David P LeBrun

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
  2. ncbi E2A basic helix-loop-helix transcription factors in human leukemia
    David P LeBrun
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Front Biosci 8:s206-22. 2003
  3. doi E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Canada
    Biochim Biophys Acta 1819:446-53. 2012
  4. pmc Critical role for a single leucine residue in leukemia induction by E2A-PBX1
    Richard Bayly
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Mol Cell Biol 26:6442-52. 2006
  5. doi Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1819:375-81. 2012
  6. doi Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1
    Christopher M Denis
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada
    Blood 120:3968-77. 2012
  7. pmc Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300
    Christopher M Denis
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Nucleic Acids Res 42:7370-82. 2014
  8. doi Inactivation of the CDKN2A tumor-suppressor gene by deletion or methylation is common at diagnosis in follicular lymphoma and associated with poor clinical outcome
    Abdulmohsen Alhejaily
    Authors Affiliations Department of Pathology and Molecular Medicine, Queen s University Clinical Research Centre and Cancer Centre of Southeastern Ontario, Kingston General Hospital, Kingston, Ontario, Canada
    Clin Cancer Res 20:1676-86. 2014
  9. doi Composite mantle cell and primary cutaneous anaplastic large cell lymphoma: case report and review of the literature
    Charles Leduc
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada and Department of Oncology, Queens University and Cancer Centre of Southeastern Ontario, Kingston General Hospital, Kingston, Ontario, Canada
    Am J Dermatopathol 37:232-6. 2015
  10. doi Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease
    Brianne Wood
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Leuk Lymphoma 54:1212-20. 2013

Collaborators

  • Robert K Slany
  • Shuang Liu
  • Feng Wang
  • GERD BLOBEL
  • Steven P Smith
  • Michael J Plevin
  • Abdulmohsen Alhejaily
  • Brandy D Hyndman
  • Christopher M Denis
  • Richard Bayly
  • Tara Baetz
  • Patrick Thompson
  • Mark W Woodcroft
  • Seth Chitayat
  • Brianne Wood
  • Charles Leduc
  • Holly L Spencer
  • Patricia L Farmer
  • Andrew G Day
  • Harriet E Feilotter
  • Dimas Yusuf
  • Kim Munro
  • Richard Casselman
  • Kyster Nanan
  • Ivan I P Blandino
  • David J Good
  • Kathrin Tyryshkin
  • Jeremy A Squire
  • Alyssa C Kirlin
  • David N Langelaan
  • Soma Sikdar
  • Shakeel Virk
  • Suk Jin Choi
  • Jerzy Ostrowski
  • Luis del Peso
  • Stefanie L Butland
  • Elizabeth M Simpson
  • Julien J Karrich
  • Kyster K Nanan
  • MICHAELA LIEDTKE
  • Seth Frietze
  • Jason Park
  • Raquel Marco-Ferreres
  • Peter John Noy
  • Bérénice A Benayoun
  • Warren A Cheung
  • Karin Dahlman-Wright
  • Lara J Monteiro
  • Michael Taggart
  • Gieri Camenisch
  • KATHLEEN JOYCE MILLEN
  • Edwin Chen
  • Christophe Heligon
  • Daniel J Peet
  • Padma Sheela Jayaraman
  • Angie Rizzino
  • Sekhar P Reddy
  • Michelle Vaz
  • Elizabeth Wederell
  • Reiner A Veitia
  • Scott Ferrell
  • Christopher T D Dickman
  • Oliver Hankinson
  • Xin M Luo
  • Astrid Eijkelenboom
  • Bruce E Torbett
  • Charles N de Leeuw
  • Graham P Côté
  • Mireille Vasseur-Cognet
  • Ralf Kist
  • Mitsuhiko Ikura
  • Douglas Forrest
  • Michal Mikula
  • Rumela Chakrabarti
  • Juan Hou
  • Pamela A Hoodless
  • Matthew E Witek
  • Farhad Vesuna
  • Magdalena I Swanson
  • Christopher J Harvey
  • Henriette O'Geen
  • Philip H Bradley
  • David Laperriere
  • Dominique Leprince
  • Carol F Webb
  • Sylvie Mader
  • Sam W Z Olechnowicz
  • Jonathan S Lim
  • Shyam Biswal
  • Gerhart U Ryffel

Detail Information

Publications13

  1. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
    ..TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe...
  2. ncbi E2A basic helix-loop-helix transcription factors in human leukemia
    David P LeBrun
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Front Biosci 8:s206-22. 2003
    ..In this article, I review the evidence pertaining to leukemogenesis by the well-characterized E2A-fusion proteins and consider its mechanistic implications...
  3. doi E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Canada
    Biochim Biophys Acta 1819:446-53. 2012
    ..Our findings add to a growing body of literature indicating that interactions between CBP/p300 and transcription factors can function in a specific manner to modulate HAT catalytic activity...
  4. pmc Critical role for a single leucine residue in leukemia induction by E2A-PBX1
    Richard Bayly
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Mol Cell Biol 26:6442-52. 2006
    ..Circumstantial evidence suggests that the side chain of L20 might interact with a deep hydrophobic pocket in the KIX domain. Therefore, our results serve to identify a potential new drug target...
  5. doi Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1819:375-81. 2012
    ..Our results illustrate for the first time that AD1 can both recruit, and be acetylated by, KATs and that KAT recruitment may promote transcriptional induction in part through acetylation of AD1 itself...
  6. doi Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1
    Christopher M Denis
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada
    Blood 120:3968-77. 2012
    ..These results provide molecular insights into E-protein-driven differentiation of B-cells and the mechanism of E-protein silencing, and reveal the PCET/KIX interaction as a therapeutic target for E2A-PBX1-induced leukemia...
  7. pmc Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300
    Christopher M Denis
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Nucleic Acids Res 42:7370-82. 2014
    ..Our findings suggest that redundancy between the two E2A activation domains with respect to transcriptional activation and oncogenic function is mediated by binding to the same surface of the KIX domain of CBP/p300. ..
  8. doi Inactivation of the CDKN2A tumor-suppressor gene by deletion or methylation is common at diagnosis in follicular lymphoma and associated with poor clinical outcome
    Abdulmohsen Alhejaily
    Authors Affiliations Department of Pathology and Molecular Medicine, Queen s University Clinical Research Centre and Cancer Centre of Southeastern Ontario, Kingston General Hospital, Kingston, Ontario, Canada
    Clin Cancer Res 20:1676-86. 2014
    ..We investigated the hypothesis that deletion or hypermethylation of CDKN2A might identify follicular lymphoma cases with distinct clinical or pathologic features potentially amenable to tailored clinical management...
  9. doi Composite mantle cell and primary cutaneous anaplastic large cell lymphoma: case report and review of the literature
    Charles Leduc
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada and Department of Oncology, Queens University and Cancer Centre of Southeastern Ontario, Kingston General Hospital, Kingston, Ontario, Canada
    Am J Dermatopathol 37:232-6. 2015
    ..Our case illustrates the extreme diversity associated with the cutaneous manifestations of lymphoid neoplasia and in particular of composite lymphomas, which present diagnostic challenges for clinicians and pathologists alike...
  10. doi Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease
    Brianne Wood
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Leuk Lymphoma 54:1212-20. 2013
    ....
  11. pmc Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors
    Mark W Woodcroft
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    PLoS ONE 10:e0130495. 2015
    ..Our findings indicate that the neoplastic phenotype induced by E2A-PBX1 is determined by the developmental stage of the cell into which the oncoprotein is introduced. ..
  12. doi Differential expression of cell-cycle regulatory proteins defines distinct classes of follicular lymphoma
    Abdulmohsen Alhejaily
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Hum Pathol 42:972-82. 2011
    ..Therefore, subjective quantification of cell-cycle regulatory proteins by immunohistochemistry can identify biologically and clinically distinct subsets of follicular lymphoma cases...
  13. ncbi E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells
    Richard Bayly
    Queen s University Cancer Research Institute, Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    J Biol Chem 279:55362-71. 2004
    ..Our findings suggest that some aspects of E2A-PBX1 oncogenesis involve a direct interaction with the KIX domain of CBP/p300...