Philippe Sarret

Summary

Country: Canada

Publications

  1. pmc Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development
    Valérie Bégin-Lavallée
    Department of Pharmacology and Physiology, Institut de Pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Mol Pain 12:. 2016
  2. pmc Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation
    Mounir Belkouch
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec J1H 5N4, Canada
    J Neuroinflammation 11:45. 2014
  3. ncbi request reprint [NTS2 receptor: slamming the brakes on pain]
    Philippe Sarret
    Département de Physiologie et Biophysique, Faculte de Medecine, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke Quebec, J1H 5N4 Canada
    Med Sci (Paris) 23:11-2. 2007
  4. doi request reprint Weight bearing evaluation in inflammatory, neuropathic and cancer chronic pain in freely moving rats
    Pascal Tétreault
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Physiol Behav 104:495-502. 2011
  5. doi request reprint Central delivery of Dicer-substrate siRNA: a direct application for pain research
    Louis Doré-Savard
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Mol Ther 16:1331-9. 2008
  6. pmc Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity
    Geneviève Roussy
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Mol Pain 5:38. 2009
  7. doi request reprint Spinal NTS2 receptor activation reverses signs of neuropathic pain
    Pascal Tétreault
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Ave North, Sherbrooke, QC, J1H 5N4, Canada
    FASEB J 27:3741-52. 2013
  8. doi request reprint Mammary cancer bone metastasis follow-up using multimodal small-animal MR and PET imaging
    Louis Doré-Savard
    Département de Physiologie et Biophysique, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Nucl Med 54:944-52. 2013
  9. doi request reprint A micro-imaging study linking bone cancer pain with tumor growth and bone resorption in a rat model
    Louis Doré-Savard
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada
    Clin Exp Metastasis 30:225-36. 2013
  10. doi request reprint The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a Gβγ-dependent mechanism
    Mounir Belkouch
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Neurosci 31:18381-90. 2011

Collaborators

Detail Information

Publications47

  1. pmc Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development
    Valérie Bégin-Lavallée
    Department of Pharmacology and Physiology, Institut de Pharmacologie de Sherbrooke, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Mol Pain 12:. 2016
    ....
  2. pmc Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation
    Mounir Belkouch
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec J1H 5N4, Canada
    J Neuroinflammation 11:45. 2014
    ..8 has been shown to participate in the peripheral sensitization of nociceptors. However, to date, there is no evidence for a role of Na(v)1.8 in controlling Aβ-fiber excitability following persistent inflammation...
  3. ncbi request reprint [NTS2 receptor: slamming the brakes on pain]
    Philippe Sarret
    Département de Physiologie et Biophysique, Faculte de Medecine, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke Quebec, J1H 5N4 Canada
    Med Sci (Paris) 23:11-2. 2007
  4. doi request reprint Weight bearing evaluation in inflammatory, neuropathic and cancer chronic pain in freely moving rats
    Pascal Tétreault
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Physiol Behav 104:495-502. 2011
    ..In conclusion, this new device improves methods for preclinical evaluation of discomfort and quality of life proxies and could be helpful in screening putative analgesics...
  5. doi request reprint Central delivery of Dicer-substrate siRNA: a direct application for pain research
    Louis Doré-Savard
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Mol Ther 16:1331-9. 2008
    ..Altogether, DsiRNAi represents a potent tool for dissecting nociceptive pathways and could further lead to a new class of central active drugs...
  6. pmc Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity
    Geneviève Roussy
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Mol Pain 5:38. 2009
    ..In the present study, we therefore investigated whether activation of spinal NTS2 receptors suppressed the persistent inflammatory pain symptoms observed after intraplantar injection of formalin...
  7. doi request reprint Spinal NTS2 receptor activation reverses signs of neuropathic pain
    Pascal Tétreault
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Ave North, Sherbrooke, QC, J1H 5N4, Canada
    FASEB J 27:3741-52. 2013
    ..Thus, NTS2 agonists may offer new treatment avenues for limiting pain associated with peripheral neuropathies and improve functional rehabilitation and well-being...
  8. doi request reprint Mammary cancer bone metastasis follow-up using multimodal small-animal MR and PET imaging
    Louis Doré-Savard
    Département de Physiologie et Biophysique, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Nucl Med 54:944-52. 2013
    ..Thus, the main purpose of this study was to longitudinally monitor bone tumor progression using PET/MR image coregistration to improve noninvasive imaging-assisted diagnoses...
  9. doi request reprint A micro-imaging study linking bone cancer pain with tumor growth and bone resorption in a rat model
    Louis Doré-Savard
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada
    Clin Exp Metastasis 30:225-36. 2013
    ..Altogether, these results improve our understanding of the events leading to tumor-induced bone pain and could eventually help in the design of novel strategies for the management of bone diseases...
  10. doi request reprint The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a Gβγ-dependent mechanism
    Mounir Belkouch
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Neurosci 31:18381-90. 2011
    ..8. Together, our data clearly demonstrate that CCL2 may excite primary sensory neurons by acting on the biophysical properties of Na(v)1.8 currents via a CCR2/Gβγ-dependent mechanism...
  11. doi request reprint Direct application of siRNA for in vivo pain research
    Philippe Sarret
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Methods Mol Biol 623:383-95. 2010
    ..Aiming treatment at the CNS is delicate work, and here we will describe how to perform adequate pain research using siRNA, including siRNA preparation and injection, animal behavioral models, and CNS tissue collection...
  12. doi request reprint Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions
    Alexandre Murza
    Département de Pharmacologie et Physiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, J1H 5N4 Quebec, Canada
    J Med Chem 59:2962-72. 2016
    ..Altogether, these results present ELA and 3 as potential therapeutic options in managing cardiovascular diseases. ..
  13. pmc Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain
    Alexandre J Parent
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Behav Brain Res 229:160-7. 2012
    ..Such a model could help identify/validate alternative potential targets that influence pain and cognitive dimensions of anxiety...
  14. doi request reprint Regional and subcellular distribution of the receptor-targeting protein PIST in the rat central nervous system
    Annie Chen
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Comp Neurol 520:889-913. 2012
    ..This selective distribution of PIST suggests that the protein serves distinctive roles in specific neuronal populations, establishing functionally distinct zones, for instance, in the hippocampus...
  15. doi request reprint Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats
    Marc André Dansereau
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada
    J Neurochem 106:757-69. 2008
    ..Therefore, preventing the activation of CCR2 might provide a fruitful strategy for treating pain...
  16. ncbi request reprint Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction
    Frederic Chagnon
    1Soins Intensifs Médicaux et Service de Cardiologie, Universite de Sherbrooke, Sherbrooke, QC, Canada 2Centre de Recherche du CHUS CR CHUS, Sherbrooke, QC, Canada 3IPS Therapeutique Inc, Sherbrooke, QC, Canada 4Département de Pharmacologie Physiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC, Canada 5Institut de Pharmacologie de Sherbrooke IPS, Universite de Sherbrooke, Sherbrooke, QC, Canada 6Département de Médecine, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Crit Care Med . 2016
    ..Apelin-13 is a powerful inotropic candidate that could be considered as an alternative noncatecholaminergic support in the setting of inflammatory cardiovascular dysfunction...
  17. doi request reprint Structure-activity relationship of novel macrocyclic biased apelin receptor agonists
    Alexandre Murza
    Département de pharmacologie physiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada and Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Org Biomol Chem 15:449-458. 2017
    ..These macrocyclic compounds represent very useful pharmacological tools to explore the therapeutic potential of the apelinergic system...
  18. doi request reprint α-Lipoic acid interaction with dopamine D2 receptor-dependent activation of the Akt/GSK-3β signaling pathway induced by antipsychotics: potential relevance for the treatment of schizophrenia
    Jessica Deslauriers
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 12e Avenue Nord, Sherbrooke, QC J1H 5N4, Canada
    J Mol Neurosci 50:134-45. 2013
    ....
  19. doi request reprint Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid
    Alexandre Murza
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Biopolymers 102:297-303. 2014
    ..This study pinpoints the most critical amino acids targeted by proteases and will be instrumental for the design of Pyr1-apelin-13 analogs possessing increased stability...
  20. doi request reprint Intracuff 160 mg alkalinized lidocaine reduces cough upon emergence from N2O-free general anesthesia: a randomized controlled trial
    Houssine Souissi
    Department of Anesthesiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, J1H 5N4, QC, Canada
    Can J Anaesth 63:862-70. 2016
    ....
  21. doi request reprint Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model
    Geneviève Roussy
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada
    J Neurochem 105:1100-14. 2008
    ..These results demonstrate that NTS1 receptors play a key role in the mediation of the analgesic effects of NT in persistent pain and suggest that NTS1-selective agonists may represent a new line of analgesic compounds...
  22. pmc Proven infection-related sepsis induces a differential stress response early after ICU admission
    Olivier Lesur
    Soins Intensifs Médicaux, Departement de Medecine, Universite de Sherbrooke, 3001 12th Avenue Nord, Sherbrooke, QC J1H 5N4, Canada
    Crit Care 14:R131. 2010
    ..Study aims were: (i) to portray a distinctive stress-related neuro-corticotropic systemic profile of early sepsis, (ii) to propose a combination data score, for aiding ICU physicians in diagnosing sepsis on admission...
  23. doi request reprint A two-hit model of suicide-trait-related behaviors in the context of a schizophrenia-like phenotype: Distinct effects of lithium chloride and clozapine
    Jessica Deslauriers
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 12 e Avenue Nord, Sherbrooke, QC J1H 5N4, Canada
    Physiol Behav 156:48-58. 2016
    ....
  24. pmc Behavioral, medical imaging and histopathological features of a new rat model of bone cancer pain
    Louis Doré-Savard
    Department of Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 5:e13774. 2010
    ..Our animal model demonstrates the importance of simultaneously recording pain and tumor progression and will allow us to better characterize therapeutic strategies in the future...
  25. doi request reprint Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of (±)-α-lipoic acid in SH-SY5Y neuroblastoma cells
    Jessica Deslauriers
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 12e Avenue Nord, Sherbrooke, QC, Canada, J1H 5N4
    J Mol Neurosci 52:378-83. 2014
    ....
  26. doi request reprint Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers
    Jessica Deslauriers
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 12e Avenue Nord, Sherbrooke, QC J1H 5N4, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 45:156-64. 2013
    ..This two-hit animal model may also help in studying innovative therapies dedicated to the treatment of schizophrenia, especially in its early phase...
  27. doi request reprint Understanding the continuum of radionecrosis and vascular disorders in the brain following gamma knife irradiation: An MRI study
    Julie Constanzo
    Center for Research in Radiotherapy, Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Magn Reson Med . 2016
    ..In the present study, we assessed the ability of MRI to monitor the cascade of events occurring in the healthy rat brain after stereotactic radiosurgery, which could be used to optimize the radiation treatment planning...
  28. doi request reprint Mitochondrial Dysfunction in Schizophrenia: Determination of Mitochondrial Respiratory Activity in a Two-Hit Mouse Model
    Cécile Monpays
    Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 12e Avenue Nord, Sherbrooke, QC, J1H 5N4, Canada
    J Mol Neurosci 59:440-51. 2016
    ..In conclusion, our juvenile schizophrenia THM shows an increase in mitochondrial activity reversed by LA, specifically in complex II IRA in males. Further investigations are required to determine the mechanisms of these modifications. ..
  29. doi request reprint Relationship between blood- and cerebrospinal fluid-bound neurotransmitter concentrations and conditioned pain modulation in pain-free and chronic pain subjects
    Alexandre J Parent
    Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Pain 16:436-44. 2015
    ....
  30. doi request reprint Loss of quinone reductase 2 function selectively facilitates learning behaviors
    Charles Etienne Benoit
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
    J Neurosci 30:12690-700. 2010
    ..Together, these data suggest a role for QR2 in cognitive behaviors with QR2 inhibitors possibly representing a novel therapeutic strategy toward the treatment of learning deficits especially observed in the aged brain...
  31. ncbi request reprint Immunohistochemical distribution and subcellular localization of the somatostatin receptor subtype 1 (sst1) in the rat hypothalamus
    Thomas Stroh
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801, University Street, H3A 2B4 Montreal, Quebec, Canada
    Neurochem Res 31:247-57. 2006
    ....
  32. doi request reprint Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y neuroblastoma cells
    Jessica Deslauriers
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Synapse 65:321-31. 2011
    ....
  33. doi request reprint Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory
    Charles Etienne Benoit
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec, Canada
    Trends Pharmacol Sci 32:43-52. 2011
    ..Examples of the possible functional role of some of these genes (e.g. transthyretin, quinone reductase 2) and gene products are discussed...
  34. doi request reprint Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability
    Alexandre Murza
    Departement de Pharmacologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, 3001 12eAvenue Nord, Sherbrooke, QC, J1H 5N4, Canada
    ChemMedChem 7:318-25. 2012
    ..The plasma stability of new compounds was also assessed. Several analogues were found to possess increased binding and higher stability than the parent peptide...
  35. pmc Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells
    Faïza Maloum
    Département d Anatomie et Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 300:G1065-79. 2011
    ..Our data also indicate that loss of BMP signaling in epithelial gastric cells alone is not sufficient to induce gastric neoplasia...
  36. doi request reprint Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)-Deficient Mice
    François Brial
    Department of Anatomy and Cell Biology, Universite de Sherbrooke, Quebec, Canada
    Diabetes 64:3314-20. 2015
    ..These observations open up on future strategies to counteract ghrelin action in a program that could become beneficial in controlling non-insulin-dependent diabetes. ..
  37. ncbi request reprint Subacute H2O2, but not poly(IC), upregulates dopamine D2 receptors in retinoic acid differentiated SH-SY5Y neuroblastoma
    Annie Larouche
    Department of Psychiatry, Sherbrooke University, Sherbrooke, Quebec, Canada
    Synapse 62:70-3. 2008
    ..Under our conditions, H2O2, but not poly(IC), increased NFkappaB activation (as assessed by p65 nuclear translocation), which paralleled their effects on DRD2 levels regulation...
  38. ncbi request reprint Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors
    Philippe Sarret
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    J Neurosci 25:8188-96. 2005
    ..These results suggest that NTS2 receptors play a role in the regulation of spinal nociceptive inputs and that selective NTS2 agonists may offer new avenues for the treatment of acute pain...
  39. pmc Modulation of canine cardiac sodium current by Apelin
    Caroline Chamberland
    Department of Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, QC, Canada
    J Mol Cell Cardiol 48:694-701. 2010
    ..These effects are likely to modulate cardiac conduction and excitability and may have beneficial antiarrhythmic action in sodium chanelopathies such as Brugada Syndrome where I(Na) amplitude is reduced...
  40. pmc Prevalence of claims-based recurrent low back pain in a Canadian population: a secondary analysis of an administrative database
    Nicolas Beaudet
    The PRIMUS Group, Clinical Research Centre Etienne Lebel, CHUS, Sherbrooke, Quebec, Canada
    BMC Musculoskelet Disord 14:151. 2013
    ..It is also known that a large proportion of acute LBP episodes are recurrent within 12 months. However, few studies report the annual trends in the prevalence of recurrent LBP or describe these trends according to age and sex categories...
  41. pmc Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries
    Sylvie Girard
    Laboratoire de Neurologie Pédiatrique, Departement de Pediatrie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Brain Behav Immun 26:1331-9. 2012
    ..Furthermore, our results highlight the potential for postnatal treatment of prenatal inflammatory stressors...
  42. ncbi request reprint Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2
    Louis Gendron
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Mol Pharmacol 66:1421-30. 2004
    ..In conclusion, this study demonstrates that NTS2 is a bona fide NT receptor and that activation of this receptor by NT or NT analogs results in an internalization-dependent activation of the ERK1/2 signaling cascade...
  43. ncbi request reprint Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system
    Amelie Perron
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 280:10219-27. 2005
    ..Taken together, the present results indicated that the rat vNTS2 is a functional receptor that may play a role in NT signaling in mammalian central nervous system...
  44. ncbi request reprint NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization
    Amelie Perron
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Que, Canada H3A 2B4
    Biochem Biophys Res Commun 353:582-90. 2007
    ..NTS1/NTS2 heterodimerization might therefore represent an additional mechanism in the regulation of NT-triggered responses mediated by NTS1 and NTS2 receptors...
  45. ncbi request reprint Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system
    Philippe Sarret
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Comp Neurol 461:520-38. 2003
    ....
  46. ncbi request reprint Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system
    Philippe Sarret
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Comp Neurol 461:483-505. 2003
    ..Other areas (e.g., hippocampal CA fields, cerebellar cortex, and cranial nerve motor nuclei), however, are NT-negative, suggesting that NTS3/sortilin also exerts functions unrelated to NT signaling...
  47. ncbi request reprint Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells
    Philippe Sarret
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 277:36233-43. 2002
    ..Taken together, the present results demonstrate that NTS2 receptors are present both presynaptically and postsynaptically in central neurons and that NT and levocabastine act as agonists on these receptors...