Michelle Ghert

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi request reprint Outcomes of an anatomically based approach to metastatic disease of the acetabulum
    Michelle Ghert
    McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Clin Orthop Relat Res 459:122-7. 2007
  2. ncbi request reprint Properties of the stromal cell in giant cell tumor of bone
    Michelle Ghert
    McMaster University, Hamilton Health Sciences and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Clin Orthop Relat Res 459:8-13. 2007
  3. doi request reprint Use of a calcium sulfate-calcium phosphate synthetic bone graft composite in the surgical management of primary bone tumors
    Nathan Evaniew
    Department of Surgery, Division of Orthopaedics, McMaster University, Hamilton, Ontario, Canada
    Orthopedics 36:e216-22. 2013
  4. doi request reprint Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 55:198-207. 2013
  5. pmc Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e46769. 2012
  6. doi request reprint Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
  7. doi request reprint PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone
    Robert W Cowan
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Orthop Res 30:877-84. 2012
  8. doi request reprint ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma
    Patricia F Power
    Department of Health Science Graduate Studies, McMaster University, Hamilton, Ontario, Canada
    J Orthop Res 31:493-501. 2013
  9. doi request reprint The role of TWIST as a regulator in giant cell tumor of bone
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Cell Biochem 112:2287-95. 2011
  10. pmc Collagenase expression and activity in the stromal cells from giant cell tumour of bone
    Robert W Cowan
    Faculty of Health Sciences, McMaster University and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Bone 44:865-71. 2009

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Outcomes of an anatomically based approach to metastatic disease of the acetabulum
    Michelle Ghert
    McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Clin Orthop Relat Res 459:122-7. 2007
    ..Breast cancer as the primary malignancy and the absence of visceral metastases predicted longer survival...
  2. ncbi request reprint Properties of the stromal cell in giant cell tumor of bone
    Michelle Ghert
    McMaster University, Hamilton Health Sciences and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Clin Orthop Relat Res 459:8-13. 2007
    ..The spindle like stromal cells of GCT have characteristics of osteoblast progenitors and produce active matrix-degrading proteases. These cells may therefore play a central role in bone destruction...
  3. doi request reprint Use of a calcium sulfate-calcium phosphate synthetic bone graft composite in the surgical management of primary bone tumors
    Nathan Evaniew
    Department of Surgery, Division of Orthopaedics, McMaster University, Hamilton, Ontario, Canada
    Orthopedics 36:e216-22. 2013
    ..This technique is a viable option in the reconstruction of cavitary bone defects following intralesional curettage of primary benign bone tumors...
  4. doi request reprint Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 55:198-207. 2013
    ..Based on the data presented herein, we conclude that PTHrP excreted by GCT stromal cells increases bone tumor cell local invasiveness and migration...
  5. pmc Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e46769. 2012
    ..Our results indicate a significant role of FGFR-2 signaling in osteoblastic differentiation in GCT stromal cells...
  6. doi request reprint Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
    ..Future research will involve elucidation of the role of cell-cell/matrix communication pathways in bone resorption and tumorigenesis in GCT...
  7. doi request reprint PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone
    Robert W Cowan
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Orthop Res 30:877-84. 2012
    ..These results suggest that PTHrP is expressed within GCT by the stromal cells and can contribute to the abundant RANKL expression and giant cell formation within the tumor...
  8. doi request reprint ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma
    Patricia F Power
    Department of Health Science Graduate Studies, McMaster University, Hamilton, Ontario, Canada
    J Orthop Res 31:493-501. 2013
    ..This data suggests that ETV5 has a significant role in regulating MMP2 expression and therefore matrix resorption in human chondrosarcoma, and thus may be a targetable upstream effector of the metastatic cascade in this cancer...
  9. doi request reprint The role of TWIST as a regulator in giant cell tumor of bone
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Cell Biochem 112:2287-95. 2011
    ....
  10. pmc Collagenase expression and activity in the stromal cells from giant cell tumour of bone
    Robert W Cowan
    Faculty of Health Sciences, McMaster University and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Bone 44:865-71. 2009
    ..The spindle-like stromal cells from GCT may therefore actively participate in the bone destruction that is characteristic of the tumour...
  11. doi request reprint Chronology of the Radiographic Appearances of the Calcium Sulfate-Calcium Phosphate Synthetic Bone Graft Composite Following Resection of Bone Tumors: A Follow-up Study of Postoperative Appearances
    Victoria Tan
    Department of Diagnostic Imaging, McMaster University, Hamilton, Ontario, Canada Electronic address
    Can Assoc Radiol J 67:21-7. 2016
    ....
  12. doi request reprint A novel approach to patients with acute odontoid fractures: atlantoaxial instability as a prognostic variable
    Nathan Evaniew
    Division of Orthopaedics, Department of Surgery, McMaster University, 293 Wellington St N, Suite 110, Hamilton, Ontario, Canada L8L 8E7 Electronic address
    Spine J 15:1161-3. 2015
    ..Liu S, Liu L. Re: Evaniew N, Yarascavitch B, Madden K, Ghert M, Drew B, Bhandari M, et al. Atlantoaxial instability in acute odontoid fractures is associated with nonunion and mortality. Spine J 2015;15:1160 (in this issue)...
  13. pmc High infection rate outcomes in long-bone tumor surgery with endoprosthetic reconstruction in adults: a systematic review
    Antonella Racano
    Department of Surgery, McMaster University, Juravinski Hospital and Cancer Centre, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada
    Clin Orthop Relat Res 471:2017-27. 2013
    ..The risk of a postoperative infection developing is high when compared with conventional arthroplasty and there are no appropriate guidelines for antibiotic prophylaxis...
  14. doi request reprint Transcriptomic and proteomic analyses in bone tumor cells: Deciphering parathyroid hormone-related protein regulation of the cell cycle and apoptosis
    Isabella W Y Mak
    Department of Oncology, McMaster University, Hamilton, Ontario, Canada
    J Bone Miner Res 27:1976-91. 2012
    ....
  15. doi request reprint T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone
    Robert W Cowan
    Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St W, Hamilton, ON, Canada L8S 4L8
    Biochem Biophys Res Commun 419:719-23. 2012
    ..These results suggest that T cells may potentiate the catabolic effect of GCT...
  16. pmc PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e19975. 2011
    ..Thus PTHrP neutralizing immunotherapy is an intriguing potential therapeutic strategy for this tumor...
  17. doi request reprint Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 45:377-86. 2009
    ..Our study provides the first evidence that Runx2 may play a crucial role in cytokine-mediated MMP-13 expression in GCT stromal cells...
  18. ncbi request reprint A Translational Study of the Neoplastic Cells of Giant Cell Tumor of Bone Following Neoadjuvant Denosumab
    Isabella W Y Mak
    Departments of Surgery I W Y M, N E, and M G, Pathology and Molecular Science S P, and Oncology R T, McMaster University, 711 Concession Street, Hamilton, ON L8V 1C3, Canada E mail addresses for I W Y Mak E mail address for N Evaniew E mail address for S Popovic E mail address for R Tozer E mail address for M Ghert
    J Bone Joint Surg Am 96:e127. 2014
    ..However, no studies have yet examined the viability and functional characteristics of tumor cells following denosumab treatment...
  19. pmc What are the levels of evidence on which we base decisions for surgical management of lower extremity bone tumors?
    Nathan Evaniew
    Division of Orthopaedics, Department of Surgery, McMaster University, 293 Wellington Street North, Suite 110, Hamilton, ON, L8L 8E7, Canada
    Clin Orthop Relat Res 472:8-15. 2014
    ..Observational studies are prone to confounding bias, sampling bias, and recall bias...
  20. doi request reprint Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin
    Nazihah Bakhtyar
    Division of Nephrology, Department of Medicine, St Joseph s Hospital, Hamilton, Ontario, Canada Department of Surgery, McMaster University, St Joseph s Hospital, Hamilton, Ontario, Canada Father Sean O Sullivan Research Institute, St Joseph s Hospital, Hamilton, Ontario, Canada The Hamilton Center for Kidney Research, St Joseph s Hospital, Hamilton, Ontario, Canada
    Eur J Cancer 49:3537-46. 2013
    ..Increase in periostin (PN) was reported in clear cell renal cell carcinoma (ccRCC). But how PN contributes to ccRCC pathogenesis remains unclear. This research will investigate the underlying mechanism...
  21. doi request reprint The orthopaedic in-training examination: perspectives of program directors and residents from the United States and Canada
    Nathan Evaniew
    Division of Orthopaedic Surgery, McMaster University, Hamilton, Ontario, Canada
    J Surg Educ 70:528-36. 2013
    ....
  22. pmc AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, ON, Canada L8S 4L8
    Biochem Res Int 2011:164197. 2011
    ..We conclude that there was no synergy found between RUNX2 and AP-1 in the regulation of the MMP13 expression and that these transcription factors may be independently regulated in these cells...
  23. doi request reprint Cancer cell lines release glutamate into the extracellular environment
    Eric P Seidlitz
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Exp Metastasis 26:781-7. 2009
    ....
  24. pmc Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology
    Patricia Schneider
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMJ Open 6:e011780. 2016
    ..The primary objective of this study will be to use a consensus-based approach to identify research priorities for international clinical trials in orthopaedic oncology...
  25. doi request reprint Strategies to improve the credibility of meta-analyses in spine surgery: a systematic survey
    Nathan Evaniew
    McMaster University, Department of Surgery, Division of Orthopaedics, 293 Wellington St N, Hamilton ON, Canada, L8L 8E7 Electronic address
    Spine J 15:2066-76. 2015
    ..These studies have become increasingly popular in the spine surgery literature, but the rigor with which they are being conducted has not yet been evaluated...
  26. doi request reprint Infrapatellar fat pad osteochondroma: three cases and a systematic review
    Nathan Evaniew
    Department of Surgery, Center for Evidence Based Orthopaedics, McMaster University, Hamilton, Ontario, Canada
    J Knee Surg 28:229-38. 2015
    ..Para-articular extraskeletal osteochondromas of the infrapatellar fat pad have a benign clinical history regardless of whether they are managed by arthroscopic or open marginal excision. ..
  27. doi request reprint The fragility of statistically significant findings from randomized trials in spine surgery: a systematic survey
    Nathan Evaniew
    Division of Orthopaedics, Department of Surgery, McMaster University, Hamilton, Ontario, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada Electronic address
    Spine J 15:2188-97. 2015
    ..The Fragility Index is a novel metric to inform about the robustness of statistically significant results...
  28. doi request reprint The epigenetic regulation of SOX9 by miR-145 in human chondrosarcoma
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada Department of Surgery, Juravinski Cancer Centre, Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Cell Biochem 116:37-44. 2015
    ....
  29. doi request reprint Atlantoaxial instability in acute odontoid fractures is associated with nonunion and mortality
    Nathan Evaniew
    Division of Orthopaedics, Department of Surgery, McMaster University, 293 Wellington St N, Suite 110, Hamilton, Ontario, Canada L8L 8E7 Electronic address
    Spine J 15:910-7. 2015
    ..Nonunion rates have been reported to be up to 40% and mortality up to 35%, and poor functional outcomes are common. Atlantoaxial instability (AAI) is a plausible prognostic factor, but its role has not been previously examined...
  30. doi request reprint Vitamin C to Prevent Complex Regional Pain Syndrome in Patients With Distal Radius Fractures: A Meta-Analysis of Randomized Controlled Trials
    Nathan Evaniew
    Division of Orthopaedics, Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Orthop Trauma 29:e235-41. 2015
    ..To determine whether vitamin C is effective in preventing complex regional pain syndrome (CRPS) in patients with distal radius fractures...
  31. doi request reprint Intrawound vancomycin to prevent infections after spine surgery: a systematic review and meta-analysis
    Nathan Evaniew
    Division of Orthopaedics, Department of Surgery, McMaster University, Hamilton, ON, Canada
    Eur Spine J 24:533-42. 2015
    ..vancomycin lead to reduced rates of post-operative surgical site infections? (2) Are there differences in the estimates of effect between observational studies and randomized trials? (3) What adverse events are reported in the literature?..
  32. doi request reprint Surgical management of bone metastases: quality of evidence and systematic review
    Thomas J Wood
    Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Ann Surg Oncol 21:4081-9. 2014
    ....
  33. doi request reprint A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma
    Emad Al-Absi
    McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    Ann Surg Oncol 17:1367-74. 2010
    ..The goal of this study was to determine the oncologic outcomes in localized resectable soft-tissue sarcoma after pre- versus postoperative radiation...
  34. doi request reprint A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma
    Nabeel Pervaiz
    University of Waterloo, Waterloo, Ontario, Canada
    Cancer 113:573-81. 2008
    ..The objective of this systematic review was to update the 1997 meta-analysis of randomized controlled trials (RCTs) to reassess the efficacy of doxorubicin-based chemotherapy with respect to recurrence and survival...
  35. doi request reprint A systematic review and meta-analysis of intralesional versus wide resection for intramedullary grade I chondrosarcoma of the extremities
    Michael Hickey
    Department of Surgery, McMaster University, Hamilton, ON, Canada
    Ann Surg Oncol 18:1705-9. 2011
    ..The purpose of this study was to perform a systematic review and meta-analysis of published data to determine the oncologic outcomes of intralesional versus wide resection for grade I intramedullary chondrosarcoma...
  36. pmc Impact of research investment on scientific productivity of junior researchers
    Forough Farrokhyar
    Department of Surgery, McMaster University, Hamilton, ON, Canada
    Transl Behav Med 6:659-668. 2016
    ..Further efforts are recommended to enhance the support of small grant funding programs...
  37. pmc Prophylactic antibiotic regimens in tumor surgery (PARITY) survey
    Khaled Hasan
    Department of Surgery, McMaster University, Hamilton, ON, Canada
    BMC Musculoskelet Disord 13:91. 2012
    ....
  38. doi request reprint Intra-articular nodular fasciitis of the shoulder: a case report and review of the literature
    Srinivasan Harish
    Department of Radiology, McMaster University, Hamilton, ON, Canada
    Skeletal Radiol 40:1383-6. 2011
    ..The mass developed in the subscapularis recess of the shoulder and histological evaluation showed a myofibroblastic proliferation. MRI findings of intra-articular nodular fasciitis are discussed along with a review of previous reports...
  39. ncbi request reprint The use of free vascularized fibular grafts in skeletal reconstruction for bone tumors in children
    Michelle Ghert
    Division of Orthopaedic Surgery, McMaster University, Hamilton, ON, Canada
    J Am Acad Orthop Surg 15:577-87. 2007
    ..Specific techniques are applied in the upper and lower extremity to provide long-term excellent functional results. Experience in microvascular surgery and careful postoperative care are required for the success of these procedures...
  40. pmc A novel surgical approach to lipomatous tumours of the deltoid region
    Emad Al Absi
    Department of Surgery, McMaster University and Hamilton Health Sciences, Juravinski Cancer Center, Hamilton, Ontario, Canada L8V 5C2
    Sarcoma 2010:495834. 2010
    ..We conclude that patients with large sub-deltoid lipomatous tumours who undergo resection through a previously undescribed deltoid release and reinsertion technique have excellent functional outcome with a low risk for recurrence...
  41. doi request reprint Chronology of the radiographic appearances of the calcium sulphate-calcium phosphate synthetic bone graft composite following resection of bone tumours--a preliminary study of the normal post-operative appearances
    Nikhil A Kotnis
    Department of Radiology, McMaster University, Juravinski Hospital and Juravinski Cancer Center, Hamilton, ON, Canada
    Skeletal Radiol 40:563-70. 2011
    ....