Affiliation: Nova Scotia
- Randomized placebo-controlled study of low-dose warfarin for the prevention of central venous catheter-associated thrombosis in patients with cancerStephen Couban
Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Room 417, Bethune Bldg, 1278 Tower Rd, Halifax, Nova Scotia B3H 2Y9, Canada
J Clin Oncol 23:4063-9. 2005..In this multicenter, randomized, placebo-controlled clinical trial, we studied whether warfarin 1 mg daily reduces the incidence of symptomatic central venous catheter (CVC) -associated thrombosis in patients with cancer...
- The source of cells for allograftingStephen Couban
Department of Medicine, Queen Elizaberth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada
Biol Blood Marrow Transplant 9:669-73. 2003..It is not clear, however, whether these benefits also extend to children or those undergoing matched unrelated transplantation...
- Catheter-associated thrombosis in patients with malignancySudeep P Shivakumar
Department of Medicine, Dalhousie University and Capital District Health Authority, Halifax, Nova Scotia, Canada
J Clin Oncol 27:4858-64. 2009..The care of pediatric patients with malignancy and catheter-associated thrombosis will also be addressed...
- A phase I/II study of sorafenib in combination with low dose cytarabine in elderly patients with acute myeloid leukemia or high-risk myelodysplastic syndrome from the National Cancer Institute of Canada Clinical Trials Group: trial IND.186David A Macdonald
Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada
Leuk Lymphoma 54:760-6. 2013..We conclude that this combination of sorafenib and cytarabine has limited activity in this unselected cohort of elderly patients with AML/MDS in which FLT3 mutations seemed underrepresented...
- A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantationKathryn E Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:81-91. 2008..Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia...
- Stiff-person syndrome associated with multiple myeloma following autologous bone marrow transplantationErin C Clow
Department of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 3A7, Canada
Muscle Nerve 38:1649-52. 2008..We speculate that an aberrant posttransplant immune response may have caused both the SPS and an autologous graft-versus-myeloma effect, resulting in prolonged remission posttransplant...
- Renal pathology at autopsy in patients who died after hematopoietic stem cell transplantationSomaya El-Seisi
Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
Biol Blood Marrow Transplant 9:683-8. 2003..Although we did not demonstrate associations of these histologic changes with clinical variables before death, larger studies with prospectively collected renal tissue are warranted...
- A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignanciesStephen Couban
Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada
Blood 100:1525-31. 2002....
- Outcome of hematopoietic stem cell transplant recipients admitted to the intensive care unitAndrea K Kew
Department of Medicine, Dalhousie University, and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
Biol Blood Marrow Transplant 12:301-5. 2006..However, SCT recipients requiring vasopressor support had very poor outcomes. These findings will be important in deciding which SCT patients may benefit from ICU admission and care...
- Differential effects of granulocyte colony-stimulating factor on marrow- and blood-derived hematopoietic and immune cell populations in healthy human donorsLuke R Shier
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Biol Blood Marrow Transplant 10:624-34. 2004..Accompanying effects on immune cell populations are consistent with a greater ability of G-BM to promote tolerance in allogeneic recipients, and this could contribute to a lower rate of chronic graft-versus-host disease...
- Laparoscopic accessory splenectomy: the value of perioperative localization studiesAbdulmalik M S Altaf
Queen Elizabeth II Health Sciences Center, Dalhousie University, Room 8 028 Victoria Building, 1278 Tower Road, Halifax, NS, B3H 2Y9, Canada
Surg Endosc 23:2675-9. 2009..Laparoscopic intraoperative identification of an accessory spleen can be difficult. The authors report their experience with laparoscopic accessory splenectomy (LAS) and the use of perioperative localization methods for this procedure...
- Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group StudyStephen Couban
Department of Medicine, Capital District Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada Electronic address
Biol Blood Marrow Transplant 22:1410-5. 2016..Our findings suggest that further study of this type of allograft is warranted. ..
- Lenalidomide plus melphalan without prednisone for previously untreated older patients with multiple myeloma: a phase II trialDarrell J White
Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada
Clin Lymphoma Myeloma Leuk 13:19-24. 2013..We conducted a phase II trial that evaluated the tolerability and efficacy of combining lenalidomide with melphalan in previously untreated patients with multiple myeloma who were not candidates for autologous stem cell transplantation...
- The experience of caring for a spouse undergoing hematopoietic stem cell transplantation: opening Pandora's boxBrenda Sabo
School of Nursing, Dalhousie University, Halifax, Nova Scotia, Canada
Cancer Nurs 36:29-40. 2013....
- Acute promyelocytic leukemia: a novel PML/RARalpha fusion that generates a frameshift in the RARalpha transcript and ATRA resistanceAdham Zayed
Department of Pathology and Laboratory Medicine, Dalhousie University, Halifax, NS, Canada
Leuk Lymphoma 48:489-96. 2007..Since none of the RARalpha functional domains are maintained, this case highlights the possibility that PML/RARalpha may directly affect promyelocyte differentiation through disruption of PML function...
- Platelet transfusions in children: results of a randomized, prospective, crossover trial of plasma removal and a prospective audit of WBC reductionStephen Couban
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Transfusion 42:753-8. 2002..The effectiveness of plasma reduction after storage and WBC reduction of platelet concentrates before storage was studied in pediatric recipients of platelet transfusions...
- Intracranial presentation of systemic Hodgkin's diseaseKhalid Hirmiz
Department of Radiation Oncology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada
Leuk Lymphoma 45:1667-71. 2004..Treatment has varied extensively but includes whole brain radiation with or without combination chemotherapy. Our literature review suggests that the prognosis is not dismal with appropriate treatment...
- An evaluation of the donor experience in the canadian multicenter randomized trial of bone marrow versus peripheral blood allograftingChristopher Bredeson
Medical College of Wisconsin, Milwaukee 53226, USA
Biol Blood Marrow Transplant 10:405-14. 2004..Further work is needed to decrease donor anxiety and symptoms. If both BM and PBPC donation are feasible, then the graft source should be dictated by the predicted patient outcome as determined from the results of randomized trials...
- Randomized trial of high-dose chemotherapy with autologous peripheral-blood stem-cell support compared with standard-dose chemotherapy in women with metastatic breast cancer: NCIC MA.16Michael Crump
National Cancer Institute of Canada Clinical Trials Group, Kingston, Ontario, Canada
J Clin Oncol 26:37-43. 2008....