Adnane Sellam

Summary

Affiliation: National Research Council
Country: Canada

Publications

  1. pmc Experimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high-resolution tiling arrays
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount, Montreal, Quebec, H4P 2R2, Canada
    Genome Biol 11:R71. 2010
  2. pmc A Candida albicans early stage biofilm detachment event in rich medium
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    BMC Microbiol 9:25. 2009
  3. pmc Role of transcription factor CaNdt80p in cell separation, hyphal growth, and virulence in Candida albicans
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    Eukaryot Cell 9:634-44. 2010
  4. pmc The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of Candida albicans adhesion
    Christopher Askew
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada H4P 2R2
    Mol Microbiol 79:940-53. 2011
  5. pmc Evolutionary tinkering with conserved components of a transcriptional regulatory network
    Hugo Lavoie
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada
    PLoS Biol 8:e1000329. 2010
  6. pmc Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans
    Christopher Askew
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000612. 2009
  7. pmc Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, Montreal, QC, H4P 2R2, Canada
    Mol Biol Cell 20:2389-400. 2009
  8. pmc Transcription factor substitution during the evolution of fungal ribosome regulation
    Herve Hogues
    Biotechnology Research Institute, National Research Council, Montreal, QC H4P 2R2, Canada
    Mol Cell 29:552-62. 2008
  9. pmc A novel role for the transcription factor Cwt1p as a negative regulator of nitrosative stress in Candida albicans
    Adnane Sellam
    Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC, Canada
    PLoS ONE 7:e43956. 2012
  10. pmc A toolbox for epitope-tagging and genome-wide location analysis in Candida albicans
    Hugo Lavoie
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, H4P 2R2, Canada
    BMC Genomics 9:578. 2008

Collaborators

Detail Information

Publications15

  1. pmc Experimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high-resolution tiling arrays
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount, Montreal, Quebec, H4P 2R2, Canada
    Genome Biol 11:R71. 2010
    ..Compared to other model organisms and despite the clinical relevance of the pathogenic yeast Candida albicans, no comprehensive analysis has been done to provide experimental support of its in silico-based genome annotation...
  2. pmc A Candida albicans early stage biofilm detachment event in rich medium
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    BMC Microbiol 9:25. 2009
    ..Appropriate in vitro C. albicans biofilm models are needed to probe factors that induce detachment events...
  3. pmc Role of transcription factor CaNdt80p in cell separation, hyphal growth, and virulence in Candida albicans
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    Eukaryot Cell 9:634-44. 2010
    ..Therefore, this study revealed a new role of the novel member of the fungal NDT80 transcription factor family as a regulator of cell separation, hyphal growth, and virulence...
  4. pmc The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of Candida albicans adhesion
    Christopher Askew
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada H4P 2R2
    Mol Microbiol 79:940-53. 2011
    ..We also demonstrate a role for the regulon in hyphal growth and in virulence. Our work thus establishes a new mechanism of Mcm1p-directed regulation distinct from those observed for other Mcm1p co-regulators...
  5. pmc Evolutionary tinkering with conserved components of a transcriptional regulatory network
    Hugo Lavoie
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada
    PLoS Biol 8:e1000329. 2010
    ....
  6. pmc Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans
    Christopher Askew
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000612. 2009
    ..albicans and Gal4p provides a carbon source-dependent fine-tuning of gene expression while regulating the metabolic flux between respiration and fermentation pathways...
  7. pmc Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, Montreal, QC, H4P 2R2, Canada
    Mol Biol Cell 20:2389-400. 2009
    ..Furthermore, ADA2 deletion causes a decrease in H3K9 acetylation levels of target genes, thus illustrating its importance for histone acetyl transferase activity...
  8. pmc Transcription factor substitution during the evolution of fungal ribosome regulation
    Herve Hogues
    Biotechnology Research Institute, National Research Council, Montreal, QC H4P 2R2, Canada
    Mol Cell 29:552-62. 2008
    ..cerevisiae lineage, this substitution also occurred independently at RP genes, illustrating the extreme adaptability and flexibility of transcriptional regulatory networks...
  9. pmc A novel role for the transcription factor Cwt1p as a negative regulator of nitrosative stress in Candida albicans
    Adnane Sellam
    Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC, Canada
    PLoS ONE 7:e43956. 2012
    ..albicans interacting with phagocytic host-cells. In summary, we have characterized a novel negative regulator of NSR and bring new insights into the transcriptional regulatory network governing fungal NSR...
  10. pmc A toolbox for epitope-tagging and genome-wide location analysis in Candida albicans
    Hugo Lavoie
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, H4P 2R2, Canada
    BMC Genomics 9:578. 2008
    ..Understanding aspects of the regulation of its biological functions and the assembly of its protein complexes would lead to further insight into the biology of this common disease-causing microbial agent...
  11. pmc Widespread occurrence of chromosomal aneuploidy following the routine production of Candida albicans mutants
    Mélanie Arbour
    Biotechnology Research Institute, National Research Council of Canada, Montreal, QC, Canada H4P2R2
    FEMS Yeast Res 9:1070-7. 2009
    ..To this end, we describe a new rapid testing method, based on a multiplex quantitative PCR assay, that produces eight bands of distinct sizes from either the left or right arms of each C. albicans chromosome...
  12. pmc Role of Ndt80p in sterol metabolism regulation and azole resistance in Candida albicans
    Adnane Sellam
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    Eukaryot Cell 8:1174-83. 2009
    ..albicans...
  13. pmc A functional portrait of Med7 and the mediator complex in Candida albicans
    Faiza Tebbji
    Department of Biology, McGill University, Montreal, Quebec, Canada Department of Biology, Concordia University, Montreal, Quebec, Canada
    PLoS Genet 10:e1004770. 2014
    ..In the absence of Med7, the ribosomal regulon is de-repressed, suggesting Med7 is involved in central aspects of growth control. ..
  14. pmc Recent advances on Candida albicans biology and virulence
    Adnane Sellam
    Infectious Diseases Research Centre CRI, CHU de Québec Research Center CHUQ, Universite Laval, Quebec City, Quebec, Canada Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Universite Laval, Quebec City, Quebec, Canada
    F1000Res 5:2582. 2016
    ..albicans...
  15. pmc The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans
    Julien Chaillot
    Infectious Diseases Research Centre CRI, CHU de Québec Research Center CHUQ, Universite Laval, Quebec City, Quebec, Canada
    Antimicrob Agents Chemother 59:4584-92. 2015
    ..albicans. This comprehensive chemogenomic investigation demonstrated that carvacrol exerts its antifungal activity by altering ER integrity, leading to ER stress and the activation of the UPR to restore protein-folding homeostasis. ..