R. John MacLeod

Summary

Affiliation: dept of Biomedical and Molecular Sciences, Queens University
Location: Kingston, Canada

Publications

  1. ncbi Trinitrobenzenesulphonic acid colitis alters Na 1.8 channel expression in mouse dorsal root ganglia neurons
    D E King
    Kingston General Hospital, Queen s University, ON, Canada
    Neurogastroenterol Motil 21:880-e64. 2009
  2. doi Orphan receptor kinase ROR2 is expressed in the mouse uterus
    K Hatta
    Department of Microbiology and Immunology, Queen s University, Kingston, ON K7L 3N6, Canada
    Placenta 31:327-33. 2010
  3. ncbi A new role for the extracellular calcium-sensing receptor demonstrated by using CCK-eGFP BAC mice
    R John Macleod
    Am J Physiol Gastrointest Liver Physiol 300:G526-7. 2011
  4. pmc Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction
    Jacqueline C Kelly
    Department of Physiology, Queen s University Kingston, ON, Canada
    Front Physiol 2:17. 2011
  5. pmc Regulation of villin by wnt5a/ror2 signaling in human intestinal cells
    Rebecca Cheung
    Department of Physiology, Queen s University Kingston, ON, Canada
    Front Physiol 2:58. 2011
  6. doi CaSR function in the intestine: Hormone secretion, electrolyte absorption and secretion, paracrine non-canonical Wnt signaling and colonic crypt cell proliferation
    R John Macleod
    Department of Biomedical and Molecular Sciences, GIDRU, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Best Pract Res Clin Endocrinol Metab 27:385-402. 2013
  7. doi Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/β-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci
    R John Macleod
    Department of Biomedical and Molecular Sciences, GIDRU, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Lab Invest 93:520-7. 2013
  8. doi Amphetamine stimulates Wnt3 increases in rat nucleus accumbens
    R John Macleod
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Neuroreport 23:846-50. 2012

Collaborators

  • K Hatta
  • B A Croy
  • Rebecca Cheung
  • Jacqueline C Kelly
  • D E King
  • Jacqueline Kelly
  • P Lungchukiet
  • S J Vanner

Detail Information

Publications8

  1. ncbi Trinitrobenzenesulphonic acid colitis alters Na 1.8 channel expression in mouse dorsal root ganglia neurons
    D E King
    Kingston General Hospital, Queen s University, ON, Canada
    Neurogastroenterol Motil 21:880-e64. 2009
    ..The absence of corresponding changes in transcript suggests a translational or post-translational mechanism, but the 10-fold recovery of transcript preceding this time point also demonstrates a complex transcriptional regulation...
  2. doi Orphan receptor kinase ROR2 is expressed in the mouse uterus
    K Hatta
    Department of Microbiology and Immunology, Queen s University, Kingston, ON K7L 3N6, Canada
    Placenta 31:327-33. 2010
    ..We examined expression of the receptor for WNT5A, receptor tyrosine kinase-like orphan receptor 2 (ROR2), in the uteri of cycling and pregnant mice...
  3. ncbi A new role for the extracellular calcium-sensing receptor demonstrated by using CCK-eGFP BAC mice
    R John Macleod
    Am J Physiol Gastrointest Liver Physiol 300:G526-7. 2011
  4. pmc Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction
    Jacqueline C Kelly
    Department of Physiology, Queen s University Kingston, ON, Canada
    Front Physiol 2:17. 2011
    ..Our results also suggest that canonical Wnt signaling may enhance TLR4 stimulation of TNFα secretion from murine macrophages...
  5. pmc Regulation of villin by wnt5a/ror2 signaling in human intestinal cells
    Rebecca Cheung
    Department of Physiology, Queen s University Kingston, ON, Canada
    Front Physiol 2:58. 2011
    ..Neither Wnt3a nor epidermal growth factor addition caused increases in villin protein. Our findings suggest that Wnt5a/Ror2 signaling can regulate villin expression in the intestine...
  6. doi CaSR function in the intestine: Hormone secretion, electrolyte absorption and secretion, paracrine non-canonical Wnt signaling and colonic crypt cell proliferation
    R John Macleod
    Department of Biomedical and Molecular Sciences, GIDRU, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Best Pract Res Clin Endocrinol Metab 27:385-402. 2013
    ..Colonic epithelia from conditional and global CaSR knockout mice exhibit increased proliferation with increased Wnt/β-catenin signaling, demonstrating that the CaSR negatively modulates colonic epithelial growth. ..
  7. doi Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/β-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci
    R John Macleod
    Department of Biomedical and Molecular Sciences, GIDRU, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Lab Invest 93:520-7. 2013
    ..The loss of the colonic CaSR increased the number of ACF/cm(2) in response to AOM injection, suggesting colonic CaSR may mediate the chemoprotective effect of increased dietary calcium against colorectal cancer observed in humans...
  8. doi Amphetamine stimulates Wnt3 increases in rat nucleus accumbens
    R John Macleod
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Neuroreport 23:846-50. 2012
    ..Our data support the hypothesis that proximate Wnt signalling is rapidly activated by amphetamine in the adult rat nucleus accumbens...