Iwona Rudkowska

Summary

Country: Canada

Publications

  1. doi request reprint Functional foods for health: focus on diabetes
    Iwona Rudkowska
    Lipid Research Center, CHUQ CHUL Pavilion, Quebec, Canada
    Maturitas 62:263-9. 2009
  2. doi request reprint Functional foods for cardiovascular disease in women
    Iwona Rudkowska
    Lipid Research Center, CHUQ CHUL, 2705 Laurier Blvd, TR 93, Quebec, Canada, G1V 4G2
    Menopause Int 14:63-9. 2008
  3. doi request reprint Fish oils for cardiovascular disease: Impact on diabetes
    Iwona Rudkowska
    Lipid Research Center, CHUQ CHUL Pavilion, Laval University, 2705 Laurier Blvd, TR 93, Quebec, Quebec, Canada G1V 4G2
    Maturitas 67:25-8. 2010
  4. doi request reprint Plant sterols and stanols for healthy ageing
    Iwona Rudkowska
    Lipid Research Center, CHUQ CHUL Pavilion, Quebec, Quebec, Canada
    Maturitas 66:158-62. 2010
  5. doi request reprint Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population
    Iwona Rudkowska
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Canada
    J Nutr Biochem 24:54-61. 2013
  6. doi request reprint PPARalpha L162V polymorphism alters the potential of n-3 fatty acids to increase lipoprotein lipase activity
    Iwona Rudkowska
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec, Canada
    Mol Nutr Food Res 54:543-50. 2010
  7. doi request reprint Effects of age, sex, body mass index and APOE genotype on cardiovascular biomarker response to an n-3 polyunsaturated fatty acid supplementation
    Elisabeth Thifault
    Institute of Nutrition and Functional Foods INAF, Laval University, Quebec, Quebec, Canada
    J Nutrigenet Nutrigenomics 6:73-82. 2013
  8. doi request reprint Effects of a supplementation of n-3 polyunsaturated fatty acids with or without fish gelatin on gene expression in peripheral blood mononuclear cells in obese, insulin-resistant subjects
    Iwona Rudkowska
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Quebec, Canada
    J Nutrigenet Nutrigenomics 4:192-202. 2011
  9. pmc Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation
    Annie Bouchard-Mercier
    Institute of Nutrition and Functional Foods INAF Laval University, Quebec, G1V 0A6, Canada
    J Lipid Res 54:2866-73. 2013
  10. pmc The metabolic signature associated with the Western dietary pattern: a cross-sectional study
    Annie Bouchard-Mercier
    Institute of Nutrition and Functional Foods INAF, Laval University, 2440 Hochelaga Blvd, Quebec G1V 0A6, Canada
    Nutr J 12:158. 2013

Collaborators

Detail Information

Publications42

  1. doi request reprint Functional foods for health: focus on diabetes
    Iwona Rudkowska
    Lipid Research Center, CHUQ CHUL Pavilion, Quebec, Canada
    Maturitas 62:263-9. 2009
    ....
  2. doi request reprint Functional foods for cardiovascular disease in women
    Iwona Rudkowska
    Lipid Research Center, CHUQ CHUL, 2705 Laurier Blvd, TR 93, Quebec, Canada, G1V 4G2
    Menopause Int 14:63-9. 2008
    ..Overall, incorporating functional foods into a healthy diet may be beneficial in helping to reduce lipids levels and thus the risk of CVD...
  3. doi request reprint Fish oils for cardiovascular disease: Impact on diabetes
    Iwona Rudkowska
    Lipid Research Center, CHUQ CHUL Pavilion, Laval University, 2705 Laurier Blvd, TR 93, Quebec, Quebec, Canada G1V 4G2
    Maturitas 67:25-8. 2010
    ..Overall, n-3 PUFA supplementation represents a reasonable therapeutic strategy in individuals with T2DM to decrease the risk of complications...
  4. doi request reprint Plant sterols and stanols for healthy ageing
    Iwona Rudkowska
    Lipid Research Center, CHUQ CHUL Pavilion, Quebec, Quebec, Canada
    Maturitas 66:158-62. 2010
    ..Overall, dietary intervention strategies, such as incorporating PS into a healthy diet, should be recommended and implemented in older adult populations in order to prevent ageing-associated diseases and hence promote healthy ageing...
  5. doi request reprint Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population
    Iwona Rudkowska
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Canada
    J Nutr Biochem 24:54-61. 2013
    ..Overall, traditional and novel biomarkers suggest that n-3 PUFA supplementation exerts cardioprotective effects...
  6. doi request reprint PPARalpha L162V polymorphism alters the potential of n-3 fatty acids to increase lipoprotein lipase activity
    Iwona Rudkowska
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec, Canada
    Mol Nutr Food Res 54:543-50. 2010
    ..Overall, these results indicate that n-3 FA supplementation increases the transcription rate of LPL to a greater extent in L162-PPARalpha than V162-PPARalpha...
  7. doi request reprint Effects of age, sex, body mass index and APOE genotype on cardiovascular biomarker response to an n-3 polyunsaturated fatty acid supplementation
    Elisabeth Thifault
    Institute of Nutrition and Functional Foods INAF, Laval University, Quebec, Quebec, Canada
    J Nutrigenet Nutrigenomics 6:73-82. 2013
    ..To test whether age, sex, body mass index (BMI), and the apolipoprotein E (APOE) genotype are associated with the metabolic response to an n-3 polyunsaturated fatty acid (PUFA) supplementation...
  8. doi request reprint Effects of a supplementation of n-3 polyunsaturated fatty acids with or without fish gelatin on gene expression in peripheral blood mononuclear cells in obese, insulin-resistant subjects
    Iwona Rudkowska
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Quebec, Canada
    J Nutrigenet Nutrigenomics 4:192-202. 2011
    ..To investigate gene expression changes in peripheral blood mononuclear cells (PBMCs) following an n-3 polyunsaturated fatty acid (PUFA) and n-3 PUFA plus fish gelatin (+FG) supplementation...
  9. pmc Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation
    Annie Bouchard-Mercier
    Institute of Nutrition and Functional Foods INAF Laval University, Quebec, G1V 0A6, Canada
    J Lipid Res 54:2866-73. 2013
    ..02). We conclude that the presence of certain SNPs within genes, such as ACLY and ACACA, encoding proteins involved in de novo lipogenesis seem to influence the plasma TG response following fish oil consumption. ..
  10. pmc The metabolic signature associated with the Western dietary pattern: a cross-sectional study
    Annie Bouchard-Mercier
    Institute of Nutrition and Functional Foods INAF, Laval University, 2440 Hochelaga Blvd, Quebec G1V 0A6, Canada
    Nutr J 12:158. 2013
    ..The objective was to verify associations between dietary patterns and metabolic profiles composed of amino acids (AAs) and acylcarnitines (ACs)...
  11. pmc Differences in metabolomic and transcriptomic profiles between responders and non-responders to an n-3 polyunsaturated fatty acids (PUFAs) supplementation
    Iwona Rudkowska
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Pavillon des Services, 2440, Boulevard Hochelaga, Quebec, QC, G1V 0A6, Canada
    Genes Nutr 8:411-23. 2013
    ..In sum, results highlight key differences in lipid metabolism of non-responders compared to responders after an n-3 PUFA supplementation, which may explain the inter-individual variability in plasma TG response. ..
  12. pmc Association between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation
    Hubert Cormier
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Canada
    Nutrients 4:1026-41. 2012
    ..SNP rs174546 may be an important SNP associated with plasma TG levels and FADS1 gene expression independently of a nutritional intervention with n-3 PUFA...
  13. pmc Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation
    Iwona Rudkowska
    Institute of Nutrition and Functional Foods and Laval University, Quebec, Canada Endocrinology and Nephrology and CHU de Québec Research Center, Quebec, Canada
    J Lipid Res 55:1245-53. 2014
    ..In conclusion, subjects who decrease their plasma TG levels following n-3 PUFA supplementation may have a different genetic profile than individuals who do not respond. ..
  14. doi request reprint Cardiometabolic risk factors are influenced by Stearoyl-CoA Desaturase (SCD) -1 gene polymorphisms and n-3 polyunsaturated fatty acid supplementation
    Iwona Rudkowska
    Institute of Nutrition and Functional Foods INAF, Laval University, Quebec, Canada Department of Endocrinology and Nephrology, CHU de Québec Research Center, Quebec, Canada
    Mol Nutr Food Res 58:1079-86. 2014
    ..To determine if single nucleotide polymorphisms (SNPs) in stearoyl-CoA desaturase (SCD)-1 gene that encodes a key enzyme for fatty acid metabolism are associated with the response of cardiometabolic risk factors to n-3 PUFA supplementation...
  15. pmc Associations between dietary patterns and gene expression profiles of healthy men and women: a cross-sectional study
    Annie Bouchard-Mercier
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, 2440 Hochelaga Blvd, Quebec G1V 0A6, Canada
    Nutr J 12:24. 2013
    ..Diet regulates gene expression profiles by several mechanisms. The objective of this study was to examine gene expression in relation with dietary patterns...
  16. doi request reprint Association between plasma omega-3 fatty acids and cardiovascular disease risk factors
    Véronique Garneau
    a Department of Food Science and Nutrition, Laval University, Quebec, QC G1K 7P4, Canada Genomics and Endocrinology, Laval University Medical Center, Quebec, QC G1V 4G2, Canada Institute of Nutraceuticals and Functional Foods, Laval University, 2440, Boul Hochelaga, Quebec, QC G1V 0A6, Canada
    Appl Physiol Nutr Metab 38:243-8. 2013
    ..In conclusion, higher DHA percentages in plasma PL are associated with a more favourable CVD risk profile, whereas higher DPA percentages in plasma PL are associated with a more deteriorated CVD risk profile...
  17. pmc Polymorphisms in Fatty Acid Desaturase (FADS) Gene Cluster: Effects on Glycemic Controls Following an Omega-3 Polyunsaturated Fatty Acids (PUFA) Supplementation
    Hubert Cormier
    Institute of Nutrition and Functional Foods INAF, Laval University, Quebec City, QC, G1V 0A6, Canada
    Genes (Basel) 4:485-98. 2013
    ..Polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster have been associated with the homeostasis model assessment of insulin sensitivity (HOMA-IS) and serum fatty acid composition...
  18. doi request reprint Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation
    Bastien Vallée Marcotte
    Institute of Nutrition and Functional Foods INAF, Laval University, Quebec, Que, Canada
    J Nutrigenet Nutrigenomics 9:1-11. 2016
    ..This study aimed to test whether single-nucleotide polymorphisms (SNPs) within the IQCJ, NXPH1, PHF17 and MYB genes are associated with the plasma TG response to an n-3 FA supplementation...
  19. pmc Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation
    Hubert Cormier
    Institute of Nutrition and Functional Foods INAF, Laval University, 2440 Hochelaga Blvd, Quebec, QC, G1V 0A6, Canada
    Genes Nutr 9:437. 2014
    ..SNPs within the FADS gene cluster and the ELOVL gene family may play an important role in the enzyme activity of desaturases and elongases, suggesting that an n-3 FAs supplementation may affect PUFA metabolism. ..
  20. pmc SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation
    Annie Bouchard-Mercier
    Institute of Nutrition and Functional Foods INAF, Laval University, 2440 Hochelaga Blvd, Quebec G1V 0A6, Canada
    Lipids Health Dis 13:152. 2014
    ....
  21. doi request reprint Polymorphisms in genes involved in the triglyceride synthesis pathway and marine omega-3 polyunsaturated fatty acid supplementation modulate plasma triglyceride levels
    Catherine Ouellette
    Institute of Nutrition and Functional Foods, Laval University, Quebec, Que, Canada
    J Nutrigenet Nutrigenomics 6:268-80. 2013
    ..Previous studies have demonstrated that n-3 PUFA supplementation using fish oil modified the expression levels of three genes involved in the TG synthesis pathway (GPAM, AGPAT3 and AGPAT4) in peripheral blood mononuclear cells...
  22. pmc Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels
    Véronique Garneau
    Department of Food Science and Nutrition, Laval University, Quebec, Canada
    Nutr J 11:46. 2012
    ..The aim of this study was to verify whether intakes of n-3 FA estimated from a food frequency questionnaire (FFQ) correlate with n-3 FA levels measured in plasma phospholipids (PL)...
  23. ncbi request reprint Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste Anne de Bellevue, Quebec, Canada
    J Am Coll Nutr 27:588-95. 2008
    ..6 g/d) with a meal over an afternoon snack will lead to favourable changes in plasma lipids, plasma PS concentrations, and cholesterol synthesis without negatively affecting alpha-tocopherol or carotenoids levels...
  24. pmc Expression and Sequence Variants of Inflammatory Genes; Effects on Plasma Inflammation Biomarkers Following a 6-Week Supplementation with Fish Oil
    Hubert Cormier
    Institute of Nutrition and Functional Foods INAF, Laval University, Quebec City, QC G1V 0A6, Canada
    Int J Mol Sci 17:375. 2016
    ..However, gene-diet interactions were observed between SNPs within inflammation-related genes modulating plasma inflammatory biomarker levels. ..
  25. pmc Association between polymorphisms in phospholipase A2 genes and the plasma triglyceride response to an n-3 PUFA supplementation: a clinical trial
    Bénédicte L Tremblay
    Institute of Nutrition and Functional Foods INAF, Laval University, 2440 Hochelaga Blvd, Quebec, QC, G1V 0A6, Canada
    Lipids Health Dis 14:12. 2015
    ....
  26. pmc Polymorphisms in genes involved in fatty acid β-oxidation interact with dietary fat intakes to modulate the plasma TG response to a fish oil supplementation
    Annie Bouchard-Mercier
    Institute of Nutrition and Functional Foods INAF, Laval University, 2440 Hochelaga Blvd, Quebec, QC, G1V 0A6, Canada
    Nutrients 6:1145-63. 2014
    ....
  27. pmc Gene-diet interactions with polymorphisms of the MGLL gene on plasma low-density lipoprotein cholesterol and size following an omega-3 polyunsaturated fatty acid supplementation: a clinical trial
    Catherine Ouellette
    Institute of Nutrition and Functional Foods INAF, Laval University, 2440 Hochelaga Blvd, Quebec, QC, Canada
    Lipids Health Dis 13:86. 2014
    ..The aim of this study was to investigate if polymorphisms (SNPs) of the MGLL gene influence the variability of LDL-C and LDL particle size in response to an n-3 PUFA supplementation...
  28. doi request reprint Natural Rumen-Derived trans Fatty Acids Are Associated with Metabolic Markers of Cardiac Health
    Marine S Da Silva
    Endocrinology and Nephrology, T 4 55B, CHU de Québec Research Center, CHUL 2705, Boul Laurier, Quebec, QC, G1V 4G2, Canada
    Lipids 50:873-82. 2015
    ..009) in obese subjects. These data suggest that rTFA may have beneficial effects on cardiometabolic risk factors conversely to their counterpart iTFA. Dietary sources of TFA should be taken into account in future cardiometabolic studies...
  29. pmc Transcriptomic profiles of skeletal muscle tissue following an euglycemic-hyperinsulinemic clamp in insulin-resistant obese subjects
    Iwona Rudkowska
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Pavillon des Services, bureau 2729 K, 2440, Boulevard Hochelaga, Quebec, QC, G1V 0A6, Canada
    Genes Nutr 8:91-8. 2013
    ..Overall, understanding the changes in metabolic pathways due to insulin may be a potential target for the management of insulin resistance...
  30. doi request reprint Lipid lowering with dietary supplements: focus on diabetes
    Iwona Rudkowska
    Institute of Nutraceuticals and Functional Foods, Laval University, Pavillon des Services, Bureau 2602, 2440, Boulevard Hochelaga, Quebec, Canada G1V 0A6
    Maturitas 72:113-6. 2012
    ..Overall, the addition of dietary supplements may be a therapeutic alternative to lower CVD risk factors in T2DM; however, more well-designed intervention studies are needed to assess the benefit of these dietary supplements...
  31. doi request reprint Validation of the use of peripheral blood mononuclear cells as surrogate model for skeletal muscle tissue in nutrigenomic studies
    Iwona Rudkowska
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Canada
    OMICS 15:1-7. 2011
    ..Further research on PBMC and SMT gene expression in response to other nutritional exposures is warranted...
  32. ncbi request reprint Dietary Fats and F2-isoprostanes: A Review of the Clinical EvidenceCritical Reviews in Food Science and Nutrition
    Marine S Da Silva
    a CHU de Québec Research Center Université Laval, Endocrinology and Nephrology Unit, Quebec, QC, Canada G1V 4G2
    Crit Rev Food Sci Nutr . 2016
    ..Therefore, future clinical studies should be designed in order to consider these issues in the studies of the effects of fat intake on oxidative stress...
  33. doi request reprint Interaction between Common Genetic Variants and Total Fat Intake on Low-Density Lipoprotein Peak Particle Diameter: A Genome-Wide Association Study
    Iwona Rudkowska
    Institute of Nutrition and Functional Foods INAF, Laval University, Quebec, Que, Canada
    J Nutrigenet Nutrigenomics 8:44-53. 2015
    ..The objective was to examine whether there is suggestive evidence of SNP × dietary fat intake interaction effects influencing the LDL-PPD in the Quebec Family Study (QFS) in order to generate hypotheses to be tested in larger studies...
  34. ncbi request reprint Functional foods for the prevention and treatment of cardiovascular diseases: cholesterol and beyond
    Iwona Rudkowska
    School of Dietetics and Human Nutrition McGill University, St Anne de Bellevue, Quebec, Canada
    Expert Rev Cardiovasc Ther 5:477-90. 2007
    ..Overall, these functional foods should be considered as an addition to current lipid-lowering recommendations for improving CVD risk...
  35. doi request reprint Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstone disease
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Nutr Rev 66:343-8. 2008
    ..Clearly, the ABCG5 and ABCG8 genes play an important role in cholesterol homeostasis. However, more research is needed to establish how specific polymorphisms of these genes confer to higher risk of these diseases...
  36. doi request reprint Fish nutrients decrease expression levels of tumor necrosis factor-alpha in cultured human macrophages
    Iwona Rudkowska
    Lipid Research Center, CHUL Research Center, and Nutraceuticals and Functional Foods Institute INAF, Laval University, Quebec City, Quebec, Canada G1V 4G2
    Physiol Genomics 40:189-94. 2010
    ..Hence, follow-up studies should be performed to confirm the effects of a diet rich in FPH and omega-3 FA on serum proinflammatory cytokine concentrations...
  37. pmc Omega-3 fatty acids regulate gene expression levels differently in subjects carrying the PPARalpha L162V polymorphism
    Iwona Rudkowska
    Lipid Research Center, CHUL Research Center, The Nutraceuticals and Functional Foods Institute INAF, Quebec, Canada
    Genes Nutr 4:199-205. 2009
    ..Consequently, individuals carrying the PPARalpha-V162 allele may demonstrate inferior improvements in their lipid profile due to alterations in gene expression rates in response to omega-3 FA supplementation...
  38. doi request reprint Effect of the PPAR-Alpha L162V polymorphism on the cardiovascular disease risk factor in response to n-3 polyunsaturated fatty acids
    Dominique Caron-Dorval
    Lipid Research Center, CHUQ CHUL Pavilion, Quebec, Canada
    J Nutrigenet Nutrigenomics 1:205-12. 2008
    ..Since fatty acids, including n-3 PUFAs, are natural ligands of PPARalpha, a gene-diet interaction effect could be observed...
  39. doi request reprint Novel functional foods for optimal oxidative status in healthy ageing
    Marine S Da Silva
    Endocrinology and Nephrology, CHU de Québec Research Center, Quebec, QC, Canada
    Maturitas 93:100-107. 2016
    ..Further investigation to ascertain these effects should focus on the antioxidant effects of long-term omega-3 supplementation, and of intake of dealcoholized red wine or higher dairy product consumption...
  40. pmc Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population
    Iwona Rudkowska
    Institute of Nutrition and Functional Foods INAF, Laval University, 2440, Boulevard Hochelaga, Quebec, QC, Canada
    Nutr Metab (Lond) 10:26. 2013
    ....
  41. pmc Differences in Transcriptional Activation by the Two Allelic (L162V Polymorphic) Variants of PPARalpha after Omega-3 Fatty Acids Treatment
    Iwona Rudkowska
    Lipid Research Center, CHUL Research Center, QC, Canada G1V 4G2
    PPAR Res 2009:369602. 2009
    ..In conclusion, both allelic variants of the PPARalpha L162V are activated by omega-3 FAs; however, the V162 allelic form displays a lower transcriptional activity than the wild-type variant...
  42. ncbi request reprint Phytosterols mixed with medium-chain triglycerides and high-oleic canola oil decrease plasma lipids in overweight men
    Iwona Rudkowska
    School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada H9X 3V9
    Metabolism 55:391-5. 2006
    ....