Alexander Strom

Summary

Affiliation: Ottawa Health Research Institute
Country: Canada

Publications

  1. ncbi Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Lab N1, Box 221, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Proteomics 6:26-34. 2006
  2. doi Heme Oxygenase-1 Induction Prevents Autoimmune Diabetes in Association With Pancreatic Recruitment of M2-Like Macrophages, Mesenchymal Cells, and Fibrocytes
    Mahmoud Husseini
    Chronic Disease Program M H, G S W, C P, J A C, J A N, A s, F W S, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 and Departments of Biochemistry, Microbiology, and Immunology M H, C P, A J M, J A N, F W S and Medicine F W S, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6 Food Directorate A J M, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada K1A 0K9
    Endocrinology 156:3937-49. 2015
  3. doi Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Eur J Cell Biol 90:414-9. 2011
  4. ncbi Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, ON, Canada
    Lab Invest 87:139-49. 2007
  5. pmc Peripherin-reactive antibodies in mouse, rabbit, and human blood
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Proteome Res 9:1203-8. 2010
  6. ncbi Tetracycline-regulated highly inducible expression of the human prion protein in murine 3T3 cells
    Andreas W Stuke
    German Primate Centre DPZ, Department of Virology and Immunology, Kellnerweg 4, D 37077 Gottingen, Germany
    Protein Expr Purif 39:8-17. 2005

Collaborators

  • Mahmoud Husseini
  • Andreas W Stuke
  • J Ariana Noel
  • Amanda J MacFarlane
  • Fraser W Scott
  • Jennifer A Crookshank
  • Gen Sheng Wang
  • Christopher Patrick

Detail Information

Publications6

  1. ncbi Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Lab N1, Box 221, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Proteomics 6:26-34. 2006
    ..Especially the application of this technique to investigate other neurodegenerative diseases is promising...
  2. doi Heme Oxygenase-1 Induction Prevents Autoimmune Diabetes in Association With Pancreatic Recruitment of M2-Like Macrophages, Mesenchymal Cells, and Fibrocytes
    Mahmoud Husseini
    Chronic Disease Program M H, G S W, C P, J A C, J A N, A s, F W S, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 and Departments of Biochemistry, Microbiology, and Immunology M H, C P, A J M, J A N, F W S and Medicine F W S, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6 Food Directorate A J M, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada K1A 0K9
    Endocrinology 156:3937-49. 2015
    ..Thus, short-term induction of HO-1 promoted a protective M2-like milieu in the pancreas and recruited mesenchymal cells, M2 macrophages, and fibrocytes that imparted immunoregulatory and pro-repair effects, preventing T1D...
  3. doi Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Eur J Cell Biol 90:414-9. 2011
    ..This study reveals new avenues for the elucidation of the physiological function of PrP(C) in endocrine and neuronal cells as well as the molecular mechanisms leading to prion diseases...
  4. ncbi Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, ON, Canada
    Lab Invest 87:139-49. 2007
    ..These data suggest a potential dysfunction in beta-cells of diabetes-prone rats, and point to new avenues for the study of diabetes pathogenesis...
  5. pmc Peripherin-reactive antibodies in mouse, rabbit, and human blood
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Proteome Res 9:1203-8. 2010
    ..These findings point to the need for a re-evaluation of PRPH as a T1D autoantigen in NOD mice and raise the question of the physiological relevance of such widespread immune reactivity against this peripheral nervous system protein...
  6. ncbi Tetracycline-regulated highly inducible expression of the human prion protein in murine 3T3 cells
    Andreas W Stuke
    German Primate Centre DPZ, Department of Virology and Immunology, Kellnerweg 4, D 37077 Gottingen, Germany
    Protein Expr Purif 39:8-17. 2005
    ..These clones offer a new tool to facilitate the investigation of PrP interaction with potential cellular ligands and PrP ex vivo propagation...