sibutramine and weight management - an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes trial (SCOUT)
    A M Sharma
    Royal Alexandra Hospital, University of Alberta, Alberta, Canada
    Diabetes Obes Metab 11:239-50. 2009
  7. doi request reprint A simple prediction rule for all-cause mortality in a cohort eligible for bariatric surgery
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada2Alberta Diabetes Institute, Edmonton, Alberta, Canada
    JAMA Surg 148:1109-15. 2013
  8. doi request reprint Weight loss and outcomes in wait-listed, medically managed, and surgically treated patients enrolled in a population-based Bariatric program: prospective cohort study
    Raj S Padwal
    Department of Medicine, University of Alberta Alberta Diabetes Institute Department of Surgery and CAMIS Center for the Advancement of Minimally Invasive Surgery, Royal Alexandra Hospital Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada
    Med Care 52:208-15. 2014
  9. doi request reprint Relation of epicardial fat and alanine aminotransferase in subjects with increased visceral fat
    Gianluca Iacobellis
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:179-83. 2008
  10. ncbi request reprint Relation of subepicardial adipose tissue to carotid intima-media thickness in patients with human immunodeficiency virus
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 99:1470-2. 2007

Detail Information

Publications127 found, 100 shown here

  1. pmc Parents as agents of change (PAC) in pediatric weight management: the protocol for the PAC randomized clinical trial
    Geoff D C Ball
    8B, Pediatric Centre for Weight and Health, Edmonton General Continuing Care Centre, 11111 Jasper Ave, Edmonton, AB, Canada, T5K0L4
    BMC Pediatr 12:114. 2012
    ....
  2. pmc Should I stay or should I go? Understanding families' decisions regarding initiating, continuing, and terminating health services for managing pediatric obesity: the protocol for a multi-center, qualitative study
    Geoff D C Ball
    Pediatric Centre for Weight and Health, Edmonton General Continuing Care Centre, Edmonton, AB, Canada
    BMC Health Serv Res 12:486. 2012
    ..This research aims to understand the interplay between individual, family, environmental, and systemic factors that influence families' decisions regarding the management of pediatric obesity...
  3. pmc Differential changes in serum uric acid concentrations in sibutramine promoted weight loss in diabetes: results from four weeks of the lead-in period of the SCOUT trial
    Charlotte Andersson
    Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark
    Nutr Metab (Lond) 6:42. 2009
    ..The response of uric acid to weight loss therapy (lifestyle plus sibutramine) in an overweight and obese cardiovascular high risk population was studied...
  4. pmc The weight lowering effect of sibutramine and its impact on serum lipids in cardiovascular high risk patients with and without type 2 diabetes mellitus - an analysis from the SCOUT lead-in period
    Peter Weeke
    Department of Cardiology, Gentofte Hospital, University of Copenhagen, Denmark
    BMC Endocr Disord 10:3. 2010
    ..We examined whether blood lipid changes with short term administration of the weight lowering drug, sibutramine and lifestyle modification in obese and overweight high-risk patients was associated with T2D status at screening...
  5. pmc Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study
    Arya M Sharma
    McMaster University, Hamilton, ON, Canada
    Cardiovasc Diabetol 6:28. 2007
    ....
  6. doi request reprint Blood pressure changes associated with sibutramine and weight management - an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes trial (SCOUT)
    A M Sharma
    Royal Alexandra Hospital, University of Alberta, Alberta, Canada
    Diabetes Obes Metab 11:239-50. 2009
    ..To explore vital sign changes among patient subgroups during the 6-week lead-in period of the sibutramine cardiovascular outcomes (SCOUT) trial...
  7. doi request reprint A simple prediction rule for all-cause mortality in a cohort eligible for bariatric surgery
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada2Alberta Diabetes Institute, Edmonton, Alberta, Canada
    JAMA Surg 148:1109-15. 2013
    ....
  8. doi request reprint Weight loss and outcomes in wait-listed, medically managed, and surgically treated patients enrolled in a population-based Bariatric program: prospective cohort study
    Raj S Padwal
    Department of Medicine, University of Alberta Alberta Diabetes Institute Department of Surgery and CAMIS Center for the Advancement of Minimally Invasive Surgery, Royal Alexandra Hospital Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada
    Med Care 52:208-15. 2014
    ..Multidisciplinary bariatric care is increasingly being delivered in Canada within publicly funded regional programs. Demand is high, wait lists are long, and clinical effectiveness is unknown...
  9. doi request reprint Relation of epicardial fat and alanine aminotransferase in subjects with increased visceral fat
    Gianluca Iacobellis
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:179-83. 2008
    ..However, the potential link between cardiac adiposity, emerging index of visceral adiposity, and fatty liver is still unexplored...
  10. ncbi request reprint Relation of subepicardial adipose tissue to carotid intima-media thickness in patients with human immunodeficiency virus
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 99:1470-2. 2007
    ..81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients...
  11. pmc Prioritization and willingness to pay for bariatric surgery: the patient perspective
    Richdeep S Gill
    The Department of Surgery and Center for the Advancement of Minimally Invasive Surgery CAMIS, University of Alberta, Royal Alexandra Hospital, Edmonton, Alta
    Can J Surg 57:33-9. 2014
    ..Access to publicly funded bariatric surgery is limited, potential candidates face lengthy waits, and no universally accepted prioritization criteria exist. We examined patients' perspectives regarding prioritization for surgery...
  12. pmc Health status, quality of life, and satisfaction of patients awaiting multidisciplinary bariatric care
    Raj S Padwal
    Department of Medicine, University of Alberta, 2F1, 26 Walter C, Mackenzie Health Sciences Centre, 8440 112th Street, Edmonton, AB T6G 2B7, Canada
    BMC Health Serv Res 12:139. 2012
    ..Our objective was to examine wait-listed patients' health status and perceptions regarding the consequences of prolonged wait times using a cross-sectional study design nested within a prospective cohort...
  13. doi request reprint Influence of a clinical lifestyle-based weight loss program on the metabolic risk profile of metabolically normal and abnormal obese adults
    Rebecca H Liu
    School of Kinesiology and Health Science, York University, Toronto, ON, Canada
    Obesity (Silver Spring) 21:1533-9. 2013
    ..The effect of a clinically significant WL of 5% on metabolic factors among metabolically normal and abnormal overweight and obese (MNO and MAO) individuals was examined...
  14. doi request reprint Self-reported physical activity preferences in individuals with prediabetes
    Lorian M Taylor
    Faculty of Physical Education and Recreation, University of Alberta, Alberta, Canada
    Phys Sportsmed 39:41-9. 2011
    ..The primary objective of this study was to determine the physical activity (PA) preferences in a sample of individuals with prediabetes...
  15. doi request reprint Do anthropometric indices accurately reflect directly measured body composition in men and women with chronic heart failure?
    Antigone Oreopoulos
    School of Public Health, University of Alberta, 8440 112th Street, Edmonton, AB, Canada
    Congest Heart Fail 17:90-2. 2011
    ..Anthropometric indices do not accurately reflect body composition in patients with CHF, especially in women. When accurate assessment of body composition is required, direct measurements should be obtained...
  16. pmc Prevention of cardiovascular disease: obesity, diabetes and the metabolic syndrome
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Can J Cardiol 26:18C-20C. 2010
    ..Future efforts will need to focus on these factors and pansocietal solutions will be required if&nbsp;success in reversing the population-wide weight increases that have occurred over the past several decades is to be achieved...
  17. ncbi request reprint The obese patient with diabetes mellitus: from research targets to treatment options
    Arya M Sharma
    Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med 119:S17-23. 2006
    ..Clinical trials with telmisartan are currently investigating the effects of RAS blockade on insulin sensitivity in humans...
  18. doi request reprint Weight recidivism post-bariatric surgery: a systematic review
    Shahzeer Karmali
    Center for the Advancement of Minimally Invasive Surgery CAMIS, Royal Alexandra Hospital, Room 405 CSC, 10240 Kingsway Ave, Edmonton, AB, T5H 3 V9, Canada
    Obes Surg 23:1922-33. 2013
    ..Addressing post-surgical weight regain requires a systematic approach to patient assessment focusing on contributory dietary, psychologic, medical and surgical factors. ..
  19. pmc Complications associated with adjustable gastric banding for morbid obesity: a surgeon's guides
    Iyad Eid
    The Centre for Advancement of Minimally Invasive Surgery, Department of Surgery, Division of General Surgery, University of Alberta, 10240 Kingsway Avenue, Edmonton, Alberta
    Can J Surg 54:61-6. 2011
    ..This review will prepare the general surgeon to identify, diagnose and manage the common complications encountered in patients presenting following LAGB...
  20. doi request reprint A review of laparoscopic sleeve gastrectomy for morbid obesity
    Xinzhe Shi
    Centre for Advancement of Minimally Invasive Surgery CAMIS, Royal Alexandra Hospital, 10240 Kingsway Ave, Edmonton, AB T5H 3V9, Canada
    Obes Surg 20:1171-7. 2010
    ..Although LSG is a promising treatment option for patients with morbid obesity, its role remains undefined and it should be considered an investigational procedure that may require revision in a subset of patients...
  21. doi request reprint Substantial changes in epicardial fat thickness after weight loss in severely obese subjects
    Gianluca Iacobellis
    1Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:1693-7. 2008
    ..Measurement of echocardiographic epicardial fat thickness may provide an additional tool in understanding the metabolic risk associated with variation in fat distribution...
  22. doi request reprint Effect of gastric bypass surgery on azithromycin oral bioavailability
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Antimicrob Chemother 67:2203-6. 2012
    ..Gastric bypass, a procedure that circumvents the upper gut, may compromise azithromycin plasma levels. We hypothesized that azithromycin concentrations would be reduced following gastric bypass...
  23. ncbi request reprint Obesity and cardiovascular disease: pathogenic mechanisms and potential benefits of weight reduction
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 5:25-33. 2005
    ....
  24. doi request reprint The value of current interventions for obesity
    Arya M Sharma
    Cardiovascular Obesity Research and Management in Michael deGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Nat Clin Pract Cardiovasc Med 5:S3-9. 2008
    ..If this effect can be demonstrated in humans, this type of agent might become the treatment of choice for obese or overweight people at risk of type 2 diabetes...
  25. pmc Comparative effectiveness and safety of gastric bypass, sleeve gastrectomy and adjustable gastric banding in a population-based bariatric program: prospective cohort study
    Richdeep S Gill
    From the Centre for the Advancement of Minimally Invasive Surgery CAMIS, Royal Alexandra Hospital, Edmonton, Alta Gill, Karmali the Department of Medicine, University of Alberta, Edmonton, Alta Majumdar, Rueda Clausen, Sharma, Klarenbach, Padwal and the Department of Surgery, University of Alberta, Edmonton, Alta Apte
    Can J Surg 59:233-41. 2016
    ..Our objective was to compare the effectiveness and safety of laparoscopic Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (LSG) and adjustable gastric banding (LAGB) in a publicly funded, population-based bariatric treatment program...
  26. doi request reprint Predictors of health-related quality of life in 500 severely obese patients
    Lindsey M Warkentin
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada Alberta Diabetes Institute, Edmonton, Alberta, Canada
    Obesity (Silver Spring) 22:1367-72. 2014
    ..To characterize health-related quality of life (HRQL) impairment in severely obese subjects, using several validated instruments...
  27. pmc Characteristics of the population eligible for and receiving publicly funded bariatric surgery in Canada
    Raj S Padwal
    Department of Medicine, 2F1, 26 Walter C, Mackenzie Health Sciences Centre, University of Alberta, 8440 112th Street, Edmonton, T6G 2B7, Alberta, Canada
    Int J Equity Health 11:54. 2012
    ..The purpose of this study was to quantify and characterize the bariatric surgery-eligible population in Canada in comparison to surgery-ineligible subjects and surgical recipients...
  28. pmc Managing complications associated with laparoscopic Roux-en-Y gastric bypass for morbid obesity
    P S Griffith
    The Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Can J Surg 55:329-36. 2012
    ..We discuss the principles involved in the management of each complication and the timing of referral to specialist bariatric centres...
  29. doi request reprint Laparoscopic sleeve gastrectomy with staple line buttress reinforcement in 116 consecutive morbidly obese patients
    Richdeep S Gill
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Obes Surg 22:560-4. 2012
    ....
  30. doi request reprint Single-pill combination of telmisartan/amlodipine versus amlodipine monotherapy in diabetic hypertensive patients: an 8-week randomized, parallel-group, double-blind trial
    Arya M Sharma
    Chair for Obesity Research and Management, University of Alberta, Royal Alexandra Hospital, Edmonton, Alberta, Canada
    Clin Ther 34:537-51. 2012
    ..Hypertensive patients with diabetes often require combination therapy to achieve a blood pressure (BP) goal, and evidence suggests that time to BP goal is crucial to decrease cardiovascular risk...
  31. doi request reprint Threshold values of high-risk echocardiographic epicardial fat thickness
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:887-92. 2008
    ..In this study, we sought to provide threshold values of echocardiographic epicardial fat thickness associated with metabolic and anthropometric risk factors...
  32. doi request reprint The impact of obesity on diabetes mellitus and the role of bariatric surgery
    Richdeep S Gill
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Maturitas 69:137-40. 2011
    ..However, bariatric surgery serves as one component of a multifaceted weight management strategy that is required for long-term success...
  33. doi request reprint Urinary sodium and potassium excretion and risk of cardiovascular events
    MARTIN J O'DONNELL
    Population Health Research Institute, Hamilton General Hospital, McMaster University, 237 Barton St E, Third Floor, Hamilton, ON, L8L 2X2, Canada
    JAMA 306:2229-38. 2011
    ..The precise relationship between sodium and potassium intake and cardiovascular (CV) risk remains uncertain, especially in patients with CV disease...
  34. pmc Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)
    Sonia S Anand
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e22112. 2011
    ..We sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease...
  35. doi request reprint Recommendations From Parents to Improve Health Services for Managing Pediatric Obesity in Canada
    Melissa Tremblay
    Department of Educational Psychology, Faculty of Education, University of Alberta, Edmonton, Alberta, Canada
    Acad Pediatr 16:587-93. 2016
    ..Our objective was to characterize parents' recommendations for enhancing tertiary-level health services for managing pediatric obesity in Canada...
  36. pmc The evaluating self-management and educational support in severely obese patients awaiting multidisciplinary bariatric care (EVOLUTION) trial: rationale and design
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Health Serv Res 13:321. 2013
    ..Furthermore, we hypothesize that the in-person version will be more effective but more costly than the web-based version...
  37. ncbi request reprint Can PPARgamma agonists have a role in the management of obesity-related hypertension?
    Vasudhevan T Chetty
    Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Vascul Pharmacol 45:46-53. 2006
    ..This review will highlight the role of TZDs in various models of hypertension and discuss their potential role in the management of obesity-related hypertension...
  38. pmc A weighty issue: medication as a cornerstone of medical obesity management
    Arya M Sharma
    University of Alberta, Royal Alexandra Hospital, 10240 Kingsway Ave, 406 CSC, Edmonton, AB T5H 3V9
    Can Fam Physician 54:498-9, 500-1. 2008
  39. pmc The Alberta population-based prospective evaluation of the quality of life outcomes and economic impact of bariatric surgery (APPLES) study: background, design and rationale
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Health Serv Res 10:284. 2010
    ..We hypothesize that lower indirect, out of pocket and productivity costs will offset increased direct health-care costs resulting in lower total costs for bariatric surgery...
  40. doi request reprint Robotic-assisted bariatric surgery: a systematic review
    Richdeep S Gill
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Int J Med Robot 7:249-55. 2011
    ..This study systematically reviews the literature regarding the feasibility and safety of robotic-assisted bariatric surgery in obese patients...
  41. doi request reprint New pharmacological approaches for obesity management
    Christian F Rueda-Clausen
    Alberta Diabetes Institute, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
    Nat Rev Endocrinol 9:467-78. 2013
    ..This Review presents the available data on the efficacy and safety of these three medications and discusses future perspectives and challenges related to pharmacological weight management. ..
  42. pmc Bariatric surgery: a systematic review of the clinical and economic evidence
    Raj Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Gen Intern Med 26:1183-94. 2011
    ..Use of bariatric surgery for severe obesity has increased dramatically...
  43. doi request reprint Sleeve gastrectomy and type 2 diabetes mellitus: a systematic review
    Richdeep S Gill
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Surg Obes Relat Dis 6:707-13. 2010
    ..The objective of the present study was to systematically review the effect of LSG on type 2 DM...
  44. pmc The relationship between body mass index, treatment, and mortality in patients with established coronary artery disease: a report from APPROACH
    Antigone Oreopoulos
    Department of Clinical Epidemiology, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    Eur Heart J 30:2584-92. 2009
    ..Patients with obesity may be presenting earlier and receiving more aggressive treatment compared with those with normal BMI...
  45. doi request reprint Effect of sleeve gastrectomy on gastroesophageal reflux disease: a systematic review
    Sharon Chiu
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Surg Obes Relat Dis 7:510-5. 2011
    ..Gastroesophageal reflux disease (GERD) is a common co-morbid disease in bariatric patients. The effect of SG on GERD has not been well studied; thus, the goal of the present systematic data review was to analyze the effect of SG on GERD...
  46. pmc Effect of gastric bypass surgery on the absorption and bioavailability of metformin
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Diabetes Care 34:1295-300. 2011
    ..Metformin, the first-line drug for diabetes, has low bioavailability and slow, incomplete gastrointestinal absorption. We hypothesized that gastric bypass would further reduce the absorption and bioavailability of metformin...
  47. ncbi request reprint The impact of bariatric surgery in patients with type-2 diabetes mellitus
    Richdeep S Gill
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Curr Diabetes Rev 7:185-9. 2011
    ..As the prevalence of obesity and T2DM continues to rise, so may the role of bariatric surgery to combat this growing epidemic...
  48. doi request reprint Medical tourism in bariatric surgery
    Daniel W Birch
    Center for the Advancement of Minimally Invasive Surgery, Royal Alexandra Hospital, 10240 Kingsway, Edmonton, Alberta, T5H 3V9 Canada
    Am J Surg 199:604-8. 2010
    ..The number of Canadians who self-refer for bariatric surgery outside of Canada or to private clinics within Canada remains undefined. The outcomes from this questionable practice have not been evaluated systematically to date...
  49. doi request reprint The obesity paradox in the elderly: potential mechanisms and clinical implications
    Antigone Oreopoulos
    Department of Clinical Epidemiology, School of Public Health, University of Alberta, 2F1 26 Walter C Mackenzie HSC, 8440 112 Street, Edmonton, Alberta, Canada
    Clin Geriatr Med 25:643-59, viii. 2009
    ..This article examines the evidence on these controversial issues, explores potential explanations for these findings, discusses the clinical implications, and provides recommendations for further research in this area...
  50. doi request reprint Quality of Follow-up: Systematic Review of the Research in Bariatric Surgery
    Noah J Switzer
    Department of Surgery, University of Alberta, Edmonton, Canada Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada Department of Surgery, Jewish General Hospital, McGill University, Montreal, Canada Center for the Advancement of Minimally Invasive Surgery, Royal Alexandra Hospital, Edmonton, Canada Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada Department of Surgery, Peter Lougheed Center, University of Calgary, Calgary, Canada
    Ann Surg 263:875-80. 2016
    ..We aim to systematically review the bariatric surgery literature with regards to adequacy of patient follow-up, meeting the McMaster criteria of ≥80% follow-up...
  51. doi request reprint Understanding physical activity in individuals with prediabetes: an application of social cognitive theory
    Lorian M Taylor
    a Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    Psychol Health Med 21:254-60. 2016
    ..Further evaluative inquiry is needed to establish support for the use of the SCT as a framework for developing, implementing and evaluating PA behaviour change interventions in this population...
  52. doi request reprint Metabolic effects of telmisartan in subjects with abdominal obesity: a prospective randomized controlled trial
    V Tony Chetty
    McMaster University, Hamilton, Ontario, Canada
    Blood Press 23:54-60. 2014
    ..03; 16.5% increase from baseline in the telmisartan group). CONCLUSIONS. Telmisartan increased beta-cell function but did not decrease IMCL or liver fat content or other metabolic parameters among individuals with abdominal obesity...
  53. pmc Feasibility of an interdisciplinary program for obesity management in Canada
    Sean Wharton
    Wharton Medical Clinic, Hamilton, Ont, Canada
    Can Fam Physician 58:e32-8. 2012
    ..To assess the feasibility of a medically supervised, publicly funded interdisciplinary program for obesity management in a Canadian setting...
  54. ncbi request reprint Emergency department equipment for obese patients: perceptions of adequacy
    Navneet Singh
    Honours Program Cardiovascular Obesity Research and Management, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Adv Nurs 59:140-5. 2007
    ....
  55. doi request reprint Barriers to obesity treatment
    Marina Mauro
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Eur J Intern Med 19:173-80. 2008
    ..Failure to do so may further undermine the sense of failure, low self esteem and self efficacy already common among obese individuals. Addressing treatment barriers can save resources and increase the prospect of long-term success...
  56. ncbi request reprint The role of renin-angiotensin system blockade in the management of hypertension associated with the cardiometabolic syndrome
    Arya M Sharma
    Michael G deGroote Medical School, McMaster University, Hamilton, Ontario, Canada
    J Cardiometab Syndr 1:29-35. 2006
    ..Randomized, controlled trials conducted specifically in patients with obesity and hypertension are needed to determine the optimal therapeutic approach for these patients...
  57. ncbi request reprint The relationship of body mass index to outcomes after percutaneous coronary intervention
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton Health Sciences General Site, Hamilton, Ontario, Canada
    J Interv Cardiol 19:388-95. 2006
    ..To evaluate the effect of body mass index (BMI) on in-hospital outcomes in patients undergoing percutaneous coronary intervention (PCI) at a tertiary care hospital center in Ontario, Canada...
  58. ncbi request reprint Epicardial adipose tissue is related to carotid intima-media thickness and visceral adiposity in HIV-infected patients with highly active antiretroviral therapy-associated metabolic syndrome
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr HIV Res 5:275-9. 2007
    ..Detection of epicardial fat thickness, new index of visceral adiposity in non HIV-infected patients, might be important as diagnostic tool in HIV-infected patients on HAART...
  59. doi request reprint The role of angiotensin receptor blockers in diabetic nephropathy
    Arya M Sharma
    Obesity Research and Management, University of Alberta, Royal Alexandra Hospital, Edmonton, AB, Canada
    Postgrad Med 123:109-21. 2011
    ..The incidence of ESRD is predicted to increase as the prevalence of type 2 diabetes mellitus and obesity continue to increase...
  60. pmc Severe Obesity Is Associated With Increased Risk of Early Complications and Extended Length of Stay Following Coronary Artery Bypass Grafting Surgery
    Tasuku Terada
    Department of Occupational Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Am Heart Assoc 5:. 2016
    ..We examined the relationship of obesity with the incidence of early adverse outcomes and in-hospital length of stay following coronary artery bypass grafting surgery...
  61. ncbi request reprint The Effect of Bariatric Surgery on Mobility, Health-Related Quality of Life, Healthcare Resource Utilization, and Employment Status
    Jean Eric Tarride
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 43 Charlton Ave E 2nd Floor, Hamilton, ON, L8N 1Y3, Canada
    Obes Surg . 2016
    ..A sub-study of the Ontario Bariatric Registry was conducted to evaluate the impact of bariatric surgery on mobility, health-related quality of life (HRQoL), healthcare resource utilization (HRU), and employment status...
  62. pmc Adiposity and immune-muscle crosstalk in South Asians &Europeans: A cross-sectional study
    M Constantine Samaan
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Sci Rep 5:14521. 2015
    ....
  63. doi request reprint Multimorbidity in a prospective cohort: prevalence and associations with weight loss and health status in severely obese patients
    Calypse B Agborsangaya
    Department of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Alberta Diabetes Institute, Edmonton, Alberta, Canada
    Obesity (Silver Spring) 23:707-12. 2015
    ..To examine the prevalence of multimorbidity (≥2 chronic conditions) in severely obese patients and its associations with weight loss and health status over 2 years...
  64. doi request reprint Income status and approval for bariatric surgery in a publicly funded regional obesity program
    Kieran Halloran
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Obes Surg 21:373-8. 2011
    ..Whether this relationship is also present in a universally accessible, publicly funded health care system is not currently known...
  65. pmc Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 33:1629-34. 2010
    ..To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance...
  66. ncbi request reprint Treatment of obesity: a challenging task
    Arya M Sharma
    Department of Medicine, Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, Hamilton, Canada
    Contrib Nephrol 151:212-20. 2006
    ..Successful obesity treatment should be defined as long-term weight loss maintenance. In this chapter, we briefly review the current evidences regarding the treatment of obesity...
  67. ncbi request reprint Different "weight" of cardiac and general adiposity in predicting left ventricle morphology
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 14:1679-84. 2006
    ..Nevertheless, the close anatomical and functional relationship of epicardial adipose tissue to the adjacent myocardium should readily allow local, paracrine interactions between these tissues...
  68. doi request reprint Health Benefits of Long-Term Weight-Loss Maintenance
    Christian F Rueda-Clausen
    Obesity Research and Management, Clinical Research Unit, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2E1 Canada email
    Annu Rev Nutr 35:475-516. 2015
    ..However, the degree of weight loss that must be achieved and sustained to reap these benefits varies widely between comorbidities. ..
  69. pmc Sex differences in skeletal muscle phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: a cross-sectional study
    M Constantine Samaan
    1 Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada 2 Division of Pediatric Endocrinology, McMaster Children s Hospital, Hamilton, Ontario, Canada
    Sci Rep 5:9154. 2015
    ..001) when compared to men after correction for age, ethnicity, HOMA-IR, fat mass and sex. We conclude that the downregulation of muscle PTEN may explain the retention of insulin sensitivity with higher adiposity in women compared to men. ..
  70. doi request reprint Exploring collaboration between clinicians and parents to optimize pediatric weight management
    Biagina Carla Farnesi
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    Patient Educ Couns 87:10-7. 2012
    ..To explore the understanding of collaboration between clinicians working in pediatric weight management and parents of overweight children...
  71. doi request reprint Metabolic syndrome and acute hyperglycemia are associated with endoplasmic reticulum stress in human mononuclear cells
    Andrew T Sage
    Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 20:748-55. 2012
    ..These findings suggest that there is an association between both acute and chronic dysglycemia and ER stress in humans...
  72. ncbi request reprint The management of hypertension in the overweight and obese patient: is weight reduction sufficient?
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Drugs 64:795-803. 2004
    ..Additional studies are needed to determine the long-term (>1 year) efficacy and safety of antihypertensive and anti-obesity management strategies in the overweight and obese hypertensive patient...
  73. ncbi request reprint Is there a rationale for angiotensin blockade in the management of obesity hypertension?
    Arya M Sharma
    McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, ON, Canada
    Hypertension 44:12-9. 2004
    ....
  74. ncbi request reprint A patient with personal control of the adjustable gastric band and bulimia: a psychiatric complication
    Valerie H Taylor
    Mood Disorders Program, Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada
    Obes Surg 16:1386-7. 2006
    ..Self-adjustment of the gastric band for control of intake is a potential problem. Preoperative psychiatric evaluation is desirable to identify and treat eating disorders and depression, and to indicate surveillance...
  75. ncbi request reprint Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism
    Arya M Sharma
    Canada Research Chair for Cardiovascular Obesity Research and Management, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    J Clin Endocrinol Metab 92:386-95. 2007
    ..e. adipocytes display morphological differences alongside aberrant endocrine and metabolic function and low-grade inflammation)...
  76. ncbi request reprint Do cardiac and perivascular adipose tissue play a role in atherosclerosis?
    Gianluca Iacobellis
    Department of Medicine, St Joseph s Hospital, 50 Charlton Avenue East, 5th Fontbonne Building, Hamilton, Ontario, L8N 4A6, Canada
    Curr Diab Rep 8:20-4. 2008
    ..The double role of epicardial and perivascular adipose tissue in the development of cardiovascular pathology and/or in protecting the heart and arteries warrants further studies...
  77. pmc Health status, hospitalizations, day procedures, and physician costs associated with body mass index (BMI) levels in Ontario, Canada
    Jean Eric Tarride
    Programs for Assessment of Technology in Health PATH Research Institute, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    Clinicoecon Outcomes Res 4:21-30. 2012
    ..Obesity is today's principal neglected public health problem, as a rising proportion of adults will succumb to the medical complications of obesity. However, little is known about the burden of obesity in adults living in Ontario...
  78. doi request reprint Physical activity and health-related quality of life in individuals with prediabetes
    Lorian M Taylor
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    Diabetes Res Clin Pract 90:15-21. 2010
    ..e., achieving >or=600METmin per week) compared to those who are inactive...
  79. ncbi request reprint Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  80. ncbi request reprint Metabolic profile and exercise capacity outcomes: their relationship to overweight and obesity in a Canadian cardiac rehabilitation setting
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    J Cardiopulm Rehabil 24:405-13. 2004
    ....
  81. pmc Managing weighty issues on lean evidence: the challenges of bariatric medicine
    Arya M Sharma
    Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ont
    CMAJ 172:30-1. 2005
  82. ncbi request reprint Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  83. ncbi request reprint Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
    ..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
  84. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..This notion has not been tested in overweight and obese patients...
  85. ncbi request reprint Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  86. ncbi request reprint Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  87. ncbi request reprint Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
    ..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
  88. ncbi request reprint Telmisartan: the ACE of ARBs?
    Arya M Sharma
    Hypertension 47:822-3. 2006
  89. ncbi request reprint Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
  90. ncbi request reprint Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension
    Stefan Engeli
    Franz Volhard Clinic, Helios Klinikum Buch Charité, Medical Faculty of the Humboldt University Berlin, Germany
    Curr Opin Cardiol 17:355-9. 2002
    ....
  91. ncbi request reprint Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertension
    Arya M Sharma
    Franz Volhard Klinik Charité, Berlin, Germany and Teaching Diabetic Division, University Hospital Geneva, Switzerland
    J Hypertens 20:1873-8. 2002
    ..To investigate the effects of long-term weight management with orlistat on blood pressure in obese hypertensive patients...
  92. pmc 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]
    David C W Lau
    Department of Medicine, Julia McFarlane Diabetes Research Centre, Diabetes and Endocrine Research Group, University of Calgary, Calgary, Alta
    CMAJ 176:S1-13. 2007
  93. ncbi request reprint Effect of forced titration of nebivolol on response rate in obese hypertensive patients
    Tobias Pischon
    Am J Hypertens 16:98-100. 2003
  94. ncbi request reprint Optimizing blood pressure control in the obese patient
    Tobias Pischon
    Franz Volhard Clinic Charité, Wiltbergstrasse 50, 13125 Berlin, Germany
    Curr Hypertens Rep 4:358-62. 2002
    ..The role of antiobesity drugs in the management of the obese hypertensive patient also remains to be defined...
  95. ncbi request reprint Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure
    Andreas Busjahn
    Franz Volhard Clinic, HELIOS Kliniken Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Hypertension 40:256-60. 2002
    ..This combined effect of the polymorphisms was confirmed in an independent sample of 260 young normotensive men. We conclude that the SGK1 gene is relevant to blood pressure regulation and probably to hypertension in man...
  96. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  97. ncbi request reprint Plasma-renin response to isotonic volume contraction in young salt-sensitive normotensive men
    Ulrike Schorr
    Franz Volhard Klinik at the Max Delbrück Center for Molecular Medicine, Universitatsklinikum Charite, Humboldt Universitat zu Berlin, Germany
    Am J Hypertens 15:48-52. 2002
    ..These findings point to an intrinsic difference in the regulation of renin release between salt-sensitive and salt-resistant subjects that may account for the different BP responses to changes in dietary sodium intake...
  98. ncbi request reprint The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation
    Maik Gollasch
    HELIOS Klinikum Berlin Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    J Hypertens 20:927-33. 2002
    ..We tested the hypothesis that variants in the gene (KCNMB1) coding for the BK beta1 subunit are associated with baroreflex function...
  99. ncbi request reprint Resistin gene expression in human adipocytes is not related to insulin resistance
    Jurgen Janke
    Franz Volhard Clinic Charité, the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Obes Res 10:1-5. 2002
    ..Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance...
  100. ncbi request reprint Genetics of obesity and obesity-related hypertension
    Andreas Hamann
    Department of Internal Medicine, University of Heidelberg, Germany
    Semin Nephrol 22:100-4. 2002
    ..This knowledge should help develop new strategies for the treatment of obesity and associated risk factors for hypertension and related cardiovascular disorders...
  101. ncbi request reprint HYDRA: possible determinants of unsatisfactory hypertension control in German primary care patients
    U Muscha Steckelings
    Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Charite, Berlin, Germany
    Blood Press 13:80-8. 2004
    ..These insights into the causes of unsatisfactory hypertension control may help to direct future educational programmes designed to improve hypertension management specifically to these deficits and thereby to improve control rates...