Tarek K Rajji

Summary

Country: Canada

Publications

  1. pmc Cognition and Dopamine D2 Receptor Availability in the Striatum in Older Patients with Schizophrenia
    Tarek K Rajji
    Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Electronic address
    Am J Geriatr Psychiatry 25:1-10. 2017
  2. ncbi Neuroplasticity-based brain stimulation interventions in the study and treatment of schizophrenia: a review
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Can J Psychiatry 58:93-8. 2013
  3. doi Insight into illness in late-life schizophrenia: a function of illness severity and premorbid intellectual function
    Philip Gerretsen
    University of Toronto and Centre for Addiction and Mental Health, Toronto, ON, Canada
    Schizophr Res 150:217-22. 2013
  4. doi The influence of medical burden severity and cognition on functional competence in older community-dwelling individuals with schizophrenia
    Christopher Tsoutsoulas
    Division of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Canada Department of Psychiatry, University of Toronto, Toronto, Canada
    Schizophr Res 170:330-5. 2016
  5. pmc Alterations of superficial white matter in schizophrenia and relationship to cognitive performance
    Arash Nazeri
    Kimel Family Translational Imaging Genetics Laboratory, Toronto, ON, Canada
    Neuropsychopharmacology 38:1954-62. 2013
  6. pmc Cognitive performance of individuals with schizophrenia across seven decades: a study using the MATRICS consensus cognitive battery
    Tarek K Rajji
    Centre for Addiction and Mental Health, Toronto, Canada
    Am J Geriatr Psychiatry 21:108-18. 2013
  7. doi Age and sex impact clozapine plasma concentrations in inpatients and outpatients with schizophrenia
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 20:53-60. 2012
  8. doi Cholinergic pathways and cognition in patients with schizophrenia: a pilot study
    Tarek K Rajji
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 139:46-52. 2012
  9. pmc Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia
    Aristotle N Voineskos
    Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Cereb Cortex 23:2044-57. 2013
  10. doi Clozapine and global cognition in schizophrenia
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Canada
    J Clin Psychopharmacol 30:431-6. 2010

Collaborators

Detail Information

Publications71

  1. pmc Cognition and Dopamine D2 Receptor Availability in the Striatum in Older Patients with Schizophrenia
    Tarek K Rajji
    Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Electronic address
    Am J Geriatr Psychiatry 25:1-10. 2017
    ..To assess the impact of reducing the dose of antipsychotics on cognition and dopaminergic D2 receptor availability in the whole striatum, and identify their relationship in patients with schizophrenia aged 50 years or older...
  2. ncbi Neuroplasticity-based brain stimulation interventions in the study and treatment of schizophrenia: a review
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Can J Psychiatry 58:93-8. 2013
    ..Numerous brain stimulation approaches have been developed to treat resistant dimensions of schizophrenia. Notwithstanding some promising reports, optimization of the methods and large randomized controlled trials are still needed...
  3. doi Insight into illness in late-life schizophrenia: a function of illness severity and premorbid intellectual function
    Philip Gerretsen
    University of Toronto and Centre for Addiction and Mental Health, Toronto, ON, Canada
    Schizophr Res 150:217-22. 2013
    ..In contrast, premorbid intellectual function continues to be a strong predictor of insight in late life, which highlights the need to better understand and enhance cognitive function early in the course of schizophrenia...
  4. doi The influence of medical burden severity and cognition on functional competence in older community-dwelling individuals with schizophrenia
    Christopher Tsoutsoulas
    Division of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Canada Department of Psychiatry, University of Toronto, Toronto, Canada
    Schizophr Res 170:330-5. 2016
    ..Thus, we assessed the relationship among, cognition, medical burden, and functional competence in older individuals with schizophrenia...
  5. pmc Alterations of superficial white matter in schizophrenia and relationship to cognitive performance
    Arash Nazeri
    Kimel Family Translational Imaging Genetics Laboratory, Toronto, ON, Canada
    Neuropsychopharmacology 38:1954-62. 2013
    ..SWM may be an important neurobiological substrate of cognitive performance and a novel cortical treatment target for cognitive deficits in schizophrenia patients...
  6. pmc Cognitive performance of individuals with schizophrenia across seven decades: a study using the MATRICS consensus cognitive battery
    Tarek K Rajji
    Centre for Addiction and Mental Health, Toronto, Canada
    Am J Geriatr Psychiatry 21:108-18. 2013
    ..The objectives of this study were to determine the effect of aging, schizophrenia, and their interaction on cognitive function...
  7. doi Age and sex impact clozapine plasma concentrations in inpatients and outpatients with schizophrenia
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 20:53-60. 2012
    ..The objective of this study was to assess the magnitude and variability of plasma concentrations of clozapine and norclozapine across the lifespan in a real-world clinical setting...
  8. doi Cholinergic pathways and cognition in patients with schizophrenia: a pilot study
    Tarek K Rajji
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 139:46-52. 2012
    ..The objective of this study was to evaluate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia...
  9. pmc Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia
    Aristotle N Voineskos
    Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Cereb Cortex 23:2044-57. 2013
    ....
  10. doi Clozapine and global cognition in schizophrenia
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Canada
    J Clin Psychopharmacol 30:431-6. 2010
    ..The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies...
  11. doi Frontotemporoparietal asymmetry and lack of illness awareness in schizophrenia
    Philip Gerretsen
    Multimodal Imaging Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 34:1035-43. 2013
    ....
  12. doi Can repetitive magnetic stimulation improve cognition in schizophrenia? Pilot data from a randomized controlled trial
    Mera S Barr
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 73:510-7. 2013
    ..The objectives were to evaluate the effects of rTMS on working memory performance in schizophrenia patients and evaluate whether rTMS normalizes performance to healthy subject levels...
  13. doi The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease
    Aristotle N Voineskos
    Department of Psychiatry, Geriatric Mental Health Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 68:198-206. 2011
    ..Imaging-genetics strategies may clarify the manner in which BDNF gene variation predicts the risk of AD via characterization of its effects on at-risk structures or neural networks susceptible in this disorder...
  14. pmc The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 36:1871-8. 2011
    ..Our findings link genetic, imaging, and cognitive susceptibility relevant to both schizophrenia and bipolar disorder...
  15. pmc Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    PLoS ONE 6:e20982. 2011
    ..However, the manner in which NRXN1 gene variation may be related to brain morphology to confer risk for ASD or schizophrenia is unknown...
  16. doi Evaluation of Antipsychotic Dose Reduction in Late-Life Schizophrenia: A Prospective Dopamine D2/3 Receptor Occupancy Study
    Ariel Graff-Guerrero
    Multimodal Imaging Group Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada2Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada3Department of Psychiatry, Faculty of Medicin
    JAMA Psychiatry 72:927-34. 2015
    ..Treatment guidelines endorse lower antipsychotic doses. However, the optimal dose of antipsychotics and associated dopamine D2/3 receptor (D2/3R) occupancies remain largely unexplored in patients with LLS...
  17. pmc Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neurobiol Aging 33:21-34. 2012
    ..e., splenium) of the corpus callosum with memory and executive function. Our findings suggest that decline in the microstructural integrity of white matter fibers can account for cognitive decline in normal aging...
  18. pmc The Relationship Between Cortical Inhibition and Electroconvulsive Therapy in the Treatment of Major Depressive Disorder
    Daphne Voineskos
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Sci Rep 6:37461. 2016
    ..There were no changes in CSP or SICI after administration of the ECT course. Our findings suggest that duration of pre-treatment CSP may be a useful predictor of therapeutic response to ECT in patients with TRD...
  19. doi Characterization of Glutamatergic and GABAA-Mediated Neurotransmission in Motor and Dorsolateral Prefrontal Cortex Using Paired-Pulse TMS-EEG
    Robin F H Cash
    Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 42:502-511. 2017
    ..This may facilitate future research attempting to ascertain the role of these neurotransmitters in the pathophysiology and treatment of neurological and psychiatric disorders...
  20. pmc A combined TMS-EEG study of short-latency afferent inhibition in the motor and dorsolateral prefrontal cortex
    Yoshihiro Noda
    Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada and
    J Neurophysiol 116:938-48. 2016
    ..These findings establish the neural signature of SAI in DLPFC. Future studies could explore whether DLPFC-SAI is neurophysiological marker of cholinergic dysfunction in cognitive disorders. ..
  21. doi Indicators for Remission of Suicidal Ideation Following Magnetic Seizure Therapy in Patients With Treatment-Resistant Depression
    Yinming Sun
    Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    JAMA Psychiatry 73:337-45. 2016
    ..Magnetic seizure therapy (MST) is a novel therapeutic option for treatment-resistant depression (TRD). Suicidal ideation is often associated with TRD and contributes to the increased mortality and morbidity of the disorder...
  22. pmc Lack of association between dopaminergic antagonism and negative symptoms in schizophrenia: a positron emission tomography dopamine D2/3 receptor occupancy study
    Gagan Fervaha
    Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychopharmacology (Berl) 233:3803-3813. 2016
    ..However, direct evidence for a relationship among antipsychotic medications, their direct effects on neurotransmitter systems, and negative symptoms in schizophrenia remains controversial...
  23. doi Deficits in GABAA receptor function and working memory in non-smokers with schizophrenia
    Alanna C Bridgman
    Schizophrenia Division, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, ON M6J 1H4, Canada
    Schizophr Res 171:125-30. 2016
    ..It is therefore crucial to evaluate working memory and its underlying mechanisms in non-smokers with schizophrenia to eliminate the confounding effects of nicotine on behavior and neurophysiology...
  24. pmc Differentiating the cognitive profile of schizophrenia from that of Alzheimer disease and depression in late life
    Christina Ting
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    PLoS ONE 5:e10151. 2010
    ..To compare the cognitive profile of older patients with schizophrenia to those with other neuropsychiatric disorders assessed in a hospital-based memory clinic...
  25. doi Treatment resistant schizophrenia and response to antipsychotics: a review
    Takefumi Suzuki
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Schizophr Res 133:54-62. 2011
    ..There remains a lack of agreement regarding criteria for treatment-resistant schizophrenia (TRS) and definition of response...
  26. doi Management of schizophrenia in late life with antipsychotic medications: a qualitative review
    Takefumi Suzuki
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, ON, Canada
    Drugs Aging 28:961-80. 2011
    ..However, data on geriatric patients with schizophrenia are generally scarce, particularly for treatment-resistant subpopulations, underscoring the need for more research in this important area...
  27. doi Threshold of Dopamine D2/3 Receptor Occupancy for Hyperprolactinemia in Older Patients With Schizophrenia
    Yusuke Iwata
    Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Clin Psychiatry 77:e1557-e1563. 2016
    ..Subjects underwent [¹¹C]-raclopride PET scans to measure D2/3R occupancy before and after reducing their dose of antipsychotic by up to 40%. Blood samples were collected before each PET scan to measure prolactin levels...
  28. doi Superficial white matter as a novel substrate of age-related cognitive decline
    Arash Nazeri
    Kimel Family Translational Imaging Genetics Laboratory, Ontario, Canada Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neurobiol Aging 36:2094-106. 2015
    ..Altogether, our results indicate that SWM-FA contributes uniquely to age-related cognitive performance, and should be considered as a novel biomarker of cognitive-aging...
  29. doi Therapeutic window for striatal dopamine D(2/3) receptor occupancy in older patients with schizophrenia: a pilot PET study
    Hiroyuki Uchida
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
    Am J Geriatr Psychiatry 22:1007-16. 2014
    ..This type of empirical information is not available in late life. Our primary aim was to assess the effect of changes in D(2/3) relative receptor occupancy (RRO) on clinical outcomes in this population...
  30. pmc The impact of aging, cognition, and symptoms on functional competence in individuals with schizophrenia across the lifespan
    Sawsan M Kalache
    Division of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Canada Department of Psychiatry, University of Toronto, Toronto, Canada
    Schizophr Bull 41:374-81. 2015
    ..Thus, we assessed the relationship between cognition and functional competence in individuals with schizophrenia across 7 decades of life...
  31. pmc PAS-induced potentiation of cortical-evoked activity in the dorsolateral prefrontal cortex
    Tarek K Rajji
    1 Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada 2 Temerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 38:2545-52. 2013
    ..As this potentiation may be related to LTP, our findings provide a model through which neuroplasticity in health and disease states in the frontal cortex can be studied. ..
  32. doi D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia
    Hiroyuki Uchida
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 29:571-5. 2009
    ....
  33. doi Neuroimaging evidence for the deficit subtype of schizophrenia
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, Toronto, Canada
    JAMA Psychiatry 70:472-80. 2013
    ..Dividing schizophrenia into "deficit" and "nondeficit" subtypes may reduce heterogeneity and facilitate identification of neurobiological markers of disease...
  34. ncbi A review of evidence linking disrupted neural plasticity to schizophrenia
    Daphne Voineskos
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Can J Psychiatry 58:86-92. 2013
    ..Such pathophysiology may underlie the learning and memory deficits that are key symptoms of this disorder and may even be a key mechanism involved in treatment with antipsychotics...
  35. doi Differential effects of cannabis dependence on cortical inhibition in patients with schizophrenia and non-psychiatric controls
    Michelle S Goodman
    Schizophrenia Division, Centre for Addiction and Mental Health CAMH, 250 College Street, Toronto M5T 1R8, ON, Canada Temerty Centre for Therapeutic Brain Intervention, CAMH, 1001 Queen Street West, Toronto M6J 1H4 ON, Canada Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King s College Circle Room 2374, Toronto M5S 1A8, ON, Canada
    Brain Stimul . 2016
    ....
  36. doi An optimal combination of MCCB and CANTAB to assess functional capacity in older individuals with schizophrenia
    Sanjeev Kumar
    Division of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Canada
    Int J Geriatr Psychiatry 31:1116-23. 2016
    ..The aim of this study was to determine a minimal set of subtests across the two batteries that would be strongly associated with functional capacity in older patients with schizophrenia...
  37. doi NEUROBIOLOGICAL PREDICTORS OF RESPONSE TO DORSOLATERAL PREFRONTAL CORTEX REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN DEPRESSION: A SYSTEMATIC REVIEW
    William K Silverstein
    Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Depress Anxiety 32:871-91. 2015
    ..This review aims to systematically synthesize the literature on the neurobiological predictors of rTMS in patients with depression...
  38. pmc A comparison of the E-BEHAVE-AD, NBRS, and NPI in quantifying clinical improvement in the treatment of agitation and psychosis associated with dementia
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 21:78-87. 2013
    ....
  39. doi Clozapine exposure and the impact of smoking and gender: a population pharmacokinetic study
    Wenzie Ng
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario M5T 1R8, Canada
    Ther Drug Monit 31:360-6. 2009
    ..These findings may account for some of the variability in clozapine exposure and have important implications for individualized drug dosing and therapeutic drug monitoring...
  40. pmc Myelin-associated glycoprotein gene and brain morphometry in schizophrenia
    Daniel Felsky
    Neuroscience Research Department, Centre for Addiction and Mental Health, University of Toronto Toronto, ON, Canada
    Front Psychiatry 3:40. 2012
    ....
  41. ncbi Ordering Information in Working Memory and Modulation of Gamma by Theta Oscillations in Humans
    Tarek K Rajji
    Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health Department of Psychiatry, University of Toronto, Toronto, ON, M6J1H4, Canada Temerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health, Toronto, ON, M6J1H4, Canada
    Cereb Cortex . 2016
    ..They also highlight the potential of using theta-gamma coupling as a neurophysiological marker of brain function in health or disease states...
  42. doi Systematic Review of Cognitive Effects of Electroconvulsive Therapy in Late-Life Depression
    Sanjeev Kumar
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 24:547-65. 2016
    ..Electroconvulsive therapy (ECT) and newer nonconvulsive electrical and magnetic brain stimulation interventions have been shown to have cognitive effects in patients with neuropsychiatric disorders...
  43. pmc A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation
    Apoorva Bhandari
    Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario M6J 1H4, Canada
    Clin Neurophysiol 127:2834-45. 2016
    ..This review aims to quantitatively synthesize the literature on age-related differences in cortical excitability and plasticity, examined by TMS...
  44. pmc Unilateral and bilateral MRI-targeted repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled study
    Daniel M Blumberger
    From the Temerty Centre for Therapeutic Brain Intervention, and Campbell Family Research Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont, Canada Blumberger, Thomson, Mulsant, Rajji, Maher, Daskalakis the Monash Alfred Psychiatry research centre, The Alfred and Monash University Central Clinical School, Melbourne, Australia Maller, Fitzgerald Cancer Care Ontario and the Dalla Lana School of Public Health, University of Toronto, Toronto, Ont, Canada Brown the Toronto Western Hospital, University Health Network, Department of Psychiatry, University of Toronto, Toronto, Ont, Canada Downar and the Non Invasive Neurostimulation Therapies laboratory, Department of Psychiatry, University of British Columbia, Vancouver, B C, Canada Vila Rodriguez
    J Psychiatry Neurosci 41:E58-66. 2016
    ..These factors include unilateral stimulation (i.e., treatment of only the left dorsolateral prefrontal cortex [DLPFC]), suboptimal methods of targeting the DLPFC and insufficient stimulation intensity (based on coil-to-cortex distance)...
  45. doi Gray Matter Neuritic Microstructure Deficits in Schizophrenia and Bipolar Disorder
    Arash Nazeri
    Kimel Family Translational Imaging Genetics Laboratory, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry . 2016
    ..This technique may bridge the gap between neuroimaging and histopathological findings...
  46. pmc Neuroimaging predictors of functional outcomes in schizophrenia at baseline and 6-month follow-up
    Tina Behdinan
    Kimel Family Translational Imaging Genetics Research Lab, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada Institute of Medical Science, University of Toronto, 27 King s College Circle, Toronto, ON M5S, Canada
    Schizophr Res 169:69-75. 2015
    ..We assessed whether these same neural circuits are directly linked to functional outcomes across schizophrenia patients...
  47. doi Clozapine potentiation of GABA mediated cortical inhibition in treatment resistant schizophrenia
    Tyler S Kaster
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 165:157-62. 2015
    ..However, it is not clear if these differences in CI are a result of treatment-resistant illness which necessitates clozapine or are related to clozapine treatment...
  48. doi Hippocampal (subfield) volume and shape in relation to cognitive performance across the adult lifespan
    Aristotle N Voineskos
    Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Hum Brain Mapp 36:3020-37. 2015
    ....
  49. pmc Imaging-based neurochemistry in schizophrenia: a systematic review and implications for dysfunctional long-term potentiation
    Bahar Salavati
    Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Bull 41:44-56. 2015
    ..The review concludes with a model illustrating how these abnormalities could lead to impaired LTP in patients with schizophrenia and consequently cognitive deficits. ..
  50. pmc Disrupted prefrontal interhemispheric structural coupling in schizophrenia related to working memory performance
    Anne L Wheeler
    Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Schizophr Bull 40:914-24. 2014
    ..In contrast, little is known regarding alterations of structural coupling between regions in schizophrenia and how these alterations may be related to cognitive impairments in this disorder...
  51. pmc Cognition, function, and disability in patients with schizophrenia: a review of longitudinal studies
    Tarek K Rajji
    Assistant Professor, Department of Psychiatry, University of Toronto Chief, Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario
    Can J Psychiatry 59:13-7. 2014
    ..Future studies should also focus on the longitudinal interactions between cognition and other dimensions of schizophrenia as well as on the biological factors that underlie these interactions. ..
  52. doi Exploring the effect of inducing long-term potentiation in the human motor cortex on motor learning
    Tarek K Rajji
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada
    Brain Stimul 4:137-44. 2011
    ..PAS-LTP has also been shown to relate to simple motor performance. However, to date, no studies have directly investigated whether the induction of PAS-LTP is associated with enhanced motor learning...
  53. pmc A Review of Impaired Neuroplasticity in Schizophrenia Investigated with Non-invasive Brain Stimulation
    Apoorva Bhandari
    Centre for Addiction and Mental Health, Temerty Centre for Therapeutic Brain Intervention, Campbell Family Mental Health Research Institute, University of Toronto, Toronto, ON, Canada
    Front Psychiatry 7:45. 2016
    ..This review will focus on summarizing the available neurophysiological evidence for impaired motor cortical plasticity in SCZ assessed by NIBS...
  54. doi Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to N-desmethylclozapine
    Tarek K Rajji
    From the Geriatric Psychiatry Division, The Campbell Family Mental Health Research Institute, and the Schizophrenia Division, Centre for Addiction and Mental Health, Toronto and the Department of Psychiatry, University of Toronto, Toronto
    Am J Psychiatry 172:579-85. 2015
    ..The authors hypothesized that the ratio of serum clozapine and NDMC concentrations would be inversely associated with working memory performance in schizophrenia...
  55. pmc Effects of antipsychotic D2 antagonists on long-term potentiation in animals and implications for human studies
    Rae Price
    Institute of Medical Science, Faculty of Medicine, University of Toronto, Canada Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 54:83-91. 2014
    ..Further studies using patients with schizophrenia receiving chronic antipsychotic treatment are needed to better understand the effects of these medications in this population. ..
  56. pmc Brain stimulation in the treatment of late-life severe mental illness other than unipolar nonpsychotic depression
    Angela Y Liu
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 22:216-40. 2014
    ..These interventions could also be combined with other non-brain stimulation treatments for possible synergistic effects. ..
  57. doi Use of lithium in the treatment of bipolar disorder in late-life
    Ramsey D'Souza
    Division of Geriatric Psychiatry, University of Toronto, and Geriatric Mental Health Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
    Curr Psychiatry Rep 13:488-92. 2011
    ..Careful monitoring and adjustment of lithium dosage is especially important in older adults to minimize the risk of toxicity...
  58. pmc Diffusion tensor tractography findings in schizophrenia across the adult lifespan
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto M5T 1R8, Canada
    Brain 133:1494-504. 2010
    ..The absence of accelerated age-related decline, or differences between older community-dwelling patients and controls, suggests that these patients may possess resilience to white matter disruption...
  59. ncbi Use of antidepressants in late-life depression
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Drugs Aging 25:841-53. 2008
    ..Overall, the current literature is adequate for guiding acute and maintenance pharmacotherapy of LLD but further research is urgently needed to guide clinical strategies in non-remission...
  60. pmc The MMSE is not an adequate screening cognitive instrument in studies of late-life depression
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada M6J 1H4
    J Psychiatr Res 43:464-70. 2009
    ....
  61. doi Alcohol Intoxication by Binge Drinking Impairs Neuroplasticity
    Genane Loheswaran
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Ontario M5S 2S1, Canada Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, University of Toronto, 1001 Queen Street West, Unit 4 1, Toronto, Ontario M6J 1H4, Canada
    Brain Stimul 9:27-32. 2016
    ..However, the effect of binge drinking on neuroplasticity has not been evaluated in humans...
  62. doi Cognitive remediation for older community-dwelling individuals with schizophrenia: a pilot and feasibility study
    Angela C Golas
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Int J Geriatr Psychiatry 30:1129-34. 2015
    ..Cognitive remediation (CR) improves cognition in individuals with schizophrenia. This study aims at assessing the feasibility and potential effect of CR in patients with schizophrenia 60 years of age or older...
  63. pmc Functional consequences of neurite orientation dispersion and density in humans across the adult lifespan
    Arash Nazeri
    Kimel Family Translational Imaging Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 35:1753-62. 2015
    ..Our in vivo findings align very closely with the postmortem data and provide evidence for vulnerability and compensatory neural mechanisms of aging in GM microstructure that have functional and cognitive impact in vivo. ..
  64. doi Magnetic seizure therapy-induced mania: a report of 2 cases
    Yoshihiro Noda
    From the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada Campbell Family Mental Health Research Institute and Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Canada Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Victoria, Australia and MRI Guided rTMS Clinic, University Health Network, Toronto, Ontario, Canada
    J ECT 31:e4-6. 2015
    ..It is currently being investigated as a potential alternative treatment to electroconvulsive therapy. To our knowledge, there have not been any previous reports of MST-induced mania...
  65. doi Brief cognitive screening instruments: an update
    Zahinoor Ismail
    Department of Psychiatry, Faculty of Medicine, University of Toronto, Geriatric Mental Health Program, Centre for Addiction and Mental Health, Canada
    Int J Geriatr Psychiatry 25:111-20. 2010
    ..To review the recent literature on cognitive screening with a focus on brief screening methods in primary care as well as geriatric services...
  66. doi A randomized double-blind sham-controlled comparison of unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant major depression
    Daniel M Blumberger
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    World J Biol Psychiatry 13:423-35. 2012
    ..There are few published reports on the efficacy of sequential bilateral rTMS compared to HFL and sham rTMS. Therefore, this study evaluated the efficacy of HFL and sequential bilateral rTMS compared to sham in TRD...
  67. pmc The VAGUS insight into psychosis scale--self-report and clinician-rated versions
    Philip Gerretsen
    Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Division of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Electronic address
    Psychiatry Res 220:1084-9. 2014
    ..Using a 10-point Likert scale for each item, the VAGUS has the capacity to detect small, temporally sensitive changes in insight, which is essential for intervention studies with neurostimulation or rapidly acting medications. ..
  68. pmc The effects of aging on insight into illness in schizophrenia: a review
    Philip Gerretsen
    University of Toronto and the Centre for Addiction and Mental Health, Toronto, ON, Canada
    Int J Geriatr Psychiatry 29:1145-61. 2014
    ..Ultimately, we propose a trajectory of insight in schizophrenia across the lifespan...
  69. pmc Oxidative stress in older patients with bipolar disorder
    Ana Cristina Andreazza
    Department of Psychiatry, University of Toronto, Canada Departments of Pharmacology and Toxicology, University of Toronto, Canada Centre for Addition and Mental Health, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 23:314-9. 2015
    ..Changes in oxidative stress are also associated with the natural aging process. Thus, the investigation of oxidative stress across the life span of patients with BD is crucial...
  70. doi Age-related differences in working memory evoked gamma oscillations
    Mera S Barr
    Biobehavioural Addictions and Concurrent Disorders Laboratory BACDRL, Schizophrenia Division, Complex Mental Illness Program Center for Addiction and Mental Health, 250 College Street, M5T 1R8 Toronto, Ontario, Canada Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, 1001 Queen Street West, M6J 1H4 Toronto, Ontario, Canada Department of Psychiatry, Brain and Therapeutics Division, University of Toronto, 250 College Street, M5T 1R8 Toronto, Ontario, Canada Electronic address
    Brain Res 1576:43-51. 2014
    ..The objective of this study was to evaluate working memory evoked gamma oscillations in adults aged 19-29 years (mean 23.32 ± 2.85 1 SD) compared to adults aged 30-60 years (mean 39.10 ± 8.11 1 SD)...
  71. doi Nature and course of cognitive function in late-life schizophrenia: a systematic review
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, and Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 102:122-40. 2008
    ..To systematically review the literature on the nature and course of cognition in late-life schizophrenia (LLS)...