Robert B Zipursky
Affiliation: McMaster University
- PET and SPECT imaging in psychiatric disordersRobert B Zipursky
Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario
Can J Psychiatry 52:146-57. 2007..To review recent findings from positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies that investigate the pathophysiology and treatment of schizophrenia, depression, and dementia...
- Preferences for Early Intervention Mental Health Services: A Discrete-Choice Conjoint ExperimentMackenzie P E Becker
Ms Becker is with the Department of Psychology, Neuroscience and Behaviour, and Dr Cunningham, Ms Furimsky, Ms Rimas, Ms Wilson, Dr Bieling, Ms Chen, Ms Mielko, and Dr Zipursky are with the Department of Psychiatry and Behavioural Neurosciences, all at McMaster University, Hamilton, Ontario, Canada Ms Furimsky, Ms Wilson, Dr Bieling, and Dr Zipursky are also with the Mental Health and Addiction Program, St Joseph s Healthcare Hamilton, Hamilton, Ontario, where Ms Jeffs and Ms Madsen are affiliated Dr Cunningham is also with the Department of Psychiatry, McMaster Children s Hospital, Hamilton, Ontario Ms Chen is also with the School of Business, University of Alberta, Edmonton, Alberta Dr Christensen is with the Research School of Psychology, Australian National University, Canberra, Australia Send correspondence to Dr Zipursky e mail
Psychiatr Serv 67:184-91. 2016..Incorporating patients' preferences in the design of interventions improves engagement. A discrete-choice conjoint experiment was conducted in Canada to identify EIS attributes that encourage treatment initiation...
- Why are the outcomes in patients with schizophrenia so poor?Robert B Zipursky
St Joseph s Healthcare Hamilton, 100 West 5th St, Hamilton, ON, L8N 3K7, Canada
J Clin Psychiatry 75:20-4. 2014....
- Risk of symptom recurrence with medication discontinuation in first-episode psychosis: a systematic reviewRobert B Zipursky
Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, St Joseph s Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario L8N 3K7, Canada Electronic address
Schizophr Res 152:408-14. 2014....
- An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysisOfer Agid
Schizophrenia Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, M5T 1R8, Canada
J Clin Psychiatry 72:1439-44. 2011..Employing a naturalistic design, we examined response rates over 3 circumscribed antipsychotic trials...
- Electrophysiological evidence for primary semantic memory functional organization deficits in schizophreniaMichael Kiang
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
Psychiatry Res 196:171-80. 2012....
- Test-retest reliability and stability of N400 effects in a word-pair semantic priming paradigmMichael Kiang
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Clin Neurophysiol 124:667-74. 2013..Validating N400 semantic priming effects as a clinical biomarker requires characterizing their test-retest reliability...
- Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulationZafiris J Daskalakis
Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Psychopharmacology (Berl) 170:255-62. 2003..Therefore, single administration of an antipsychotic has no effect on CI or resting motor threshold. Whether chronic, repeated administration of antipsychotics has effects on CI requires further investigation...
- Early use of clozapine for poorly responding first-episode psychosisOfer Agid
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
J Clin Psychopharmacol 27:369-73. 2007..The present findings suggest that clozapine may have an important role in the early treatment of first-episode patients whose psychosis does not remit with other second-generation antipsychotics during the first months of treatment...
- Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophreniaOfer Agid
Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 32:1209-15. 2007....
- Association of abnormal semantic processing with delusion-like ideation in frequent cannabis users: an electrophysiological studyMichael Kiang
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
Psychopharmacology (Berl) 225:95-104. 2013..Frequent cannabis use is a risk marker for schizophrenia and delusions, but the neurocognitive mechanisms of this relationship remain unclear...
- The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disordersRomina Mizrahi
CAMH, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Schizophr Res 88:111-8. 2006....
- The effect of antipsychotic treatment on Theory of MindRomina Mizrahi
Centre for Addiction and Mental Health, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
Psychol Med 37:595-601. 2007..However, it remains unclear whether TOM deficits constitute a trait- or a state-related deficit and whether they respond to antipsychotic treatment, and also whether the change in TOM and change in psychosis are associated...
- Specialized home treatment versus hospital-based outpatient treatment for first-episode psychosis: a randomized clinical trialCarolyn S Dewa
Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Early Interv Psychiatry 3:304-11. 2009..This pilot study compared the effectiveness of specialized care that was home based versus hospital based for individuals experiencing their first psychotic episode...
- Depth-of-processing effects on semantic activation deficits in schizophrenia: an electrophysiological investigationMichael Kiang
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Ontario, Canada L8S 4K1
Schizophr Res 133:91-8. 2011..These data provide support for further research on semantic-cueing strategies for cognitive remediation of verbal memory in schizophrenia...
- MRI-targeted repetitive transcranial magnetic stimulation of Heschl's gyrus for refractory auditory hallucinationsDaniel M Blumberger
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Brain Stimul 5:577-85. 2012..Priming stimulation (6 Hz) prior to LFL stimulation (hereby simply referred to as priming) has been shown to enhance the neurophysiological effects of LFL rTMS alone and, as such, may lead to greater attenuation of AH...
- CE verbal episodic memory impairment in schizophrenia: a comparison with frontal lobe lesion patientsBruce K Christensen
Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Ontario, Canada
Clin Neuropsychol 27:647-66. 2013..These data support tentative arguments that verbal episodic memory deficits in SCZ may be mediated by frontal dysfunction in the right hemisphere...
- Cognitive function and brain structure in females with a history of adolescent-onset anorexia nervosaHarold T Chui
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Pediatrics 122:e426-37. 2008....
- The formation of abnormal associations in schizophrenia: neural and behavioral evidenceJimmy Jensen
Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 33:473-9. 2008..The aberrant activations and response are consistent with the idea that patients aberrantly assign motivational salience to neutral stimuli, and this process may be one of the aberrations that predisposes them to psychosis...
- A 'navigator' model in emerging mental illness?Peter J Bieling
St Joseph s Healthcare Hamilton, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
Early Interv Psychiatry 7:451-7. 2013..Outside of the area of psychosis, there is little evidence to guide us around a model of care that might be effective, efficient and linked to existing mental health systems...
- Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative studyKate McKenna
Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Psychiatry 66:444-9; quiz 546. 2005..Atypical antipsychotics have been on the market since the mid-1990s, and to date there are no prospective comparative studies regarding use during pregnancy...
- Early detection of psychosis: finding those at clinical high riskJean Addington
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Early Interv Psychiatry 2:147-53. 2008..The aim of this paper was to describe the development of a research clinic for individuals who appear to be at risk of developing a psychosis and the process for educating the community and obtaining referrals...
- Illness intrusiveness and subjective well-being in schizophreniaMonica Bettazzoni
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Nerv Ment Dis 196:798-805. 2008..41). Path analysis indicated that lifestyle disruption mediates the impact of symptoms and treatment on well-being. Implications for these findings and future directions for research are discussed...
- Characterizing outcome preferences in patients with psychotic disorders: a discrete choice conjoint experimentRobert B Zipursky
Department of Psychiatry and Behavioural Neuroscience, Michael G DeGroote School of Medicine, McMaster University, 100 West 5th Street, Hamilton, Ontario L8N3K7, Canada Schizophrenia and Community Integration Service, St Joseph s Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario L8N3K7, Canada Electronic address
Schizophr Res . 2016..New approaches to improve outcomes for patients with psychotic disorders should be informed by a greater understanding of patient preferences and priorities...
- Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejectedOfer Agid
Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Arch Gen Psychiatry 60:1228-35. 2003..To understand the mechanism of action of antipsychotic drugs, it is critical to recognize the time course over which these medications take effect. Current models of antipsychotic action presume a "delayed onset" of action...
- Strategies to enhance patient recruitment and retention in research involving patients with a first episode of mental illnessIvana Furimsky
Mental Health and Addictions Program, St Joseph s Healthcare Hamilton, Hamilton, ON, Canada
Contemp Clin Trials 29:862-6. 2008..Strategies that were implemented to enhance recruitment and retention in these two studies are also discussed. Finally, ethical issues to consider when implementing these strategies are also highlighted...
- Event-related brain potential study of semantic priming in unaffected first-degree relatives of schizophrenia patientsMichael Kiang
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada St Joseph s Healthcare, Hamilton, Ontario, Canada Electronic address
Schizophr Res 153:78-86. 2014..N400 amplitudes for unrelated targets did not differ between the three groups. Thus, N400 semantic priming deficits in a visual word-pair paradigm may be an illness biomarker for schizophrenia. ..
- Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulationZafiris J Daskalakis
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto Western General Hospital, University of Toronto, Ontario, Canada
Arch Gen Psychiatry 59:347-54. 2002....
- The myth of schizophrenia as a progressive brain diseaseRobert B Zipursky
To whom correspondence should be addressed St Joseph s Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario L8N3K7, Canada tel 905 522 1155 x 36250, fax 905 381 5633, E mail
Schizophr Bull 39:1363-72. 2013....
- Substance use and abuse in first-episode psychosis: prevalence before and after early interventionSuzanne Archie
Department of Psychiatry and Behavioural Neurosciences, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Schizophr Bull 33:1354-63. 2007..Despite the high prevalence of substance abuse among first-episode psychosis (FEP) populations, few studies examine whether early intervention (EI) improves substance abuse...
- Treatment response to olanzapine and haloperidol and its association with dopamine D receptor occupancy in first-episode psychosisRobert B Zipursky
Department of Psychiatry, University of Toronto, Ontario
Can J Psychiatry 50:462-9. 2005..We undertook this study to determine whether response to the atypical antipsychotic olanzapine occurs at lower levels of D2 receptor occupancy...
- Stable deficits in gray matter volumes following a first episode of schizophreniaRobert B Zipursky
Schizophr Res 71:515-6. 2004
- Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up studySitra Tauscher-Wisniewski
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Toronto, Canada
Schizophr Res 58:185-8. 2002..Both groups demonstrated a significant 9% decline in caudate volume. We were unable to replicate previous reports of caudate enlargement in patients receiving antipsychotic treatment...
- Psychotic recurrence after antipsychotic discontinuationRobert B Zipursky
Am J Psychiatry 159:1441-2; author reply 1442. 2002
- Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635Johannes Tauscher
PET Centre, Toronto, Ontario
Arch Gen Psychiatry 59:514-20. 2002....
- Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic actionShitij Kapur
Department of Psychiatry, University of Toronto, Toronto M5S 3H6, Canada
Neuroreport 13:831-5. 2002..The implications for the design of future antipsychotics is discussed...
- Visual feature conjunction in patients with schizophrenia: an event-related brain potential studyClaude Alain
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, ON, Canada M6A 2E1
Schizophr Res 57:69-79. 2002....
- Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndromeEva W C Chow
Department of Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Biol Psychiatry 51:208-15. 2002..In the current study, we used magnetic resonance imaging to characterize the structural brain abnormalities found in adults who have both 22q11 Deletion Syndrome and schizophrenia...
- Use of atypical antipsychotics during pregnancy and the risk of neural tube defects in infantsGideon Koren
Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ont, Canada
Am J Psychiatry 159:136-7. 2002..Atypical antipsychotics cause various degrees of weight gain. The authors assessed folate status and obesity among patients with schizophrenia receiving atypical antipsychotics...
- Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockadeSitra Tauscher-Wisniewski
Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
J Clin Psychiatry 63:992-7. 2002..We treated patients experiencing their first episode of schizophrenia with a single daily dose of quetiapine to achieve a transient daily peak of D(2) receptor blockade, to determine if this would lead to an antipsychotic response...
- Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodromeScott W Woods
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 54:453-64. 2003..The prodromal phase of schizophrenic disorders has been described prospectively. The present study aimed to determine the short-term efficacy and safety of olanzapine treatment of prodromal symptoms compared with placebo...
- Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophreniaRomina Mizrahi
Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
Am J Psychiatry 164:630-7. 2007..The authors present the first double-blind controlled study to examine the relationship between striatal and extrastriatal dopamine D(2) receptor binding potential and occupancy values and adverse subjective experience...
- Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosisSitra Tauscher-Wisniewski
Department of Neuropsychiatry for Children and Adolescents, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Psychiatr Res 39:365-70. 2005..441). In contrast to previous studies in patients treated with typical neuroleptics, this cross-sectional MRI study did not find significant differences in CNV of neuroleptic-naive first-episode patients compared to healthy controls...
- Imaging mental disorders in the 21st centuryRobert B Zipursky
Can J Psychiatry 52:133-4. 2007
- Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychoticsJohannes Tauscher
University of Toronto Department of Psychiatry, Schizophrenia Program
Am J Psychiatry 161:1620-5. 2004....
- Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episodeDiana O Perkins
Department of Psychiatry, C B 7160, University of North Carolina School of Medicine, Chapel Hill, 27599 7160, USA
Schizophr Res 83:53-63. 2006..Factors associated with treatment adherence in patients with chronic schizophrenia include beliefs about severity of illness and need for treatment, treatment with typical versus atypical antipsychotic and medication side effects...
- A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention servicesAshok Malla
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Quebec
Can J Psychiatry 52:563-71. 2007..The aim of this study was to determine 1-year symptomatic outcome and its predictors in patients with FEP treated at 3 different publicly funded sites...
- A longitudinal study of neurocognitive function in individuals at-risk for psychosisRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Schizophr Res 88:26-35. 2006..The time course and predictive value of cognitive deficits in the development of psychosis has not been established...
- Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary reportTony A Cohn
Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario
Can J Psychiatry 51:382-6. 2006..To compare the insulin sensitivity and adiponectin levels of medication-free patients suffering from schizophrenia or schizoaffective disorder with that of matched healthy volunteers...
- Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosisThomas H McGlashan
Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, New Haven, CT 06519, USA
Am J Psychiatry 163:790-9. 2006..This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia...
- How antipsychotics work: the patients' perspectiveRomina Mizrahi
Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada M5T 1R8
Prog Neuropsychopharmacol Biol Psychiatry 29:859-64. 2005..Most previous studies of the patient's perspective have focused on drug tolerability and acceptability-rather than their effects on psychosis per se...
- Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidolRobert B Zipursky
Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Br J Psychiatry 187:537-43. 2005..Substantial weight gain is common with many atypical antipsychotics...
- Neurobiology of early psychosisMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
Br J Psychiatry Suppl 48:s8-18. 2005..Neurobiological studies of the early course of psychoses, such as schizophrenia, allow investigation of pathophysiology without the confounds of illness chronicity and treatment...