A D Cox

Summary

Affiliation: National Research Council
Country: Canada

Publications

  1. ncbi request reprint Investigating the candidacy of a lipoteichoic acid-based glycoconjugate as a vaccine to combat Clostridium difficile infection
    Andrew D Cox
    Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 30:843-55. 2013
  2. pmc Identification, structure, and characterization of an exopolysaccharide produced by Histophilus somni during biofilm formation
    Indra Sandal
    Center for Molecular Medicine and Infectious Diseases, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA
    BMC Microbiol 11:186. 2011
  3. doi request reprint Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: immunology of glycoconjugates with high carbohydrate loading
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, 100, Sussex Drive, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 27:643-8. 2010
  4. ncbi request reprint Structural analysis of the lipooligosaccharide from the commensal Haemophilus somnus strain 1P
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Room 3101, 100 Sussex Drive, ON, K1A 0R6, Ottawa, Canada
    Carbohydr Res 338:1223-8. 2003
  5. ncbi request reprint Identification of a novel inner-core oligosaccharide structure in Neisseria meningitidis lipopolysaccharide
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, Canada
    Eur J Biochem 270:1759-66. 2003
  6. doi request reprint Investigating the potential of conserved inner core oligosaccharide regions of Moraxella catarrhalis lipopolysaccharide as vaccine antigens: accessibility and functional activity of monoclonal antibodies and glycoconjugate derived sera
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 28:165-82. 2011
  7. doi request reprint Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, 100, Sussex Drive, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 27:401-17. 2010
  8. ncbi request reprint Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits
    A D Cox
    Institute for Biological Sciences, National Research Council, 100, Sussex Drive, Ottawa, Ont, Canada K1A 0R6
    Vaccine 23:5045-54. 2005
  9. ncbi request reprint Parenteral immunization with a glycoconjugate vaccine containing the O157 antigen of Escherichia coli O157:H7 elicits a systemic humoral immune response in mice, but fails to prevent colonization by the pathogen
    J W Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Canada
    Can J Microbiol 45:279-86. 1999
  10. ncbi request reprint Structural analysis of the lipopolysaccharide from the nontypable Haemophilus influenzae strain SB 33
    A D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, ON, Canada
    Eur J Biochem 268:5278-86. 2001

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Investigating the candidacy of a lipoteichoic acid-based glycoconjugate as a vaccine to combat Clostridium difficile infection
    Andrew D Cox
    Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 30:843-55. 2013
    ..This study has illustrated that the LTA polymer is a highly conserved surface polymer of C. difficile that is easily accessible to the immune system and as such merits consideration as a vaccine antigen to combat C. difficile infection...
  2. pmc Identification, structure, and characterization of an exopolysaccharide produced by Histophilus somni during biofilm formation
    Indra Sandal
    Center for Molecular Medicine and Infectious Diseases, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA
    BMC Microbiol 11:186. 2011
    ..somni. However, H. somni does form a biofilm in vitro and in vivo, and the biofilm matrix of most bacteria consists of a polysaccharide...
  3. doi request reprint Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: immunology of glycoconjugates with high carbohydrate loading
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, 100, Sussex Drive, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 27:643-8. 2010
    ....
  4. ncbi request reprint Structural analysis of the lipooligosaccharide from the commensal Haemophilus somnus strain 1P
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Room 3101, 100 Sussex Drive, ON, K1A 0R6, Ottawa, Canada
    Carbohydr Res 338:1223-8. 2003
    ..Specifically, the inability of this commensal strain to sialylate its LOS suggests that LOS sialylation could be a crucial virulence factor for H. somnus...
  5. ncbi request reprint Identification of a novel inner-core oligosaccharide structure in Neisseria meningitidis lipopolysaccharide
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, Canada
    Eur J Biochem 270:1759-66. 2003
    ..The determination of this novel structural feature identified a further degree of variability within the inner-core oligosaccharide of meningococcal LPS which may contribute to the interaction of meningococcal strains with their host...
  6. doi request reprint Investigating the potential of conserved inner core oligosaccharide regions of Moraxella catarrhalis lipopolysaccharide as vaccine antigens: accessibility and functional activity of monoclonal antibodies and glycoconjugate derived sera
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 28:165-82. 2011
    ..catarrhalis...
  7. doi request reprint Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates with good carbohydrate loading
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, 100, Sussex Drive, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 27:401-17. 2010
    ....
  8. ncbi request reprint Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits
    A D Cox
    Institute for Biological Sciences, National Research Council, 100, Sussex Drive, Ottawa, Ont, Canada K1A 0R6
    Vaccine 23:5045-54. 2005
    ....
  9. ncbi request reprint Parenteral immunization with a glycoconjugate vaccine containing the O157 antigen of Escherichia coli O157:H7 elicits a systemic humoral immune response in mice, but fails to prevent colonization by the pathogen
    J W Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, Canada
    Can J Microbiol 45:279-86. 1999
    ..Thus, the results of this study suggest that parenteral vaccination might be an unsuitable strategy for combatting E. coli O157:H7 organisms located in the gut...
  10. ncbi request reprint Structural analysis of the lipopolysaccharide from the nontypable Haemophilus influenzae strain SB 33
    A D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, ON, Canada
    Eur J Biochem 268:5278-86. 2001
    ..The major LPS glycoforms were identified as 2-Hex, 3-Hex and 4-Hex species according to the number of hexose residues present...
  11. ncbi request reprint Structural analysis of the phase-variable lipooligosaccharide from Haemophilus somnus strain 738
    A D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, ON, Canada
    Eur J Biochem 253:507-16. 1998
    ..The elucidation of these structures has increased our understanding of the relationship between the phase-variable LOS and the pathogenic potential of this organism...
  12. ncbi request reprint Structure and functional genomics of lipopolysaccharide expression in Haemophilus influenzae
    J C Richards
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario, DA, K1A 0R6, Canada
    Adv Exp Med Biol 491:515-24. 2001
    ..Using this functional genomics approach, we have gained considerable insight into the genetic basis for intra-strain and strain-to-strain variation in epitope expression...
  13. ncbi request reprint Structural analysis of the lipopolysaccharide from Vibrio cholerae serotype O22
    A D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, ON, Canada
    Carbohydr Res 304:191-208. 1997
    ..formula: see text] The elucidation of this structure provided a chemical basis for the serological cross-reactions observed between this strain and V. cholerae serogroup O139...
  14. ncbi request reprint Oral immunization of mice with a glycoconjugate vaccine containing the O157 antigen of Escherichia coli O157:H7 admixed with cholera toxin fails to elicit protection against subsequent colonization by the pathogen
    J W Conlan
    National Research Council Canada, Institute for Biological Sciences, Ottawa, ON
    Can J Microbiol 46:283-90. 2000
    ..coli O157:H7 as unvaccinated control mice. These results indicate that this vaccination approach is unlikely to be straightforward in target bovine or human hosts...
  15. ncbi request reprint Structural analysis of the lipopolysaccharide from Neisseria meningitidis strain BZ157 galE: localisation of two phosphoethanolamine residues in the inner core oligosaccharide
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Rm 3089, ON, K1A 0R6, Ottawa, Canada
    Carbohydr Res 337:1435-44. 2002
    ..The determination of this structure has identified a further degree of variability within the inner core OS of meningococcal LPS that could contribute to the interaction of meningococcal strains with their host...
  16. ncbi request reprint Mapping bacterial glycolipid complexity using capillary electrophoresis and electrospray mass spectrometry
    J Li
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario
    Methods Enzymol 405:369-97. 2005
    ..The ability to detect a diverse LPS population over a wide dynamic range of expression using CE-MS enables the correlation of structural changes between bacterial strains and isogenic mutants to assign functional gene relationship...
  17. ncbi request reprint Structural analysis of the core oligosaccharide from Pasteurella multocida strain X73
    Frank St Michael
    Institute for Biological Sciences, 100 Sussex Drive, National Research Council, Ottawa, ON, Canada K1A 0R6
    Carbohydr Res 340:1253-7. 2005
    ....
  18. ncbi request reprint Electrophoretic and mass spectrometric strategies for profiling bacterial lipopolysaccharides
    Jianjun Li
    Institute for Biological Sciences, National Research Council, Ottawa, ON, Canada K1A 0R6
    Mol Biosyst 1:46-52. 2005
    ..influenzae strain 375 (375.1) were studied using on-line CE-MS/MS. With the separation provided by CE, two isomeric glycoforms differing in the location of phosphoethanolamine substituents were characterized by tandem mass spectrometry...
  19. ncbi request reprint Structural characterization of sialylated glycoforms of H. influenzae by electrospray mass spectrometry: fragmentation of protonated and sodiated O-deacylated lipopolysaccharides
    Jianjun Li
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada, K1A 0R6
    Rapid Commun Mass Spectrom 21:952-60. 2007
    ..This methodology is of general applicability for determination of common sialylated oligosaccharide extension in bacterial LPS...
  20. pmc Functional characterization of Lpt3 and Lpt6, the inner-core lipooligosaccharide phosphoethanolamine transferases from Neisseria meningitidis
    Cory Q Wenzel
    Institute for Biological Sciences, 100 Sussex Drive, National Research Council, Ottawa, ON, Canada K1A 0R6
    J Bacteriol 192:208-16. 2010
    ....
  21. ncbi request reprint Application of capillary electrophoresis- electrospray-mass spectrometry to the separation and characterization of isomeric lipopolysaccharides of Neisseria meningitidis
    Jianjun Li
    Institute for Biological Sciences, National Research Council, Ottawa, ON, Canada
    Electrophoresis 25:2017-25. 2004
    ..meningitidis strains F1576 A4+ and A4-. The occurrence of isomeric LPS glycoforms differing by the location or presence of neutral sugar residues, such as hexoses, can also be characterized using MS/MS...
  22. pmc Development, characterization, and functional activity of a panel of specific monoclonal antibodies to inner core lipopolysaccharide epitopes in Neisseria meningitidis
    Margaret Anne J Gidney
    Institute for Biological Sciences, National Research Council, Ottawa, ON, K1A OR6, Canada
    Infect Immun 72:559-69. 2004
    ..meningitidis strains. These findings are provocative with respect to the requirements for protective activity of antibodies and the development of inner core LPS vaccines against invasive meningococcal disease...
  23. ncbi request reprint Identification and structural characterization of a sialylated lacto-N-neotetraose structure in the lipopolysaccharide of Haemophilus influenzae
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, Canada
    Eur J Biochem 269:4009-19. 2002
    ....
  24. doi request reprint Phosphoethanolamine is located at the 6-position and not at the 7-position of the distal heptose residue in the lipopolysaccharide from Neisseria meningitidis
    Frank St Michael
    Institute for Biological Sciences, National Research Council, Ottawa, ON, K1A 0R6, Canada
    Glycobiology 19:1436-45. 2009
    ..We discuss the implications of these findings with respect to the immunotyping scheme for the meningococci and in the context of LPS-based vaccine development...
  25. ncbi request reprint Structural analysis of the lipopolysaccharide derived core oligosaccharides of Actinobacillus pleuropneumoniae serotypes 1, 2, 5a and the genome strain 5b
    Frank St Michael
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, ON, Canada K1A 0R6
    Carbohydr Res 339:1973-84. 2004
    ..All sugars were in the pyranose ring form apart from the open-chain N-acetylgalactosamine, the identification of which in the serotype 1 LPS was of interest...
  26. pmc Structural and genetic basis for the serological differentiation of Pasteurella multocida Heddleston serotypes 2 and 5
    Frank St Michael
    Institute for Biological Sciences, 100 Sussex Drive, National Research Council, Ottawa, Ontario K1A 0R6, Canada
    J Bacteriol 191:6950-9. 2009
    ..These data indicate that the serological classification of strains into Heddleston serotypes 2 and 5 is dependent on the presence or absence of PEtn on Hep II...
  27. ncbi request reprint Structural analysis of the lipooligosaccharide from the commensal Haemophilus somnus genome strain 129Pt
    Frank St Michael
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Room 3101, Ottawa, ON, Canada K1A 0R6
    Carbohydr Res 339:529-35. 2004
    ..Minor amounts of glycoforms containing nonstoichiometric substituents glycine and phosphate at the distal heptose residue were also identified...
  28. ncbi request reprint Structural analysis of the lipooligosaccharide-derived oligosaccharide of Histophilus somni (Haemophilus somnus) strain 8025
    Frank St Michael
    Institute for Biological Sciences, 100, Sussex Drive, National Research Council, Ottawa, ON, Canada K1A 0R6
    Carbohydr Res 341:281-4. 2006
    ..Since genetic manipulation has been achieved with this strain, the identification of the core OS structure will enable experiments designed to identify the role of glycosyltransferases involved in LOS biosynthesis...
  29. pmc Phosphorylation of the lipid A region of meningococcal lipopolysaccharide: identification of a family of transferases that add phosphoethanolamine to lipopolysaccharide
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario K1A 0R6, Canada
    J Bacteriol 185:3270-7. 2003
    ..We propose that NMB1638 encodes a phosphoethanolamine transferase specific for lipid A and propose naming the gene "lptA," for "LPS phosphoethenolamine transferase for lipid A."..
  30. ncbi request reprint Structural analysis of the lipopolysaccharide of Pasteurella multocida strain VP161: identification of both Kdo-P and Kdo-Kdo species in the lipopolysaccharide
    Frank St Michael
    Institute for Biological Sciences, National Research Council, Ottawa, ON, K1A 0R6, Canada
    Carbohydr Res 340:59-68. 2005
    ..This variation in the Kdo region of the LPS was also observed in several other Pasteurella multocida strains investigated including the genome strain Pm70...
  31. ncbi request reprint Identification and localization of glycine in the inner core lipopolysaccharide of Neisseria meningitidis
    Andrew D Cox
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario K1A 0R6, Canada
    Eur J Biochem 269:4169-75. 2002
    ..Nuclear magnetic resonance studies confirmed and extended this observation locating the glycine residue at the 7-position of the HepII molecule in L3 and L4 immunotype strains...
  32. ncbi request reprint Structural analysis of the lipopolysaccharide from Pasteurella multocida genome strain Pm70 and identification of the putative lipopolysaccharide glycosyltransferases
    Frank St Michael
    Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada, K1A 0R6
    Glycobiology 15:323-33. 2005
    ..Identification of the core oligosaccharide structure enabled a search for glycosyltransferase homologs in the Pm70 genome and revealed a clustering of the genes putatively responsible for outer core oligosaccharide biosynthesis...
  33. ncbi request reprint Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: conjugates based on core oligosaccharides
    F St Michael
    Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, 100, Sussex Drive, Ottawa, ON, K1A 0R6, Canada
    Glycoconj J 31:25-39. 2014
    ..This comprehensive study has, despite our best efforts, cast significant doubt as to the utility of the conserved inner core region of the meningococcal LPS as a potential vaccine antigen. ..
  34. ncbi request reprint Structural analysis of the oligosaccharide of Histophilus somni (Haemophilus somnus) strain 2336 and identification of several lipooligosaccharide biosynthesis gene homologues
    Frank St Michael
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6
    Carbohydr Res 340:665-72. 2005
    ....
  35. ncbi request reprint Production of a D-glycero-D-manno-heptosyltransferase mutant of Mannheimia haemolytica displaying a veterinary pathogen specific conserved LPS structure; development and functionality of antibodies to this LPS structure
    Susan M Logan
    Institute for Biological Sciences, National Research Council, Ottawa, Ont, Canada K1A 0R6
    Vet Microbiol 116:175-86. 2006
    ..This illustrates that it is possible to raise functional antibodies against the conserved inner core LPS structure...
  36. ncbi request reprint Three genes, lgtF, lic2C and lpsA, have a primary role in determining the pattern of oligosaccharide extension from the inner core of Haemophilus influenzae LPS
    Derek W Hood
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Microbiology 150:2089-97. 2004
    ..Thus, lgtF, lic2C and lpsA make significant but very distinct contributions to the conservation and variable patterns of oligosaccharide extensions seen in H. influenzae LPS...
  37. pmc Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of Haemophilus influenzae and its role in bacterial resistance to complement-mediated killing
    Ruth Griffin
    Centre for Molecular Microbiology and Infection, Level 3, Flowers Building, Imperial College, London SW7 2AZ, United Kingdom
    Infect Immun 73:2213-21. 2005
    ..influenzae LPS, and we show that the ability to synthesize this novel tetrasaccharide was associated with enhanced bacterial resistance to complement-mediated killing...
  38. ncbi request reprint The role of lex2 in lipopolysaccharide biosynthesis in Haemophilus influenzae strains RM7004 and RM153
    Ruth Griffin
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Microbiology 149:3165-75. 2003
    ..Investigation of the expression of the lex2 locus indicated that the genes are co-transcribed and that both reading frames are required for addition of this second beta-glucose in a phase-variable manner...
  39. pmc lpt6, a gene required for addition of phosphoethanolamine to inner-core lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae
    J Claire Wright
    Molecular Infectious Diseases Group, Dept of Pediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Bacteriol 186:6970-82. 2004
    ..meningitidis and H. influenzae lpt6 genes have conserved residues across their lengths and are part of a family of proven or putative PEtn transferases present in a wide range of gram-negative bacteria...
  40. ncbi request reprint Identification of a bifunctional lipopolysaccharide sialyltransferase in Haemophilus influenzae: incorporation of disialic acid
    Kate L Fox
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, United Kingdom
    J Biol Chem 281:40024-32. 2006
    ....
  41. pmc Biosynthesis of cryptic lipopolysaccharide glycoforms in Haemophilus influenzae involves a mechanism similar to that required for O-antigen synthesis
    Derek W Hood
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Bacteriol 186:7429-39. 2004
    ..influenzae genome, the hmg locus, is involved in the synthesis of glycoforms in which tetrasaccharide units are added en bloc, not stepwise, to the normal core glycoforms, similar to the biosynthesis of an O-antigen...
  42. pmc Incorporation of N-acetylneuraminic acid into Haemophilus somnus lipooligosaccharide (LOS): enhancement of resistance to serum and reduction of LOS antibody binding
    Thomas J Inzana
    Center for Molecular Medicine and Infectious Diseases, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0342, USA
    Infect Immun 70:4870-9. 2002
    ..LOS sialylation may therefore be an important virulence mechanism to protect H. somnus against the host immune system...
  43. pmc Digalactoside expression in the lipopolysaccharide of Haemophilus influenzae and its role in intravascular survival
    Ruth Griffin
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, UK
    Infect Immun 73:7022-6. 2005
    ..Expression of two digalactosides, rather than one, was associated with increased virulence of H. influenzae in vivo...
  44. ncbi request reprint Identification of a gene (lpt-3) required for the addition of phosphoethanolamine to the lipopolysaccharide inner core of Neisseria meningitidis and its role in mediating susceptibility to bactericidal killing and opsonophagocytosis
    Fiona G Mackinnon
    Molecular Infectious Diseases Group, University of Oxford Department of Paediatrics, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Mol Microbiol 43:931-43. 2002
    ....
  45. ncbi request reprint Characterisation of a tetrasaccharide released on mild acid hydrolysis of LPS from two rough strains of Shewanella species representing different DNA homology groups
    Anne L Moule
    Department of Chemistry, University of Hull, Hull HU6 7RX, UK
    Carbohydr Res 339:1185-8. 2004
    ..oneidensis strain MR-1 and may be characteristic of genomic groups II and III of S. putrefaciens and related strains. (1S)-d-GalaNAc-(1-->4,6)-alpha-d-Galp-(1-->6)-alpha-d-Galp-(1-->3)-d-Gal...
  46. ncbi request reprint Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity
    Sanjay Ram
    Section of Infectious Diseases, Evans Biomedical Research Center, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 278:50853-62. 2003
    ....
  47. pmc A heptosyltransferase mutant of Pasteurella multocida produces a truncated lipopolysaccharide structure and is attenuated in virulence
    Marina Harper
    Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
    Infect Immun 72:3436-43. 2004
    ..Furthermore, we have shown that mutant AL251 is unable to cause fowl cholera in chickens and that the attenuation observed is not due to increased serum sensitivity...
  48. doi request reprint Mutation in the LPS outer core biosynthesis gene, galU, affects LPS interaction with the RTX toxins ApxI and ApxII and cytolytic activity of Actinobacillus pleuropneumoniae serotype 1
    Mahendrasingh Ramjeet
    Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, QC, Canada J2S 7C6
    Mol Microbiol 70:221-35. 2008
    ..The present study suggests that a lack of binding between LPS and ApxI/II affects the cytotoxicity and virulence of A. pleuropneumoniae...
  49. doi request reprint A unique glycosyltransferase involved in the initial assembly of Moraxella catarrhalis lipooligosaccharides
    Johanna M Schwingel
    Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Glycobiology 18:447-55. 2008
    ..catarrhalis adding the primary glucose to the KDO(2)-lipid A-OH in LOS biosynthesis. The function of Lgt6 is required for the completion of both the major and minor oligosaccharide chains in M. catarrhalis...
  50. pmc Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistance
    Sanjay Ram
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 322, 364 Plantation Street, Worcester, MA 01605, USA
    Infect Immun 75:4071-81. 2007
    ..This study provides mechanistic insights into how HepI LOS substitutions affect the serum resistance of N. gonorrhoeae...
  51. ncbi request reprint Truncation of the lipopolysaccharide outer core affects susceptibility to antimicrobial peptides and virulence of Actinobacillus pleuropneumoniae serotype 1
    Mahendrasingh Ramjeet
    Groupe de Recherche sur les Maladies Infectieuses du Porc and the Département de Pathologie et Microbiologie, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec J2S 7C6, Canada
    J Biol Chem 280:39104-14. 2005
    ..pleuropneumoniae against cationic peptides and that deletion of specific residues in the outer LPS core results in the attenuation of the virulence of A. pleuropneumoniae serotype 1...
  52. pmc Isolation of an atypical strain of Actinobacillus pleuropneumoniae serotype 1 with a truncated lipopolysaccharide outer core and no O-antigen
    Mario Jacques
    Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, C P 5000, St Hyacinthe, Quebec, Canada J2S 7C6
    J Clin Microbiol 43:3522-5. 2005
    ..Veterinary diagnostic laboratories should be vigilant, since infections caused by such an isolate will not be detected by serological tests based on LPS O-antigen...
  53. pmc Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases
    Marina Harper
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Victoria 3800, Australia
    Infect Immun 75:3885-93. 2007
    ....