Tiffany W Chow
Affiliation: Rotman Research Institute
- MMSE scores decline at a greater rate in frontotemporal degeneration than in ADTiffany W Chow
Rotman Research Institute of Baycrest, University of Toronto Department of Medicine, Division of Neurology, Toronto, Canada
Dement Geriatr Cogn Disord 22:194-9. 2006..018). Changes in MMSE subscores paralleled the clinical diagnostic criteria for FTD. The more rapid progression on the language subscore was observed in both language and behavioral variants of FTD...
- Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophyTiffany W Chow
Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ont, Canada
Dement Geriatr Cogn Disord 26:79-88. 2008..We explored the extent to which subcortical atrophy on structural magnetic resonance imaging may indicate a subcortical contribution to the progression of FTD...
- Structural neuroimaging in the diagnosis of dementiaTiffany Chow
The Rotman Research Institute Baycrest Centre for Geriatric Care, Department of Medicine, Neurology Division, University of Toronto, Toronto, Ontario, Canada
Alzheimers Dement 3:333-5. 2007..Although the consensus group concurs that it is possible to specify circumstances in which structural imaging has a role to rule out pathology, it also has a role in ruling in concomitant cerebrovascular disease for patient management...
- Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's diseaseTiffany W Chow
The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
Neuropsychiatr Dis Treat 3:627-36. 2007..We performed a systematic review for preclinical and human clinical trial evidence to support the use of SSRIs specifically for the management of cognitive decline in AD...
- Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementiaTiffany W Chow
Division of Neurology, Baycrest
Neuropsychiatr Dis Treat 7:415-24. 2011..We hypothesized that participants with frontotemporal dementia taking memantine would show an increased cortical metabolic activity in frontal regions, temporal regions, or in salience network hubs...
- Comparison of manual and semi-automated delineation of regions of interest for radioligand PET imaging analysisTiffany W Chow
Rotman Research Institute, Baycrest, Toronto, Canada
BMC Nucl Med 7:2. 2007..The purpose of this study was to ascertain improvements in image processing time and reproducibility of a semi-automated brain region extraction (SABRE) method over manual delineation of regions of interest (ROIs)...
- Fluorodeoxyglucose positron emission tomography in semantic dementia after 6 months of memantine: an open-label pilot studyTiffany W Chow
Division of Neurology, Baycrest, Toronto, Canada
Int J Geriatr Psychiatry 28:319-25. 2013..To follow up on the increases we reported in normalized metabolic activity in salience network hubs from a 2-month open-label study of memantine in frontotemporal dementia (FTD)...
- A case of semantic variant primary progressive aphasia with severe insular atrophyT W Chow
Baycrest Rotman Research Institute, Brain Health Complex, Toronto, ON, Canada
Neurocase 18:450-6. 2012..s (2007 , Alzheimer Disease & Associated Disorders, 21, S50) hypothesis that von Economo neurons and fork cell-rich brain regions, particularly in the insula, are targeted in additional subtypes of FTD beyond the behavioral variant...
- Alzheimer's disease neuropathologic changes in semantic dementiaTiffany W Chow
Rotman Research Institute and Division of Neurology, Baycrest, Toronto, ON, Canada
Neurocase 16:15-22. 2010..This case series examines retrospectively which clinical parameters might have pointed to the neuropathological diagnosis of AD...
- Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer typeTiffany W Chow
Baycrest Rotman Research Institute, University of Toronto, Toronto, Ontario M6A 2E1, Canada
Arch Neurol 66:888-93. 2009..Apathy is a common and significant problem in patients with dementia, regardless of its cause. Observations about frontosubcortical circuit syndromes indicate that apathy may have affective, behavioral, or cognitive manifestations...
- Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adultsTiffany W Chow
The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
BMC Med Imaging 9:12. 2009..The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old...
- Overlap in frontotemporal atrophy between normal aging and patients with frontotemporal dementiasTiffany W Chow
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada
Alzheimer Dis Assoc Disord 22:327-35. 2008..While volumetry identified left-sided atrophy as useful for identifying FTD cases, future studies should determine whether clinicians could make these distinctions on viewing routine diagnostic magnetic resonance imaging scans...
- What are the different initial presentations of frontotemporal dementia?Tiffany W Chow
Department of Medicine, Division of Neurology, University of Toronto, Rotman Research Institute, 3560 Bathurst St, Toronto, ON, M6A 2E1, Canada
J Mol Neurosci 45:710-2. 2011....
- Treatment approaches to symptoms associated with frontotemporal degenerationTiffany W Chow
The Rotman Research Institute, 3560 Bathurst Street, 8th Floor, Posluns Building, Toronto, Ontario M6A 2E1, Canada
Curr Psychiatry Rep 7:376-80. 2005..There is Class II evidence for use of rivastigmine in FTD behavioral disturbances, although there is no consistent evidence of cholinergic deficit in this illness...
- Referral patterns for syndromes associated with frontotemporal lobar degenerationTiffany W Chow
The Rotman Research Institute, University of Toronto, Toronto, Ontario
Alzheimer Dis Assoc Disord 19:17-9. 2005..Clinics specializing in FTD recruit more language presentation cases. There were statistical but not clinically significant differences in ages at onset...
- A case of apathy due to frontotemporal dementia responsive to memantineKira A Links
Baycrest, Rotman Research Institute, Toronto, ON, Canada
Neurocase 19:256-61. 2013..To study the effect of memantine on apathy, a common symptom of behavioral variant frontotemporal dementia (bvFTD)...
- Apathy is not associated with basal ganglia atrophy in frontotemporal dementiaKira A Links
Division of Neurology, Rotman Research Institute, Baycrest, Toronto, ON, Canada M6A 2E1
Am J Geriatr Psychiatry 17:819-21. 2009..To determine whether basal ganglia atrophy, known to be associated with apathy in nondementia populations, was associated with presence of apathy in patients with frontotemporal dementia (FTD)...
- Trajectories of behavioral disturbance in dementiaTiffany W Chow
Rotman Research Institute of Baycrest, Toronto, ON, Canada
J Alzheimers Dis 31:143-9. 2012..These results support a crescendo-decrescendo trajectory of behavioral symptoms in bvFTD but do not suggest that there is a similar pattern in AD, and further longitudinal data collection is necessary...
- Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolationNorman A S Farb
Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
Cortex 49:1856-73. 2013..Recent neuroimaging research also associates FTD with alterations in the brain's intrinsic connectivity networks. The present study explored the relationship between neural network connectivity and specific behavioral symptoms in FTD...
- Cholinergic pathways and cognition in patients with schizophrenia: a pilot studyTarek K Rajji
Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 139:46-52. 2012..The objective of this study was to evaluate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia...
- Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume correctionsHiroyuki Uchida
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Int J Geriatr Psychiatry 26:1300-8. 2011....
- Amyloid deposition in semantic dementia: a positron emission tomography studyEric E Brown
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Int J Geriatr Psychiatry 31:1064-74. 2016..Asymptomatic Aβ deposition has been reported consistently in some healthy older subjects. Of patients with frontotemporal dementia, those who have later onset have a higher potential for Aβ deposition...
- Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive AphasiaNaida L Graham
Department of Speech Language Pathology, Faculty of Medicine, University of Toronto, Ont, Canada Toronto Rehabilitation Institute, Toronto, Ont, Canada
Dement Geriatr Cogn Dis Extra 6:407-423. 2016..This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis...
- Occupation attributes relate to location of atrophy in frontotemporal lobar degenerationR Nathan Spreng
Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada
Neuropsychologia 48:3634-41. 2010..Alternatively, long-term engagement of activities associated with these occupations contributed to left-lateralized reserve, right-lateralized dysfunction, or both...
- Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasiaGraeme C Schwindt
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Hum Brain Mapp 34:973-84. 2013..Further, they suggest that differences in the relative sensitivity of diffusion metrics may reflect differences in the nature of underlying white matter pathology in these two subtypes...
- Recollection and familiarity for public events in neurologically intact older adults and two brain-damaged patientsRaluca Petrican
Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario M5S 3G3, Canada
Neuropsychologia 48:945-60. 2010..We discuss the present results in the context of neuroanatomical and process-oriented theories of how memories age...
- Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)Yana Yunusova
Department of Speech Language Pathology, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 11:e0147573. 2016..primary cognitive-linguistic deficits, and in contrast to healthy controls...
- Verb production in the nonfluent and semantic variants of primary progressive aphasia: the influence of lexical and semantic factorsKarine Marcotte
a Toronto Rehabilitation Institute, Toronto, Canada
Cogn Neuropsychol 31:565-83. 2014..The present findings suggest that lexicosemantic attributes affect verb production in the semantic variant, whereas both lexicosemantic and syntactic attributes affect verb production in the nonfluent variant. ..
- Incorporating new diagnostic schemas, genetics, and proteinopathy into the evaluation of frontotemporal degenerationTiffany W Chow
Baycrest Rotman Research Institute, 3560 Bathurst Street, 8th Floor Brain Health Complex, Toronto, ON M6A 2E1, Canada
Continuum (Minneap Minn) 19:438-56. 2013..Neurologists, neuropsychologists, and speech pathologists are particularly involved in the diagnosis and recognition of etiologies for patients with deficits in frontal lobe function and language...
- 100 years after Alzheimer: contemporary neurology practice assessment of referrals for dementiaTiffany W Chow
Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
Am J Alzheimers Dis Other Demen 23:516-27. 2008..The prevalence of dementia is placing an increased burden on specialists...
- An international needs assessment of caregivers for frontotemporal dementiaTiffany W Chow
Rotman Research Institute, Baycrest, 3560 Bathurst Street, 8th Floor Brain Health Complex, Toronto, Ontario, M6A 2E1, Canada
Can J Neurol Sci 38:753-7. 2011..To guide development of public awareness and caregiver support resources for frontotemporal dementia (FTD) syndromes...
- Trajectories of Behavioural Disturbances Across Dementia TypesAlexandra B Linds
2Rotman Research Institute of Baycrest, Mt Sinai, Toronto, Ontario, Canada
Can J Neurol Sci 42:389-94. 2015..We evaluated longitudinal tracking with both the Frontal Behavioural Inventory (FBI) and NPI, comparing bvFTD against other dementias...
- Grey matter atrophy in mild cognitive impairment / early Alzheimer disease associated with delusions: a voxel-based morphometry studyWindsor Kwan Chun Ting
Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute, St Michael s Hospital, 209 Victoria Street, Toronto, ON, Canada, M5B 1T8
Curr Alzheimer Res 12:165-72. 2015....
- Lifetime History of Depression Predicts Increased Amyloid-β Accumulation in Patients with Mild Cognitive ImpairmentJun Ku Chung
Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada Multimodal Imaging Group Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
J Alzheimers Dis 45:907-19. 2015..Increased Aβ in the bilateral frontal lobes may be a biomarker of depressive symptomology in aMCI patients. Further studies should test whether higher Aβ predicts future conversion into AD in this population. ..
- Development of supportive services for frontotemporal dementias through community engagementAdriana Shnall
Baycrest Health Sciences, Toronto, Ontario, Canada
Int Rev Psychiatry 25:246-52. 2013..The strength of these interventions is that services were developed with involvement of stakeholders in FTD care from the start, to deal with gaps in services in a sustainable way...
- Exploring the recognition memory deficit in Parkinson's disease: estimates of recollection versus familiarityPatrick S R Davidson
The Rotman Research Institute, Baycrest Centre for Geriatric Care Toronto, Ontario, Canada
Brain 129:1768-79. 2006..We discuss how this pattern may be related to dysfunction of striatal, prefrontal and/or medial temporal regions in Parkinson's disease...
- Distraction during relational reasoning: the role of prefrontal cortex in interference controlDaniel C Krawczyk
Center for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA
Neuropsychologia 46:2020-32. 2008..These results demonstrate that intact prefrontal cortex (PFC) is necessary for controlling interference from perceptual and semantic distractors in order to reason from relational structure...
- Frontotemporal dementias: clinical features and managementTiffany W Chow
Department of Neurology, University of Southern California, Downey, CA, USA
Semin Clin Neuropsychiatry 8:58-70. 2003..Although there is currently no disease-modifying therapeutic agent, symptomatic pharmacotherapy helps to control the marked mood and behavioral disturbances that may distinguish this syndrome from other causes of dementia...
- Goals in symptomatic pharmacologic management of frontotemporal lobar degenerationTiffany W Chow
University of Southern California at Los Angeles, USA
Am J Alzheimers Dis Other Demen 17:267-72. 2002..Behavioral disturbances can be alleviatedpharmacologically, but further research might determine guidelines for management of this non-Alzheimer's dementia syndrome that could decrease the frequency of adverse drug events...
- Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementiaMaria Jesus Sobrido
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 9095, USA
Arch Neurol 60:698-702. 2003..A subset of familial cases (FTDP-17) of frontotemporal dementia (FTD) are caused by mutations in the tau gene. The role of tau gene mutations and haplotypes in sporadic FTD and the functional consequences of tau polymorphisms are unknown...
- Randomized controlled trials in long-term care residents with dementia: a systematic reviewEdward J Mills
The University of Oxford
J Am Med Dir Assoc 4:302-7. 2003..To evaluate the quality of reporting of randomized controlled trials for pharmacologic interventions in long-term care residents with dementia...
- A neurocomputational model of analogical reasoning and its breakdown in frontotemporal lobar degenerationRobert G Morrison
Department of Psychology, University of California, Los Angelesm 90095 1563, USA
J Cogn Neurosci 16:260-71. 2004..Using the "Learning and Inference with Schemas and Analogies" model, we provide a specific account of how such deficits may arise within neural networks supporting analogical problem solving...
- Frontotemporal lobar degeneration: demographic characteristics of 353 patientsJulene K Johnson
Department of Neurology, Memory and Aging Center, University of California, San Francisco, 94117, USA
Arch Neurol 62:925-30. 2005..The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia...
- The differential diagnosis of pseudobulbar affect (PBA). Distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meetingDavid B Arciniegas
Neuropsychiatry Service, Department of Psychiatry, University of Colorado School of Medicine, Denver, Colorado 80211, USA
CNS Spectr 10:1-14; quiz 15-6. 2005..The material presented in this monograph will help clinicians better recognize, diagnose, and treat PBA, and will form a foundation for understanding and interpreting future studies of this condition...
- Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directionsKatya Rascovsky
Memory and Aging Center, University of California, San Francisco, CA 94117, USA
Alzheimer Dis Assoc Disord 21:S14-8. 2007..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...