Robert M K W Lee

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Mas receptors in modulating relaxation induced by perivascular adipose tissue
    Robert M K W Lee
    Smooth Muscle Research Program and Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    Life Sci 89:467-72. 2011
  2. doi request reprint Alteration of perivascular adipose tissue function in angiotensin II-induced hypertension
    Robert M K W Lee
    Smooth Muscle Research Program and Department of Anesthesia, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Can J Physiol Pharmacol 87:944-53. 2009
  3. doi request reprint Endothelium-dependent relaxation factor released by perivascular adipose tissue
    Robert M K W Lee
    Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    J Hypertens 27:782-90. 2009
  4. doi request reprint Effects of hyperglycemia on the modulation of vascular function by perivascular adipose tissue
    Robert M K W Lee
    Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    J Hypertens 27:118-31. 2009
  5. ncbi request reprint Alterations in hypertensive arteries
    Robert M K W Lee
    Smooth Muscle Research Programme, Department of Anesthesia HSC 2U3, McMaster University, Hamilton, ON, Canada
    Can J Physiol Pharmacol 83:675-80. 2005
  6. doi request reprint The mechanisms of propofol-induced vascular relaxation and modulation by perivascular adipose tissue and endothelium
    Saira I Kassam
    Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    Anesth Analg 112:1339-45. 2011
  7. doi request reprint Superoxide anion mediates angiotensin II-induced potentiation of contractile response to sympathetic stimulation
    Chao Lu
    Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, Hamilton, ON, Canada
    Eur J Pharmacol 589:188-93. 2008
  8. ncbi request reprint Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion
    Yu Jing Gao
    Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Cardiovasc Res 71:363-73. 2006
  9. doi request reprint Effects of fetal and neonatal exposure to nicotine on blood pressure and perivascular adipose tissue function in adult life
    Yu Jing Gao
    Smooth Muscle Research Program, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Eur J Pharmacol 590:264-8. 2008
  10. ncbi request reprint The effects of quinapril and atorvastatin on artery structure and function in adult spontaneously hypertensive rats
    Lufang Yang
    Smooth Muscle Research Programme and Department of Anaesthesia, HSC 2U3, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Eur J Pharmacol 518:145-51. 2005

Collaborators

Detail Information

Publications28

  1. doi request reprint Mas receptors in modulating relaxation induced by perivascular adipose tissue
    Robert M K W Lee
    Smooth Muscle Research Program and Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    Life Sci 89:467-72. 2011
    ..Using aorta from Mas-knockout (K/O) and wild type (FVB) mice, we wished to establish the essential role of Mas receptors in mediating the endothelium-dependent relaxation response induced by relaxation factors from PVAT...
  2. doi request reprint Alteration of perivascular adipose tissue function in angiotensin II-induced hypertension
    Robert M K W Lee
    Smooth Muscle Research Program and Department of Anesthesia, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Can J Physiol Pharmacol 87:944-53. 2009
    ....
  3. doi request reprint Endothelium-dependent relaxation factor released by perivascular adipose tissue
    Robert M K W Lee
    Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    J Hypertens 27:782-90. 2009
    ..Here, we examined if angiotensin 1-7 [Ang-(1-7)] is one of the relaxation factors released by PVAT...
  4. doi request reprint Effects of hyperglycemia on the modulation of vascular function by perivascular adipose tissue
    Robert M K W Lee
    Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    J Hypertens 27:118-31. 2009
    ..To study the acute and chronic effect of hyperglycemia on perivascular adipose tissue (PVAT) function in rat aorta...
  5. ncbi request reprint Alterations in hypertensive arteries
    Robert M K W Lee
    Smooth Muscle Research Programme, Department of Anesthesia HSC 2U3, McMaster University, Hamilton, ON, Canada
    Can J Physiol Pharmacol 83:675-80. 2005
    ..Here I recount some of that experience, and describe some of the lessons I have learned from this experience, as my tribute to Dr. Daniel on the occasion of his 80th birthday...
  6. doi request reprint The mechanisms of propofol-induced vascular relaxation and modulation by perivascular adipose tissue and endothelium
    Saira I Kassam
    Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    Anesth Analg 112:1339-45. 2011
    ..Whether PVAT affects the action of anesthetics on vascular function is unknown. We studied the mechanisms of propofol-induced relaxation in relation to the involvement of PVAT and endothelium...
  7. doi request reprint Superoxide anion mediates angiotensin II-induced potentiation of contractile response to sympathetic stimulation
    Chao Lu
    Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, Hamilton, ON, Canada
    Eur J Pharmacol 589:188-93. 2008
    ..These results showed that superoxide mediated angiotensin II-induced potentiation of contractile response to EFS and tyrosine kinase-MAPK/ERK activation was involved...
  8. ncbi request reprint Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion
    Yu Jing Gao
    Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Cardiovasc Res 71:363-73. 2006
    ..In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS)...
  9. doi request reprint Effects of fetal and neonatal exposure to nicotine on blood pressure and perivascular adipose tissue function in adult life
    Yu Jing Gao
    Smooth Muscle Research Program, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Eur J Pharmacol 590:264-8. 2008
    ..Alterations in perivascular adipose tissue composition and modulatory function are some of the mechanisms associated with this blood pressure increase...
  10. ncbi request reprint The effects of quinapril and atorvastatin on artery structure and function in adult spontaneously hypertensive rats
    Lufang Yang
    Smooth Muscle Research Programme and Department of Anaesthesia, HSC 2U3, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Eur J Pharmacol 518:145-51. 2005
    ..An increase in apoptotic smooth muscle cells may be one of the mechanisms underlying the structural improvement...
  11. ncbi request reprint Control of vascular changes by renin-angiotensin-aldosterone system in salt-sensitive hypertension
    Zhao hua Zeng
    Smooth Muscle Research Program and Department of Anesthesia, McMaster University, Department of Anesthesiology HSC 2u3, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Eur J Pharmacol 503:129-33. 2004
    ..The renin-angiotensin-aldosterone system is involved in this salt-sensitive model because treatment that interfered with this system also prevented the development of hypertension and vascular remodeling...
  12. doi request reprint Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: the role of adipocyte-derived angiotensin II
    Chao Lu
    Smooth Muscle Research Program, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Eur J Pharmacol 634:107-12. 2010
    ..These results showed that adipocyte-derived angiotensin II is critically involved in PVAT-mediated potentiation of EFS-evoked contraction in rat mesenteric arteries...
  13. ncbi request reprint Alteration of arterial smooth muscle potassium channel composition and BKCa current modulation in hypertension
    Yongde Zhang
    Department of Medicine, McMaster University, Canada
    Eur J Pharmacol 514:111-9. 2005
    ..The changes in K+ current type may indicate an underlying defect in Ca2+-handling that predisposes smooth muscle cells to the hypertensive phenotype...
  14. pmc Hydrogen peroxide is an endothelium-dependent contracting factor in rat renal artery
    Yu Jing Gao
    Smooth Muscle Research Program and Department of Anesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Br J Pharmacol 146:1061-8. 2005
    ..Therefore, H2O2 is most likely the EDCF in rat renal artery in response to ACh stimulation...
  15. doi request reprint Alterations in perivascular adipose tissue structure and function in hypertension
    Chao Lu
    Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 656:68-73. 2011
    ..The functional impairment observed in SHR PVAT may be related to changes in adipocyte composition but not to reduced PVAT mass in SHR...
  16. doi request reprint Modulation of vein function by perivascular adipose tissue
    Chao Lu
    Smooth Muscle Research Program and Department of Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 657:111-6. 2011
    ..We conclude that venous PVAT attenuates agonist-induced contraction by releasing Ang-(1-7), which causes relaxation of smooth muscle through endothelial NO release and activation of K(v) channels...
  17. ncbi request reprint Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adipose tissue function
    Yu Jing Gao
    Department of Anaesthesia HSC 2U3, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Obes Res 13:687-92. 2005
    ..The aim of this study was to examine the effect of fetal and neonatal exposure to nicotine, the major addictive component of cigarette smoke, on postnatal adiposity and blood vessel function...
  18. pmc Arterial internal elastic lamina holes: relationship to function?
    Shaun L Sandow
    Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    J Anat 214:258-66. 2009
    ....
  19. pmc Vascular relaxation response to hydrogen peroxide is impaired in hypertension
    Yu Jing Gao
    Smooth Muscle Research Program, Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 142:143-9. 2004
    ..These results suggest that alteration in K(+) channel activation by reactive oxygen species may play a role in the development of hypertension in SHR...
  20. doi request reprint Flow-induced vascular remodeling in the mesenteric artery of spontaneously hypertensive rats
    Yu Jing Gao
    Smooth Muscle Research Program and Department of Anesthesia, McMaster University, 1200 Main Street West, Hamilton, ON L8N3Z5, Canada
    Can J Physiol Pharmacol 86:737-44. 2008
    ....
  21. ncbi request reprint Perivascular adipose tissue modulates vascular function in the human internal thoracic artery
    Yu Jing Gao
    Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1130-6. 2005
    ..The purpose of the present study was to examine whether this vasodilator is also present in human internal thoracic arteries...
  22. ncbi request reprint Detrimental effects of papaverine on the human internal thoracic artery
    Yu Jing Gao
    Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
    J Thorac Cardiovasc Surg 126:179-85. 2003
    ..We sought to determine the effects of papaverine on human and canine internal thoracic artery function and structure...
  23. ncbi request reprint Quinapril effects on resistance artery structure and function in hypertension
    Lufang Yang
    Smooth Muscle Research Programme and Department of Anaesthesia, McMaster University, Hamilton, ON, Canada, L8N 3Z5
    Naunyn Schmiedebergs Arch Pharmacol 370:444-51. 2004
    ..An increase in apoptotic process of medial smooth muscle cells is one of the mechanisms underlying the vascular structural improvement...
  24. ncbi request reprint Arterial structural changes in hypertensive rats induced by capsaicin and salt loading
    Zhao hua Zeng
    Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Pharmacol Physiol 31:502-5. 2004
    ..A long-term high-sodium load induced hypertension in normal Wistar rats, which was accompanied by cardiovascular hypertrophy...
  25. pmc Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery
    Yu Jing Gao
    Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 138:1085-92. 2003
    ....
  26. ncbi request reprint Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function
    Kumiko Takemori
    Department of Pathology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Hypertension 49:365-72. 2007
    ....
  27. ncbi request reprint Arterial structural changes in hypertension: a consideration of methodology, terminology and functional consequence
    Stuart J Bund
    Department of Human Anatomy and Physiology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    J Vasc Res 40:547-57. 2003
    ..In particular, a simple descriptor terminology is proposed that describes such structural differences but makes no assumptions concerning the underlying processes that account for altered arterial structure in hypertension...
  28. ncbi request reprint Changes in endothelium-derived hyperpolarizing factor and myogenic response in rats with chronic renal failure and their association with hypertension
    Robert M K W Lee
    J Hypertens 24:2153-5. 2006