Colin A Nurse

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha
    Josef Buttigieg
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Neurosci 29:7137-47. 2009
  2. pmc Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, L8S 4K1, Canada
    J Physiol 592:3419-26. 2014
  3. doi request reprint Potential roles of ATP and local neurons in the monitoring of blood O2 content by rat aortic bodies
    N A Piskuric
    C A Nurse Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Exp Physiol 99:248-61. 2014
  4. doi request reprint Signal processing at mammalian carotid body chemoreceptors
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1
    Semin Cell Dev Biol 24:22-30. 2013
  5. ncbi request reprint Neurotransmission and neuromodulation in the chemosensory carotid body
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    Auton Neurosci 120:1-9. 2005
  6. ncbi request reprint Synaptic mechanisms during re-innervation of rat arterial chemoreceptors in co-culture
    C A Nurse
    Department of Biology, McMaster University, 1280 Main St W, Hamilton, L8S 4K1, Ontario, Canada
    Comp Biochem Physiol A Mol Integr Physiol 130:241-51. 2001
  7. doi request reprint Neurotransmitter and neuromodulatory mechanisms at peripheral arterial chemoreceptors
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Exp Physiol 95:657-67. 2010
  8. doi request reprint Carotid body: new stimuli and new preparations--invited article
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    Adv Exp Med Biol 648:29-38. 2009
  9. ncbi request reprint Carotid body chemoreceptors in dissociated cell culture
    C A Nurse
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Microsc Res Tech 59:249-55. 2002
  10. doi request reprint Regulation of oxygen sensitivity in adrenal chromaffin cells
    Colin A Nurse
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Ann N Y Acad Sci 1177:132-9. 2009

Collaborators

Detail Information

Publications69

  1. doi request reprint Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha
    Josef Buttigieg
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Neurosci 29:7137-47. 2009
    ..The therapeutic potential of K(ATP) channel blockers was validated in experiments in which hypoxia-induced neonatal mortality in nicotine-exposed pups was significantly reduced after pretreatment with glibenclamide...
  2. pmc Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, L8S 4K1, Canada
    J Physiol 592:3419-26. 2014
    ....
  3. doi request reprint Potential roles of ATP and local neurons in the monitoring of blood O2 content by rat aortic bodies
    N A Piskuric
    C A Nurse Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Exp Physiol 99:248-61. 2014
    ..We propose a working model whereby local neurons, red blood cells, ATP signalling and low blood flow contribute to the unique ability of the aortic body to monitor blood O2 content...
  4. doi request reprint Signal processing at mammalian carotid body chemoreceptors
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1
    Semin Cell Dev Biol 24:22-30. 2013
    ..Included in this model is a novel hypothesis for a potential role of type II cells as an amplifier for the release of a key excitatory carotid body neurotransmitter, ATP, via P2Y purinoceptors and pannexin-1 channels...
  5. ncbi request reprint Neurotransmission and neuromodulation in the chemosensory carotid body
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    Auton Neurosci 120:1-9. 2005
    ..This review will highlight recent advances in understanding the role of these neuroactive ligands in carotid body function...
  6. ncbi request reprint Synaptic mechanisms during re-innervation of rat arterial chemoreceptors in co-culture
    C A Nurse
    Department of Biology, McMaster University, 1280 Main St W, Hamilton, L8S 4K1, Ontario, Canada
    Comp Biochem Physiol A Mol Integr Physiol 130:241-51. 2001
    ..These data further support a co-transmitter role for ATP and the involvement of heteromeric P2X2/P2X3 purinoceptors in carotid body function...
  7. doi request reprint Neurotransmitter and neuromodulatory mechanisms at peripheral arterial chemoreceptors
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Exp Physiol 95:657-67. 2010
    ..This review highlights some of these developments, which have contributed to our current understanding of information processing at CB chemoreceptors...
  8. doi request reprint Carotid body: new stimuli and new preparations--invited article
    Colin A Nurse
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    Adv Exp Med Biol 648:29-38. 2009
    ....
  9. ncbi request reprint Carotid body chemoreceptors in dissociated cell culture
    C A Nurse
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Microsc Res Tech 59:249-55. 2002
    ....
  10. doi request reprint Regulation of oxygen sensitivity in adrenal chromaffin cells
    Colin A Nurse
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Ann N Y Acad Sci 1177:132-9. 2009
    ..Thus, nicotinic AChR activation may contribute to the suppression of hypoxic sensitivity in AMC, and this pathway could provide the basis for the loss of hypoxia tolerance in the offspring of smoking mothers...
  11. pmc Postsynaptic action of GABA in modulating sensory transmission in co-cultures of rat carotid body via GABA(A) receptors
    Min Zhang
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Physiol 587:329-44. 2009
    ..These data suggest that GABA, released from the CB during hypoxia, inhibits sensory discharge postsynaptically via a shunting mechanism involving GABA(A) receptors...
  12. pmc GABA mediates autoreceptor feedback inhibition in the rat carotid body via presynaptic GABAB receptors and TASK-1
    Ian M Fearon
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    J Physiol 553:83-94. 2003
    ..Thus GABAB receptor-mediated activation of TASK-1 or a related channel provides a presynaptic autoregulatory feedback mechanism that modulates fast synaptic transmission in the rat carotid body...
  13. pmc Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body
    Min Zhang
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada, L8S 4K1
    J Physiol 578:735-50. 2007
    ..Taken together these data indicate that CB receptors act as direct glucosensors, and that processing of hypoglycaemia utilizes similar neurotransmitter and neuromodulatory mechanisms as hypoxia...
  14. pmc P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP
    Min Zhang
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario L8S 4K1, Canada
    J Physiol 590:4335-50. 2012
    ..We propose that CB type II cells may function as ATP amplifiers during chemotransduction via paracrine activation of P2Y2Rs and Panx-1 channels...
  15. ncbi request reprint Expression of multiple P2X receptors by glossopharyngeal neurons projecting to rat carotid body O2-chemoreceptors: role in nitric oxide-mediated efferent inhibition
    Veronica A Campanucci
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Neurosci 26:9482-93. 2006
    ..Activation of this pathway will lead to calcium influx and efferent inhibition of CB chemoreceptors via NO synthesis and consequent release...
  16. ncbi request reprint Chronic nicotine in utero selectively suppresses hypoxic sensitivity in neonatal rat adrenal chromaffin cells
    Josef Buttigieg
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    FASEB J 22:1317-26. 2008
    ....
  17. pmc Chronic exposure of neonatal rat adrenomedullary chromaffin cells to opioids in vitro blunts both hypoxia and hypercapnia chemosensitivity
    Shaima Salman
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Physiol 591:515-29. 2013
    ....
  18. doi request reprint Glucosensing in an immortalized adrenomedullary chromaffin cell line: role of ATP-sensitive K+ channels
    Nikol A Piskuric
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Neurosci Lett 445:94-8. 2008
    ..Thus, this cell line appears as an attractive model for studying the molecular mechanisms of glucosensing...
  19. ncbi request reprint O2-sensing mechanisms in efferent neurons to the rat carotid body
    Veronica A Campanucci
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Adv Exp Med Biol 536:179-85. 2003
  20. pmc Effects of chemostimuli on [Ca2+]i responses of rat aortic body type I cells and endogenous local neurons: comparison with carotid body cells
    Nikol A Piskuric
    Department of Biology, McMaster University, Life Sciences Building, Hamilton, Ontario, Canada
    J Physiol 590:2121-35. 2012
    ..Unlike the CB, however, they also associate with a special group of endogenous neurons which we propose may subserve a sensory function in local cardiovascular reflexes...
  21. ncbi request reprint Potential oxygen sensing pathways in the zebrafish gill
    Michael G Jonz
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Adv Exp Med Biol 536:217-23. 2003
  22. ncbi request reprint Expression and function of presynaptic neurotransmitter receptors in the chemoafferent pathway of the rat carotid body
    Ian M Fearon
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
    Adv Exp Med Biol 536:297-303. 2003
  23. doi request reprint Divergent roles of reactive oxygen species in the responses of perinatal adrenal chromaffin cells to hypoxic challenges
    Stephen T Brown
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    Respir Physiol Neurobiol 174:252-8. 2010
    ..We propose that the physiological responses of perinatal AMC to hypoxia and the ensuing directional changes in ROS are dependent on the pattern and duration of the hypoxic exposure...
  24. doi request reprint Purinergic stimulation of carotid body efferent glossopharyngeal neurones increases intracellular Ca2+ and nitric oxide production
    Michael Lowe
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Exp Physiol 98:1199-212. 2013
    ..Taken together, these data indicate that ATP may contribute to negative feedback inhibition of CB sensory discharge via purinergic stimulation of NO production in efferent fibres. ..
  25. pmc Presynaptic modulation of rat arterial chemoreceptor function by 5-HT: role of K+ channel inhibition via protein kinase C
    Min Zhang
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Physiol 551:825-42. 2003
    ....
  26. ncbi request reprint CO2/pH chemosensory signaling in co-cultures of rat carotid body receptors and petrosal neurons: role of ATP and ACh
    Min Zhang
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Neurophysiol 92:3433-45. 2004
    ..Thus co-release of ACh and ATP is an important neurotransmitter mechanism for processing isohydric and acidic hypercapnia in the rat carotid body...
  27. doi request reprint Ammonia sensing by neuroepithelial cells and ventilatory responses to ammonia in rainbow trout
    Li Zhang
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1
    J Exp Biol 214:2678-89. 2011
    ....
  28. ncbi request reprint Development of oxygen sensing in the gills of zebrafish
    Michael G Jonz
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    J Exp Biol 208:1537-49. 2005
    ..At earlier stages, however, O(2)-sensing must occur through another pathway. The possibility that a new type of 5-HT-positive NEC of the gill arches may account for this earlier hypoxic response is discussed...
  29. pmc Neuroepithelial oxygen chemoreceptors of the zebrafish gill
    Michael G Jonz
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    J Physiol 560:737-52. 2004
    ..This appears to be a fundamental mechanism of O(2) sensing that arose early in vertebrate evolution, and was adopted later in mammalian O(2) chemoreceptors...
  30. doi request reprint Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line
    Stephen T Brown
    Department of Biology, McMaster University, Hamilton, Ontario, L8S 4K1 Canada
    Am J Physiol Cell Physiol 294:C1305-12. 2008
    ..These data suggest that in this O2-sensitive cell line, mitochondrial O2 consumption, rather than changes in ROS, regulates HIF-2alpha during hypoxia...
  31. ncbi request reprint Comparative study of gill neuroepithelial cells and their innervation in teleosts and Xenopus tadpoles
    Heather A Saltys
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, ON, L8S 4K1, Canada
    Cell Tissue Res 323:1-10. 2006
    ..This report constitutes the first comparative study of gill NECs in fish and amphibians and highlights the significance of gill NECs as an evolutionary model for studying O(2) sensing in vertebrates...
  32. ncbi request reprint Autonomic innervation of the carotid body: role in efferent inhibition
    Veronica A Campanucci
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Respir Physiol Neurobiol 157:83-92. 2007
    ..Finally, we discuss recent data linking the action of hypoxia and a key CB neurotransmitter, i.e. ATP, to potential mechanisms for activating this efferent pathway...
  33. ncbi request reprint Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body
    Josef Buttigieg
    Department of Biology, McMaster University, Hamilton, Ont, Canada L8S 4K1
    Biochem Biophys Res Commun 322:82-7. 2004
    ..These data strongly support a neurotransmitter role for ATP in carotid body function...
  34. doi request reprint Enhanced adenosine A2b receptor signaling facilitates stimulus-induced catecholamine secretion in chronically hypoxic carotid body type I cells
    Simon Livermore
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Cell Physiol 305:C739-50. 2013
    ..Taken together, these data suggest that paracrine Ado A2b receptor signaling contributes to stimulus-evoked catecholamine secretion in Nox and CHox CB chemoreceptors; however, the effects of Ado are more robust after CHox...
  35. doi request reprint Developmental regulation of glucosensing in rat adrenomedullary chromaffin cells: potential role of the K(ATP) channel
    Simon Livermore
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Adv Exp Med Biol 758:191-8. 2012
    ..Lastly, we show that the Kir6.2 subunit of the KATP channel, is upregulated in the adrenal medulla in juvenile animals providing a potential mechanism for the developmental regulation of glucosensing...
  36. doi request reprint Peripheral chemoreceptors in air- versus water- breathers
    Michael G Jonz
    Department of Biology, University of Ottawa, Ottawa, ON, Canada
    Adv Exp Med Biol 758:19-27. 2012
    ....
  37. ncbi request reprint Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells
    Ian M Fearon
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    Adv Exp Med Biol 580:203-8; discussion 351-9. 2006
  38. doi request reprint Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2α: role in modulating secretion
    Stephen T Brown
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Biochem Biophys Res Commun 412:466-72. 2011
    ..Thus, A2aR, adenosine, and HIF-2α are key contributors to the potentiation of CAT secretion in developing chromaffin cells during chronic hypoxia...
  39. doi request reprint Hypoxia inducible factor (HIF)-2 alpha is required for the development of the catecholaminergic phenotype of sympathoadrenal cells
    Stephen T Brown
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 110:622-30. 2009
    ..These data suggest that a basal level of HIF-2alpha function is required for the normal developmental expression of DDC and DbetaH in SA progenitor cells, and that loss of this function leads to impaired catecholamine biosynthesis...
  40. ncbi request reprint Neuroepithelial cells and associated innervation of the zebrafish gill: a confocal immunofluorescence study
    Michael G Jonz
    Department of Biology, Life Sciences Building, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Comp Neurol 461:1-17. 2003
    ..Thus, NECs of the zebrafish gill are organized in a manner reminiscent of O(2) chemoreceptors of mammalian vertebrates, suggesting a role in respiratory regulation...
  41. doi request reprint Chronic nicotine induces hypoxia inducible factor-2α in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2
    Shaima Salman
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    Am J Physiol Cell Physiol 302:C1531-8. 2012
    ..2 subunit. The data suggest that the HIF pathway may be involved in K(ATP) channel-mediated neuroprotection during brain ischemia, and in the effects of chronic nicotine on ubiquitous brain α7 nAChR...
  42. ncbi request reprint Epithelial mitochondria-rich cells and associated innervation in adult and developing zebrafish
    Michael G Jonz
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Comp Neurol 497:817-32. 2006
    ..Evidence is presented suggestive of widespread association of MRCs with the nervous system in transport epithelia and the neural control of MRC-mediated ion regulation in teleost fish...
  43. doi request reprint New developments on gill innervation: insights from a model vertebrate
    Michael G Jonz
    Department of Biology, University of Ottawa, Ottawa, ON, Canada, K1N 6N5
    J Exp Biol 211:2371-8. 2008
    ..In addition, the idea of the neural control of ion regulation in the gill based on the apparent innervation of mitochondria-rich cells, and the role of innervation in the pseudobranch, will be presented...
  44. doi request reprint Confocal immunofluorescence study of rat aortic body chemoreceptors and associated neurons in situ and in vitro
    Nikol A Piskuric
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Comp Neurol 519:856-73. 2011
    ..Thus, this coculture model is attractive for investigating the role of glomus cells and local neurons in AB function...
  45. pmc Expanding role of ATP as a versatile messenger at carotid and aortic body chemoreceptors
    Nikol A Piskuric
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario L8S 4K1, Canada
    J Physiol 591:415-22. 2013
    ..Finally, we present a hypothetical 'quadripartite model' to explain how ATP, released from red blood cells during hypoxia, could contribute to the ability of ABs to sense O(2) content...
  46. pmc O2-sensitive K+ channels in immortalised rat chromaffin-cell-derived MAH cells
    Ian M Fearon
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    J Physiol 545:807-18. 2002
    ....
  47. pmc A novel O2-sensing mechanism in rat glossopharyngeal neurones mediated by a halothane-inhibitable background K+ conductance
    Veronica A Campanucci
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    J Physiol 548:731-43. 2003
    ..g. halothane) on respiration...
  48. ncbi request reprint A maxi Cl- channel in cultured pavement cells from the gills of the freshwater rainbow trout Oncorhynchus mykiss
    M J O'Donnell
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Exp Biol 204:1783-94. 2001
    ..The channel was blocked by Zn2+, SITS, DIDS and diphenylamine carboxylate. This is the first description of a large-conductance Cl- channel in gill cells from freshwater or marine species. Possible functions of the channel are discussed...
  49. ncbi request reprint Acetylcholine contributes to hypoxic chemotransmission in co-cultures of rat type 1 cells and petrosal neurons
    C A Nurse
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Respir Physiol 115:189-99. 1999
    ..Other CB transmitter candidates (e.g. 5-HT and ATP) were found to excite PN, though their potential role as co-released sensory transmitters requires further investigation...
  50. ncbi request reprint Biophysical characterization of whole-cell currents in O2-sensitive neurons from the rat glossopharyngeal nerve
    V A Campanucci
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    Neuroscience 132:437-51. 2005
    ..These properties endow GPN neurons with an exquisite ability to regulate carotid body chemoreceptor function during hypoxia, via voltage-gated Ca2+-entry, activation of nNOS, and release of NO...
  51. ncbi request reprint Long-term modulation of inward currents in O2 chemoreceptors by chronic hypoxia and cyclic AMP in vitro
    A Stea
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Neurosci 15:2192-202. 1995
    ....
  52. pmc Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A
    Shaima Salman
    Department of Biology, McMaster University, Hamilton, Ontario, Canada and
    Am J Physiol Cell Physiol 307:C266-77. 2014
    ..Collectively, these data reveal novel mechanisms by which chronic opioids blunt asphyxial chemosensitivity in AMCs, thereby contributing to abnormal arousal responses in the offspring of opiate-addicted mothers...
  53. doi request reprint Ontogeny of O2 and CO2//H+ chemosensitivity in adrenal chromaffin cells: role of innervation
    Shaima Salman
    Department of Biology, McMaster University, Hamilton, ON, Canada, L8S 4K1
    J Exp Biol 217:673-81. 2014
    ..These data suggest that the ontogeny of O2 and CO2/H(+) chemosensitivity in chromaffin cells can be regulated by the tonic release of presynaptic neurotransmitters. ..
  54. doi request reprint Methodologies for studying peripheral O₂ chemosensing: past, present, and future
    Josef Buttigieg
    University of Regina, Department of Biology, Regina, Saskatchewan, S4S 0A2, Canada
    Respir Physiol Neurobiol 181:194-201. 2012
    ..This review aims to discuss the advantages and disadvantages of the various experimental models employed in studying the mechanisms by which acute peripheral chemosensing occurs...
  55. ncbi request reprint A rotenone-sensitive site and H2O2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells
    R J Thompson
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Neuroscience 145:130-41. 2007
    ..Interestingly, juvenile AMC display at least two modifications, i.e. an uncoupling of the O2-sensor from ROS regulation, and an apparent insensitivity of outward current to decreased ROS...
  56. ncbi request reprint O2 sensing by recombinant TWIK-related halothane-inhibitable K+ channel-1 background K+ channels heterologously expressed in human embryonic kidney cells
    V A Campanucci
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Canada ON L8S 4K1
    Neuroscience 135:1087-94. 2005
    ..Given the O2 sensitivity of THIK-1 channels and their abundant expression in the CNS, we raise for the first time the possibility of a physiological and/or pathological role for these channels during brain ischemia...
  57. doi request reprint Purinergic signalling mediates bidirectional crosstalk between chemoreceptor type I and glial-like type II cells of the rat carotid body
    Sindhubarathi Murali
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada, L8S 4K1
    J Physiol 594:391-406. 2016
    ..We propose that reciprocal crosstalk between type I and type II cells contributes to sensory processing in the carotid body via purinergic signalling pathways...
  58. doi request reprint Paracrine Signaling in Glial-Like Type II Cells of the Rat Carotid Body
    Sindhubarathi Murali
    Department of Biology, McMaster University, Hamilton, ON, L8S 4K1, Canada
    Adv Exp Med Biol 860:41-7. 2015
    ..These data suggest that paracrine activation of type II cells by endogenous neuromodulators may be a common feature of signal processing in the rat CB...
  59. doi request reprint Enhanced BDNF signalling following chronic hypoxia potentiates catecholamine release from cultured rat adrenal chromaffin cells
    Angela L Scott
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    J Physiol 593:3281-99. 2015
    ....
  60. doi request reprint Functional mitochondria are required for O2 but not CO2 sensing in immortalized adrenomedullary chromaffin cells
    J Buttigieg
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Cell Physiol 294:C945-56. 2008
    ..We also show for the first time that, like their neonatal chromaffin cell counterparts, MAH cells are CO(2) sensors; however, this property is independent of functional mitochondria...
  61. ncbi request reprint Basic FGF localization in rat carotid body: paracrine role in O2 -chemoreceptor survival
    M Paciga
    Department of Biology, McMaster University, 1280 Main Street West Hamilton, Ontario, Canada
    Neuroreport 12:3287-91. 2001
    ..Thus, autocrine/ paracrine actions of endogenous bFGF may help promote CB chemoreceptor survival...
  62. pmc Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling
    M Prasad
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
    J Physiol 537:667-77. 2001
    ..Taken together, these data indicate that ATP and P2X2-P2X3 purinoceptors play important roles in the peripheral control of respiration by carotid body chemoreceptors...
  63. doi request reprint Low glucose sensitivity and polymodal chemosensing in neonatal rat adrenomedullary chromaffin cells
    S Livermore
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Cell Physiol 301:C1104-15. 2011
    ..These data suggest that together with hypoxia and acid hypercapnia, low glucose is another important metabolic stimulus that contributes to the vital asphyxia-induced catecholamine surge from AMCs at birth...
  64. ncbi request reprint Oxygen sensing in neuroepithelial and adrenal chromaffin cells
    C A Nurse
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Novartis Found Symp 272:106-14; discussion 114-8, 131-40. 2006
    ..We propose thatchanges in ROS serve as a common link between the O2 sensor and secretion in perinatal NEBs and chromaffin cells. However, the subcellular localization of the O2 sensor appears to be different between these two cell types...
  65. ncbi request reprint Expression of functional nicotinic acetylcholine receptors in neuroepithelial bodies of neonatal hamster lung
    Xiao Wen Fu
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, 555 Univ Ave, Toronto, Ontario, Canada M5G 1X8
    Am J Physiol Lung Cell Mol Physiol 285:L1203-12. 2003
    ....
  66. ncbi request reprint Developmental regulation of O(2) sensing in neonatal adrenal chromaffin cells from wild-type and NADPH-oxidase-deficient mice
    Roger J Thompson
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pflugers Arch 444:539-48. 2002
    ..Thus, mouse AMC possess a developmentally regulated O(2)-sensing mechanism, but NADPH oxidase does not function as the primary O(2)sensor in these cells...
  67. ncbi request reprint Expression of functional purinergic receptors in pulmonary neuroepithelial bodies and their role in hypoxia chemotransmission
    Xiao Wen Fu
    Division of Pathology, Department of Pediatric Laboratory Medicine, The Research Institute, The Hospital for Sick Children and University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Biol Chem 385:275-84. 2004
    ..These data suggest that functional P2X2/3 heteromeric receptors are expressed in NEB cells. The possible function of these purinoreceptors in NEB cells could include modulation of hypoxia chemotransmission...
  68. ncbi request reprint Ion channel compartments in photoreceptors: evidence from salamander rods with intact and ablated terminals
    Peter R MacLeish
    Department of Anatomy and Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Neurophysiol 98:86-95. 2007
    ..1-2 microM). These data indicate that rod photoreceptors possess discrete targeting mechanisms that preferentially sort ion channels mediating I(Cl(Ca)) to the terminal...
  69. ncbi request reprint Ontogenesis of oxygen chemoreception in aquatic vertebrates
    Michael G Jonz
    Department of Physiology and Biophysics, Dalhousie University, 5859 University Avenue, Halifax, NS, Canada B3H 4H7
    Respir Physiol Neurobiol 154:139-52. 2006
    ..The developmental and evolutionary significance of the internal migration of O(2)-chemoreceptive sites with changes in respiratory organs is also discussed...